The invention discloses a multi-cell large-scale MIMO interference elimination method based on antenna selection and interference alignment, and belongs to the technical field of mobile wireless communication. The method comprises the steps: enabling a base station to obtain a channel matrix, respectively calculating the norm of a column vector corresponding to each transmitting antenna, selecting the former Ns antennas with the maximum norms as active antennas, and turning off other antennas; enabling the columns vectors corresponding to the active antennas to serve as a new channel matrix, calculating the interference alignment precoding vector of each base station, calculating a receiving zero-forcing vector of each receiving end according to the interference alignment precoding vectors and the new channel matrix, and updating the receiving zero-forcing vectors based on transmitting power; finally enabling a current base station to generate transmission data corresponding to a receiving end based on the interference alignment precoding vector, the current receiving zero-forcing vector and the transmitting power of each data flow, and transmitting the transmission data. According to the embodiment of the invention, the method can reduce the calculation complexity, improves the transmission rate, and reduces the bit error rate.