The invention relates to the field of articles for daily life, and in particular relates to a toothbrush provided with a cleaning device. The toothbrush comprises a brush handle and a brush head, wherein the brush head comprises a brush head base and a plurality of brush bristle clusters positioned on the brush head base, and the brush bristle clusters are uniformly distributed; the toothbrush further comprises a cleaning device, the cleaning device is a cleaning head, the cleaning head comprises a cleaning handle, a cleaning base and a cleaning brush head, and the cleaning brush head is provided with the plurality of cleaning bristle clusters. According to the toothbrush, the food residues on the brush head can be cleaned, so that the cleanness of the brush head can be maintained; meanwhile, vent holes are designed, so that the aeration-drying of the brush head can be maintained, the water retention can be prevented, the bacteria bred due to the contact of the water and food are avoided, the breeding of the bacteria is effectively inhibited, and the tooth-brushing health and sanitation are guaranteed. The cleaning bristle clusters are provided with fine and soft bristles, so that the cleaning process is thorough, meanwhile, the cleaning area of the brush head is greatly increased, and therefore, the toothbrush has great market and economic prospects.