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1. 发明申请

WO2022190066A1 FLOW MODULE SELECTOR 审中-公开
公开(公告)号：WO2022190066A1
公开(公告)日：2022-09-15
申请号：PCT/IB2022/052224
申请日：2022-03-11
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： IYER, Ravi , KUCHER, Andrew , NEYER, David , ROUSHALL, Randy , VAN SOEST, Remco , YANG, Hao
IPC分类号： G01N30/32 , G01N30/24 , G01N30/72 , G01N30/20 , G01N30/34
摘要： In one aspect, a system for adjusting flow rate of at least one mobile phase delivered to a liquid chromatography (LC) column is disclosed, which includes a first plurality of pre-calibrated flow modules each configured to receive a first mobile phase at an inlet port thereof and to provide a pre-calibrated range of output flow rates of said first mobile phase at its outlet port, wherein said first plurality of flow modules are configured to provide different ranges of output flow rates of said first mobile phase, and a first selector valve in fluid communication with said first plurality of pre-calibrated flow modules for selecting among said first plurality of pre-calibrated flow modules for selective delivery of said first mobile phase to said LC column, thereby adjusting the flow rate of the first mobile phase delivered to said LC column.

2. 发明申请

WO2022127925A1 一种液相合成自动监测系统审中-公开
公开(公告)号：WO2022127925A1
公开(公告)日：2022-06-23
申请号：PCT/CN2021/139389
申请日：2021-12-18
申请人：北京大学
发明人：叶新山 , 姚文龙 , 熊德彩
IPC分类号： G01N1/14 , G01N30/06 , G01N30/20
摘要：一种液相合成自动监测系统，包括：反应器（1）、取样模块（2）、动力模块（3）、监测分析模块（4）和上位机（5 ）；取样模块（2）与动力模块（3）的管路连接；动力模块（3）监测分析模块(4)的管路连接；取样模块(2)、动力模块(3)和监测分析模块(4)均与上位机(5)电连接；取样模块(2)用于吸取新型反应器(1)中盛装的反应溶液；动力模块(3)用于根据上位机(5)中的吸取指令为取样模块(2)提供吸取力，并用于将吸取的反应溶液注入监测分析模块(4)中；监测分析模块(4)用于根据反应溶液生成监测报告后，将监测报告传输给上位机(5)；上位机(5)根据监测报告生成分析结果。以上结构设置，能够实现对反应溶液的自动取样、进样、监测和报告分析，进而提高实验监测效率、降低实验操作投入的人力成本。

3. 发明申请

WO2022073121A1 INJECTION MODULE 审中-公开
公开(公告)号：WO2022073121A1
公开(公告)日：2022-04-14
申请号：PCT/CA2021/051403
申请日：2021-10-06
申请人： 2287225 ALBERTA LTD.
发明人： JOHNSTON, Darren , CULLEN, Mark , MACNEIL, Tara
IPC分类号： G01N30/22 , B01D15/14 , G01N30/16 , G01N30/20
摘要： An injection module having an injection valve and a restriction tubing permitting fluid flow from the injection valve to a column. The injection valve having a sample inlet port, a mobile phase inlet port, a waste port, a column port and a sample loop. The restriction tubing having a valve end coupled to the column port, and a column end configured for coupling to a column; wherein the restriction tubing is configured for reducing separation of a sample into a gas phase and a liquid phase when the injection valve permits fluid flow from the injection valve to the column. The injection module can be used for analysis of samples having multiple phases, and is attachable to a gas chromatogram (GC). Also disclosed is a method for analyzing a sample having multiple phases, a GC having the injection module and a system having the injection module.

4. 发明申请

WO2022005950A1 CHROMATOGRAPHIC DIMENSION SELECTION IN MULTIDIMENSIONAL LIQUID CHROMATOGRAPHY 审中-公开
公开(公告)号：WO2022005950A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/039337
申请日：2021-06-28
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： FOGWILL, Michael O.
IPC分类号： G01N30/46 , B01D15/18 , G01N2030/027 , G01N2030/202 , G01N2030/326 , G01N30/20 , G01N30/32 , G01N30/468 , G01N30/7233 , G01N30/74
摘要： A system capable of performing both single and multidimensional liquid chromatography includes a solvent delivery system, a sample injection system, a first dimension column path configured to perform a separation process in a first dimension, a second dimension column path configured to perform a separation process in a second dimension that is different than the first dimension, a valve system; and a sample injection system fluidically connected to the valve system. The valve system is configured to direct flow from a sample injection system to a first dimension column path when the valve system is in a first position, and to direct flow from the sample injection system to the second dimension column path without the flow path flowing through the first dimension column path in the chromatography system when the valve system is in a second position.

5. 发明申请

WO2021133646A1 SAMPLE METERING AND INJECTION FOR LIQUID CHROMATOGRAPHY 审中-公开
公开(公告)号：WO2021133646A1
公开(公告)日：2021-07-01
申请号：PCT/US2020/065802
申请日：2020-12-18
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： BURNETT, Joshua, A. , SOLOW, Rose , SIMPSON, David, A.
IPC分类号： G01N30/20 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N30/24 , G01N30/36
摘要： Described are a method and a fluidic network for acquiring and injecting a chromatographic sample into a chromatography system flow. The fluidic network includes a metering pump module 60, a sample needle 50, a needle seal 52 and an injection valve48. The metering pump module includes a metering pump and a pressure transducer in serial fluidic communication. When the injection valve 48 is in a first valve state, the injection valve is configured to fluidically terminate ports of the metering pump module 60. When the injection valve 48 is in a second valve state, the injection valve is configured to fluidically couple a fluidic path that includes the metering pump module 60 and sample needle 50 into the system flow of a chromatography system without resulting in a substantial change in the pressure of the system flow.

6. 发明申请

WO2020074863A1 SYSTEM AND METHOD FOR ANALYSING THE COMPOSITION OF A QUENCHED FLOW REACTION LIQUID 审中-公开
公开(公告)号：WO2020074863A1
公开(公告)日：2020-04-16
申请号：PCT/GB2019/052818
申请日：2019-10-07
申请人： APPLIED PHOTOPHYSICS LIMITED
发明人： COLE, Dr Lindsay John
IPC分类号： G01N33/68 , G01N30/06 , G01N30/88 , G01N30/72 , G01N30/20
摘要： The present invention relates to a system for analysing the composition of a quenched flow reaction liquid comprising a quenched flow reactor, and a high performance liquid chromatography (HPLC) apparatus; wherein the quenched flow reactor is in fluid communication with the HPLC apparatus.

7. 发明申请

WO2018105076A1 流体クロマトグラフ审中-公开
公开(公告)号：WO2018105076A1
公开(公告)日：2018-06-14
申请号：PCT/JP2016/086474
申请日：2016-12-08
申请人：株式会社島津製作所
发明人：山本　慎太郎
IPC分类号： G01N30/20 , G01N30/02
摘要：流体クロマトグラフでは、計量ポンプをサンプリング流路の基端側に接続するサンプリング状態、移動相送液部をサンプリング流路の基端側に接続するとともにニードルポートと分析流路との間を接続する全量導入状態、計量ポンプをサンプリング流路の基端側に接続するとともにニードルポートと第２サンプルループとの間を接続する注入状態、及び移動相送液部をサンプルループの一端側に接続するとともに分析流路をサンプルループの他端側に接続するループ導入状態のいずれかの状態に切り替えるように構成された流路切替部を備えている。

8. 发明申请

WO2017070154A3 SYSTEMS, METHODS AND DEVICES FOR CROSS-STREAM INJECTION CHROMATOGRAPHY 审中-公开
标题翻译：用于横流注射层析的系统，方法和装置
公开(公告)号：WO2017070154A3
公开(公告)日：2017-04-27
申请号：PCT/US2016/057612
申请日：2016-10-19
申请人： WATERS TECHNOLOGIES CORPORATION
发明人： TARAFDER, Abhijit
IPC分类号： G01N30/16 , G01N30/20 , G01N30/22 , G01N30/38
摘要： A significant reduction in extra-column band broadening can be achieved by decoupling the injection system from the main solvent flow line. Systems and methods for such decoupling can allow for the injection of larger volumes of sample without compromising separation yield, increase the column loading per batch, and increase the overall yield of separations. For example, a mixture of co-solvent and sample can be prepared separately from the main flow of mobile phase and co-solvent (e.g., a mixture of CO 2 and methanol), loaded onto an injection loop, and then injected directly into the main flow of mobile phase and co-solvent before the chromatography column.
摘要翻译：通过将注入系统与主溶剂流动管线分离，可以实现柱外带宽加宽的显着减少。用于这种分离的系统和方法可以允许注入更大体积的样品，而不会影响分离收率，增加每批色谱柱的装载量，并提高分离的总收率。例如，共溶剂和样品的混合物可以与流动相和共溶剂（例如，CO 2和甲醇的混合物）的主流分开制备，加载到注射回路中然后在色谱柱前直接注入流动相和共溶剂主流中。

9. 发明申请

WO2016107809A1 VALVE MANIFOLDS FOR SIMULATED MOVING BED CHROMATOGRAPHY 审中-公开
标题翻译：用于模拟移动床色谱的阀门模块
公开(公告)号：WO2016107809A1
公开(公告)日：2016-07-07
申请号：PCT/EP2015/081179
申请日：2015-12-23
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： GEBAUER, Klaus , OLOVSSON, Bjorn, Markus
IPC分类号： G01N30/20 , B01D15/18 , G01N30/88 , G01N30/42
CPC分类号： B01D15/1842 , G01N30/20 , G01N30/42 , G01N30/88 , G01N2030/205 , G01N2030/8881
摘要： Disclosed is a device for chromatographic separations comprising: a manifold comprising a manifold body defining an elongate central duct, the central duct comprising a centrally- located closable duct valve providing selective fluid communication between a first portion of the central duct and an opposed second portion of the central duct, a first plurality of connectors, each connector of the first plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; a second plurality of connectors, each connector of the second plurality of connectors for connecting to a distinct chromatographic separation column and/or feed or extraction tubing or to a connector of an adjacent manifold; wherein said manifold body further defines: a first plurality of branch ducts, each branch duct of which extending from the first portion of the central duct to an individual one of the first plurality of connectors, each of the branch ducts of the first plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the first portion of the central duct, a second plurality of branch ducts, each branch duct of which extending from the second portion of the central duct to an individual one of the second plurality of connectors, each of the branch ducts of the second plurality of branch ducts comprising a closable branch valve providing selectable fluid communication between a respective connector and the second portion of the central duct; first and second ports in fluid communication with the centrally- located closable duct valve wherein said first port communicates with said first portion of the central duct and said second port communicates with said second portion of said central duct, wherein one of said first and second ports is further positioned to communicate with said central duct at a location between the centrally-located closable duct valve and the first and second plurality of branch ducts, respectively.
摘要翻译：公开了一种用于色谱分离的装置，包括：歧管，其包括限定细长中心管道的歧管主体，所述中心管道包括位于中心的可闭合管道阀，所述歧管主体在中心管道的第一部分和相对的第二部分之间提供选择性流体连通所述中心管道，第一多个连接器，所述第一多个连接器中的每个连接器用于连接到不同的色谱分离柱和/或进料或提取管道或相邻歧管的连接器; 第二多个连接器，第二多个连接器的每个连接器，用于连接到不同的色谱分离柱和/或进料或提取管道或相邻歧管的连接器; 其中所述歧管主体还限定：第一多个分支管道，其每个分支管道从中心管道的第一部分延伸到第一多个连接器中的单独的一个连接器，第一多个分支中的每个分支管道管道包括可关闭的分支阀，其在相应的连接器和中心管道的第一部分之间提供可选择的流体连通，第二多个分支管道，每个分支管道从中心管道的第二部分延伸到第二多个连接器，第二多个分支管道的每个分支管道包括可闭合的分支阀，其在相应的连接器和中心管道的第二部分之间提供可选择的流体连通; 第一和第二端口与中心定位的可关闭管道阀流体连通，其中所述第一端口与中心管道的所述第一部分连通，并且所述第二端口与所述中心管道的所述第二部分连通，其中所述第一和第二端口进一步定位成分别在位于中心位置的可关闭管道阀和第一和第二多个分支管道之间的位置处与所述中心管道连通。

10. 发明申请

WO2016082154A1 一种液相色谱仪审中-公开
公开(公告)号：WO2016082154A1
公开(公告)日：2016-06-02
申请号：PCT/CN2014/092379
申请日：2014-11-27
申请人：王峰
发明人：王峰
IPC分类号： G01N30/02 , G01N30/20 , G01N30/88
CPC分类号： G01N1/34 , B01D15/163 , B01D15/426 , G01N30/20 , G01N30/40 , G01N30/463 , G01N30/465 , G01N30/6039 , G01N30/88 , G01N35/1097 , G01N2030/027 , G01N2030/402
摘要：一种具有在线清洗功能的液相色谱仪，包括第一流道（L3）、第二流道（L21）、分析流道（L22）、废液流道、清洗流道（L25）、方向切换阀（V1）和多流道切换阀（V2）等。液相色谱仪通过改变各二位切换阀之间的连通关系，从而改变液体流路，分别实现了对第一色谱柱（C1）、中间色谱柱（C2）、过滤器或者保护器（B2）的在线清洗功能，并且可以同时对第一色谱柱（C1）和中间色谱柱（C2）进行在线清洗。

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