The invention discloses a purple sweet potato lily persimmon leaf health-care wine, which is prepared from the following raw materials by weight part: 30-34 of fresh and tender persimmon leaf, 54-56 of purple sweet potato, 14-15 of dried tangerine peel slice, 26-28 of lily, 34-36 of Artocarpus heterophyllus Lam, 28-30 of Lablab purpureus, 3-3.2 of fructus arctii, 3-3.2 of Suberect Spatholobus Stem, 2.7-2.9 of hibiscus, 18-20 of medical stone, a proper amount of wine brewing dry yeast, 103-105 of white granulated sugar and a proper amount of water. The persimmon leaf wine provided by the invention not only has abundant processing raw materials, rich nutrition, delicious taste, but also improves the content of flavone in persimmon leaf extract during processing, at the same time the fructus arctii, Suberect Spatholobus Stem, hibiscus and other Chinese herbal medicines involved in the processing process make the processed wine have better health preserving and health care efficacy and higher nutritional value.