![控制蝶酸含量的叶酸生产方法](/CN/2011/1/58/images/201110290885.jpg)
基本信息:
- 专利标题: 控制蝶酸含量的叶酸生产方法
- 专利标题(英):Folic acid production method for controlling content of technical pteroic acid
- 申请号:CN201110290885.X 申请日:2011-09-29
- 公开(公告)号:CN102432610A 公开(公告)日:2012-05-02
- 发明人: 刘晓莲 , 徐亚威 , 马胜义 , 贾树红 , 张志强 , 陈剑芳 , 刘向军 , 蔡颂公 , 辛秀彪 , 张磊
- 申请人: 河北冀衡(集团)药业有限公司
- 申请人地址: 河北省衡水市建设北大街368号
- 专利权人: 河北冀衡(集团)药业有限公司
- 当前专利权人: 河北冀衡(集团)药业有限公司
- 当前专利权人地址: 河北省衡水市建设北大街368号
- 代理机构: 北京五洲洋和知识产权代理事务所
- 代理人: 刘春成; 张向琨
- 主分类号: C07D475/04
- IPC分类号: C07D475/04
The invention provides a folic acid production method for controlling the content of technical pteroic acid and is characterized in that the folic acid production method comprises the following processing steps of: a crude product production step of using an intermediate for the folic acid production to prepare a folic acid crude product; an acid dissolution step of dissolving the folic acid crude product in an acid dissolution elutriation container by using a dilute sulfuric acid solution with the concentration of 25%-35% and carrying out elutriation and press filtration on the dissolved folic acid crude product to obtain an acid extract; an alkali dissolution and refining step of carrying out alkali dissolution on the acid extract by using alkali lye to obtain an alkali dissolution filtrate and refining the alkali dissolution filtrate for salt formation by using dilute acid so as to obtain the folic acid finished product. By reducing the concentration of dilute sulfuric acid, folic acid (the content of impurity technical pteroic acid is less than or equal to 0.6%) which accords with the requirement of European pharmacopeia is produced, and the production cost of folic acid is reduced.
公开/授权文献:
- CN102432610B 控制蝶酸含量的叶酸生产方法 公开/授权日:2013-07-31
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07D | 杂环化合物 |
------C07D475/00 | 含蝶啶环系的杂环化合物 |
--------C07D475/02 | .有1个氧原子直接连在位置4 |
----------C07D475/04 | ..有1个氮原子直接连在位置2 |