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    • 5. 发明申请
    • INSECT PROTEIN COMPOSITION FOR THE PREVENTION AND TREATMENT OF CONDITIONS RELATED TO INTESTINAL OXIDATIVE STRESS DAMAGE
    • WO2022250527A1
    • 2022-12-01
    • PCT/NL2022/050236
    • 2022-05-02
    • PROTIX B.V.
    • PAUL, AmanTOME, NuriaCHAKRABORTY, Arpita
    • A61P1/00A61P29/00A61K35/64A23J3/04A23K10/20A23L33/18A61K38/01
    • The invention relates to an insect protein composition for use as a food supplement or a feed supplement, or a medicament, or to an insect protein composition for use in a method for the prophylaxis or treatment of inflammation, in particular inflammatory intestinal diseases, such as IBD and chronic enteropathy. Typically, the insect is black soldier fly larvae. Typically, the protein is water-soluble protein such as a water-soluble protein fraction from insect, and/or enzymatically hydrolysed protein, such as enzymatically hydrolysed insect protein. As part of the invention, the insect protein composition inhibits and/or prevents oxidative damage induced by macrophages and/or inhibits and/or prevents macrophage activation and/or inhibits and/or prevents cell lysis and/or inhibits and/or prevents reactive oxygen species formation by a cell and/or comprises glucosamine. The invention also relates to a food or feed supplement, ingredient or product, comprising the insect protein composition. Furthermore, the invention relates to a non-therapeutic method of prevention against, providing relief from or amelioration of inflammatory intestinal disease, in particular IBD or chronic enteropathy, in a human subject or an animal such as a horse, a pet such as a dog or a cat, preferably a human subject or a dog, the method comprising orally administering to the human subject or the animal the insect protein composition. The invention also relates to a pharmaceutical composition comprising the insect protein composition, and to the pharmaceutical composition for use as a medicament and for use in the treatment or prevention of inflammation.