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1. 发明申请

WO2020141439A1 HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS 审中-公开
公开(公告)号：WO2020141439A1
公开(公告)日：2020-07-09
申请号：PCT/IB2019/061441
申请日：2019-12-30
申请人： INTEGRAL BIOSCIENCES PRIVATE LIMITED
发明人： CHAKRAVARTY, Sarvajit , PENDHARKAR, Dhananjay , RAMACHANDRAN, Sreekanth A. , BATHULA, Chandramohan , SONI, Sanjeev , KUMAR, Vivek , SAEED, Uzma , DANODIA, Abhinandan Kumar , SHARMA, Ankesh , JADHAVAR, Pradeep S.
IPC分类号： A61K31/00 , C07D251/00 , C07D251/46 , C07D401/12 , C07D403/12
摘要： The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed. Formula (1A)

2. 发明申请

WO2016054284A3 ANTIMICROBIAL COMPOUNDS, METHODS OF MAKING THE SAME AND ARTICLES COMPRISING THEM 审中-公开
标题翻译：抗微生物化合物，其制备方法和包含其的文章
公开(公告)号：WO2016054284A3
公开(公告)日：2016-09-01
申请号：PCT/US2015053354
申请日：2015-09-30
申请人： MEDICAL TECH RES INC
发明人： KARANDIKAR BHALCHANDRA M
IPC分类号： C07D251/02 , A61K31/53 , A61K33/38 , A61P31/00 , A61P31/04 , A61P31/10 , C07D251/00
CPC分类号： A61K31/53 , C07D251/16 , C07D251/32
摘要： The present disclosure pertains to antimicrobial compounds that include silver (Ag) and an s-triazine ring with substitutions at nitrogen or carbon atoms of the s-triazine ring. In one example, the antimicrobial silver s-triazine may be readily incorporated in a variety of compositions and devices in both medical and non-medical settings. In another example, the said compounds may possess broad spectrum antimicrobial activity against bacteria, viruses, fungi and other microbes.
摘要翻译：本公开涉及包含银（Ag）和在三嗪环的氮或碳原子上具有取代的s-三嗪环的抗微生物化合物。在一个实例中，抗微生物银s-三嗪可以容易地并入在医学和非医学环境中的各种组合物和装置中。在另一个实例中，所述化合物可具有针对细菌，病毒，真菌和其它微生物的广谱抗微生物活性。

3. 发明申请

WO2012024210A1 NOVEL COMPOSITIONS AND METHODS TO PRODUCE TRIAZINE-ARYLHYDROXY-ALDEHYDE CONDENSATES WITH IMPROVED SOLUBILITY 审中-公开
标题翻译：新型组合物和生产具有改善溶解性的三芳基 - 二羟基 - 二氢呋喃的方法
公开(公告)号：WO2012024210A1
公开(公告)日：2012-02-23
申请号：PCT/US2011/047730
申请日：2011-08-15
申请人： MOMENTIVE SPECIALTY CHEMICALS INC. , MOMENTIVE SPECIALTY CHEMICALS RESEARCH BELGIUM S.A , VISWANATHAN, Ganapathy, S. , SUBRAYAN, Raman, C. , MALHOTRA, Vinay
发明人： VISWANATHAN, Ganapathy, S. , SUBRAYAN, Raman, C. , MALHOTRA, Vinay
IPC分类号： C07D251/00
CPC分类号： C08G14/10 , C08G59/623 , C08G59/68 , C08K5/05 , C08L61/34 , C08L63/00 , C08L63/04
摘要： Compositions and methods for forming condensates and resin compositions are provided. In one embodiment, a condensate is formed from a reaction mixture including a triazine monomer, an arylhydroxy monomer, an aldehyde monomer and an acid catalyst having a pKa value of greater than 3.8. The condensates contain up to 28 wt.% of nitrogen and have a melt viscosity of 3,000 cps or less at 175 °C. The condensates may have a solubility of at least 80 wt.% solids dissolved in an organic solvent for 120 hours or greater. Also disclosed are methods for the manufacture of the condensate as well as the condensate's use in fire-retardant epoxy resin compositions suitable for the manufacture of laminates for electronic applications. There is also disclosed a glycidylated triazine- arylhydroxy-aldehyde condensate of this invention.
摘要翻译：提供了用于形成冷凝物和树脂组合物的组合物和方法。在一个实施方案中，缩合物由包含三嗪单体，芳基羟基单体，醛单体和pKa值大于3.8的酸催化剂的反应混合物形成。缩合物含有高达28重量％的氮，并且在175℃下的熔融粘度为3,000cps或更低。缩合物可以具有溶解在有机溶剂中的至少80重量％固体的溶解度达120小时或更长时间。还公开了用于制造冷凝物的方法以及冷凝物在适用于制造用于电子应用的层压材料的阻燃环氧树脂组合物中的用途。还公开了本发明的缩水甘油基三嗪 - 芳基羟基 - 醛缩合物。

4. 发明申请

WO2008028217A1 ULTRAVIOLET LIGHT ABSORBING OPTICAL ELEMENTS AND COMPOSITIONS AND METHODS FOR MANUFACTURE 审中-公开
标题翻译：超紫外线吸收光学元件及其制造方法及制造方法
公开(公告)号：WO2008028217A1
公开(公告)日：2008-03-13
申请号：PCT/AU2007/001263
申请日：2007-08-30
申请人： CARL ZEISS VISION AUSTRALIA HOLDINGS LIMITED , CHEN, Fang
发明人： CHEN, Fang
IPC分类号： G02B1/04 , C07D251/00 , C08K5/3492 , G02B5/22 , G02C7/00
CPC分类号： G02B5/208 , C07D251/24 , C08K5/3492 , G02C7/108
摘要： The present invention relates to a UV absorbing optical element comprising a polymer optical element substrate, and a UV light absorbing amount of a tris-aryltriazine-based UV absorber incorporated in said substrate. The present invention also provides a method for forming a UV absorbing optical element.
摘要翻译：本发明涉及一种包含聚合物光学元件基底的紫外线吸收光学元件以及并入所述基底中的紫外光吸收量的三芳基三嗪基紫外线吸收剂。本发明还提供一种形成UV吸收光学元件的方法。

5. 发明申请

WO2004078746A2 2-OXO-1,3,5-PERHYDROTRIAZAPINE DERIVATIVES USEFUL IN THE TREATMENT OF HYPER-PROLIFERATIVE, ANGIOGENESIS, AND INFLAMMATRORY DISORDERS 审中-公开
标题翻译：用于治疗高血压，血管生成和炎症的2-OXO-1,3,5-倍他他嗪衍生物
公开(公告)号：WO2004078746A2
公开(公告)日：2004-09-16
申请号：PCT/US2004006283
申请日：2004-03-01
申请人： BAYER PHARMACEUTICALS CORP , BOYER STEPHEN , DUMAS JACQUES , PHILLIPS BARTON , SCOTT WILLIAM J , SMITH ROGER A , CHEN JIANQING , JAMES BENJAMIN , WANG GAN
发明人： BOYER STEPHEN , DUMAS JACQUES , PHILLIPS BARTON , SCOTT WILLIAM J , SMITH ROGER A , CHEN JIANQING , JAMES BENJAMIN , WANG GAN
IPC分类号： A61K31/35 , A61P35/00 , C07D213/00 , C07D251/00 , C07D401/12
CPC分类号： A61K31/35 , C07D213/00 , C07D251/00 , C07D401/12
摘要： This invention relates to novel diaryl ureas, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and angiogenesis disorders, as a sole agent or in combination with cytotoxic therapies.
摘要翻译：本发明涉及新的二芳基脲，含有这些化合物的药物组合物以及这些化合物或组合物用于治疗高增殖和血管生成障碍，作为唯一试剂或与细胞毒性疗法组合的用途。

6. 发明申请

WO2004041922A8 NEW CARBAMATE - MELAMINE FORMALDEHYDE CROSS-LINKING AGENTS 审中-公开
标题翻译：新的氨基甲酸酯 - 三聚氰胺甲醛交联剂
公开(公告)号：WO2004041922A8
公开(公告)日：2004-07-29
申请号：PCT/EP0312070
申请日：2003-10-30
申请人： AKZO NOBEL NV
发明人： SCHUTYSER JAN ANDRE JOZEF , DE JONG AALBERT JOHANNES
IPC分类号： C07D251/00 , C07D251/70 , C08K5/3492
CPC分类号： C07D251/70
摘要： The present invention pertains to carbamate-melamine formaldehyde cross-linking agents of the formula (I), wherein X is selected from the group consisting of -COOR, -(CH2-O)l-H, -(CH2-O)l-R, -(CH2-O)k-CH2-N(X)-Q, and -(CH2-O)k-CH2-N(Y)-Q; Y is independently selected from the group consisting of -H, -(CH2-O)l-H, -(CH2-O)l-R, -(CH2-O)k-CH2-N(X)-Q, and -(CH2-O)k-CH2-N(Y)-Q; with each k independently being 0-10, and each l independently being 1-10;each R being independently selected from the group consisting of alkyl, cycloalkyl, and alkylaryl groups; Q being (II) and wherein said agents comprise, on average , at least 0.05, but fewer than 2 carbamate groups per triazine moiety. The present invention further relates to the preparation of these types of cross-linking agents, to a curable coating composition comprising said cross-linking agents and at least one polyhydroxy group-containing polymer, and to the use of said curable coating composition.
摘要翻译：本发明涉及式（I）的氨基甲酸酯 - 三聚氰胺甲醛交联剂，其中X选自-COOR， - （CH2-O）1H， - （CH2-O）1R， - （（X）-Q和 - （CH2-O）k-CH2-N（Y）-Q; Y独立地选自-H， - （CH 2 -O）1 H， - （CH 2 -O）1 R， - （CH 2 -O）k -CH 2 -N（X）-Q和 - O）K-CH2-N（Y）-Q; 每个k独立地为0-10，并且每个l独立地为1-10;每个R独立地选自烷基，环烷基和烷基芳基; Q为（II），并且其中所述试剂平均每个三嗪部分包含至少0.05个但少于2个氨基甲酸酯基团。本发明进一步涉及这些类型的交联剂的制备，包含所述交联剂和至少一种含多羟基基团的聚合物的可固化涂料组合物，以及所述可固化涂料组合物的用途。

7. 发明申请

WO02051817A2 PROCESS FOR PREPARING 2-METHOXY-4-METHYL-6-METHYLAMINO-1,3,5-TRIAZINE 审中-公开
标题翻译：制备2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪的方法
公开(公告)号：WO02051817A2
公开(公告)日：2002-07-04
申请号：PCT/EP2001/015245
申请日：2001-12-21
IPC分类号： C07D251/46 , C07D251/18 , C07D251/00
CPC分类号： C07D251/18
摘要： A process is described for preparing 2-methoxy-4-methyl-6-methylamino-1,3-5-triazine in three steps consisting of: (a) the preparation of zinc bis(imino-bis-carbimic acid methyl ester); (b) subsequent reaction of the intermediate from step (a) with acetic anhydride to give 2,4-dimethoxy-6-methyl-1,3,5-triazine; and (c) reaction of the 2,4-dimethoxy-6-methyl-1,3,5-triazine formed in step (b), with methylamine to give the end product, which comprises preparing in step (a) zinc bis(imino-bis-carbimic acid methyl ester) by reaction of sodium dicyanamide with zinc acetate in methanol, then reacting in step (b) the reaction product formed in step (a) in dried or methanol-moist form, with acetic anhydride at from 30 to 80 DEG C without addition of a solvent and finally, after removal of the byproducts from steps (a) and (b), converting in step (c) 2,4-dimethoxy-6-methyl-1,3,5-triazine by reaction with methylamine in methanolic solution at from 0 to 30 DEG C into the end product. In this manner, the desired end product can be prepared in good yields and in high purity, without the need to use highly dangerous zinc dicyanamide in step (a), and also without the need to add a solvent in step (b).
摘要翻译：描述了用于制备2-甲氧基-4-甲基-6-甲基氨基-1,3,5-三嗪的方法，其由以下三个步骤组成：（a）双（亚氨基 - 双 - 二氨基甲酸甲酯）锌的制备; （b）步骤（a）的中间体随后与乙酸酐的反应，得到2,4-二甲氧基-6-甲基-1,3,5-三嗪; 和（c）步骤（b）中形成的2,4-二甲氧基-6-甲基-1,3,5-三嗪与甲胺反应得到最终产物，其包括在步骤（a）中制备双亚氨基双碳代甲酸甲酯），然后在步骤（b）中将步骤（a）中形成的干燥或甲醇 - 潮湿形式的反应产物与乙酸酐在30℃下反应至80℃，最后在步骤（a）和（b）除去副产物后，在步骤（c）中转化2,4-二甲氧基-6-甲基-1,3,5-三嗪通过与甲胺在0-30℃的甲醇溶液中反应成最终产物。以这种方式，可以以良好的产率和高纯度制备所需的最终产物，而不需要在步骤（a）中使用高度危险的二氰化二锌，并且也不需要在步骤（b）中加入溶剂。

8. 发明申请

WO99059982A2 BISOXIMETHER DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THE PRODUCTION THEREOF, AND THEIR USE FOR COMBATING FUNGICIDAL PESTS AND ANIMAL PESTS 审中-公开
标题翻译：双肟醚衍生物，处理和中间产物在防治有害真菌和动物害虫的生产和使用
公开(公告)号：WO99059982A2
公开(公告)日：1999-11-25
申请号：PCT/EP1999/003003
申请日：1999-05-04
IPC分类号： C07C251/38 , A01N37/40 , C07C49/303 , C07C251/42 , C07C251/50 , C07C251/52 , C07C251/60 , C07D251/00
CPC分类号： C07C251/60 , C07C2601/14
摘要： The invention relates to bisoximether derivatives of formula (I) in which the variables have the following meanings: R represents halogen, C1-C4 alkyl, C1-C4 alkyl halide, C1-C4 alkoxy or C1-C4 alkoxy halide; n is 1 to 5, whereby the radicals R can be different if n is not equal to 1; R represents C1-C4 alkyl, C3-C6 alkenyl or C3-C6 alkynyl, whereby these groups can be partially or completely halogenated; Q represents C(=CHOCH3)-COOCH3, C(=CHCH3)-COOCH3, C(=NOCH3)-COOCH3 or C(=NOCH3)-CONHCH3. The invention also relates to the salts of the bisoximether derivatives, to methods and intermediate products for the production of these compounds and to their use for combating animal pests and fungicidal pests.
摘要翻译：式（I），其中各变量具有以下含义的双肟醚衍生物，R <1>为卤素，C1-C4烷基，C1-C4卤代烷基，C1-C4烷氧基或C1-C4卤代烷氧基; n为1至5，其中基团可以是与R <1>不同的，当n不为1; [R <2> C1-C4烷基，C3-C6链烯基或C3-C6炔基，其中这些基团可以部分或完全被卤代; Q为C（= CHOCH 3）-COOCH 3，C（= CHCH 3）-COOCH 3，C（= NOCH 3）-COOCH 3或C（= NOCH 3）-CONHCH 3; 和它们的盐，方法和中间体制备这些化合物和它们用于控制动物害虫和有害真菌中的用途。

9. 发明申请

WO99001434A1 INHIBITORS OF FARNESYL PROTEIN TRANSFERASE 审中-公开
标题翻译：番茄红素转移酶抑制剂
公开(公告)号：WO99001434A1
公开(公告)日：1999-01-14
申请号：PCT/US1998/012549
申请日：1998-06-16
IPC分类号： C07D403/08 , A61K31/4709 , A61K31/55 , A61P35/00 , A61P37/02 , A61P43/00 , C07D233/54 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/14 , C07D233/02 , A61K31/33 , A61K31/395 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/53 , A61K31/54 , C07D215/16 , C07D215/38 , C07D215/44 , C07D217/22 , C07D217/26 , C07D221/02 , C07D223/10 , C07D223/14 , C07D225/00 , C07D225/04 , C07D233/04 , C07D235/02 , C07D237/30 , C07D239/00 , C07D239/72 , C07D249/00 , C07D249/16 , C07D251/00 , C07D257/04 , C07D257/08 , C07D257/10 , C07D271/02 , C07D271/04 , C07D271/08 , C07D285/02 , C07D285/04 , C07D295/00 , C07D401/00 , C07D403/00 , C07D403/02 , C07D417/00 , C07D453/02 , C07D453/04 , C07D471/02 , C07D475/00 , C07D487/00 , C07D491/00 , C07D491/02 , C07D498/00 , C07D513/00 , C07D513/02 , C07D513/12 , C07D513/22
CPC分类号： C07D401/06 , C07D403/06 , C07D403/12 , C07D409/14
摘要： Disclosed are quinoline and benzazepine derivatives that inhibit farnesylprotein transferase (FTase) and the farnesylation of the oncogenic protein Ras. Thus, the compounds are useful as anti-cancer agents. The compounds are also useful in the treatment of diseases other than cancer.
摘要翻译：公开了抑制法呢基蛋白转移酶（FTase）和致癌蛋白Ras的法呢基化的喹啉和苯并氮杂衍生物。因此，这些化合物可用作抗癌剂。所述化合物还可用于治疗除癌症以外的疾病。

10. 发明申请

WO2018002106A1 NOVEL TRIAZINE-PRECONDENSATE-ALDEHYDE CONDENSATION PRODUCTS AND METHOD FOR OBTAINING THE SAME 审中-公开
标题翻译：新的三嗪前体 - 醛 - 醛缩合产物及其获得方法
公开(公告)号：WO2018002106A1
公开(公告)日：2018-01-04
申请号：PCT/EP2017/065940
申请日：2017-06-28
申请人： BOREALIS AGROLINZ MELAMINE GMBH
发明人： GABRIEL, Herbert , DICKE, René , PUCHBERGER, Helmut
IPC分类号： C07D251/00
摘要： The present invention relates to a triazine-precondensate-aldehyde condensation products is provided that is obtainable by reacting a) at least one triazine compound of the general formulae (I), b) at least one aldehyde, in particular formaldehyde, and c) at least one triazine precondensate of the general formula (II),, wherein R 1 means Q 1 or a moiety of the formula R 3 -N-R 4 connected with the nitrogen atom to the triazine ring of the structure of formula (I), wherein R9 means Q1 or a moiety of the formula R 7 -N-R 8 connected with the nitrogen atom to the triazine ring of the structure of formula (I), wherein R 2 , R 3 , R 4 and R 6 mean independently from each other H, Q 1 or formula, R 7 and R 8 mean independently from each other H, Q 1 , formula, R 10 and R 11 mean independently from each other R 7 or R 8 ; R 5 means linear or branched C 2 -C 20 -alkyl that can be interrupted by one or more oxygen atoms, sulphur atoms, substituted and non-substituted nitrogen atoms, R x , R y mean independently from each other H, OH, Q 1 , -[C 1 C 18 ]-OH or formula, wherein Q 1 means linear or branched C 1 -C- 20 -alkyl, linear or branched C 2 -C 20 -alkenyl, linear or branched C 2 -C 20 -alkinyl, C 3 -C 10 -cycloalkyl, C 5 -C 7 -cycloalkenyl, which in each case can be interrupted by one or more oxygen atoms, sulphur atoms, substituted or non-substituted nitrogen atoms and/or by one or more groups of the type -C(O)O-, -OC(O)-, -C(O)-, -NHC(0)0-, -OC(O) NH- and/or -OC(O)O-; and wherein n = 0-10, preferably 1 -8, most preferably 1 - 5, and m = 0-8, preferably 1 -7, most preferably 1 - 5 or mixtures thereof.
摘要翻译：本发明涉及三嗪 - 预缩合物 - 醛缩合产物，其可通过使a）至少一种通式（I）的三嗪化合物，b）至少一种醛，特别是甲醛，和c）至少一种通式（II）的三嗪预缩合物，其中R 1表示Q 1或式R 1部分（I）结构的三嗪环与氮原子连接，其中R 9是指Q1或下式的部分R 7：（I）结构的三嗪环与氮原子连接，其中R 2，R 3，R 3， R 4和R 6彼此独立地表示H，Q 1或式R 7和 R 8彼此独立地表示H，Q 1，式，R 10和R 11 意思是相互独立的R _{7或R _{8; R5 5是指可以被一个或多个氧原子，硫原子，取代的和被一个或多个氧原子间隔的直链或支链C 2 -C 20烷基未取代的氮原子，R x，R y相互独立地表示H，OH，Q 1， - [C≡N] 1 C18] - OH或式，其中Q 1表示直链或支链的C 1 -C 20 - 直链或支链的C 2 -C 20 - 烯基，直链或支链的C 2 -C 20 低级烷基，C 3 -C 10 - 环烷基，C 5 -C 7 - 环烯基其在每种情况下可以被一个或多个氧原子，硫原子，取代或未取代的氮原子和/或一个或多个-C（O）O - ， - OC（O） - ，-C（O） - ， - NHC（O）O - ， - OC（O）NH-和/或-OC（O）O-。并且其中n = 0-10，优选1-8，最优选1-5和m = 0-8，优选1-7，最优选1-5或其混合物。}}

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