![一种合成2-[2-(2,4-二氟苯基)烯丙基]-1,3-丙二酸二乙酯的方法](/CN/2016/1/4/images/201610022153.jpg)
基本信息:
- 专利标题: 一种合成2-[2-(2,4-二氟苯基)烯丙基]-1,3-丙二酸二乙酯的方法
- 专利标题(英):Method for synthesizing diethyl 2-[2-(2,4-difluorophenyl)allyl]-1,3-malonate
- 申请号:CN201610022153.5 申请日:2016-01-14
- 公开(公告)号:CN105622412A 公开(公告)日:2016-06-01
- 发明人: 骆成才 , 危凤 , 库拉里
- 申请人: 宁波新凯生物科技有限公司
- 申请人地址: 浙江省宁波市高新区菁华路188号2幢1048室
- 专利权人: 宁波新凯生物科技有限公司
- 当前专利权人: 天圣制药集团股份有限公司
- 当前专利权人地址: 浙江省宁波市高新区菁华路188号2幢1048室
- 代理机构: 宁波市鄞州甬致专利代理事务所
- 代理人: 沈春红
- 主分类号: C07C67/343
- IPC分类号: C07C67/343 ; C07C69/65
The invention relates to a method for synthesizing diethyl 2-[2-(2,4-difluorophenyl)allyl]-1,3-malonate. The method comprises the following steps: dropwisely adding 1,2,3-trichloropropane into 1,3-difluorobenzene, adding aluminum trichloride, extracting and washing; drying with anhydrous Na2SO4, filtering, evaporating to obtain 1,3-dichloro-2-(2,4-difluorophenyl)propane, adding the 1,3-dichloro-2-(2,4-difluorophenyl)propane and potassium hydroxide into an alcohol, and refluxing; removing the alcohol, adding ice water, neutralizing with hydrochloric acid at 5 to -5 DEG C, extracting with dichloromethane three times, drying with anhydrous Na2SO4, filtering, adding the obtained 1-chloro-2-(2,4-difluorophenyl)-3-propanol and potassium hydrogen sulfate into chlorobenzene, and heating under reflux; washing with water to a neutral state, drying with anhydrous Na2SO4, filtering to obtain 1-(1-chloromethylvinyl)-2,4-difluorobenzene, dissolving the 1-(1-chloromethylvinyl)-2,4-difluorobenzene in DMSO (dimethyl sulfoxide), adding diethyl malonate and hydroxide to react, extracting, washing, and carrying out reduced pressure distillation to obtain the target product. The synthesis route is disclosed in the specification.
公开/授权文献:
- CN105622412B 一种合成2-[2-(2,4-二氟苯基)烯丙基]-1,3-丙二酸二乙酯的方法 公开/授权日:2017-11-24
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C67/00 | 羧酸酯的制备 |
--------C07C67/28 | .改变酯中的羟基部分,这种改变不是引进酯基 |
----------C07C67/317 | ..裂解氢或官能团;官能团的氢解 |
------------C07C67/343 | ...增加碳原子数 |