The invention discloses a primary and secondary module unit combination structure of high-rise module building space. The structure comprises main module units and secondary module units which are scientifically combined on the plane and in the space to form an integral combination structure system. The main module units are main weight bearing structures and bear the weight of the main module units and the secondary module units, a lateral force resistance support structure is arranged each the main module unit, and an effect of effectively resisting wind and earthquakes is achieved. The secondary module units only bear self weight and transfer vertical force and horizontal action to the main module units through relative connection. The secondary module units are often arranged between the main module units, connection node plates are reserved on main module unit frame columns, every two main modules are connected through a connection steel beam, the connection steel beams and the like are utilized as an operation platform to weld frame columns of the main module units on two sides into a whole, then the secondary module units are arranged on the connection steel beams, and the secondary module units can be arranged every two layers or layer by layer to form the integral structure with the main module units.