基本信息:
- 专利标题： 用于治疗疾病的取代的炔属化合物
- 专利标题（英）：Substituted acetylenic compounds useful for the treatment of diseases
- 申请号：CN200780034414.4 申请日：2007-08-16
- 公开(公告)号：CN101516360A 公开(公告)日：2009-08-26
- 发明人： 梁锡福 , T·霍耶 , J·芬肖尔特 , S·E·阿韦 , B·诺雷马克
- 申请人： 利奥制药有限公司
- 申请人地址： 丹麦巴勒鲁普
- 专利权人： 利奥制药有限公司
- 当前专利权人： 利奥制药有限公司
- 当前专利权人地址： 丹麦巴勒鲁普
- 代理机构： 北京市中咨律师事务所
- 代理人： 黄革生; 林柏楠
- 优先权： 60/838,380 2006.08.18 US
- 国际申请： PCT/DK2007/000375 2007.08.16
- 国际公布： WO2008/019690 EN 2008.02.21
- 进入国家日期： 2009-03-17
- 主分类号： A61K31/137
- IPC分类号： A61K31/137 ; A61K31/381 ; A61K31/4045 ; A61K31/357 ; C07C211/30 ; C07C215/24 ; C07C215/28 ; C07C229/30 ; C07C255/58 ; C07D209/20 ; C07D231/38 ; C07D317/58 ; C07D333/58 ; C07F7/08 ; C07F7/18
The invention relates to novel compounds according to formula Ia and Ib; (Formula Ia and Ib) wherein A represents substituted or unsubstituted C1-10heteroaryl, C6-14aryl or C6- 10heterocycloalkylaryl; R1 is C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C3-6 cycloalkyl, or C1-6heterocycloalkyl, each of which are optionally substituted; X represents -CR3R4-(CR5R6)n-(CR7=CR8)m-(C6-14aryl)r-(C1-10heteroaryl)s-(CR9R10)p- (CR11 = CR12)q, R2 represents C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C1-6hydroxyalkyl, C1-6haloalkyl, C1-6amino, C1-12alkylsilyl, C6-30alkylarylsilyl, C1-10heteroaryl, C6-14aryl, C1-10heterocycloalkyl, C1-10heterocycloalkenyl, C1-8cycloalkyl, C1-18cycloalkenyl, each of which is optionally substituted, or R2 represents hydrogen, carboxy, or hydroxy; or a pharmaceutically acceptable salt, solvate, or ester thereof; to processes for the preparation thereof, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, wherein said compounds being useful, e.g. in the treatment of diseases associated with disturbances of CaSR activity, such as hyperparathyroidism.
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/135 | ..有芳环的，例如美沙酮 |
| ------------A61K31/137 | ...芳基烷基胺，例如苯丙胺、肾上腺素、沙丁胺醇、麻黄碱 |