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1. 发明申请

WO2023035068A1 IMMUNOMODULATORY COMBINATIONS OF ANTIGEN AND DRUG-LIPID CONJUGATE 审中-公开
公开(公告)号：WO2023035068A1
公开(公告)日：2023-03-16
申请号：PCT/CA2022/051340
申请日：2022-09-07
申请人： INTEGRATED NANOTHERAPEUTICS INC.
发明人： CHEN, Sam , NGUYEN, Anne , ZAIFMAN, Joshua
IPC分类号： A61K39/00 , A61K9/51 , A61K9/127 , A61K39/385 , A61K47/54 , A61P37/02 , C07C59/44 , C07C69/28 , C07C69/527 , C07C69/533 , C07C69/587 , C07C69/732 , C07J7/00 , C12N15/10
摘要： An immunomodulatory combination including: (i) a lipid conjugate comprising an immunomodulatory agent covalently linked to a lipophilic moiety by a cleavable linkage or through a cleavable linker; and (ii) an antigen and/or one or more nucleic acids that encode the antigen. The antigen is a protein, polypeptide, peptide, lipoprotein, glycolipid, polynucleotide, or polysaccharide. The lipid conjugate and the antigen and/or the one or more nucleic acids that encode the antigen are formulated in separate delivery vehicles or co-formulated in the same delivery vehicle.

2. 发明申请

WO2021058877A1 RENEWABLE CHEMICAL PRODUCTION ENGAGING METATHESIS AND MICROBIAL OXIDATION 审中-公开
公开(公告)号：WO2021058877A1
公开(公告)日：2021-04-01
申请号：PCT/FI2020/050632
申请日：2020-09-25
申请人： NESTE OYJ
发明人： HIETALA, Jukka , RÄSÄNEN, Jukka , LEMINEN, Anja , RÄMÖ, Virpi
IPC分类号： C07C6/04 , C07C11/02 , C07C67/333 , C07C69/533 , C12P7/64
摘要： Herein is provided a process for combined renewable 1-decene and renewable carboxylic diacid production from a fatty acid ester containing feedstock, wherein the feedstock is first subjected to metathesis reaction conditions, recovery of 1-decene and then to microbial oxidation to yield diacids in a fermentation broth. Diacids of unusual carbon chains lengths are thereby obtainable.

3. 发明申请

WO2017087710A2 PRODUCTION OF FATTY OLEFIN DERIVATIVES VIA OLEFIN METATHESIS 审中-公开
标题翻译：通过烯烃产物生产脂肪族烯烃衍生物
公开(公告)号：WO2017087710A2
公开(公告)日：2017-05-26
申请号：PCT/US2016/062595
申请日：2016-11-17
申请人： PROVIVI, INC. , ONDI, Levente , MEHDI, Hasan
发明人： ONDI, Levente , MEHDI, Hasan , WAMPLER, Keith M. , MEINHOLD, Peter , COELHO, Pedro , BUI, Vu
IPC分类号： C07C67/293 , C07C69/533
CPC分类号： B01J31/2278 , B01J2231/543 , B01J2531/64 , B01J2531/66 , C07B2200/09 , C07C6/04 , C07C29/147 , C07C45/41 , C07C67/08 , C07C67/293 , C07C67/343 , C07C2531/22 , C07C69/533 , C07C33/025 , C07C69/145 , C07C47/21 , C07C11/21
摘要： The invention provides a method for synthesizing a fatty olefin derivative. In some embodiments, the method includes: a) contacting an unsaturated olefin with an unsaturated fatty acid ester in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product and b) converting the metathesis product to the fatty olefin derivative. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is an insect pheromone. Pheromone compositions and methods of using them are also described.
摘要翻译：本发明提供了用于合成脂肪烯烃衍生物的方法。在一些实施方案中，该方法包括：a）在足以形成复分解产物的条件下，在易位催化剂存在下，使不饱和烯烃与不饱和脂肪酸酯接触，和b）将复分解产物转化为脂肪烯烃衍生物。在某些实施方案中，复分解催化剂是钨催化剂或钼催化剂。在不同的实施方案中，脂肪烯烃衍生物是昆虫信息素。还介绍了信息素组合物及其使用方法。

4. 发明申请

WO2017029580A1 CETYLATED FATTY ACIDS, SYSTEM FOR THE PREPARATION THEREOF AND USE THEREOF 审中-公开
标题翻译：辛酸脂肪酸，其制备及其用途的系统
公开(公告)号：WO2017029580A1
公开(公告)日：2017-02-23
申请号：PCT/IB2016/054788
申请日：2016-08-09
申请人： PHARMANUTRA S.P.A.
发明人： LACORTE, Andrea , TARANTINO, Germano , BONDIOLI, Paolo
IPC分类号： C07C67/08 , C07C69/24 , C07C69/533 , A61K31/23 , C11C3/08
CPC分类号： C11C3/003 , A61K31/23 , C07C67/08 , Y02P20/582 , C07C69/26 , C07C69/58
摘要： The present invention relates to a process for preparing a mixture of cetylated fatty acids and a system for carrying out said process. Furthermore, the present invention relates to a composition comprising, or alternatively, consisting of said mixture of cetylated fatty acids. Finally, the present invention relates to said composition for use in the treatment and/or prevention of: (i) rheumatoid arthritis of inflammatory and non-inflammatory origin, in particular osteoarthritis; (ii) other inflammatory joint conditions; (iii) psoriasis, lupus, periodontal diseases or cardiovascular or heart diseases; (iv) all post-traumatic osteoarticular pathologies including sports injuries; (v) all degenerative joint pathologies (arthrosis, gonarthrosis, coxarthrosis, etc.), and (vi) inflammatory-traumatic tendon and muscular conditions. Furthermore, it is envisaged that the composition of the present invention be used in the treatment and/or prevention of the above-mentioned pathologies and disorders (i)-(vi) in association with a rehabilitative therapy. The composition comprising said mixture is formulated in a pharmaceutical form for oral use (novel food, supplement or medical device), i.e. in the form of a pill, pastille, capsule, tablet, granules, dispersible powder, syrup, solution or sprayable solution; for topical use, i.e. in the form of a cream, unguent, ointment, gel or spray to be used as such for application on the skin, or else for transdermal use in the form of a patch.
摘要翻译：本发明涉及一种制备鲸蜡基化脂肪酸和用于进行所述方法的系统的混合物的方法。此外，本发明涉及包含或替代地由所述鲸蜡基化脂肪酸的混合物组成的组合物。最后，本发明涉及用于治疗和/或预防：（i）炎性和非炎性起源的类风湿性关节炎，特别是骨关节炎的所述组合物; （ii）其他炎症关节病症; （iii）牛皮癣，狼疮，牙周病或心血管或心脏病; （iv）所有创伤后骨关节病变，包括运动损伤; （v）所有退行性关节病变（关节病，关节病，coxarthrosis等），和（vi）炎症性创伤性肌腱和肌肉病症。此外，设想本发明的组合物用于治疗和/或预防与康复治疗相关的上述病症和病症（i） - （vi）。包含所述混合物的组合物配制成用于口服使用的药物形式（新型食品，补充剂或医疗装置），即以丸剂，药片，胶囊，片剂，颗粒剂，可分散粉末，糖浆，溶液或可喷雾溶液的形式; 用于局部使用，即以霜剂，无护套，软膏，凝胶或喷雾剂的形式，用于皮肤上施用，或以贴剂形式经皮用途。

5. 发明申请

WO2016103677A1 METHOD FOR PRODUCING OMEGA-HYDROXY FATTY ACID ESTER AND PRECURSOR COMPOUND THEREOF 审中-公开
标题翻译：制备欧米茄 - 羟基脂肪酸酯及其前体化合物的方法
公开(公告)号：WO2016103677A1
公开(公告)日：2016-06-30
申请号：PCT/JP2015/006382
申请日：2015-12-22
申请人： KAO CORPORATION
发明人： NAKAZAWA, Yuki , AOKI, Takashi
IPC分类号： C07C69/533 , C07C69/593 , C07D315/00
CPC分类号： C07D315/00 , C07C67/343 , C07C67/475 , C07C69/73
摘要： Provided is a method for producing a compound represented by Formula (III) while the production of by-products due to, for example, dimerization of a raw material or isomerization of a double bond position is suppressed. The method is a method for producing omega-hydroxy fatty acid ester and a precursor compound thereof of Formula (III), in which an alcohol derivative and a carboxylic acid derivative are subjected to a metathesis reaction in the presence of a catalyst to obtain a compound of Formula (III), wherein the alcohol derivative is at least one selected from the group consisting of a compound of Formula (VI) and a compound of Formula (I), and the carboxylic acid derivative is at least one selected from the group consisting of a compound of Formula (VII) and a compound of Formula (II), wherein the case where the alcohol derivative is formed of a compound of Formula (I) and the carboxylic acid derivative is formed of a compound of Formula (II) is excluded,
摘要翻译：本发明提供一种制备由式（III）表示的化合物的方法，同时由于例如原料的二聚反应或双键位置的异构化而产生副产物。该方法是生产式（III）的ω-羟基脂肪酸酯及其前体化合物的方法，其中醇衍生物和羧酸衍生物在催化剂存在下进行复分解反应，得到化合物的式（III）化合物，其中醇衍生物是选自式（VI）的化合物和式（I）的化合物中的至少一种，并且所述羧酸衍生物是选自下列的至少一种：的式（Ⅶ）化合物和式（Ⅱ）化合物，其中醇衍生物由式（Ⅰ）化合物和羧酸衍生物形成的情况由式（Ⅱ）化合物形成，排除在外，

6. 发明申请

WO2014068303A1 METHOD OF MONITORING AND/OR CONTROLLING THYSANOPTERA 审中-公开
标题翻译：监测和/或控制THYSANOPTERA的方法
公开(公告)号：WO2014068303A1
公开(公告)日：2014-05-08
申请号：PCT/GB2013/052822
申请日：2013-10-30
申请人： KEELE UNIVERSITY
发明人： KIRK, William Daniel John , HAMILTON, James Gordon Campbell
IPC分类号： C07C69/533 , A01N31/02 , A01M1/02 , A01M1/14
CPC分类号： A01N49/00 , C07C69/533
摘要： The present invention provides a method of monitoring or controlling Thysanoptera (hereafter thrips) using a behaviour-modifying compound of Formula (1), wherein Formula (1) is: where R 1 is a C 2 -C 8 straight or branched alkenyl group and the * denotes a stereocentre. Suitably, the method involves providing the behaviour-modifying compound at a pre- determined location. Typically the behaviour-modifying compound is released or broadcast within an area infested (or potentially infested) by thrips. This can be achieved by using a lure or other release device comprising a compound of Formula (1), for example to attract the thrips to a trap.
摘要翻译：本发明提供使用式（1）的行为修饰化合物监测或控制缨翅目（以下称蓟马）的方法，其中式（1）为：其中R1为C2-C8直链或支链烯基，*表示立体中心合适地，该方法包括在预定位置提供行为修饰化合物。通常，行为修饰化合物在通过蓟马感染（或可能感染）的区域内被释放或广播。这可以通过使用包含式（1）化合物的诱饵或其它释放装置来实现，例如以将蓟马吸引到陷阱。

7. 发明申请

WO2012131027A1 PROCESS FOR THE PREPARATION OF ALKANOIC ACID ESTERS IN A CARBONYLATION PROCESS USING PALLADIUM BIDENTATE BIPHOSPHATE LIGANDS 审中-公开
标题翻译：使用双磷酸双磷酸酯配体在碳化过程中制备碱性酸酯的方法
公开(公告)号：WO2012131027A1
公开(公告)日：2012-10-04
申请号：PCT/EP2012/055768
申请日：2012-03-30
申请人： DSM IP Assets B.V. , DE VRIES, Johannes Gerardus , SEREINIG, Natascha , VAN DE VONDERVOORT, Elisabeth Wilhelmina Maria , JANSSEN, Michèle Catherine Christianne
发明人： DE VRIES, Johannes Gerardus , SEREINIG, Natascha , VAN DE VONDERVOORT, Elisabeth Wilhelmina Maria , JANSSEN, Michèle Catherine Christianne
IPC分类号： C07C67/38 , C07C67/03 , C07C69/44 , C07C69/533 , C07C51/09 , C07C55/14 , C07C209/48 , C07C211/12 , C07C253/00 , C07D307/33
CPC分类号： C07C67/36 , C07C51/09 , C07C67/03 , C07C67/38 , C07C209/48 , C07C253/00 , C07D307/33 , C07C211/12 , C07C255/04 , C07C69/533 , C07C69/44 , C07C55/14 , C07C59/185
摘要： The invention relates to a carbonylation process for the preparation of an alkanoic acid ester comprising reacting: (a) an alkene; (b) a source of Pd; (c) a bidentate phosphine ligand of formula I; R 1 R 2 P - R 3 - R - R 4 - PR 5 R 6 (I) wherein P represents a phosphorus atom; R1, R2, R 5 and R 6 can independently represent the same or different optionally substituted organic groups containing a tertiary carbon atom through which the group is linked to the phosphorus atom; R 3 and R 4 independently represent optionally substituted lower alkylene groups and R represents an optionally substituted aromatic group; (d) a source of anions derived from an acid with a pKa
摘要翻译：本发明涉及一种用于制备链烷酸酯的羰基化方法，包括：（a）烯烃; （b）Pd源; （c）式I的二齿膦配体; R1R2P-R3-R-R4-PR5R6（I）其中P表示磷原子; R1，R2，R5和R6可以独立地表示相同或不同的含有叔碳原子的任选取代的有机基团，该基团通过该有机基团与磷原子连接; R3和R4独立地表示任选取代的低级亚烷基，R表示任选取代的芳族基团; （d）源自pKa <3的酸的阴离子源; （e）一氧化碳; 和（f）链烷醇; 其特征在于该方法在0.1至3重量％的水的存在下进行。该方法有利地具有高转化率，并且适用于生产己二酸二甲酯，己二酸酯和六亚甲基二胺及其衍生产物，例如来自可再生能源的废尼龙6,6，例如植物废物，污水废物等，而不是使用化石源。

9. 发明申请

WO2011055251A1 ESTERS AS PERFUMING INGREDIENTS 审中-公开
标题翻译：作为丰富的成分
公开(公告)号：WO2011055251A1
公开(公告)日：2011-05-12
申请号：PCT/IB2010/054673
申请日：2010-10-15
申请人： FIRMENICH SA , FANKHAUSER, Peter , MADDALENA, Umberto
发明人： FANKHAUSER, Peter , MADDALENA, Umberto
IPC分类号： C07C69/24 , C07C69/533 , C07C69/608 , C11B9/00
CPC分类号： C07C69/533 , C07C69/24 , C07C69/608 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C11B9/003 , C11B9/0034
摘要： The present invention relates to some perfuming ingredients which are esters of formula (I) wherein R 1 and R 2 represent each a hydrogen atom or a methyl or ethyl group; and R 3 represents a C 5 -C 8 group of formula satured or unsatured linear, branched or cyclic group.
摘要翻译：本发明涉及一些加香成分，其是式（I）的酯，其中R 1和R 2各自表示氢原子或甲基或乙基; 并且R 3表示通式或不饱和的直链，支链或环状基团的C5-C8基团。

10. 发明申请

WO2009152917A2 STABILIZATION OF THE COMPOSITION OF A MIXTURE 审中-公开
标题翻译：混合物组合物的稳定性
公开(公告)号：WO2009152917A2
公开(公告)日：2009-12-23
申请号：PCT/EP2009003666
申请日：2009-05-23
申请人： ZELLER MAX SOEHNE AG , TOFF STEPHAN , PARLAR HARUN
发明人： TOFF STEPHAN , PARLAR HARUN
IPC分类号： C07C67/62 , A61K31/22 , A61P37/08 , C07C67/58 , C07C69/533
CPC分类号： A61K9/205 , A61K9/2031 , C07C67/62 , C07C2602/26 , C07C69/533
摘要： Described is a method for slowing the speed of the isomerisation of petasin and neopetasin to isopetasin, and the isomerisation of S-petasin and neo-S-petasin to iso-S-petasin, especially in extracts from plants of the genus Petasites, preferably Petasites hybridus, by the addition of at least one suitable stabilizer and/or the removal of at least one destabilizing substance, e.g. a fatty acid.
摘要翻译：描述了一种降低petasin和neopetasin异构体异速分解速度的方法，以及将S-petasin和neo-S-petasin异构化为异S帕西汀，特别是在Petasites属植物的提取物中，优选Petasites 通过添加至少一种合适的稳定剂和/或去除至少一种不稳定物质，例如，一种脂肪酸。

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