The invention provides a safety self-destruction syringe, belonging to the technical field of medical apparatuses and instruments and solving the problem that a patient feels very pain when the traditional syringe is used for injecting the patient. The safety self-destruction syringe comprises an injection cylinder, an injection rod, a rubber plug and a cylindrical needle head holder, wherein the rubber plug is fixedly connected to the front part of the injection rod, the needle head holder is connected to the inner side of the front end of the injection cylinder, the front part of the injection rod is provided with a rod head penetrating through the rubber plug and extending out of the rubber plug, the end part of the rod head is provided with a positioning piece, the inner wall of the needle head seat is provided with a convex body, when the rod head is inserted into the needle head holder, the positioning piece passes through the convex body by utilizing the positioning piece per se or the elasticity of the convex body and ensures that the positioning piece and the convex body form a clamping structure, and the clamping structure has the function of preventing the rod head from exiting the needle head holder. The invention has the advantages of reasonable design, capability of effectively lightening the pain of the patient during the operation, and the like.