![一种异噁唑类化合物及其中间体的制备方法](/CN/2014/1/144/images/201410720121.jpg)
基本信息:
- 专利标题: 一种异噁唑类化合物及其中间体的制备方法
- 申请号:CN201410720121.3 申请日:2014-12-02
- 公开(公告)号:CN105712944B 公开(公告)日:2018-08-21
- 发明人: 苏叶华 , 史界平 , 陆建鑫 , 张天浩 , 蔡国平 , 虞小华 , 陈邦池
- 申请人: 浙江省诸暨合力化学对外贸易有限公司
- 申请人地址: 浙江省杭州市滨江区滨康路603号
- 专利权人: 浙江省诸暨合力化学对外贸易有限公司
- 当前专利权人: 浙江省诸暨合力化学对外贸易有限公司
- 当前专利权人地址: 浙江省杭州市滨江区滨康路603号
- 代理机构: 杭州求是专利事务所有限公司
- 代理人: 张法高
- 主分类号: C07D261/08
- IPC分类号: C07D261/08 ; C07C205/58 ; C07C201/12 ; C07C323/62 ; C07C319/14
Disclosed is a preparation method for an isoxazole compound and an intermediate thereof, the method comprising: a compound (I), as the starting material, is subjected to a substitution reaction with a compound (II) in the presence of a base, and subsequently to an oxidation reaction to prepare an intermediate acid (III); the intermediate acid (III) is methyl esterified to obtain an intermediate (IV); the intermediate (IV) is subjected to thionation to obtain an intermediate (VI); the intermediate (VI) is condensed with cyclopropyl methanone under a basic condition to obtain an intermediate (VIII); the intermediate (VIII) is subjected to alkene etherification reaction with ortho-formate and cyclized with hydroxylamine hydrochloride to obtain an intermediate (X); the methylthio of the intermediate (X) is oxidized by hydrogen peroxide to obtain isoxazole compound (XI). The starting material used in the present preparation method is readily available, and the preparation method has high productivity and purity, produces less industrial waste water, gas and residue, and has low cost and good industrial value.
公开/授权文献:
- CN105712944A 一种异噁唑类化合物及其中间体的制备方法 公开/授权日:2016-06-29
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D261/00 | 杂环化合物,含有1,2-唑环或氢化1,2-唑环 |
--------C07D261/02 | .不与其他环稠合 |
----------C07D261/06 | ..环原子间或环原子与非环原子间有两个或更多个双键 |
------------C07D261/08 | ...仅有氢原子、烃基或取代烃基直接连在环碳原子上 |