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1. 发明申请

WO2022226116A1 GHRELIN TREATMENT OF BRAIN DYSFUNCTION DUE TO VIRAL INFECTION 审中-公开
公开(公告)号：WO2022226116A1
公开(公告)日：2022-10-27
申请号：PCT/US2022/025634
申请日：2022-04-20
申请人： OXEIA BIOPHARMACEUTICALS, INC.
发明人： WYAND, Michael , SWISS, Gerald
IPC分类号： G01N33/74 , A01N57/00 , A61K31/165 , A61K31/395
摘要： Disclosed are methods for mitigating one or more debilitating symptoms of sustained brain dysfunction due to viral infection, e.g., SARS-CoV-2. These methods comprise administering an effective amount of ghrelin or a variant thereof.

2. 发明申请

WO2019226604A1 SELECTIVE HERBICIDAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2019226604A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033234
申请日：2019-05-21
申请人： NABORS, James
发明人： NABORS, James
IPC分类号： A01N33/00 , A01N33/02 , A01N33/12 , A01N57/00 , A01N57/20 , A01P13/00
摘要： Disclosed are selective herbicidal compositions and methods for control of annual bluegrass (Poa annua) and rough bluegrass (Poa trivialis) weeds. The compositions comprise trialkylbenzyl ammonium salts of the chemical formula below, at a concentration between 0.1% and 1.4%, C 6 H 5 -CH 2 -N(+)R 1 R 2 R 3 X(-) wherein, R 1 and R 2 are each independently C 1 to C 4 alkyl; R 3 is C 8 to C 18 alkyl or alkenyl; and X is chloride or another agriculturally acceptable anion. The compositions of the present invention have been found to exhibit strong herbicidal effects on these bluegrass weeds, without significant negative effects on desirable turf plants.

3. 发明申请

WO2018236716A1 COMPOSITIONS AND METHODS FOR INCREASING CROP YIELD 审中-公开
公开(公告)号：WO2018236716A1
公开(公告)日：2018-12-27
申请号：PCT/US2018/038013
申请日：2018-06-18
申请人： AGRINOS AS
发明人： AUSTIN, Michael
IPC分类号： A01N27/00 , A01N31/00 , A01N35/00 , A01N37/00 , A01N41/00 , A01N43/00 , A01N57/00 , A01N59/00
摘要： Compositions that include a first component comprising nitrogen, potassium, protein, free amino acids, and trace elements and a second component comprising one or more fungicide, such as one or more strobilurin and/or one or more triazole or triazolinthione fungicide are provided. In some examples, the first component is HYT B, where HYT B is a liquid fraction obtained from fermentation of chitin-containing arthropods with a microbial composition. Methods of using the compositions are also provided. Such methods include contacting soil, plants (such as plant foliage, stems, roots, seedlings, or other plant parts), or seeds with a composition described herein.

4. 发明申请

WO2017086970A1 MOLECULES HAVING PESTICIDAL UTILITY, PESTICIDAL COMPOSITIONS, AND PROCESSES, RELATED THERETO 审中-公开
公开(公告)号：WO2017086970A1
公开(公告)日：2017-05-26
申请号：PCT/US2015/061549
申请日：2015-11-19
申请人： DOW AGROSCIENCES LLC
发明人： GOMEZ, Luis E. , SRIGIRIRAJU, Lakshmipathi , ROY, Agamananda
IPC分类号： A01N57/00
CPC分类号： A01N43/56 , A01N25/00 , A01N25/04 , A01N25/14
摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests.

5. 发明申请

WO2017048675A1 SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE 审中-公开
标题翻译：取代的杂芳基化合物和使用方法
公开(公告)号：WO2017048675A1
公开(公告)日：2017-03-23
申请号：PCT/US2016/051440
申请日：2016-09-13
申请人： SUNSHINE LAKE PHARMA CO., LTD. , CALITOR SCIENCES, LLC
发明人： DAI, Weilong , XI, Ning , LI, Minxiong , ZHANG, Tao , LI, Xiaobo , HU, Haiyang , CHEN, Wuhong , WANG, Tingjin , LIU, Jun
IPC分类号： A01N57/00
CPC分类号： C07D493/04 , A61K31/506 , A61K31/5377 , A61K45/06 , A61K2300/00
摘要： The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.
摘要翻译：本发明提供了新的杂芳基化合物，其药学上可接受的盐和制剂。它们可用于预防，管理，治疗或减轻蛋白激酶介导的疾病的严重程度。本发明还提供了包含这种化合物的药学上可接受的组合物以及使用该组合物治疗蛋白激酶介导的疾病的方法。

6. 发明申请

WO2017035405A1 AMINO COMPOUNDS FOR TREATMENT OF IMMUNE AND INFLAMMATORY DISORDERS 审中-公开
标题翻译：用于治疗免疫和炎症性疾病的氨基化合物
公开(公告)号：WO2017035405A1
公开(公告)日：2017-03-02
申请号：PCT/US2016/048783
申请日：2016-08-25
申请人： ACHILLION PHARMACEUTICALS, INC.
发明人： WILES, Jason, Allan , PHADKE, Avinash, S. , DESHPANDE, Milind , AGARWAL, Atul , CHEN, Dawei , GADHACHANDA, Venkat, Rao , HASHIMOTO, Akihiro , PAIS, Godwin , WANG, Qiuping , WANG, Xiangzhu , GREENLEE, William
IPC分类号： A01N57/00
CPC分类号： C07D401/14 , A61K45/06 , C07D209/12 , C07D401/12 , C07D403/12 , C07D403/14 , C07D405/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07D519/00
摘要： Compounds, methods of use, and processes for making inhibitors of complement Factor D are provided comprising Formula I, I" and Γ" or a pharmaceutically acceptable salt or composition thereof. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade. The inhibitors of Factor D described herein reduces the excessive activation of complement.
摘要翻译：提供化合物，使用方法和制备补体因子D的抑制剂的方法，其包括式I，I“和Γ”或其药学上可接受的盐或组合物。本文描述的抑制剂靶因子D并抑制或调节补体级联。本文所述因子D的抑制剂减少补体的过度活化。

7. 发明申请

WO2017024026A1 3-(1H-INDOL-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： 3-（1H-吲哚-2-基）-1H-吡唑并[3,4-C]吡啶及其治疗用途
公开(公告)号：WO2017024026A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/045333
申请日：2016-08-03
申请人： SAMUMED, LLC
发明人： KC, Sunil Kumar , WALLACE, David Mark , CAO, Jianguo , CHIRUTA, Chandramouli , HOOD, John
IPC分类号： A01N57/00
CPC分类号： C07D471/04 , C07D519/00
摘要： 6-Azaindazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of a 6-azaindazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.
摘要翻译：公开了用于治疗各种疾病和病症的6-氮杂吲唑化合物。更具体地说，本公开内容涉及6-氮杂咔唑化合物或其类似物在治疗特征在于Wnt途径信号传导（例如，癌症，异常细胞增殖，血管生成，纤维化病症，骨或软骨疾病和骨关节炎），由Wnt途径信号传导介导的细胞事件的调节，以及由于Wnt途径的突变或失调和/或一种或多种Wnt信号成分引起的遗传疾病和神经病症/疾病/疾病。还提供了治疗Wnt相关疾病状态的方法。

8. 发明申请

WO2016209787A1 SUSTAINED RELEASE FORMULATION AND TABLETS PREPARED THEREFROM 审中-公开
标题翻译：可持续发布的配方和片剂
公开(公告)号：WO2016209787A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038456
申请日：2016-06-21
申请人： MERCK SHARP & DOHME CORP. , GUPTA, Pranav , MONTEITH, David
发明人： GUPTA, Pranav , MONTEITH, David
IPC分类号： A01N57/00
CPC分类号： A61K47/32 , A61K9/20 , A61K31/519 , A61K47/00 , A61K47/10 , A61K47/12 , A61K47/34 , A61K47/38
摘要： Disclosed are formulations and tablets made therefrom comprising the compound of Formula IA or Formula IB which have sustained-release properties, and the dispersion containing the compounds of Formula IA or IB which facilitates such sustained release: Formula IA, Formula IB.
摘要翻译：公开了由其制备的制剂和片剂，其包含具有缓释性质的式IA或式IB的化合物，和含有促进这种缓释的式IA或IB化合物的分散体：式IA，式IB。

9. 发明申请

WO2016145138A1 SOLID DISPERSIONS 审中-公开
标题翻译：固体分散剂
公开(公告)号：WO2016145138A1
公开(公告)日：2016-09-15
申请号：PCT/US2016/021671
申请日：2016-03-10
申请人： SHIONOGI INC.
发明人： CHEN, Zhengming , CHEN, Xiaoming , HALLORAN, Kevin
IPC分类号： A01N57/00
CPC分类号： A61K9/146 , A61K31/085 , A61K47/32 , A61K47/38
摘要： An ospemifene solid dispersion for enhancing solubility and bioavailability,, and methods of preparation thereof are disclosed. The solid dispersion comprises an active pharmaceutical ingredient, such as ospemifene, and a hydfophilie carrier, such as copovidone, hypromellose acetate succinate, polyvinylpyrrolidine, a polyvinylpyrrolidine/vinyl acetate co-polymer, hydroxy! propyl methylcellulose, hypromellose acetate succinate, a Eudragit® compound, hydroxypropylcellulose, a polyvinyl caprolactam-polyvinyl acetate polyethylene glycol graft co-polymer, hydroxypropyl methylcellulose phthalate, and mixtures thereof, and optionally a surfactant The ospemifene solid, dispersions can be used in methods of treating a symptom related, to menopause, such as vaginal dryness or sexual dysfunction, or in methods of treating osteoporosis.
摘要翻译：公开了一种用于增强溶解度和生物利用度的欧司哌米芬固体分散体及其制备方法。固体分散体包含活性药物成分，如欧司哌米芬，以及亲水载体，如共聚维酮，乙酸琥珀酸羟丙甲纤维素，聚乙烯吡咯烷酮，聚乙烯吡咯烷酮/乙酸乙烯酯共聚物，丙基甲基纤维素，醋酸羟丙甲纤维素琥珀酸酯，化合物，羟丙基纤维素，聚乙烯基己内酰胺 - 聚乙酸乙烯酯聚乙二醇接枝共聚物，羟丙基甲基纤维素邻苯二甲酸酯及其混合物，以及任选的表面活性剂奥斯美芬固体，分散体可用于治疗与绝经相关的症状，如阴道干燥或性功能障碍，或治疗骨质疏松症的方法。

10. 发明申请

WO2016044463A3 MK2 INHIBITORS AND USES THEREOF 审中-公开
标题翻译： MK2抑制剂及其用途
公开(公告)号：WO2016044463A3
公开(公告)日：2016-09-01
申请号：PCT/US2015050495
申请日：2015-09-16
申请人： CELGENE AVILOMICS RES INC
发明人： ALEXANDER MATTHEW DAVID , CHUAQUI CLAUDIO , MALONA JOHN , MCDONALD JOSEPH JOHN , NI YIKE , NIU DEQIANG , PETTER RUSSELL C , SINGH JUSWINDER , PABBA CHITTARI
IPC分类号： A01N57/00
CPC分类号： C07D495/14 , A61P35/00 , A61P37/00
摘要： The present invention provides compounds, compositions thereof, and methods of using the same.
摘要翻译：本发明提供了化合物，其组合物及其使用方法。

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