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1. 发明申请

WO2010096123A3 AMINO ACID SALTS OF PROSTAGLANDINS 审中-公开
公开(公告)号：WO2010096123A3
公开(公告)日：2010-08-26
申请号：PCT/US2009/062590
申请日：2009-10-29
申请人： AERIE PHARMACEUTICALS, INC. , DELONG, Mitchell, A. , STURDIVANT, Jill, Marie
发明人： DELONG, Mitchell, A. , STURDIVANT, Jill, Marie
IPC分类号： A61K31/155 , A61K31/5575 , C07C279/14 , C07C291/02 , C07C405/00
摘要： The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.

2. 发明申请

WO2010096123A2 AMINO ACID SALTS OF PROSTAGLANDINS 审中-公开
标题翻译：氨基酸的氨基酸盐
公开(公告)号：WO2010096123A2
公开(公告)日：2010-08-26
申请号：PCT/US2009062590
申请日：2009-10-29
申请人： AERIE PHARMACEUTICALS INC , DELONG MITCHELL A , STURDIVANT JILL MARIE
发明人： DELONG MITCHELL A , STURDIVANT JILL MARIE
IPC分类号： A61K31/155 , A61K31/5575 , C07C279/14 , C07C291/02 , C07C405/00
CPC分类号： C07C405/00 , A61K31/155 , A61K31/5575 , C07B2200/07 , C07C279/14 , C07C2601/08
摘要： The present invention is directed to novel amino acid prostaglandin salts and methods of making and using them.
摘要翻译：本发明涉及新型氨基酸前列腺素盐及其制备和使用方法。

3. 发明申请

WO2008051558A2 ISOLATED HYDROXY AND N-OXIDE METABOLITES AND DERIVATIVES OF O-DESMETHYLVENLAFAXINE AND METHODS OF TREATMENT 审中-公开
标题翻译：分离的羟基和N-氧化物代谢物及其衍生物及其治疗方法
公开(公告)号：WO2008051558A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022525
申请日：2007-10-24
申请人： WYETH , HOFFMANN, Matthew, John , DEMAIO, William , WANG, Jim , ULLRICH, John, William
发明人： HOFFMANN, Matthew, John , DEMAIO, William , WANG, Jim , ULLRICH, John, William
IPC分类号： C07C215/64 , C07C291/02 , C07C305/20 , C07C305/24 , A61K31/135 , A61K31/351 , A61K31/095
CPC分类号： C07C215/64 , C07C291/04 , C07C2601/14
摘要： The present invention provides novel isolated compounds characterized as metabolites or derivatives of desmethylvenlafaxine including hydroxy-DV metabolites, hydroxy-DV-glucuronide metabolites, N-oxide-DV metabolites, and benzyl-hydroxy-DV metabolites. The invention includes pharmaceutical compositions comprising any of the metabolites or derivatives of the invention in combination with a pharmaceutically acceptable carrier or excipient. The invention also includes a method of treating at least one central nervous system disorder in a mammal comprising providing to a mammal in need thereof an effective amount of the compounds of the invention.
摘要翻译：本发明提供了新型分离的化合物，其特征在于代谢物或脱甲基蓝法的衍生物，包括羟基-DV代谢物，羟基-DV-葡糖苷酸代谢物，N-氧化物-DL代谢物和苄基羟基-DV代谢物。本发明包括药物组合物，其包含本发明的任何代谢物或衍生物与药学上可接受的载体或赋形剂的组合。本发明还包括治疗哺乳动物中的至少一种中枢神经系统病症的方法，其包括向有需要的哺乳动物提供有效量的本发明化合物。

4. 发明申请

WO2005065361A3 COMPOUNDS AND COMPOSITIONS FOR TREATING DYSPROLIFERATIVE DISEASES, AND METHODS OF USE THEREOF 审中-公开
标题翻译：用于治疗失血性疾病的化合物和组合物及其使用方法
公开(公告)号：WO2005065361A3
公开(公告)日：2006-10-05
申请号：PCT/US2004043894
申请日：2004-12-31
申请人： KASHFI KHOSROW
发明人： KASHFI KHOSROW
IPC分类号： A61K31/21 , A61K31/195 , A61K31/24 , C07C69/65 , C07C69/732 , C07C69/76 , C07C69/80 , C07C69/88 , C07C203/04 , C07C205/37 , C07C229/00 , C07C233/15 , C07C233/66 , C07C235/38 , C07C235/56 , C07C235/64 , C07C291/02 , C07C307/02
CPC分类号： C07C205/37 , C07C69/65 , C07C69/732 , C07C69/80 , C07C69/88 , C07C203/04 , C07C233/15 , C07C233/66 , C07C235/38 , C07C235/56 , C07C235/64 , C07C291/02 , C07C307/02
摘要： Compounds are disclosed with activity towards killing dysproliferative cells in vitro and treating cancer in vivo. Cancers such as cancer of the colon, pancreas, prostate, lung, breast, urinary bladder, skin and liver are exemplary. Compounds, pharmaceutical compositions and methods of use are described.
摘要翻译：公开了具有在体外杀死增殖性增殖细胞和体内治疗癌症的活性的化合物。癌症如结肠癌，胰腺癌，前列腺癌，肺癌，乳腺癌，膀胱癌，皮肤癌和肝癌是典型的。描述了化合物，药物组合物和使用方法。

5. 发明申请

WO0183567A3 NITROAROMATIC SOLUBILIZER FOR NITROXYLS IN AROMATIC SOLVENTS 审中-公开
标题翻译：用于芳香族溶剂中硝基的硝基自由基溶解剂
公开(公告)号：WO0183567A3
公开(公告)日：2002-06-06
申请号：PCT/US0110625
申请日：2001-04-03
申请人： UNIROYAL CHEM CO INC
发明人： GEELAN BRENDAN J , BENAGE BRIGITTE , ABRUSCATO GERALD J , SCHLUP KIRK A , GREWAL RUBEN S , EISENSTEIN ANDREW J
IPC分类号： C09K3/00 , C07B63/04 , C07C291/02 , C07D211/94 , C07D295/24 , C08F2/00 , C08F4/04
CPC分类号： C07D295/24 , C07B63/04 , C07C291/02 , C07D211/94
摘要： Disclosed herein is a method for increasing the solubility of a compound having the structural formula (I), in an aromatic hydrocarbon solvent comprising adding to said solvent a nitroaromatic compound having the structure (II) wherein, in formula (II), R25, R26, R27, R28, R29 and R30 are independently selected from the group consisting of hydrogen, alkyl, aryl, cycloalkyl, heterocyclic, substituted alkyl, substituted aryl, OR11, NR11R12, SR11, NO2, NO, CN, COR11, COOR11, CONR11R12, NR11COR12, halogen, and/or any two adjacent groups can be taken together to form ring structures(s) of five to seven members, provided that at least one of R25, R26, R27, R28, R29 and R30 is NO2, and R11 and R12 are independently selected from the group consisting of hydrogen, alkyl, aryl, benzyl, cyclic, heterocyclic, and substituted alkyl or aryl where the substituents are C, O, N, S, or P, or R11 and R12 can be taken together to form a ring structure of five to seven members and, in formula (I), R1 and R4 are independently selected from the group consisting of hydrogen, alkyl, and heteroatom-substituted alkyl and R2 and R3 are independently selected from the group consisting of alkyl and heteroatom-substituted alkyl; and X1 and X2 (1) are independently selected from the group consisting of halogen, cyano, COOR7, -S-COR7, -OCOR7, (wherein R7 is alkyl or aryl), amido, -S-C6H5, carbonyl, alkenyl, or alkyl of 1 to 15 carbon atoms, or (2) taken together, form a ring structure of five to seven members with the nitrogen.
摘要翻译：本文公开了一种在芳族烃溶剂中提高具有结构式（I）的化合物的溶解度的方法，包括向所述溶剂中加入具有结构式（II）的硝基芳族化合物，其中在式（II）中，R 25，R 26 R27，R28，R29和R30独立地选自氢，烷基，芳基，环烷基，杂环，取代的烷基，取代的芳基，OR11，NR11R12，SR11，NO2，NO，CN，COR11，COOR11，CONR11R12， NR 11 COR 12，卤素和/或任何两个相邻基团可以一起形成五至七个成员的环结构，条件是R 25，R 26，R 27，R 28，R 29和R 30中的至少一个是NO 2，R 11 R 12独立地选自氢，烷基，芳基，苄基，环状，杂环和取代的烷基或芳基，其中取代基是C，O，N，S或P，或者R 11和R 12可以一起形成5至7个成员的环结构，并且在式（I）中，R 1和R 3 4独立地选自氢，烷基和杂原子取代的烷基，并且R 2和R 3独立地选自烷基和杂原子取代的烷基; 和X 1和X 2（1）独立地选自卤素，氰基，COOR 7，-S-COR 7，-OCOR 7，（其中R 7是烷基或芳基），酰氨基，-S-C 6 H 5，羰基，烯基或 1〜15个碳原子的烷基，或（2）一起，与氮形成5〜7个成员的环结构。

6. 发明申请

WO99001427A2 NOVEL NITRIC OXIDE-RELEASING AMIDINE- AND ENAMINE-DERIVED DIAZENIUMDIOLATES, COMPOSITIONS AND USES THEREOF AND METHOD OF MAKING SAME 审中-公开
标题翻译：新二醇二氮烯衍生物脒烯胺RELEASING一氧化氮成分含有它们的其用途和制备方法
公开(公告)号：WO99001427A2
公开(公告)日：1999-01-14
申请号：PCT/US1998/013723
申请日：1998-07-01
IPC分类号： C07D295/06 , A61K31/13 , A61K31/4164 , A61P43/00 , C07C251/08 , C07C291/02 , C07C291/08 , C07D211/72 , C07D233/20 , C07D233/24 , C07D295/023 , C07D295/13 , C07D405/04 , C07C291/00
CPC分类号： C07D295/023 , C07C251/08 , C07C291/02 , C07C291/08 , C07C2601/14 , C07D211/72 , C07D233/20 , C07D233/24 , C07D295/13 , C07D405/04 , Y10S514/934
摘要： The present invention relates to nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates, compositions comprising such compounds, methods of using such compounds and compositions, and to a method for the preparation of nitric oxide-releasing amidine- and enamine-derived diazeniumdiolates via the direct reaction of nitric oxide with amidines and enamines, and to a method of converting amines into such compounds.
摘要翻译：本发明涉及衍生物，二醇二氮烯脒和烯胺一氧化氮释放，含有这些化合物的组合物，使用这些化合物和组合物，二醇二氮烯用于制备脒衍生物的方法以及通过一氧化氮与脒和烯胺的直接反应烯胺释放一氧化氮，以及将胺转化成这些化合物的方法。

7. 发明申请

WO9517488A3 LUBRICANT COMPOSITION CONTAINING A POLYMERIC ANTIOXIDANT 审中-公开
标题翻译：含有聚合物抗氧化剂的润滑剂组合物
公开(公告)号：WO9517488A3
公开(公告)日：1995-07-20
申请号：PCT/US9414496
申请日：1994-12-13
申请人： EXXON RESEARCH ENGINEERING CO
发明人： BERLOWITZ PAUL J
IPC分类号： C07C211/58 , C10M133/12 , C10M159/12 , C10M169/04 , C10N30/10 , C10N40/13 , C10N60/04 , C10N70/00 , C07C291/02
CPC分类号： C10M169/04 , C07C211/58 , C10M105/32 , C10M133/12 , C10M2207/2805 , C10M2207/281 , C10M2207/282 , C10M2207/283 , C10M2207/286 , C10M2207/34 , C10M2207/345 , C10M2215/06 , C10M2215/064 , C10M2215/065 , C10M2215/066 , C10M2215/067 , C10M2215/068 , C10M2217/00 , C10M2217/02 , C10M2217/04 , C10N2240/14
摘要： An aviation gas turbine lubricant composition which comprises an antioxidant composition comprising the reaction product of specific molar ratios of diphenylamines and N-aryl naphthylamines in the presence of controlled amounts of an organic peroxide. The antioxidant composition is mainly homo-oligomers of diphenylamines and cross oligomers of diphenylamines and N-aryl naphthylamines.

8. 发明申请

WO2017133429A1 一种萜品烯醇类化合物及其制备方法和应用审中-公开
公开(公告)号：WO2017133429A1
公开(公告)日：2017-08-10
申请号：PCT/CN2017/071217
申请日：2017-01-16
申请人：浙江省中医药研究院
发明人：朱婉萍 , 胡永洲 , 刘霞 , 孔繁智 , 王昱霁
IPC分类号： C07C67/14 , C07C69/24 , C07C29/17 , C07C31/135 , C07C229/12 , C07D295/15 , C07C291/02 , C07D211/74 , A61K31/045 , A61K31/22 , A61K31/5375
CPC分类号： A61K31/045 , A61K31/22 , A61K31/5375 , C07C29/17 , C07C31/135 , C07C67/14 , C07C69/24 , C07C229/12 , C07C291/02 , C07D211/74 , C07D295/15
摘要：本发明公开了一种萜品烯醇类化合物及其制备方法和应用，该萜品烯醇类化合物的结构如式(Ⅰ)或(Ⅱ)所示，式(Ⅰ)中，R独立地选自C 12 ～C 16 烷基、-NR 1 R 2 、-SR 3 或-OR 4 ；R 1 、R 2 、R 3 和R 4 独立地选自C 1 ～C 6 烷基或-NO 2 ，所述的C 1 ～C 6 烷基可被OH取代；或者所述的R 1 、R 2 与连接它们的N共同形成五元环或者六元环，所述的五元环或者六元环可以含有一个O或者C＝O。活性测试结果表明，该萜品烯醇类化合物具有较好的抗哮喘作用、抗炎作用和抗肺动脉高压作用，具有重要的药学意义。

9. 发明申请

WO2013003666A3 HOLOGRAPHIC RECORDING MEDIUM 审中-公开
标题翻译：全息记录介质
公开(公告)号：WO2013003666A3
公开(公告)日：2013-07-04
申请号：PCT/US2012044778
申请日：2012-06-29
申请人： SABIC INNOVATIVE PLASTICS IP , NAIK SHANTARAM NARAYAN , TAKEMORI MICHAEL T , JAIN SUMEET , NADKARNI PRADEEP , CHEVERTON MARK A , PUTHAMANE KIRAN ARUNKUMAR , VASUDEVAN VINODKUMAR , DAVIS GARY
发明人： NAIK SHANTARAM NARAYAN , TAKEMORI MICHAEL T , JAIN SUMEET , NADKARNI PRADEEP , CHEVERTON MARK A , PUTHAMANE KIRAN ARUNKUMAR , VASUDEVAN VINODKUMAR , DAVIS GARY
IPC分类号： C07C291/02 , G03F7/00 , G03F7/004 , G03H1/02
CPC分类号： G03H1/0236 , C07C291/02 , G03F7/001 , G03H1/0248 , G03H2260/52 , G11B7/24044 , G11B7/245 , G11B2007/240025
摘要： Disclosed herein are novel nitrone compounds, holographic recording media that include the nitrone compound(s) and a polymer binder, a method of manufacturing a holographic recording medium where the nitrone compound, as a photochromic dye, is mixed with a polymer binder to form a holographic composition and molding the holographic composition into holographic data recording medium. Disclosed herein too is a method for recording a hologram by exposing the holographic recording medium to mutually coherent signal and reference light sources at a wavelength that causes a change in the chemical structure of the nitrone compound.
摘要翻译：本文公开了新的硝酮化合物，包括硝酮化合物和聚合物粘合剂的全息记录介质，制备全息记录介质的方法，其中将硝酮化合物作为光致变色染料与聚合物粘合剂混合以形成全息组合物并将全息组合物模制成全息数据记录介质。这里也公开了通过将全息记录介质暴露于导致硝酮化合物的化学结构变化的波长的相互相干的信号和参考光源来记录全息图的方法。

10. 发明申请

WO2009127398A2 CONJUGATED LINOLEIC ACID DERIVATIVES 审中-公开
标题翻译：连接的亚油酸衍生物
公开(公告)号：WO2009127398A2
公开(公告)日：2009-10-22
申请号：PCT/EP2009/002746
申请日：2009-04-15
申请人： UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND , BELTON, Orina , FITZGERALD, Desmond , DEVOCELLE, Marc , COX, Clare , ARDÈS-GUISOT, Nicolas
发明人： BELTON, Orina , FITZGERALD, Desmond , DEVOCELLE, Marc , COX, Clare , ARDÈS-GUISOT, Nicolas
IPC分类号： C07C203/04 , A61K31/21 , A61P9/00 , A61P9/10 , A61P3/10 , C07C291/02
CPC分类号： C07C203/04
摘要： A conjugated linoleic acid (CLA) derivative having the structure (I) wherein n is an integer from 1 to 10; and wherein the broken lines at positions 9 and 11, or at positions 10 and 12, are each double bonds separated by a single bond, and wherein the remaining broken line is a single bond.
摘要翻译：具有结构（I）的共轭亚油酸（CLA）衍生物，其中n是1至10的整数; 并且其中位置9和11或位置10和12处的虚线是由单键分隔的双键，并且其中剩余的虚线是单键。

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