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1. 发明申请

WO2021144322A1 DETECTION OF PLASTIC MICROPARTICLES IN A POWDER-BASED SAMPLE BY FLOW CYTOMETRY 审中-公开
公开(公告)号：WO2021144322A1
公开(公告)日：2021-07-22
申请号：PCT/EP2021/050609
申请日：2021-01-14
申请人： SOCIÉTÉ DES PRODUITS NESTLÉ SA
发明人： COMINETTI ALLENDE, Ornella , DE FRANCESCHI, Filippo , PINTO PEIXOTO, Rafael , PALINI, Alessio G.
IPC分类号： G01N15/14 , G01N15/02 , G01N1/40 , G01N1/44 , G01N33/02 , G01N1/38 , G01N15/00 , G01N1/4044 , G01N1/4077 , G01N2001/386 , G01N2001/4088 , G01N2015/0053 , G01N2015/1486 , G01N33/04
摘要： The present invention relates generally to the field of plastic microparticles. In particular, the present invention relates to the detection of plastic microparticles in a powder-based sample. An embodiment of the present invention relates to a process for detecting plastic microparticles in a powder-based sample comprising the analysis 5 of the sample by flow cytometry. In accordance with the present invention, the process described herein may comprise the processing of the recorded flow cytometry data by a machine learning algorithm that can distinguish and categorize each particle based on its unique spectrum to characterize, for example, the plastic microparticles.

2. 发明申请

WO2020154484A1 METHODS AND APPARATUS TO SELECTIVELY EXTRACT CONSTITUENTS FROM BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2020154484A1
公开(公告)日：2020-07-30
申请号：PCT/US2020/014758
申请日：2020-01-23
申请人： BECTON, DICKINSON AND COMPANY
发明人： XU, Qihua , WEIDEMAIER, Kristin , SALOMON, John, E. , LASTOVICH, Alexander, G. , FALLOWS, Eric, A. , CONNELL, Sean , HERR, Joshua , WOLFGANG, Meghan , BRASCH, Michael, A. , MOORE, Richard, L. , SEBBA, David, S. , CLAVIJO, Cristian , NG, Shirley , ABBOT, Richard , PAPP, Alexander, Adam , FU, Henry, Li-wei , AUSTIN, Caitlin, Marie , DOWLING, Sean, Patrick , JOYCE, Owen, Lewis , KIPLINGER, Michael, L. , CARPENTER, William, Kevin
IPC分类号： B01L3/00 , G01N1/40 , A61M5/165 , B01D61/18 , C12M1/00 , A61M2005/1657 , B01D2311/25 , B01D2315/10 , B01D61/142 , B01D63/087 , B01D67/0032 , B01L2200/0652 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2400/0478 , B01L2400/049 , B01L3/502753 , B01L3/502761 , C12M33/14 , C12M47/04 , G01N1/4005 , G01N1/4077 , G01N2001/4088
摘要： Methods and apparatus provide filtration for concentrating analytes, such as bacteria or exosomes, of a biological sample, such as blood or urine. The technology may employ membrane devices that implement one or more tangential flow filtration processes such as in stages. An example membrane device may typically include a membrane having sides and ends. The membrane may selectively permit constituent(s) of the sample to pass through while retaining other constituents at one side. An input chamber of the device may include an inlet near one end and an outlet near the other end, and that may permit a tangential flow of the sample along the first side surface, and a trans-membrane passing of constituent(s). An output chamber of the device may be configured at the second side surface to receive the passing constituents. Such devices may be provided in a kit to facilitate targeting of a desired biological analyte concentration.

3. 发明申请

WO2021144321A1 DETECTION OF PLASTIC MICROPARTICLES IN A MILK BASED SAMPLE BY FLOW CYTOMETRY 审中-公开
公开(公告)号：WO2021144321A1
公开(公告)日：2021-07-22
申请号：PCT/EP2021/050607
申请日：2021-01-14
申请人： SOCIÉTÉ DES PRODUITS NESTLÉ SA
发明人： DE FRANCESCHI, Filippo , COMINETTI ALLENDE, Ornella , PINTO PEIXOTO, Rafael , PALINI, Alessio G.
IPC分类号： G01N1/40 , G01N15/14 , G01N33/02 , G01N1/44 , G01N1/38 , G01N15/00 , G01N1/4044 , G01N1/4077 , G01N15/1459 , G01N2001/386 , G01N2001/4088 , G01N2015/0053 , G01N2015/1493 , G01N33/04
摘要： The present invention relates generally to the field of plastic microparticles. In particular, the present invention relates to the detection of plastic microparticles in a milk-based sample. An embodiment of the present invention relates to a process for detecting plastic microparticles in a milk-based sample comprising the analysis of the sample by flow cytometry. In accordance with the present invention, the process described herein may comprise the processing of the recorded flow cytometry data by a machine learning algorithm that can distinguish and categorize each particle based on its unique spectrum to characterize, for example, the plastic microparticles.

4. 发明申请

WO2021126818A1 SYSTEMS, METHODS, AND DEVICES FOR AUTOMATED NUCLEIC ACID AND PROTEIN ISOLATION 审中-公开
公开(公告)号：WO2021126818A1
公开(公告)日：2021-06-24
申请号：PCT/US2020/065055
申请日：2020-12-15
申请人： LIFE TECHNOLOGIES CORPORATION
发明人： VLASSOV, Alexander , BARTA, Timothy , SETTERQUIST, Robert , INSLEE, Justin , GENTERT, Ethan , SMITH, Robert , THIELE, Sara , ADAMS, Carolyn , KRUGER, Kraig , SCHNEIDER, Robert , LUKIANOW, Wade , GRECO, Jay , JONES, Jason , CERRONE, David , GHOSH, Sumonto , VAJDA, Brian , BASTA, Andrew , EVANS, Allan , CROWLEY, Christopher , COX, Anne , MAYERNICK, Mark
IPC分类号： C12N15/10 , C12M1/00 , G01N1/34 , G01N35/10 , B01D2311/2642 , B01D2313/44 , B01D2313/50 , B01D2313/58 , B01D2319/025 , B01D2325/42 , B01D61/58 , B01D69/02 , C12M47/06 , C12M47/10 , C12M47/12 , C12N15/1003 , G01N1/405 , G01N1/4077 , G01N2001/4088 , G01N2035/00316 , G01N2035/0436 , G01N2035/0491 , G01N2035/1025 , G01N2035/1053 , G01N21/59 , G01N35/00 , G01N35/00584 , G01N35/1016 , G01N35/1081 , G01N35/1095
摘要： Purifying target biomolecules, such as nucleic acids or proteins, from a biological source is a time intensive process and is typically performed by a skilled technician or scientist owing to the highly technical nature of the work. Systems, devices, and methods disclosed herein enable the automated bioprocessing and purification of target biomolecules from a biological source. For example, an instrument and disposable cartridge are provided for automatedly isolating and purifying nucleic acids (such as plasmid DNA from a bacterial culture) or for isolating protein from any biological sample. Such an exemplary instrument and cartridge can work in concert to timely release, mix, and move the target biomolecule and various reagents and buffers through a target biomolecule purification process, resulting in a purified target biomolecule with less manual oversight than traditional approaches.

5. 发明申请

WO2022231447A2 FLOW DEPROTEINIZER AND A METHOD OF DEPROTEINIZATION OF LIQUID BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：WO2022231447A2
公开(公告)日：2022-11-03
申请号：PCT/PL2022/000028
申请日：2022-04-29
申请人： UNIWERSYTET WARSZAWSKI
发明人： MALICKA, Iga , LEWIŃSKA, Izabela , MICHALEC, Michał , TYMECKI, Łukasz
IPC分类号： G01N1/34 , G01N1/40 , G01N1/4077 , G01N2001/4083 , G01N2001/4088
摘要： The flow deproteinizer, comprising the line for the liquid sample containing the protein, the deproteinization chamber and the line for discharging the liquid deproteinized sample, is characterized by the fact that it operates in a precipitation mode and is equipped with a vibration system ensuring the possibility of shaking the contents of the deproteinization chamber (2) which has a volume of 1.2-1.8 cm3, preferably 1.5 cm3, and the shape of a prism or inverted cartridge oriented in the vertical axis, the height of which is greater than the diagonal of the base, thanks to which it is possible to easily spontaneously separate the deproteinized fraction from the fraction containing the protein precipitate, whereby the deproteinizer is connected to the analytical system by means of flexible lines enabling it to vibrate, and it also includes a deproteinized sample drainage system, a protein-containing precipitate drainage system, a deproteinization chamber cleaning system and a venting system, whereby all inlet and outlet channels are equipped with electronically controlled valves and, preferably, an optical system for measuring the turbidity of the deproteinized sample. The method of deproteinizing liquid biological samples using a protein denaturation reaction with a precipitating agent is characterized in that the denaturation reaction of a protein contained in a biological sample is initiated by introducing a precipitation agent and carried out in the flow deproteinizer described above. The flow deproteinizer which enables the deproteinization of biological samples in the flow-through mode, allows to shorten the analysis time and simplify the procedure of sample preparation in relation to the deproteinization performed in the manual mode, as well as to reduce the costs of analysis and operation of the system in relation to the deproteinization in the flow-through mode with membranes.

6. 发明申请

WO2022046653A2 DIAGNOSTIC AND THERAPEUTIC FOR THE IDENTIFICATION AND TREATMENT OF SARS-COV-2 审中-公开
公开(公告)号：WO2022046653A2
公开(公告)日：2022-03-03
申请号：PCT/US2021/047183
申请日：2021-08-23
申请人： FLUOROME, INC.
发明人： VLACHAKIS, Dimitrios , NEBLETT, Charles , KASTI, Maria
IPC分类号： G01N33/558 , G01N21/64 , G01N33/543 , G01N33/68 , A61K45/06 , B01L2300/0681 , B01L3/508 , G01N1/4077 , G01N2001/1056 , G01N2001/1427 , G01N2001/4088 , G01N2333/165 , G01N2469/10 , G01N2800/7095 , G01N33/54388 , G16C20/40 , G16C20/50
摘要： The present invention provides methods and diagnostic kits for the detection or prediction of SARS-CoV-2. More particularly, the present invention provides for the diagnosis of SARS-CoV-2 by detecting in a human biological sample inhibition of protein translation by the phosphorylation of the eukaryotic initiation factor-2a (eIF-2a), and the formation of stress granules (SGs) known to be affected by Sars-CoV-2

7. 发明申请

WO2022149135A2 FILTRATION SAMPLING DEVICES 审中-公开
公开(公告)号：WO2022149135A2
公开(公告)日：2022-07-14
申请号：PCT/IL2022/050024
申请日：2022-01-06
申请人： HERO SCIENTIFIC LTD.
发明人： FELDMAN, Zvi , LEVITZ, Robert Eric , LIBRUS, Michael , ADI, Rinat , FLEISHMAN, Zeev
IPC分类号： G01N1/10 , G01N1/40 , G01N1/4077 , G01N2001/1006 , G01N2001/4088
摘要： A sampling device (20, 1420, 1520, 1620, 1720) is provided for concentrating a liquid specimen sample, including a filtration assembly (24, 1424, 1524, 1624, 1724), which includes a tubular container (30, 1430) and a plunger (40, 1440, 1540, 1640, 1740). The plunger (40, 1440, 1540, 1640, 1740) includes a plunger head (42, 1442, 1542, 1642, 1742) and a plunger rod (82, 1482, 1782) that is shaped so as to define an internal plunger space (86, 1486, 1586, 1686, 1786) having a plunger-space proximal opening (90, 1490, 1590, 1690, 1790) through a proximal end (88, 1488) of the plunger rod (82, 1482, 1782). The sampling device (20, 1420, 1520, 1620, 1720) is configured such that a filter (60) is removable from the tubular container (30, 1430) via the plunger-space proximal opening (90, 1490, 1590, 1690, 1790) while the plunger head (42, 1442, 1542, 1642, 1742) is within the tubular container (30, 1430). Other embodiments are also described.

8. 发明申请

WO2021254380A1 水样预处理装置、水样预处理系统及水样预处理方法审中-公开
公开(公告)号：WO2021254380A1
公开(公告)日：2021-12-23
申请号：PCT/CN2021/100326
申请日：2021-06-16
申请人：力合科技（湖南）股份有限公司
发明人：文立群 , 李智 , 郭珍 , 张卫斌
IPC分类号： G01N1/04 , B08B13/00 , B08B9/0936 , C02F1/001 , C02F1/38 , C02F2001/007 , C02F9/00 , G01N1/38 , G01N1/4077 , G01N2001/386 , G01N2001/4083 , G01N2001/4088 , G01N33/18
摘要：一种水样预处理装置、水样预处理系统及水样预处理方法，包括：用于对源水进行静置沉降的水箱（10），水箱（10）连通有源水供给装置（20），水箱（10）还连通有配水装置（30），配水装置（30）用于将水箱（10）中的上清液配入检测仪器（50）内，源水供给装置（20）和配水装置（30）分别与控制装置相连。水箱（10）内设有用于对源水的浊度或上清液的浊度进行实时检测的浊度检测器（60），浊度检测器（60）与控制装置相连。配水装置（30）连通有二次处理装置（70），二次处理装置（70）用于对由配水装置（30）配送的上清液进行预处理，以使配入检测仪器（50）的上清液浊度值等于或小于系统预设阀值，二次处理装置（70）与控制装置相连。

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