基本信息:
- 专利标题： 一种青蒿素的高效合成方法
- 专利标题（英）：High-efficiency synthesis method of artemisinin
- 申请号：CN201310100682.9 申请日：2012-06-05
- 公开(公告)号：CN103172645A 公开(公告)日：2013-06-26
- 发明人： 张万斌 , 刘德龙 , 袁乾家
- 申请人： 上海交通大学
- 申请人地址： 上海市闵行区东川路800号
- 专利权人： 上海交通大学
- 当前专利权人： 上海交通大学
- 当前专利权人地址： 上海市闵行区东川路800号
- 代理机构： 上海汉声知识产权代理有限公司
- 代理人： 郭国中
- 分案原申请号： 2012101815617 2012.06.05
- 主分类号： C07D493/20
- IPC分类号： C07D493/20
The invention discloses a high-efficiency synthesis method of artemisinin. The method comprises the following steps of: enabling dihydroartemisinic acid to be subjected to carboxyl protection so as to obtain a dihydroartemisinic acid derivative, and oxidizing the dihydroartemisinic acid derivative into a corresponding peroxidized dihydroartemisinic acid derivative by peroxide in the presence of a catalyst, thus obtaining a target product, namely artemisinin, in a high-yield manner under the catalysis of acid and the action of oxygen gas. Compared with the prior art, the method has the following advantages that applied reagents are cheap and easily available, a synthesis route is short, the reaction selectivity is high, the preparation process is environment-friendly, the operation and after-treatment are simple, and the overall yield is high, thereby being applicable to industrial production.
公开/授权文献:
- CN103172645B 一种青蒿素的高效合成方法 公开/授权日：2015-05-20
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D493/00 | 杂环化合物，在稠环系中含有氧原子作为仅有的杂环原子 |
| --------C07D493/02 | .在稠环系中含有两个杂环 |
| ----------C07D493/20 | ..螺稠合系 |