The invention relates to a multifunctional cooling box which comprises a sealing box body with a front door. The box body is provided with an inner container. The inner container comprises a top portion, a bottom portion, a first side wall, a second side wall and a rear wall. The inner side of the top portion, the inner side of the bottom portion, the inner side of the first side wall, the inner side of the second side wall and the inner side of the rear wall of the inner container are provided with ventilation plates. Each ventilation plate is provided with a plurality of ventilation holes. The multifunctional cooling box further comprises cooling assemblies, a condenser and a compressor. The cooling assemblies are arranged between the ventilation plates and the inner container. The cooling assemblies are communicated with the condenser and the compressor. The multifunctional cooling box further comprises a water supply device. The water supply device is connected with the condenser. The size and direction of the ventilation holes are adjusted in an alternate mode through side plates movably arranged on the two sides to enable air flow to be evenly distributed in the box, the cooling and air drying effects are better, the cooling and air drying costs are lowered, heat in the multifunctional cooling box is recycled through the water supply device and reused, and the energy loss is lowered.