The present invention discloses a zone area reasonable line loss prediction method based on a data mining technology. The beneficial effects of the present invention are that: the method of the present invention aims to discover the potential correlation between the zone area characteristic data and the zone area line loss by using the actual sampling data of the zone area line loss and utilizing a data mining means to process the mass data, is reliable in data source by being compared with a conventional theoretical line loss calculation method, and can reflect the on-site actual line loss status better; the algorithm flow is simple and practical, and the efficiency is higher; a multiple linear regression model is compact in structure, can reflect the influence degrees of the characteristic parameters to the zone area line loss visually, and is easy to analyze the status of a zone area of unreasonable line loss; the method is easy for software realization, and can be integrated in a line loss management system more conveniently.