基本信息:
- 专利标题： 花生四烯酸作为黄嘌呤氧化酶抑制剂的用途及在制备治疗高尿酸血症或痛风药物中的应用
- 专利标题（英）：Application of arachidonic acid as xanthine oxidase inhibitor and in preparation of medicines for treating hyperuricemia or gout
- 申请号：CN201110008531.1 申请日：2011-01-14
- 公开(公告)号：CN102133214A 公开(公告)日：2011-07-27
- 发明人： 王昌禄 , 李亚迪 , 陈勉华 , 李风娟 , 王玉荣
- 申请人： 天津科技大学
- 申请人地址： 天津市塘沽区经济技术开发区十三大街29号
- 专利权人： 天津科技大学
- 当前专利权人： 山东新瑞生物科技有限公司
- 当前专利权人地址： 天津市塘沽区经济技术开发区十三大街29号
- 代理机构： 天津盛理知识产权代理有限公司
- 代理人： 王来佳
- 主分类号： A61K31/202
- IPC分类号： A61K31/202 ; A61P19/06
The invention relates to application of arachidonic acid as a xanthine oxidase inhibitor and in the preparation of medicines for treating hyperuricemia or gout. Xanthine oxidase is a key enzyme for the generation and the development of the hyperuricemia or the gout, most substrates of the xanthine oxidase are cyclic small molecules, and the arachidonic acid is long chain polyunsaturated fatty acid; a three dimensional structure of the xanthine oxidase is downloaded from a protein data bank (PDB) of a website; a three dimensional structure of the arachidonic acid is downloaded from a pubchem; molecular docking between the arachidonic acid and the xanthine oxidase is performed by iGEMDOCK software and docking energy is computed; and in-vitro enzyme activity tests prove that the arachidonic acid has an inhibition effect on the xanthine oxidase. By the application, another important physiological function of the arachidonic acid is discovered, and a wider way is provided for screening the xanthine oxidase inhibitor from a natural product to treat the hyperuricemia or the gout simultaneously.
公开/授权文献:
- CN102133214B 花生四烯酸作为黄嘌呤氧化酶抑制剂的用途及在制备治疗高尿酸血症或痛风药物中的应用 公开/授权日：2012-04-11
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/19 | ..羧酸；例如丙戊酸 |
| ------------A61K31/195 | ...含氨基的 |
| --------------A61K31/202 | ....含3个或3个以上双键的，例如亚麻酸 |