专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2023049365A1 MATRICES AND SYSTEMS FOR PRESERVATION OF BIOMOLECULES IN VACUUM 审中-公开
公开(公告)号：WO2023049365A1
公开(公告)日：2023-03-30
申请号：PCT/US2022/044560
申请日：2022-09-23
申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： COON, Joshua Jacques , WESTPHALL, Michael Scott , LEE, Kenneth , SALOME, Austin , GRANT, Timothy , LODGE, Jean
IPC分类号： G01N1/28 , G01N1/36 , G01N1/40 , G01N1/42
摘要： Methods for preparing imaging samples by applying a liquid or semiliquid substance to a substrate surface in order to mitigate the deleterious effects of vacuum and other conditions used for sample preparation, thereby preserving the structure of at least a portion of deposited samples. These methods are useful for MS-based electron microscopy (EM) sample preparation at room temperature, but are also applicable to other imaging methods. These methods also enable transmission electron microscopy (TEM) structural confirmation of ions passing through a mass spectrometer. Additionally, only entry-level negative staining techniques for TEM are required, making this technique much more widely available than cryogenic electron microscopy (cryo-EM).

2. 发明申请

WO2023029909A1 一种透射电镜观察用原位体外培养细胞的样品处理方法审中-公开
公开(公告)号：WO2023029909A1
公开(公告)日：2023-03-09
申请号：PCT/CN2022/111315
申请日：2022-08-10
申请人：南通大学
发明人：朱昌来 , 贺小琴 , 刘小曼 , 刘芳 , 王莹洁
IPC分类号： G01N1/28 , G01N1/30 , G01N1/36 , G01N1/40
摘要：本发明公开了一种透射电镜观察用原位体外培养细胞的样品处理方法，通过制备琼脂凝胶置于细胞培养板的孔底，并对琼脂凝胶进行酸化、漂洗及表面的阳离子活性处理，将待观察细胞接种于所得琼脂凝胶表面，在后续样品处理制备中，经过锇酸固定、漂洗后，用手术刀和显微镊切去含有细胞生长的琼脂凝胶块，转移至另一培养板中，进行后续脱水、渗透，并在胶囊型包埋板中进行样品包埋，随后进行常规的切片、染色及上机观察。该方法可以避免常规样品处理方式所造成的培养细胞原始生长位置的改变和超微结构变化，而使得实验结果判断的谬误；同时，对于培养细胞的原位电镜观察及研究相邻细胞间超微结构关系具有重要意义。

3. 发明申请

WO2022266459A1 AUTOMATED BIOPSY SAMPLE PROCESSING SYSTEMS AND METHODS THEREOF 审中-公开
公开(公告)号：WO2022266459A1
公开(公告)日：2022-12-22
申请号：PCT/US2022/034018
申请日：2022-06-17
申请人： BIOPTEK, LLC
发明人： RAPUANO, Nanetta , MIKULASOVICH, Michael Peter
IPC分类号： G01N35/04 , G01N1/36
摘要： Automated systems for processing a biopsy sample are disclosed herein, as well as methods for automating the processing of a biopsy sample. A benefit to the automated systems and methods herein can be the efficient and cost-effective processing of large numbers of biopsy samples. Another benefit to the automated systems and methods herein can be increased personnel safety for processing biopsy samples. Additional benefits to the automated systems and methods herein can be greater patient safety by increasing accuracy in biopsy sample processing, and preventing errors in biopsy sample processing that may lead to misdiagnosis and improper treatments.

4. 发明申请

WO2022261955A1 CASSETTE AND TISSUE EMBEDDING METHOD USING SAME 审中-公开
公开(公告)号：WO2022261955A1
公开(公告)日：2022-12-22
申请号：PCT/CN2021/100984
申请日：2021-06-18
申请人： LEICA BIOSYSTEMS NUSSLOCH GMBH , LEICA MICROSYSTEMS LTD., SHANGHAI
发明人： LI, Augustine , WU, Frank , CHEN, Jay , YU, Edison , CHEN, Albert , JIN, Chris
IPC分类号： B01L3/00 , G01N1/31 , G01N1/36
摘要： The present disclosure relates to a cassette and a tissue embedding method using the cassette. The cassette includes a frame, a cover and a base. The frame defines an accommodating cavity through a first face and a second face of the frame arranged oppositely in a first direction. The cover is detachably mounted to the frame. The base is detachably mounted to the frame, and the base and the cover are configured to hold and orient a tissue sample therebetween. The base is slidable relative to the frame in a second direction different from the first direction to open and close the accommodating cavity.

5. 发明申请

WO2022240307A1 КОНТЕЙНЕР ДЛЯ ОБРАБОТКИ И ЗАЛИВКИ ГИСТОЛОГИЧЕСКИХ ОБРАЗЦОВ 审中-公开
公开(公告)号：WO2022240307A1
公开(公告)日：2022-11-17
申请号：PCT/RU2021/000195
申请日：2021-05-13
申请人： ТЯН, Элеонора Ильинична
发明人： ТЯН, Элеонора Ильинична TJAN, Eleonora Iljinichna
IPC分类号： B01L3/00 , G01N1/36
摘要： Изобретение относится к устройствам для подготовки гистологических и биологических образцов для микроскопических исследований. Контейнер устройства выполнен с возможностью штабелирования с обеспечением возможности поступления обрабатывающих жидкостей внутрь штабеля и содержит корпус с рамкой, соединяющейся с основанием, имеющим углубление для размещения образца, а также съемную крышку в форме гистологической кассеты с рамкой, перетянутой проницаемым эластичным материалом. Рамка корпуса контейнера выполнена из упругого и деформируемого при сжатии материала. Две противоположные стороны рамки корпуса образуют боковые стенки, продолжающиеся вверх и вниз от линии соединения с основанием, при этом их высота превышает суммарную величину глубины углубления для образца, толщины дна углубления для образца и толщины крышки контейнера не менее, чем на 0,1 мм. На верхних и нижних гранях боковых стенок основания выполнено замковое соединение, элементы которого при штабелировании входят в зацепление с элементами замкового соединения нижеразмещенного контейнера. Задача контейнера направлена на эффективную обработку и пропитку гистологических и биологических образцов, и последующую заливку блоков для микротомирования.

6. 发明申请

WO2022207847A1 CODING METHOD FOR EMBEDDING CASSETTES AND APPARATUS USED THEREFORE 审中-公开
公开(公告)号：WO2022207847A1
公开(公告)日：2022-10-06
申请号：PCT/EP2022/058671
申请日：2022-03-31
申请人： CUCCHI, Maurizio
发明人： CUCCHI, Maurizio
IPC分类号： G01N1/36 , G06K7/10 , B01L3/00 , G01N1/31 , B01L2300/021 , B01L2300/023 , B01L2300/027 , B01L3/545 , B01L9/52 , G01N2001/315 , G06K7/10821 , G06K7/1417
摘要： The present invention is directed to a system for identifying embedding cassettes in a lab or in a hospital, the system comprising a set of cassettes, wherein each cassette contains a two-dimensional code onto a face of the cassette, which code has a number of possible combination higher than 109; an apparatus comprising at least one hub for storing cassettes; and a CCD for reading code of the cassettes; and a processor adapted for associating the bidimensional code of the cassette to the information relating to the histological content of the cassette, to the patient and to other possible information decided by the lab and/or hospital, wherein the system does not comprise a printer. The invention is also directed to a corresponding method performed on an apparatus for dispensing cassettes for histological inclusion.

7. 发明申请

WO2022078235A1 一种细胞块自动制备机和方法审中-公开
公开(公告)号：WO2022078235A1
公开(公告)日：2022-04-21
申请号：PCT/CN2021/122474
申请日：2021-09-30
申请人：赵稳兴
发明人：赵稳兴 ZHAO, Wenxing
IPC分类号： G01N1/28 , G01N1/36 , G01N1/42 , G01N1/44 , G01N35/00
摘要：本发明涉及一种细胞块自动制备机和方法。细胞块自动制备机包括本体以及设于本体上的离心组件、温控组件、机械臂、液路系统和台式主机等。基于该细胞块制备机平台，通过细胞块制备管和基质的离心作用，将细胞学标本中的细胞分离富集在一个平面上，并自动制备成细胞块，实现了细胞块制备的自动化、标准化和高质量。

8. 发明申请

WO2021260654A1 PSORIASIS AND OTHER AUTOIMMUNE DISEASES ANTIGEN IMMUNE MODULATOR (AIM) THERAPEUTIC PLATFORM 审中-公开
公开(公告)号：WO2021260654A1
公开(公告)日：2021-12-30
申请号：PCT/IB2021/055712
申请日：2021-06-25
申请人： PHAIM PHARMA LTD , ORBAN, Tihamer
发明人： HEYMAN, Jalahej , DAUBENEY, Nara , DAUBENEY, Piers
IPC分类号： G01N33/68 , G01N1/28 , A61K35/17 , A61P17/06 , A61P37/06 , C12N5/0636 , G01N1/06 , G01N1/2813 , G01N1/286 , G01N1/36 , G01N1/4077 , G01N1/42 , G01N2001/284 , G01N2001/2873 , G01N2800/205 , G01N2800/24 , G01N2800/56 , G01N33/505 , G01N33/5091 , G01N33/6893
摘要： Provided are methods of preparing an immune cell sample from a subject having an autoimmune disorder, the method comprising: obtaining a tissue sample from the subject; and isolating a single immune cell in situ from the tissue sample using laser capture microdissection.

9. 发明申请

WO2021236666A1 METHOD AND APPARATUS FOR PROCESSING ARCHIVED TISSUE SAMPLES 审中-公开
公开(公告)号：WO2021236666A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/033001
申请日：2021-05-18
申请人： S2 GENOMICS, INC.
发明人： JOVANOVICH, Stevan Bogdan , BASHKIN, John , PEREIRA, Nathan
IPC分类号： C12M1/34 , C12M1/33 , G01N1/31 , G01N1/36 , C12M1/00
摘要： A system, methods, and apparatus are described to collect and prepare cells, nuclei, subcellular components, and biomolecules from specimens including FFPE and OCT preserved tissues. The system can perform deparaffinization, rehydration, enzymatic and/or chemical and physical disruption of the FFPE tissue, or residue removal of the OCT tissue, to dissociate it into a single cell or nuclei suspension.

10. 发明申请

WO2021201233A1 染色方法及び顕微鏡観察方法、並びに染色剤及び染色キット审中-公开
公开(公告)号：WO2021201233A1
公开(公告)日：2021-10-07
申请号：PCT/JP2021/014173
申请日：2021-04-01
申请人：公立大学法人名古屋市立大学 , 株式会社林原
发明人：稲垣　宏 , 高瀬　弘嗣 , 草野　創 , 永池　宏 , 有安　利夫
IPC分类号： C12Q1/28 , G01N1/28 , G01N1/30 , G01N1/36 , G01N33/48 , G01N33/536 , G01N33/58
摘要：クマリン系蛍光色素を用いて生物学的試料を染色した蛍光染色試料を得て、前記蛍光染色試料を四酸化オスミウムに接触させ、さらにエポキシ樹脂内に包埋した後、切片化することにより、前記蛍光染色試料を含んだ切片試料を得る染色方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式