基本信息:
- 专利标题： 一种异噁唑类化合物及其中间体的制备方法
- 专利标题（英）：Preparation method of isoxazole compound and isoxazole compound intermediate
- 申请号：CN201410720121.3 申请日：2014-12-02
- 公开(公告)号：CN105712944A 公开(公告)日：2016-06-29
- 发明人： 苏叶华 , 史界平 , 陆建鑫 , 张天浩 , 蔡国平 , 虞小华 , 陈邦池
- 申请人： 浙江省诸暨合力化学对外贸易有限公司
- 申请人地址： 浙江省杭州市滨江区滨康路603号
- 专利权人： 浙江省诸暨合力化学对外贸易有限公司
- 当前专利权人： 浙江省诸暨合力化学对外贸易有限公司
- 当前专利权人地址： 浙江省杭州市滨江区滨康路603号
- 代理机构： 杭州求是专利事务所有限公司
- 代理人： 张法高
- 主分类号： C07D261/08
- IPC分类号： C07D261/08 ; C07C205/58 ; C07C201/12 ; C07C323/62 ; C07C319/14
The present invention discloses a preparation method of an isoxazole compound and an isoxazole compound intermediate. According to the method, an intermediate acid (III) is prepared by substitution reaction of a compound (I) as a raw material and a compound (II) in the presence of a base and then oxidation reaction; an intermediate (IV) is prepared by methyl esterification of the intermediate acid (III); an intermediate (VI) is prepared by thionation of the intermediate (IV); an intermediate (VIII) is prepared by condensation of the intermediate (VI) and cyclopropyl methyl ketone under basic conditions; an intermediate (X) is prepared by ene-etherification reaction of the intermediate (VIII) and ortho-formate and then cyclization with hydroxylamine hydrochloride; and the isoxazole compound (XI) is prepared by oxidation of methylthio groups of the intermediate (X) by hydrogen peroxide. Raw materials are readily available, yield is high, purity is high, three-waste is low, cost is low, and the preparation method has good industrial value.
公开/授权文献:
- CN105712944B 一种异噁唑类化合物及其中间体的制备方法 公开/授权日：2018-08-21
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D261/00 | 杂环化合物，含有1,2-唑环或氢化1,2-唑环 |
| --------C07D261/02 | .不与其他环稠合 |
| ----------C07D261/06 | ..环原子间或环原子与非环原子间有两个或更多个双键 |
| ------------C07D261/08 | ...仅有氢原子、烃基或取代烃基直接连在环碳原子上 |