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1. 发明申请

WO2023091740A1 METHODS FOR DETERMINATION OF VIRUS TITER IN A SAMPLE USING RAMAN SPECTROSCOPY 审中-公开
公开(公告)号：WO2023091740A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050543
申请日：2022-11-21
申请人： JANSSEN BIOTECH, INC. , OHIO STATE INNOVATION FOUNDATION
发明人： BALSS, Karin, M. , SCHULTZ, Zachary , MORDER, Courtney, J.
IPC分类号： C12Q1/70 , G01J3/44 , G01N21/65 , G01N33/483
摘要： Disclosed is a method of quantifying virus titer in a sample using Raman spectroscopy. This method comprises providing a sample; providing a model for determining viral titer in the sample; irradiating the sample with a light source; and acquiring a Raman spectrum of the sample. The method further involves quantifying the viral titer of the sample by applying a virus component of the Raman spectrum to the model for determining viral titer. Other aspects of the disclosure relate to a method for generating a model suitable for quantifying viral titer in a sample.

2. 发明申请

WO2023069453A1 METHODS OF QUANTITATING CARBON DIOXIDE HYDRATION IN AQUEOUS SOLUTIONS 审中-公开
公开(公告)号：WO2023069453A1
公开(公告)日：2023-04-27
申请号：PCT/US2022/047044
申请日：2022-10-18
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： LI, Jiachen , DAI, Hongjie , GUO, Jinyu
IPC分类号： G01N21/65 , G01J3/44 , G01J3/45 , G01N21/3577
摘要： Provided are methods and devices for quantitating CO2 hydration in aqueous solutions. In some embodiments, the methods comprise disposing a sample of the aqueous solution in an optical cell, wherein the sample is disposed as a layer having a thickness of from 5 to 200 µm. Such methods further comprise performing transmission Fourier transform infrared (FTIR) spectroscopy on the sample layer to determine CO2(aq) vibrational features in the sample, and quantitating CO2 hydration in the aqueous solution based on the CO2(aq) vibrational features. Also provided are methods and devices for quantitating HCO3- and CO32- ions in aqueous solutions by enhanced Raman spectroscopy, as well as methods and devices for determining the pH of aqueous solutions by electrochemical cyclic voltammetry.

3. 发明申请

WO2023039291A1 SYSTEM AND METHOD FOR ADJUSTING OPTICAL DATA TO ACCOUNT FOR VARIATIONS INTRODUCED IN AN OPTICAL SYSTEM 审中-公开
公开(公告)号：WO2023039291A1
公开(公告)日：2023-03-16
申请号：PCT/US2022/043368
申请日：2022-09-13
申请人： MKS TECHNOLOGY (D/B/A SNOWY RANGE INSTRUMENTS)
发明人： ZEMTSOP, Celestin , VOHRA, Quaid , YU, Wei , CARRON, Keith
IPC分类号： G01J3/44 , G01N21/65 , G01N21/63
摘要： Optical data captured in an optical system may be distorted or otherwise affected by various factors, such as but not limited to physical interference, fluorescence, noise or other factors. The effects on the optical data may interfere with any number of uses of the optical data, such as identification, presentation, or the like. Although various embodiments are provided, such as but not limited to spectroscopy, chromatography, and image processing, these are merely example embodiments, and the processing and/or removal of one or more components within the optical data to account for the distortions or other effects. Other applications may include any x,y or x,y,z dataset of optical data.

4. 发明申请

WO2023014802A1 SYSTEMS AND METHODS FOR SEPSIS DETECTION AND MANAGEMENT IN PATIENTS 审中-公开
公开(公告)号：WO2023014802A1
公开(公告)日：2023-02-09
申请号：PCT/US2022/039290
申请日：2022-08-03
申请人： DEEPULL DIAGNOSTICS S.L. , CARRERA FABRA, Jordi , BRU GIBERT, Rafael , IVEY, Richard Max
发明人： CARRERA FABRA, Jordi , BRU GIBERT, Rafael , IVEY, Richard Max
IPC分类号： G01N33/50 , C12Q1/68 , G01J3/44 , H01S3/108 , G06N20/00
摘要： A sepsis detection system includes a first subsystem configured to detect a presence of an infection in a patient, a second subsystem configured to detect a presence of a dysregulated host response in the patient, a third subsystem configured to detect organ dysfunction in the patient, a fourth subsystem configured to detect antimicrobial resistance (AMR) of a pathogen in the patient, and a processing device. The first, second, third, and fourth subsystems and the processing device are communicatively coupled together via a network. The processing device is configured to determine a presence of sepsis in the patient based on the presence of the infection, the presence of the dysregulated host response, and clinical data indicative of the organ dysfunction in the patient. The subsystems utilize at least one of polymerase chain reaction (PCR) processing, Raman spectroscopy, clinical data, electronic health record (EHR) data, and antimicrobial susceptibility testing (AST).

5. 发明申请

WO2023013325A1 顕微ラマン分光装置审中-公开
公开(公告)号：WO2023013325A1
公开(公告)日：2023-02-09
申请号：PCT/JP2022/026204
申请日：2022-06-30
申请人：株式会社島津製作所
发明人：篠山　智生
IPC分类号： G01N21/65 , G01J3/06 , G01J3/44 , G02B21/00
摘要：分光器の構造単純化によって小型化と低コスト化を実現することができるとともに、試料を常に高精度で分析することができる顕微ラマン分光装置を提供すること。【課題】顕微ラマン分光装置１は、波長の異なる励起レーザ光（励起光）Ｌ１，Ｌ２を出射するレーザ発振器（励起用光源）２，３と、レーザ発振器２又は３からの励起レーザ光Ｌ１又はＬ２の照射によって試料Ｓから放射されるラマン散乱光Ｒ１又はＲ２を回折格子１２又は１３によって分光する分光器１０と、該分光器１０によって分光されたラマン散乱光Ｒ１又はＲ２を検出して光電変換するＣＣＤ検出器２０を備え、分光器１０は、入射開口１１ａ，１１ｂと、入射開口１１ａ，１１ｂから入射するラマン光Ｒ１又はＲ２を回折格子１２又は１３へと導く複数（２つ）の光学系I，IIを備え、回折格子１２または１３によって分光された複数の光束を１つの結像レンズ１４にタンデムに入射させる。

6. 发明申请

WO2023287924A1 METHOD, APPARATUS AND SYSTEM OF INTERFERING-AGENT COMPATIBLE BIOMOLECULE STORAGE, TRANSPORT AND QUANTIFICATION 审中-公开
公开(公告)号：WO2023287924A1
公开(公告)日：2023-01-19
申请号：PCT/US2022/037021
申请日：2022-07-13
申请人： PROTIFI, LLC
发明人： WILSON, John, Paul
IPC分类号： G01N21/17 , G01N33/48 , G01N33/68 , G01J3/10 , G01J3/32 , G01J3/44 , G01N1/00
摘要： A method of quantifying target molecules comprising the steps of: binding target molecules to a surface, wherein the target molecules are presented for a quantification assay; cleaning the target molecules of contaminating reagents, wherein the target molecules remain bound to the surface; directly quantifying the target molecules, wherein the target molecules remain bound to the surface, wherein direct quantification of the target molecules is performed by measurement of intrinsic fluorescence of the target molecules.

7. 发明申请

WO2022258951A1 METHOD AND APPARATUS FOR REMOVING NOISE FROM DATA 审中-公开
公开(公告)号：WO2022258951A1
公开(公告)日：2022-12-15
申请号：PCT/GB2022/051412
申请日：2022-06-06
申请人： RENISHAW PLC
发明人： BELL, Ian, Mac
IPC分类号： G01J3/28 , G01J3/44
摘要： A method for removing noise from spectral data recorded using a spectrometer. The method comprises normalising (103) spectral data to generate normalised method and apparatus for removing noise from data spectral data and applying (104) a machine learning model to the normalised spectral data. The machine learning model is trained to remove noise from spectral data using normalised training data, wherein the spectral data is normalised based on a different scaling to the normalisation of the training data.

8. 发明申请

WO2022251666A2 SYSTEM AND METHODS FOR ANALYZING BIOSENSOR TEST RESULTS 审中-公开
公开(公告)号：WO2022251666A2
公开(公告)日：2022-12-01
申请号：PCT/US2022/031384
申请日：2022-05-27
申请人： CARBON HOLDINGS INTELLECTUAL PROPERTIES, LLC
发明人： ATKINS, Charles Agee , LINDEMANN, Garrett W.
IPC分类号： G01N21/65 , G01N21/17 , G01N21/25 , G01N21/31 , G01N21/00 , G01J3/44 , G01N15/1475 , G06T7/30 , G06V20/693 , G06V20/698
摘要： A system for analyzing biological specimens by spectral imaging includes a biosensor comprising at least one graphene layer on a substrate and a memory in communication with a processor. The biosensor is configured to acquire a biological specimen sample. The memory and the processor are configured to conduct Raman spectroscopy to obtain spectral data for the sample, transmit the spectral data to a hub for direct or indirect transmission to one or more servers, perform multivariate analysis on the spectral data, and deliver a report based on the multivariate analysis of the spectral data.

9. 发明申请

WO2022250197A1 결로 온도를 이용한 수분 함량 측정을 동반한 잔류 가스 및 표면 이온 분석 시스템 审中-公开
公开(公告)号：WO2022250197A1
公开(公告)日：2022-12-01
申请号：PCT/KR2021/008098
申请日：2021-06-28
申请人： 주식회사 선반도체
发明人： 최용규
IPC分类号： G01N21/3554 , G01N21/3504 , G01N1/22 , G01N21/65 , G01J3/44
摘要： 본 발명은 결로 온도를 이용한 수분 함량 측정을 동반한 잔류 가스 및 표면 이온 분석 시스템에 관한 것으로, 공기를 이슬점 이하로 냉각시키는 쿨러; 상기 쿨러의 외주면에 배치되고, 상기 쿨러의 구동으로 냉각되는 반사판; 및 상기 반사판에 대향 배치되고, 결로 되어 상기 반사판에 형성된 수분막으로 광원을 조사하여 수분 함량 및 잔류 가스와 표면 이온의 정성 및 정량을 분석하는 분석부;를 포함하는 것을 특징으로 한다.

10. 发明申请

WO2022235147A1 A METHOD FOR CLASSIFYING OIL PALM FRUIT RIPENESS 审中-公开
公开(公告)号：WO2022235147A1
公开(公告)日：2022-11-10
申请号：PCT/MY2022/050031
申请日：2022-04-29
申请人： UNIVERSITI KEBANGSAAN MALAYSIA
发明人： HASHIM, Fazida Hanim , RAJ, Thinal , HUSSAIN, Aini , IBRAHIM, Mohd Faisal , BASERI HUDDIN, Aqilah Binti
IPC分类号： G01N21/65 , G01N33/02 , G01J3/44 , G01N21/84
摘要： The present invention relates to a method for classifying oil palm fruit ripeness comprising: preparing oil palm fruitlets (100); characterised in that obtaining Raman spectrum of the oil palm fruit by scanning outer layer of the oil palm fruitlets using Raman spectrometer (200); locating Raman peaks from the obtained Raman spectrum (300); identifying lycopene, β-carotene, lutein and neoxanthin representation from the Raman peaks intensity (400); categorizing the oil palm fruitlets as unripe (500); categorizing the oil palm fruitlets as ripe (600); and categorizing the oil palm fruitlets as over-ripe (700). The present invention demonstrates that the Raman spectroscopy is a rapid, reliable and accurate technique for assessing the ripeness of oil palm fruits. Furthermore, this technique is robust against the effects of lighting and noise caused by moisture. The analysis has shown that β-carotene, lycopene, lutein and neoxanthin are the carotenoids found in the oil palm fruit skin.

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