The invention relates to strontium ranelate orally disintegrating tablets and a preparation method of the tablets. The strontium ranelate orally disintegrating tablets are characterized in that the strontium ranelate orally disintegrating tablets are prepared from the following components by mass: 1-2 parts of strontium ranelate, 0.5-2 parts of filler, 0.1-0.5 parts of disintegrant, 0.02-0.2 parts of corrective, and 0.02-0.2 parts of lubricant. The preparation method comprises the following steps: sieving strontium ranelate, filler, corrective and lubricant, and mixing in a mixing machine; and selecting a proper mold, and tableting with a tableting machine to obtain strontium ranelate orally disintegrating tablets. Compared with the existing preparation, the strontium ranelate orally disintegrating tablets prepared using the method of the invention is more suitable for patients to take, increases the compliance of patients, and has the adavntages of rapid absorption, high bioavailability and the like in addition to convenience in administration. Therefore, the development of this project can obtain wide social and economic benefits.