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1. 发明申请

WO2015097285A1 PROCESS FOR THE PREPARATION OF HIGHER ALCOHOLS FROM LOWER ALCOHOLS BY GUERBET CONDENSATION 审中-公开
标题翻译：通过凝胶浓缩从低级醇制备高级醇的方法
公开(公告)号：WO2015097285A1
公开(公告)日：2015-07-02
申请号：PCT/EP2014/079306
申请日：2014-12-24
申请人： ABENGOA BIOENERGIA NUEVAS TECNOLOGIAS, S.A.
发明人： SANZ YAGUE, Juan Luis , MARTINEZ PEREZ, Jose David , PENA GOMEZ, Yolanda , REYES VALLE, Carmen Maria , RAMOS SANCHEZ, Mario
IPC分类号： C07C39/34
CPC分类号： C07C29/34 , Y02P20/132 , C07C31/12
摘要： The present invention generally relates to processes for preparation of higher alcohols such as n- butanol from lower alcohols such as ethanol by Guerbet condensation. In some aspects, the present invention relates to improvements in n -butanol yield and selectivity by the selection of process reaction conditions such as, but not limited to, mole ratio of hydrogen to ethanol, mole ratio of acetaldehyde to ethanol, mole ratio of ethyl acetate to ethanol and/or mole ratio of carbon monoxide to ethanol.
摘要翻译：本发明一般涉及通过Guerbet缩合从低级醇如乙醇制备高级醇如正丁醇的方法。在一些方面，本发明涉及通过选择工艺反应条件（例如但不限于氢与乙醇的摩尔比，乙醛与乙醇的摩尔比，乙醇的摩尔比，乙酸乙酯和/或一氧化碳与乙醇的摩尔比。

2. 发明申请

WO00028077A1 ENHANCED CATALYZED REPORTER DEPOSITION 审中-公开
标题翻译：增强催化剂报告沉积
公开(公告)号：WO00028077A1
公开(公告)日：2000-05-18
申请号：PCT/US1999/026327
申请日：1999-11-08
IPC分类号： C07C235/20 , C12Q1/28 , C07C39/00 , C07C39/02 , C07C39/04 , C07C39/24 , C07C39/34 , C07F5/02 , C07F9/02 , G01N33/566
CPC分类号： C12Q1/28 , C07C235/20
摘要： A method for enhancing the conversion of a phenol substrate to a product by a peroxidase enzyme comprises the steps of reacting a conjugate comprising a detectably labeled phenol with a peroxidase enzyme in the presence of an enhancing reagent, the enhancing reagent comprising an inorganic salt, an organic compound having formula (I) wherein when X is B(OH)2, Y is I, or wherein when X is OH, Y is a halogen, or Q-R wherein Q is a linear or branched 1-12 heteroatom alkyl wherein the heteroatoms are selected from C, N, O, and S, wherein the bonds connecting the heteroatom alkyl chain are single or double, wherein any carbon atom in the heteroatom alkyl chain optionally includes a substituent selected from -OH, -COOH, -NH2, and -SH, and wherein R is selected from -OH, -COOH, -NH2, and -CH3; or mixtures of the inorganic salt and the organic compound. A compound having formula (II) wherein R is -CH2OH, -COOH, and n is 1-8.
摘要翻译：通过过氧化物酶增强苯酚底物转化为产物的方法包括以下步骤：在增强试剂存在下使包含可检测标记的苯酚的缀合物与过氧化物酶反应，所述增强剂包含无机盐，具有式（I）的有机化合物，其中当X为B（OH）2时，Y为I，或其中当X为OH时，Y为卤素或QR，其中Q为直链或支链1-12杂原子烷基，其中杂原子选自C，N，O和S，其中连接杂原子烷基链的键是单或双键，其中杂原子烷基链中的任何碳原子任选地包括选自-OH，-COOH，-NH 2和 -SH，其中R选自-OH，-COOH，-NH 2和-CH 3; 或无机盐和有机化合物的混合物。具有式（II）的化合物，其中R 1是-CH 2 OH，-COOH和n是1-8。

3. 发明申请

WO2013010102A3 HALOGENATED PHENOLS FOR DIAGNOSTICS, ANTIOXIDANT PROTECTION AND DRUG DELIVERY 审中-公开
标题翻译：用于诊断，抗氧化剂保护和药物输送的氢化酚
公开(公告)号：WO2013010102A3
公开(公告)日：2013-03-07
申请号：PCT/US2012046725
申请日：2012-07-13
申请人： LATHAM KEITH R
发明人： LATHAM KEITH R
IPC分类号： C07C39/24 , C07C39/34 , C07C205/00
CPC分类号： A61K47/48023 , A61K49/006 , A61K49/0438 , A61K51/0446 , C07C43/295 , C07C217/60 , C07C229/36 , C07C233/25 , C07C323/52 , C07D209/36 , C07D475/08 , C07D489/02 , C07D499/897 , C07J1/0022 , C07J5/0053 , G01N33/52 , Y10T436/145555
摘要： The present invention provides compositions and methods for the administration and targeted delivery, release and/or formation of a drug compound from a halogenated phenol starting compound of the present invention at site(s) within the body of an individual having high FROS, such as within a diseased and/or inflamed tissue. The present invention further provides compositions and methods for the administration of FROS scavenging compounds to an individual to protect cells and tissues from damage that might be caused by FROS. The present invention further provides compositions and methods for the detection of a detectable product, such as an indigo-like compound or other product of a dehalogenation reaction, formed from a compound of the present invention as a measurement or indication of the amount and/or localization of high FROS levels in the body of an individual.
摘要翻译：本发明提供了组合物和方法，用于在具有高FROS的个体的体内的位置处施用和靶向递送，释放和/或形成来自本发明的卤代苯酚起始化合物的药物化合物，例如在患病和/或发炎的组织内。本发明进一步提供了用于向个体施用FROS清除化合物以保护细胞和组织免受可能由FROS引起的损伤的组合物和方法。本发明还提供了用于检测由本发明化合物形成的可检测产物，例如靛蓝样化合物或其它脱卤反应产物的组合物和方法，作为量和/或剂量的测量或指示个人身体中高FROS水平的本地化。

4. 发明申请

WO2007112296A3 METHOD FOR REDUCING MICROCONTAMINANTS DURING SYNTHESIS OF PENTACHLOROPHENOL 审中-公开
标题翻译：丁香酚合成期间降低微生物的方法
公开(公告)号：WO2007112296A3
公开(公告)日：2008-10-02
申请号：PCT/US2007064752
申请日：2007-03-23
申请人： UNIV MICHIGAN , SAVAGE PHILLIP E , YU JIANLI
发明人： SAVAGE PHILLIP E , YU JIANLI
IPC分类号： C07C37/68 , C07C39/24 , C07C39/34
CPC分类号： C07C37/62 , C07C39/36
摘要： A method for reducing contaminants during synthesis of pentachlorophenol includes providing a phenol-based starting material and a catalyst, which form a reaction mixture. A chlorine flow is introduced so that it is in contact with the reaction mixture, and the starting material and chlorine are reacted via a temperature-programmed reaction. The chlorine flow is terminated at a predetermined temperature prior to an end of the temperature-programmed reaction and/or at a point where the yield of pentachlorophenol is less than about 95%.
摘要翻译：合成五氯苯酚期间减少污染物的方法包括提供形成反应混合物的酚类起始原料和催化剂。引入氯流使其与反应混合物接触，并且原料和氯通过温度程序化反应进行反应。在温度程序化反应结束之前和/或在五氯苯酚的产率小于约95％的点处，氯流在预定温度下终止。

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