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1. 发明申请

WO2019136435A1 SURFACE RETARDER FORMULATION AND METHOD FOR REPLICATING AN ACID ETCH OR SAND BLAST ASPECT ON CEMENTITIOUS MATERIAL 审中-公开
公开(公告)号：WO2019136435A1
公开(公告)日：2019-07-11
申请号：PCT/US2019/012680
申请日：2019-01-08
申请人： GCP APPLIED TECHNOLOGIES INC.
发明人： BURNS, Elizabeth, G. , GEARY, Daivd, T. , VINCENT, Dany , BUI, Huy, The
IPC分类号： C04B41/72 , C04B24/34 , C04B26/22 , C07C59/235
摘要： Disclosed are surface retarder composition and method for etching cementitious materials which achieve a desirable light "acid etch" look without using muriatic (hydrochloric) acid or sand blasting, removing the human health and environmental concerns. Formulations in accordance with embodiments disclosed herein are easier to remove from formwork or molds after demolding than conventional retarder paints. Surface retarders prevent the hydration of cement particles, which allows the uncured layer of paste next to the form to be removed such as by washing with water or other fluids, or by brushing, revealing aggregates. Also disclosed are molded cement and concrete materials or articles exhibiting such light etch.

2. 发明申请

WO2018205037A1 TOOLS AND METHODS FOR GENOME EDITING ISSATCHENKIA ORIENTALIS AND OTHER INDUSTRIALLY USEFUL YEAST 审中-公开
公开(公告)号：WO2018205037A1
公开(公告)日：2018-11-15
申请号：PCT/CA2018/050569
申请日：2018-05-14
申请人： BIOAMBER INC.
发明人： RYAN, Owen
IPC分类号： C12N15/81 , C07C59/08 , C07C59/235 , C07C59/245 , C07C15/113 , C12P7/46 , C12P7/56
摘要： The present description relates to genetic tools and methods to facilitate transformation and genetic engineering of industrially-useful yeast/fungal species, such as Issatchenkia orientalis , for which a robust set of genetic tools such as stably inherited and maintained plasmids and functional control sequences is presently lacking. Thus, the present description relates to autonomously replicating sequences (ARSs), RNA polymerase II/III promoters, RNA polymerase II/III terminators, expression cassettes, and vectors comprising same are described herein, as well as uses and methods relating to same, which are functional in I. orientalis .

3. 发明申请

WO2018049216A1 MONOMERIC BIMETAL HYDROXYCITRIC ACID COMPOUNDS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：单体双甲羟基酸化合物及其制备和使用方法
公开(公告)号：WO2018049216A1
公开(公告)日：2018-03-15
申请号：PCT/US2017/050759
申请日：2017-09-08
申请人： GLYKON TECHNOLOGIES GROUP, LLC
发明人： CLOUATRE, Daniel E. , BANGUN, Nimpan , CLOUATRE, Dallas L.
IPC分类号： A61K31/19 , A61K31/185 , A61K31/194 , C07C59/235 , C07C59/245 , C07C59/265
摘要： Monomeric bimetal hydroxycitric acid (HCA) compounds are provided. The subject compounds include a divalent metal (X) bonded to the carboxylic acids of C2 and C3 and a monovalent metal (Y) bonded to the carboxylic acid of C1. Also provided are methods of preparing the subject compounds from a dimeric starting material (e.g., X3(HCA)2) which include acidifying the dimer to produce a monomeric intermediate which is subsequently neutralized with YOH base. Methods of alleviating at least one symptom associated with a target disease or condition in a subject are provided. Also provided are compositions including the subject monomeric bimetal HCA compounds which find use in a variety of therapeutic applications.
摘要翻译：提供了单体双金属羟基柠檬酸（HCA）化合物。主题化合物包括与C2和C3的羧酸键合的二价金属（X）和与C1的羧酸键合的单价金属（Y）。还提供了从二聚原料（例如X3（HCA）2）制备主题化合物的方法，其包括酸化二聚体以产生随后用YOH碱中和的单体中间体。提供了减轻受试者中与目标疾病或病症相关的至少一种症状的方法。还提供了包含可用于各种治疗应用的目标单体双金属HCA化合物的组合物。

4. 发明申请

WO2014043182A3 ALTERNATIVE PATHWAYS TO ADIPATES AND ADIPIC ACID BY COMBINED FERMENTATION AND CATALYTIC METHODS 审中-公开
标题翻译：联合发酵和催化方法合成脂肪酸和脂肪酸的替代途径
公开(公告)号：WO2014043182A3
公开(公告)日：2014-05-08
申请号：PCT/US2013059170
申请日：2013-09-11
申请人： BIOAMBER INC
发明人： MILLIS JAMES R , LAU MAN KIT
IPC分类号： C12P7/44 , C07C51/36 , C07C51/377 , C07C51/38 , C07C59/235 , C12P7/50
CPC分类号： C07C51/38 , C07C51/347 , C07C51/36 , C07C51/373 , C07C51/377 , C12P7/44 , C12P7/48 , C12P7/50 , C07C59/245 , C07C55/14
摘要： Processes process for producing adipate or adipic acid using biological pathways and chemical catalyzes are disclosed. Homocitric acid may be a substrate in reaction pathways leading to adipic acid or a salt thereof.
摘要翻译：公开了使用生物途径和化学催化剂生产己二酸或己二酸的方法。同型柠檬酸可以是导致己二酸或其盐的反应途径中的底物。

5. 发明申请

WO2015183132A1 СОЛЬ ЦИНКА ИЛИ МЕДИ (II) И ЕЕ ПРИМЕНЕНИЕ В КАЧЕСТВЕ БИОЦИДА 审中-公开
标题翻译：锌或铜（II）盐和作为生物体使用
公开(公告)号：WO2015183132A1
公开(公告)日：2015-12-03
申请号：PCT/RU2015/000251
申请日：2015-04-20
申请人： ЗОТКИН, Игорь Иванович , КУЗНЕЦОВА, Надежда Владимировна
发明人： ЗОТКИН, Игорь Иванович , КУЗНЕЦОВА, Надежда Владимировна , КАБАНОВА, Лариса Владимировна
IPC分类号： C01G3/00 , C01G9/00 , C07C229/24 , C07C55/02 , C07C59/01 , C07C59/235 , C07C59/50 , A01N55/02 , C09D5/14 , D21H25/02
CPC分类号： C07C59/50 , A01N55/02 , A01N59/16 , A01N59/20 , C01G3/00 , C01G9/00 , C07C55/08 , C07C55/10 , C07C57/04 , C07C59/06 , C07C59/08 , C07C59/105 , C07C59/245 , C07C59/255 , C07C229/24 , C07C229/76 , C07F1/00 , C07F1/005 , C07F3/003 , C09D5/14 , D21H25/02
摘要： Применяемая в качестве биоцида соль цинка или меди (II) общей формулы CH 2 =C(R 1 )COO-M-OCOR 2 (OH) m (COOH) n , где М - Zn или Сu, R 1 выбран из группы, включающей водород и метил, R 2 - замещенный С 1 -С 5 алкил, m=0-5, n=0-2, m+n=1-5.
摘要翻译：可以用作杀生物剂的锌或铜（II）的盐，具有通式CH 2 = C（R 1）COO-M-OCOR 2（OH）m（COOH）n，其中M是Zn或Cu，R 1是选自包括氢和甲基的基团，R 2是取代的C 1 -C 5烷基，m = 0-5，n = 0-2和m + n = 1-5。

6. 发明申请

WO01053247A1 BIODEGRADABLE OLEIC ESTOLIDE ESTER HAVING SATURATED FATTY ACID END GROUP USEFUL AS LUBRICANT BASE STOCK 审中-公开
标题翻译：具有饱和脂肪酸末端组的可生物降解的油酰胺酯可用作润滑剂基料
公开(公告)号：WO01053247A1
公开(公告)日：2001-07-26
申请号：PCT/US2001/002248
申请日：2001-01-24
IPC分类号： C10M101/04 , C10M105/32 , C10M107/30 , C10M107/32 , C07C59/235 , C10M101/00 , C10M105/00
CPC分类号： C10M101/04 , C10M105/32 , C10M107/30 , C10M107/32 , C10M2207/28 , C10M2209/00 , C10M2209/02 , C10M2209/10 , C10N2240/00 , C10N2240/22 , C10N2240/30 , C10N2240/50 , C10N2240/52 , C10N2240/54 , C10N2240/56 , C10N2240/58 , C10N2240/60 , C10N2240/66
摘要： Esters of estolides derived from oleic acids and C-6 to C-14 saturated fatty acids are characterized by superior properties for use as lubricant base stocks. These estolides may also be used as lubricants without the need for fortifying additives normally required to improve the lubricating properties of base stocks.
摘要翻译：衍生自油酸和C-6至C-14饱和脂肪酸的炔诺醇酯的特征在于用作润滑剂基础油料的优异性能。这些耳塞体也可以用作润滑剂，而不需要通常需要的增强添加剂以改善基础油的润滑性能。

7. 发明申请

WO01004337A1 SEPARATION AND PURIFICATION OF CARBOXYLIC ACIDS FROM FERMENTATION BROTHS 审中-公开
标题翻译：来自发酵链的羧酸的分离和纯化
公开(公告)号：WO01004337A1
公开(公告)日：2001-01-18
申请号：PCT/US2000/018447
申请日：2000-07-06
IPC分类号： C07C51/43 , C07K14/46 , C12P7/44 , C07C57/00 , C07C57/13 , C07C59/235
CPC分类号： C07K14/46 , C07C51/43 , C07C57/13 , C07C55/02
摘要： Carboxylic acids, particularly dicarboxylic acids, are separated from a fermentation broth by adjusting the pH of the fermentation broth to about 2.0 or below, and then heating the broth to a temperature sufficient to cause formation of three immiscible phases, one of which is an organic phase containing the carboxylic acids.
摘要翻译：通过将发酵液的pH调节到约2.0或更低，然后将培养基加热到足以引起三个不混溶相的温度的温度，从发酵液中分离出羧酸，特别是二羧酸，其中之一是有机物相含有羧酸。

8. 发明申请

WO2018195163A1 GEMCABENE, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, COMPOSITIONS THEREOF AND METHODS OF USE THEREFOR 审中-公开
公开(公告)号：WO2018195163A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028113
申请日：2018-04-18
申请人： GEMPHIRE THERAPEUTICS INC.
发明人： ONICIU, Daniela Carmen , BISGAIER, Charles Larry , GOMES, José Rui , HECKHOFF, Stefan
IPC分类号： A61K31/075 , C07C59/235
摘要： This present invention provides gemcabene pharmaceutically acceptable salts having a PSD90 of 35 µm to about 90 µm, methods for purifying crude gemcabene, pharmaceutically acceptable salts of purified gemcabene, pharmaceutical compositions of a gemcabene pharmaceutically acceptable salt and therapeutic and prophylactic methods useful for various conditions, including dyslipidemia.

9. 发明申请

WO2008079901A2 METHOD OF MAKING FATTY ACID ESTER DERIVATIVES 审中-公开
标题翻译：制备脂肪酸酯衍生物的方法
公开(公告)号：WO2008079901A2
公开(公告)日：2008-07-03
申请号：PCT/US2007088224
申请日：2007-12-19
申请人： US AGRICULTURE , ERHAN SEVIM Z , DOLL KENNETH M , SHARMA BRAJENDRA K
发明人： ERHAN SEVIM Z , DOLL KENNETH M , SHARMA BRAJENDRA K
IPC分类号： C07C51/00 , C07C59/235
CPC分类号： C07C67/26 , C07C69/716
摘要： Fatty acid ester derivatives and a process for their production from unsaturated fatty acids are disclosed. The process comprises: a) reacting an unsaturated fatty acid or an ester thereof having one or more sites of unsaturation, with an epoxidation reagent to form a fatty acid epoxide wherein at least one of the sites of unsaturation of the fatty acid or fatty acid ester is converted to an oxirane ring; and b) reacting the fatty acid epoxide produced in a) with a carboxylic acid to form a hydroxy fatty acid ester derivative wherein the oxirane ring is opened and converted to a hydroxy ester comprising a hydroxyl group at one carbon of the opened oxirane ring and an ester of the carboxylic acid at the other carbon of the opened oxirane ring.
摘要翻译：公开了脂肪酸酯衍生物及其从不饱和脂肪酸制备它们的方法。该方法包括：a）使具有一个或多个不饱和位点的不饱和脂肪酸或其酯与环氧化试剂反应以形成脂肪酸环氧化物，其中脂肪酸或脂肪酸酯的至少一个不饱和位点被转化为环氧乙烷环; 和b）使a）中产生的脂肪酸环氧化物与羧酸反应以形成羟基脂肪酸酯衍生物，其中环氧乙烷环被打开并转化为在打开的环氧乙烷环的一个碳处包含羟基的羟基酯和在打开的环氧乙烷环的另一个碳上的羧酸酯。

10. 发明申请

WO0241827A9 METHODS EMPLOYING AND COMPOSITIONS CONTAINING DEFINED OXIDIZED PHOSPHOLIPIDS FOR PREVENTION AND TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：含有定义氧化磷脂的方法和组合物用于预防和治疗甲状腺功能亢进
公开(公告)号：WO0241827A9
公开(公告)日：2003-05-30
申请号：PCT/IL0101080
申请日：2001-11-22
申请人： VASCULAR BIOGENICS LTD , HARATS DROR , GEORGE JACOB , HALPERIN GIDEON
发明人： HARATS DROR , GEORGE JACOB , HALPERIN GIDEON
IPC分类号： A61K45/06 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/24 , A61K31/6615 , A61K31/685 , A61P9/08 , A61P9/10 , A61P41/00 , C07C43/178 , C07F9/10 , A61K31/12 , C07C43/11 , C07C59/235 , C07F9/02
CPC分类号： C07F9/106 , A61K31/075 , A61K31/08 , A61K31/11 , A61K31/19 , A61K31/20 , A61K31/215 , A61K31/24 , A61K31/685 , C07C43/1785 , C07C43/1787
摘要： Novel synthetic forms of etherified oxidized phospholipids and methods of utilizing same for preventing and treating atherosclerosis and other related disorders are provided. In addition, methods of synthesizing esterified oxidized phospholipids and using same for preventing and treating atherosclerosis and other related disorders are also provided.
摘要翻译：本发明提供了新型合成形式的醚化氧化磷脂及其用于预防和治疗动脉粥样硬化及其它相关疾病的方法。此外，还提供了合成酯化的氧化磷脂并用于预防和治疗动脉粥样硬化等相关病症的方法。

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