The invention provides sequence distribution in a communication system, a processing method and a corresponding device. Sequences in each sequence group are divided into a plurality of sub groups; sequences in each sub group are selected from a candidate sequence set corresponding to the sub group according to certain rules; a system enables determined sequences to be distributed to cells, as for a sub group i, a function fi (.) corresponding to the sub group is determined, and a definitional domain of the function is the candidate sequence set corresponding to the sub group; and sequences of the sub group i in a sequence group k are selected from and determined by n sequences, which enable a value of a function d(fi(.), Gk) to be smaller, of the candidate sequence set, wherein the k is a group number of the sequence group, the i is a serial number of the sub group, the n is a natural number, d (a, b) is a function of two variables, and the Gk is a quantity determined by the group number k. A situation that the sequence relative to sequence strength in a certain length occurs in other sequence groups is avoided, strong interference is accordingly reduced, a form for storing large-scale sequence groups is not needed, and system complexity is reduced.