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1. 发明申请

WO2006053899A1 PROCEDE DE PREPARATION DE LA CABERGOLINE 审中-公开
标题翻译：化合物制备方法
公开(公告)号：WO2006053899A1
公开(公告)日：2006-05-26
申请号：PCT/EP2005/056070
申请日：2005-11-18
申请人： ARCHEMIS , LHERMITTE, Frédéric
发明人： LHERMITTE, Frédéric
IPC分类号： C07D457/06 , C07D457/04 , A61K31/48 , A61P25/16
CPC分类号： C07D457/04 , C07D457/06 , Y02P20/55
摘要： L'invention concerne un procédé de préparation de cabergoline comprenant la réaction d'un dérivé de formule générale III dans laquelle Rl représente un groupe protecteur de la fonction aminé secondaire, avec de l'isocyanate d'éthyle pour obtenir un dérivé protégé de la cabrgoline, puis une réaction de déprotection appropriée pour enlever le groupe protecteur Rl .
摘要翻译：本发明涉及一种卡麦角林制备方法，其包括通式III的衍生物（其中R 1表示仲胺官能保护基团）与异氰酸乙酯的反应，以获得卡氏体的受保护的衍生物，然后依次进行合适的脱保护反应以除去R1保护基。

2. 发明申请

WO2003078392A3 PROCESS FOR PREPARING CRYSTALLINE FORM I OF CABERGOLINE 审中-公开
公开(公告)号：WO2003078392A3
公开(公告)日：2003-09-25
申请号：PCT/US2003/007138
申请日：2003-03-10
申请人： PHARMACIA CORPORATION , SHEIKH, Ahmad, Y.
发明人： SHEIKH, Ahmad, Y.
IPC分类号： C07D457/04
摘要： A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/heptane or toluene/hexane mixture starting from raw cabergoline, followed by recovery and removal of the solvent from the resulting toluene solvate Form X. The new solvate Form X of cabergoline, useful intermediate, and its preparation are also provided.

3. 发明申请

WO01002395A1 METHOD FOR PREPARING LYSERGIC ACID 审中-公开
标题翻译：制备柠檬酸的方法
公开(公告)号：WO01002395A1
公开(公告)日：2001-01-11
申请号：PCT/FR2000/001820
申请日：2000-06-29
IPC分类号： C07B61/00 , C07D457/04
CPC分类号： C07D457/04
摘要： The invention concerns a novel method for preparing lysergic acid by isomerization of paspalic acid using a tetraalkylammonium hydroxide.
摘要翻译：本发明涉及一种通过使用四烷基氢氧化铵异构化帕斯卡酸来制备麦角酸的新方法。

4. 发明申请

WO2022023813A1 ADMINISTRATION OF MODULATORS OF 5-HT AND/OR AMPA RECEPTORS FOR TREATING NEUROLOGICAL CONDITIONS 审中-公开
公开(公告)号：WO2022023813A1
公开(公告)日：2022-02-03
申请号：PCT/IB2021/000494
申请日：2021-07-28
申请人： THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY
发明人： GOBBI, Gabriella , DE GREGORIO, Danilo
IPC分类号： A61K31/48 , A61P25/00 , A61P25/28 , C07D457/04
摘要： Disclosed herein are methods of treating neuropsychiatric and cognitive diseases, disorders, or conditions, such as social disfunction, with repeated doses of a modulator of the AMPA receptor and/or the 5-HT2A receptor.

5. 发明申请

WO2020123607A1 COMPOSITIONS, DEVICES, AND METHODS FOR TREATING OR PREVENTING HEADACHES 审中-公开
公开(公告)号：WO2020123607A1
公开(公告)日：2020-06-18
申请号：PCT/US2019/065647
申请日：2019-12-11
申请人： SATSUMA PHARMACEUTICALS, INC.
发明人： KOLLINS, John , IWASHIMA, Fumiyoshi , ALBRECHT, Detlef , SCHULTZ, Robert David
IPC分类号： A61K31/48 , A61K9/14 , A61P25/06 , C07D457/04
摘要： Disclosed herein are pharmaceutical compositions, devices, their combinations, and their uses thereof for example in treating or preventing headaches. The present disclosure provides new methods of medical treatment or prevention (e.g, for headaches) resulting in unexpected superior pharmacokinetics compared to conventional methods. In some instances, the methods herein can produce a unique pharmacokinetic profile of a metabolite.

6. 发明申请

WO01070740A1 PROCESS FOR PREPARING CRYSTALLINE FORM I OF CABERGOLINE 审中-公开
标题翻译：制备晶体结晶形式的方法
公开(公告)号：WO01070740A1
公开(公告)日：2001-09-27
申请号：PCT/EP2001/003099
申请日：2001-03-19
IPC分类号： C07D471/04 , A61K31/48 , A61P7/00 , A61P11/08 , A61P15/16 , A61P25/00 , A61P25/16 , A61P25/28 , A61P27/06 , A61P43/00 , B01D9/02 , C07D457/04
CPC分类号： C07D457/04
摘要： A process for producing crystalline form I of cabergoline, which process comprises crystallization of the desired form from a toluene/diethyl ether mixture comprising raw cabergoline, followed by recovery and drying of the resulting crystals. A new solvate form V of cabergoline, useful as an intermediate, is also provided.
摘要翻译：一种生产卡麦角林I型结晶的方法，该方法包括将所需形式从含有原卡米哥林的甲苯/二乙醚混合物中结晶，然后回收和干燥所得晶体。还提供了可用作中间体的新的卡麦角林V型溶剂合物形式。

7. 发明申请

WO2022107095A1 METHODS AND COMPOSITIONS FOR TREATING PAIN WITH 2-BROMO-LYSERGIC ACID DIETHYLAMIDE AND THYMOQUINONE 审中-公开
公开(公告)号：WO2022107095A1
公开(公告)日：2022-05-27
申请号：PCT/IB2021/060823
申请日：2021-11-22
申请人： HAVN LIFE SCIENCES INC.
发明人： SAAD, Fadia
IPC分类号： A61K31/48 , A61K31/122 , A61K36/71 , A61P25/06 , A61P29/00 , C07C50/02 , C07D457/04 , C07D457/06
摘要： Disclosed are methods of treating pain, such as headaches, comprising administering an ergotamine and thymoquinone, wherein the ergotamine is selected from the group consisting of BOL-148, lysergic acid diethylamide (LSD), and lysergic acid amide (LSA). Also disclosed are pharmaceutical composition comprising an ergotamine and thymoquinone, wherein the ergotamine is selected from the group consisting of BOL-148, lysergic acid diethylamide (LSD), and lysergic acid amide (LSA).

8. 发明申请

WO2021081634A1 FORMULATION TO REDUCE OR PREVENT OXIDATIVE STRESS DAMAGE 审中-公开
公开(公告)号：WO2021081634A1
公开(公告)日：2021-05-06
申请号：PCT/CA2020/051439
申请日：2020-10-27
申请人： MURPHY, Kieran , KERINS, Fergal
发明人： MURPHY, Kieran , KERINS, Fergal
IPC分类号： A61K31/385 , A61K31/015 , A61K31/198 , A61K31/352 , A61K31/335 , A61K31/375 , A61K31/519 , A61K31/7048 , A61P39/06 , C07C323/59 , C07C403/24 , C07D307/62 , C07D311/04 , C07D311/28 , C07D311/72 , C07D311/74 , C07D339/04 , C07D457/04 , C07H17/07
摘要： A combination that includes: a flavonoid, for example in an amount from about 0.1 g to about 1.5 g; and one or more of: ascorbic acid, ascorbate, or a combination thereof, for example in an amount from about 0.2 g to about 2.0 g; N-acetyl cysteine, for example in an amount from about 0.10 g to about 1.2 g; alpha-lipoic acid, for example in an amount from about 0.05 g to about 0.60 g; and at least one carotenoid, for example in an amount from about 1 mg to about 50 mg. The combination may be used to mitigate or prevent nuclear DNA damage, mitochondrial DNA damage, lipid peroxidation, protein carbonylation, or any combination thereof in a subject caused by oxidative stress.

9. 发明申请

WO00044748A1 PROCESS FOR THE PREPARATION OF ALKYL MERCAPTO METHYL ERGOLINE DERIVATIVES 审中-公开
标题翻译：制备甲基丙烯酸甲酯衍生物的方法
公开(公告)号：WO00044748A1
公开(公告)日：2000-08-03
申请号：PCT/EP1999/010493
申请日：1999-12-31
IPC分类号： A61K31/48 , A61P25/16 , C07D457/02 , C07D457/04
CPC分类号： C07D457/02
摘要： The present invention relates to the preparation of ingredients active in the treatment of Parkinson's disease, having general formula (VI) wherein R4 may be, independently, a linear, branched or cyclic, saturated or unsaturated C1-8 alkyl radical, such as, for example, the radicals methyl, ethyl, propyl, butyl, isobutyl, tert-butyl, pentyl, cyclopentyl, hexyl, cyclohexyl and octyl. The process for the synthesis of those compounds uses as starting material the compound of formula (I) wherein R1 represents a linear, branched or cyclic, saturated or unsaturated C1-8 alkyl residue.
摘要翻译：本发明涉及制备治疗帕金森病的成分，具有通式（Ⅵ），其中R 4可以独立地是直链，支链或环状的饱和或不饱和的C 1-8烷基，例如乙基，丙基，丁基，异丁基，叔丁基，戊基，环戊基，己基，环己基和辛基。合成这些化合物的方法用作起始原料，其中R 1表示直链，支链或环状，饱和或不饱和的C 1-8烷基残基的式（I）化合物。

10. 发明申请

WO2014114664A1 PROCESS FOR PRODUCING 1, 4, 7, 10-TETRAAZACYCLODODECANE-1, 4, 7, 10-TETRAACETIC ACID AND COMPLEXES THEREOF 审中-公开
标题翻译： 1，4，7，10-TETRAAZACYCLODODECANE-1,4,7,10-十四酸及其复合物的制备方法
公开(公告)号：WO2014114664A1
公开(公告)日：2014-07-31
申请号：PCT/EP2014/051217
申请日：2014-01-22
申请人： AGFA HEALTHCARE
发明人： BUFFEL, Diederik , GANORKAR, Rakesh , BURT, Jennifer , BOI, Xavier
IPC分类号： C07D457/04
CPC分类号： C07D257/02 , A61K49/108 , C07D457/04
摘要： The present invention relates to a process for producing 1, 4, 7, 10-tetraazacyclododecane-1, 4, 7, 10-tetraacetic acid (DOTA) including salts and hydrates thereof of general formula (I) from the respective cyclen. Said process further involves the use of cationic- and anionic exchange resins and solvent treatments to remove the organic and inorganic contaminants. Any cations present in the raw DOTA or other contaminants resulting from the reaction of cyclen are largely reduced in early stages of the process allowing to obtain good yields of DOTA in a purified grade and in an easier and reliable way. The present invention is thus useful for the production of DOTA, of macrocyclic compounds comprising metal ions complexes thereof and of compositions comprising said macrocyclic compounds that can be used as contrast agents for magnetic resonance imaging.
摘要翻译：本发明涉及从相应的环烯烃生产包括其通式（I）的盐和其水合物的4,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（DOTA）的方法。所述方法还涉及使用阳离子和阴离子交换树脂和溶剂处理来除去有机和无机污染物。存在于原始DOTA中的任何阳离子或由环化物反应产生的其它污染物在该方法的早期阶段大大降低，从而在纯化级别中以更容易和可靠的方式获得良好的DOTA产率。因此，本发明可用于生产DOTA，其包含其金属离子络合物的大环化合物和包含可用作磁共振成像造影剂的所述大环化合物的组合物。

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