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1. 发明申请

WO2022166870A1 一种基于钯催化体系下手性四取代联烯酸类化合物的制备方法审中-公开
公开(公告)号：WO2022166870A1
公开(公告)日：2022-08-11
申请号：PCT/CN2022/074914
申请日：2022-01-29
申请人：复旦大学
发明人：麻生明 , 郑伟锋 , 钱辉
IPC分类号： C07C51/14 , C07C51/12 , C07C57/42 , C07C253/30 , C07D333/24 , C07C255/41
摘要：本发明公开了一种基于钯催化体系下手性四取代联烯酸类化合物的制备方法，即通过三级炔丙醇与一氧化碳和水，在钯催化剂、手性双膦配体、有机磷酸和有机添加剂的作用下，在有机溶剂中反应，一步直接构建含有轴手性的高光学活性联烯酸类化合物，理论产率可达100％。本发明方法操作简单，原料和试剂易得，反应条件温和，底物普适性广，官能团兼容性好，反应具有很高对映选择性(77％～96％ee)，反应同时很好的兼容含有复杂的天然产物或药物分子骨架的底物。本发明得到的高光学活性联烯酸类化合物，可作为重要的中间体用于构筑含有四取代手性季碳中心的γ-丁内酯类化合物、四取代联烯醇、四取代联烯醛、四取代联烯酮、四取代联烯酰胺等化合物。

2. 发明申请

WO2017135898A1 PROCESS FOR PREPARING MONO AND DICARBOXYLIC ACIDS 审中-公开
标题翻译：制备单羧酸和二羧酸的方法
公开(公告)号：WO2017135898A1
公开(公告)日：2017-08-10
申请号：PCT/SG2017/050051
申请日：2017-02-02
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： VAN MEURS, Martin , NOBBS, James David , STUBBS, Ludger Paul
IPC分类号： C07C67/38 , C07C51/14 , C07C67/343 , C07C51/353 , C07C51/09 , C07C51/36 , C07C67/303 , C07C29/17 , C07C6/04 , B01J31/24 , C07F15/00 , C07F9/50
CPC分类号： C07C51/353 , B01J31/24 , C07C51/09 , C07C67/08 , C07C67/303 , C07C67/333 , C07C67/343 , C07C67/38 , C07C67/475 , C07F9/5027 , C07F9/65683 , C07F15/0046 , C07C57/03 , C07C69/533 , C07C69/593 , C07C69/14 , C07C69/34 , C07C69/50 , C07C69/24
摘要： The present application relates to a process for preparing a dicarboxylic acid or dicarboxylic ester according to general formula (IV) R 1 OOC-(CH 2 ) m -CH 2 CH 2 -(CH 2 ) y -COOR 4 (IV), comprising the steps of subjecting alkenoic acid or alkenoate of formula (II) R 1 OOC-(CH 2 ) m -CH=CH-(CH 2 ) x -H (II) to a metathesis reaction in the presence of a metathesis catalyst to form a longer-chain alkenoic acid or alkenoate of formula (III) R 1 OOC-(CH 2 ) m -CH=CH-(CH 2 ) y -H (III) where x 1 OOC-(CH 2 ) m -CH 2 -(CH 2 ) y -CH 3 (XI) by subjecting an alkenoic acid or alkenoate to alkene hydrogenation; and a process for preparing an alcohol or ether according to general formula (XII) R 1 O-CH 2 -(CH 2 ) m -CH 2 -(CH 2 ) y -CH 3 (XII) by subjecting an alkenoic acid or alkenoate to hydrogenation. The use of the respective mono/dicarboxylic acid, mono/dicarboxylic ester, ethers or alcohols in a variety of applications is also disclosed.
摘要翻译：本申请涉及制备通式（IV）的二羧酸或二羧酸酯的方法：R 1 OOC-（CH 2）2 >）<子>米 -CH <子> 2 CH <子> 2 - （CH <子> 2 ）<子>ý - 包括使式（II）的链烯酸或链烯酸酯R 1 OOC-（CH 2）（II）在复分解催化剂存在下进行复分解反应以形成式（III）的长链链烯酸或链烯酸R 1 OOC-（CH 2）m -CH = CH-（CH 3）（III）其中x

3. 发明申请

WO2013147708A3 A PROCESS TO PRODUCE A DIENE FROM A LACTONE 审中-公开
公开(公告)号：WO2013147708A3
公开(公告)日：2013-10-03
申请号：PCT/SG2013/000123
申请日：2013-03-28
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： STUBBS, Ludger , LI, Chuanzhao , MEURS, Martin van
IPC分类号： C07C1/213 , C07C5/333 , C07C51/14 , C07C51/43
摘要： The invention relates to a process for the production of a diene. In the process, a lactone is heated in the presence of a first catalyst system to produce an alkene and carbon dioxide and the alkene is contacted with a second catalyst system to produce an alkyldiene. The invention further relates to a process of converting the side-product alkenoic acid through reaction with carbon monoxide, water and a third catalyst system to a dicarboxylic acid.

4. 发明申请

WO2012027428A1 REMOVAL OF BOUND WATER FROM BIO-OIL 审中-公开
标题翻译：从生物油中去除水分
公开(公告)号：WO2012027428A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/048891
申请日：2011-08-24
申请人： KIOR INC. , LIN, Ronny, W. , BARTEK, Robert
发明人： LIN, Ronny, W. , BARTEK, Robert
IPC分类号： C07C51/14
CPC分类号： C10G1/002 , C10C5/00 , C10G1/02 , C10G1/08 , C10G2300/1011 , C11B3/14 , Y02P30/20
摘要： A process and system for removing bound water from bio-oil by azeotropic distillation, The process includes combining a bound-water-containing bio-oil with an azeotrope agent and subjecting the resulting treated bio-oil to azeotropic distillation under reduced pressure. The azeotropic distillation removes a substantial portion of the bound water from the bio-oil, thus producing a water-depleted bio-oil that is less corrosive, more stable, and more readily miscible with hydrocarbons.
摘要翻译：通过共沸蒸馏从生物油中除去结合水的方法和系统。该方法包括将含结合水的生物油与共沸物混合，并将所得经处理的生物油在减压下进行共沸蒸馏。共沸蒸馏从生物油中除去大部分结合的水，从而产生较少腐蚀性，更稳定，更容易与烃混溶的贫水生物油。

5. 发明申请

WO2008075108A1 CARBONYLATION OF CONJUGATED DIENES 审中-公开
标题翻译：共轭二烯的碳化
公开(公告)号：WO2008075108A1
公开(公告)日：2008-06-26
申请号：PCT/GB2007/050775
申请日：2007-12-20
申请人： LUCITE INTERNATIONAL UK LIMITED , EASTHAM, Graham, Ronald , WAUGH, Mark , RICHARDS, Philip, Ian
发明人： EASTHAM, Graham, Ronald , WAUGH, Mark , RICHARDS, Philip, Ian
IPC分类号： C07C51/14 , C07C57/03 , C07C67/37
CPC分类号： C07C51/14 , C07C57/03
摘要： A process for the carbonylation of a conjugated diene is described. The process comprises the steps of reacting a conjugated diene with carbon monoxide and a co-reactant having an active hydrogen in the presence of a solvent system and a catalyst system. The solvent system comprises a an aromatic carboxylic acid or, under some conditions, any carboxylic acid. The catalyst system is obtainable by combining: a. a metal of Group 8, 9 or 10 or a compound thereof: and b. a bidentate ligand of general formula (I) X 1 (X 2 )- Q 2 - A - R- B - Q 1 - X 3 (X 4 ) (I) A and B each independently represent lower alkylene linking groups; R represents a cyclic hydrocarbyl structure to which Q 1 and Q 2 are linked, via the said linking group, on available adjacent cyclic atoms of the cyclic hydrocarbyl structure; the groups X 1 , X 2 , X 3 and X 4 independently represent univalent radicals of up to 30 atoms having at least one tertiary carbon atom or X 1 and X 2 and/or X 3 and X 4 together form a bivalent radical of up to 40 atoms having at least two tertiary carbon atoms wherein each said univalent or bivalent radical is joined via said at least one or two tertiary carbon atoms respectively to the appropriate atom Q 1 or Q 2 ; Q 1 and Q 2 each independently represent phosphorus, arsenic or 120 antimony; and, optionally, a source of anions. When the ratio of bidentate ligand : group 8, 9 or 10 metal is greater than 10:1 (mol:mol), the reaction proceeds with any carboxylic acid.
摘要翻译：描述了共轭二烯的羰基化方法。该方法包括在溶剂体系和催化剂体系的存在下使共轭二烯与一氧化碳和具有活性氢的共反应物反应的步骤。溶剂体系包含芳族羧酸，或在某些条件下包含任何羧酸。催化剂体系可以通过以下方式获得：a。第8,9或10族的金属或其化合物;和b。通式（I）的二齿配体X 1（X 2） - Q 2 - A - R - B - Q - （X 4）（I）A和B各自独立地表示低级亚烷基连接基团; R表示通过所述连接基团在环状烃基结构的可用相邻环状原子上连接Q 1和Q 2的环状烃基结构; 基团X 1，X 2，X 3和X 4独立地表示至多30个原子的一价基团具有至少一个叔碳原子或X 1和X 2和/或X 3和X 4和/或形成至多具有至少两个叔碳原子的至多40个原子的二价基团，其中每个所述一价或二价基团分别通过所述至少一个或两个叔碳原子连接到适当的原子Q 1或 Q ^{2 ; Q 1和Q 2各自独立地表示磷，砷或120锑; 和任选的阴离子源。当二齿配体：第8,9或10族金属的比例大于10:1（摩尔：摩尔）时，反应与任何羧酸一起进行。}

6. 发明申请

WO01051444A3 CO-PRODUCTION OF CARBOXYLIC ACIDS AND/OR THEIR ESTERS 审中-公开
标题翻译：共生产羧酸和/或其酯
公开(公告)号：WO01051444A3
公开(公告)日：2002-02-28
申请号：PCT/GB2000/004924
申请日：2000-12-21
IPC分类号： C07C51/12 , C07C51/14 , C07C67/36 , C07C67/38 , C07C53/08 , C07C53/122 , C07C69/14
CPC分类号： C07C67/36 , C07C51/12 , C07C51/14 , C07C67/38 , Y02P20/582 , C07C53/08 , C07C53/126 , C07C53/122 , C07C69/14 , C07C69/24
摘要： A process for the co-carbonylation of methanol and an olefinically unsaturated carbonylatable reactant having at least two carbon atoms, and/or reactive derivatives thereof to produce a mixture of acetic acid and a carboxylic acid having at least three carbon atoms, and/or an ester of either or both carboxylic acids, which process comprises contacting at elevated temperature and pressure (i) carbon monoxide, (ii) methanol and/or a reactive derivative thereof, (iii) an olefinically unsaturated carbonylatable reactant having at least two carbon atoms and/or a reactive derivative thereof and (iv) water in a liquid reaction composition in a carbonylation reactor, the liquid reaction composition comprising (a) a finite concentration of water, (b) a hydrocarbyl halide, (c) a rhodium and/or iridium catalyst, (d) ruthenium and/or osmium as promoter and (e) cobalt as co-promoter.
摘要翻译：和/或其活性衍生物的甲醇和具有至少两个碳原子的烯属不饱和可羰基化反应物和/或其活性衍生物的共羰基化方法，以产生具有至少三个碳原子的乙酸和羧酸的混合物，和/或所述方法包括在升高的温度和压力下接触（i）一氧化碳，（ii）甲醇和/或其反应性衍生物，（iii）具有至少两个碳原子的烯属不饱和的可羰基化反应物和 /或其活性衍生物和（iv）在羰基化反应器中的液体反应组合物中的水，该液体反应组合物包含（a）有限浓度的水，（b）烃基卤化物，（c）铑和/或铱催化剂，（d）钌和/或锇作为助催化剂，（e）钴作为助催化剂。

7. 发明申请

WO0156965A3 MANUFACTURING PROCESS FOR THE PREPARATION OF alpha , alpha , alpha ', alpha '-BRANCHED DICARBOXYLIC ACIDS 审中-公开
标题翻译：制备α，α，α'，α' - 支链二羧酸的方法
公开(公告)号：WO0156965A3
公开(公告)日：2001-12-27
申请号：PCT/EP0101233
申请日：2001-02-02
申请人： RESOLUTION RES NEDERLAND BV
发明人： PETRUS LEONARDUS , STICHTER HENDRIK , STIL HANS ARIE , WALHOF JUDITH JOHANNA BERENDIN
IPC分类号： C07C51/14 , C07C69/34 , C07D303/16 , C07C55/02 , C07C69/01
CPC分类号： C07D303/16 , C07C51/14 , C07C69/34 , C07C55/02
摘要： Manufacturing process for the preparation of alpha , alpha , alpha ', alpha '-branched dicarboxylic acids by reacting an olefin or precursor thereof, with carbon monoxide in the presence of a strong acid catalyst, characterized in that the starting olefin is an oligomer containing from 6 to 25 carbon atoms, that the acid catalyst is composed by BF3/H3PO4 in a molar ratio BF3/H3PO4 being in the range of 0.5:1 to 5.0:1, that the weight ratio of the catalyst relative to the mono-olefin is in the range of from 2:1 to 20:1, that the reaction is carried out at a temperature in the range of from 30 to 130 DEG C, and at a carbon monoxide pressure in the range of from 20 to 200 bar, that the water/catalyst weight ratio during the reaction is in the range of from 1:5 to 1:50, alpha , alpha , alpha ', alpha '-branched dicarboxylic acids mixtures obtainable by said process, and derivatives of these branched dicarboxylic acid components.
摘要翻译：通过使烯烃或其前体与一氧化碳在强酸催化剂存在下反应制备α，α，α'，α'-支链二羧酸的制造方法，其特征在于起始烯烃是含有 6至25个碳原子，所述酸催化剂由BF 3 / H 3 PO 4以BF 3 / H 3 PO 4的摩尔比在0.5:1至5.0:1的范围内组成，催化剂相对于单烯烃的重量比为在2:1至20:1的范围内，反应在30-130℃的温度和20-200巴的一氧化碳压力下进行，反应温度范围为反应过程中水/催化剂重量比在1:5至1:50的范围内，通过所述方法可获得的α，α，α'，α'-支链二羧酸混合物以及这些支化二羧酸组分的衍生物。

8. 发明申请

WO01068583A2 PROCESS FOR THE CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS 审中-公开
标题翻译：乙烯化不饱和化合物的羰基化方法
公开(公告)号：WO01068583A2
公开(公告)日：2001-09-20
申请号：PCT/EP2001/002908
申请日：2001-03-14
IPC分类号： B01J31/18 , B01J31/24 , B01J31/28 , C07B61/00 , C07C51/14 , C07C67/36 , C07C67/38 , C07C69/24 , C07C69/42 , C07C69/44 , C07C253/30 , C07C255/19
CPC分类号： C07C253/30 , B01J31/24 , B01J31/28 , B01J2231/321 , B01J2531/824 , C07C67/38 , C07C69/44 , C07C69/24 , C07C255/19
摘要： Process for the carbonylation of ethylenically unsaturated compounds having 3 or more carbon atoms by reaction with carbon monoxide and an hydroxyl group containing compound in the presence of a catalyst system. The catalyst system includes (a) a source of palladium cations; (b) a bidentate diphosphine of formula (I): R R > P - R - R - R -P R , wherein P represents a phosphorus atom; R , R , R and R independently represent the same or different optionally substituted organic groups containing a tertiary carbon atom through which the group is linked to the phosphorus atom; R and R independently represent optionally substituted alkylene groups and R represents an optionally substituted aromatic group; (c) a source of anions derived from an acid having a pKa less than 3, as measured at 18 DEG C in an aqueous solution. The process is carried out in the presence of an aprotic solvent.
摘要翻译：在催化剂体系存在下通过与一氧化碳和含羟基化合物的反应羰基化具有3个或更多个碳原子的烯属不饱和化合物的方法。催化剂体系包括（a）钯阳离子源; （b）式（I）的二齿二膦：R 1 R 2 P-R 3 -R R 4 -P

9. 发明申请

WO0147837A2 CARBONYLATION PROCESS 审中-公开
标题翻译：碳化过程
公开(公告)号：WO0147837A2
公开(公告)日：2001-07-05
申请号：PCT/US0034986
申请日：2000-12-26
申请人： UOP LLC , BAIRD LANCE A , GALPERIN LEONID B , LAWSON R JOE , JENSEN ROBERT H , ELISEEV OLEG L , LAPIDUS ALBERT L , OSTAPENCO ADUARD G
发明人： BAIRD LANCE A , GALPERIN LEONID B , LAWSON R JOE , JENSEN ROBERT H , ELISEEV OLEG L , LAPIDUS ALBERT L , OSTAPENCO ADUARD G
IPC分类号： C07B61/00 , C07C29/149 , C07C51/14 , C07C53/126 , C07C
CPC分类号： C07C51/14 , C07C29/149 , C07C53/126 , C07C31/125
摘要： Long chain alcohols and acids or other similar oxygenates such as esters are produced from paraffins (1) of similar carbon number by a process comprising paraffin dehydrogenation (2), carbonylation (9), and separation (21, 24, 30). Preferably a mixture of paraffins extending over several carbon numbers and recovered from a kerosene fraction is processed, and unconverted paraffins are recycled to a dehydrogenation zone. Alternative reaction zone configurations, catalyst systems and product recovery methods are disclosed.
摘要翻译：通过包括链烷烃脱氢（2），羰基化（9）和分离（21,24,30）的方法由类似碳数的链烷烃（1）制备长链醇和酸或其它类似的含氧化合物如酯。优选将经过数个碳数延伸并从煤油馏分中回收的石蜡混合物加工，未转化的链烷烃再循环至脱氢区。公开了替代反应区构型，催化剂体系和产物回收方法。

10. 发明申请

WO99033779A1 PROCESS FOR THE PREPARATION OF A CARBOXYLIC ACID 审中-公开
标题翻译：制备羧酸的方法
公开(公告)号：WO99033779A1
公开(公告)日：1999-07-08
申请号：PCT/NL1998/000729
申请日：1998-12-23
IPC分类号： B01J23/46 , C07C51/14 , B01J21/18 , B01J37/08 , C07C57/03
CPC分类号： C07C51/14 , B01J23/464 , C07C57/03
摘要： Process for the preparation of a carboxylic acid by carbonylating an alkenically unsaturated organic compound with carbon monoxide and water in the presence of an iodine or bromine containing promotor respectively and a supported rhodium catalyst, wherein the carbonylation is performed in the presence of an iodide or bromide salt respectively.
摘要翻译：通过在含有碘或溴的促进剂和负载的铑催化剂的存在下，用一氧化碳和水羰基化烯属不饱和有机化合物来制备羧酸的方法，其中羰基化在碘化物或溴化物存在下进行盐分。

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