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1. 发明申请

WO2022022168A1 一种环己基双胺类离子液体及其在二氧化硫吸收中的应用审中-公开
公开(公告)号：WO2022022168A1
公开(公告)日：2022-02-03
申请号：PCT/CN2021/101597
申请日：2021-06-22
申请人：中国科学院过程工程研究所 , 北京中富瑞科环保科技有限公司
发明人：周志茂 , 李世飞 , 许世彬
IPC分类号： C07C211/17 , B01D53/14
摘要：本申请公开了一种环己基双胺类离子液体及其在二氧化硫吸收中的应用，属于离子液体应用技术领域。吸收二氧化硫的过程为：(1)含有SO 2的气体与吸收前的吸收液接触，以吸收气体中SO 2形成吸收后的吸收液；吸收前的吸收液包含环己基双胺类离子液体和水；(2)对吸收后的吸收液加热和/或减压，进行解吸和吸收液再生；(3)将步骤(2)再生的吸收液应用于步骤(1)，循环步骤(2)和步骤(1)实现吸收液的循环利用。

2. 发明申请

WO2007127421A2 PROCESS FOR THE SYNTHESIS OF (+) AND (-)-1-ARYL-3-AZABICYCLO[3.1.0]HEXANES 审中-公开
标题翻译：合成（+）和（ - ） - 1-芳基-3-氮杂双环[3.1.0] HEXANES的方法
公开(公告)号：WO2007127421A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010324
申请日：2007-04-27
申请人： MERCK & CO., INC. , CORLEY, Edward, G. , MURRY, Jerry, A. , SIMMONS, Bryon , XU, Feng
发明人： CORLEY, Edward, G. , MURRY, Jerry, A. , SIMMONS, Bryon , XU, Feng
IPC分类号： C07D209/54 , C07C211/17 , C07C215/20 , C07C255/46
CPC分类号： C07D209/54 , C07C211/29 , C07C215/38 , C07C255/46 , C07C2601/02
摘要： The present invention is concerned with novel processes for the preparation of (+)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof, and (-)-1-aryl-3-azabicyclo[3,10]hexanes or a pharmaceutically acceptable salt thereof. These compounds have pharmaceutical utility and are known to be useful for treating e.g., pain, depression, anxiety disorders, eating disorders and urinary incontinence.
摘要翻译：本发明涉及制备（+） - 1-芳基-3-氮杂双环[3,10]己烷或其药学上可接受的盐的新方法，和（ - ） - 1-芳基-3-氮杂双环[3 ，10]己烷或其药学上可接受的盐。这些化合物具有药物效用并且已知可用于治疗例如疼痛，抑郁症，焦虑症，进食障碍和尿失禁。

3. 发明申请

WO2005077884A3 HYDROAMINOMETHYLATION OF OLEFINS 审中-公开
标题翻译：烯烃的水解甲醛化
公开(公告)号：WO2005077884A3
公开(公告)日：2005-11-24
申请号：PCT/US2005001624
申请日：2005-01-21
申请人： UNION CARBIDE CHEM PLASTIC , BRIGGS JOHN R , WHITEKER GREGORY T , KLOSIN JERZY
发明人： BRIGGS JOHN R , WHITEKER GREGORY T , KLOSIN JERZY
IPC分类号： C07C29/60 , C07C33/30 , C07C69/732 , C07C209/26 , C07C209/60 , C07C211/03 , C07C211/17 , C07C231/12 , C07C237/08 , C07C311/08 , C07D211/22 , C07D215/22 , C07D215/227 , C07D295/023
CPC分类号： C07C209/60 , C07C33/30 , C07C69/732 , C07C231/12 , C07C311/08 , C07D211/22 , C07D215/227 , C07D295/023 , C07C211/17 , C07C237/08
摘要： The present invention relates to a method comprising the step of contacting under hydroaminomethylation conditions, an olefin, an amine, a rhodium-phosphorous ligand, and synthesis gas (syngas). In particular, it has been discovered that, under some circumstances, a neutral rhodium-monodentate phosphite ligand is prescribed. The invention provides a simple way of making, in high yields and regiospecificity, a variety of products, including pharmacologically active products such as ibutilide, terfenadine, and fexofenadine, and derivatives thereof.
摘要翻译：本发明涉及包括在氢氨基甲基化条件下接触烯烃，胺，铑 - 磷配体和合成气（合成气）的步骤的方法。特别地，已经发现，在某些情况下，规定了中性铑 - 单齿亚磷酸酯配体。本发明提供了以高产率和区域特异性制备各种产品，包括药理活性产物如伊布利特，特非那定和非索非那定及其衍生物的简单方法。

4. 发明申请

WO2003064372A1 2-ADAMANTYLALKYLAMINES AND THEIR USE IN THE TREATMENT OF CONDITIONS GENERALLY ASSOCIATED WITH ABNORMALITIES IN GLUTAMATERGIC TRANSMISSION 审中-公开
标题翻译： 2-氨基甲酰胺及其在治疗与GLUTAMATERGIC传播异常有关的病症中的应用
公开(公告)号：WO2003064372A1
公开(公告)日：2003-08-07
申请号：PCT/GB2003/000315
申请日：2003-01-27
申请人： VERNALIS RESEARCH LIMITED , DAWSON, Claire, Elizabeth , RUSTON, Victoria, Jane , BLENCH, Toby, Jonathan
发明人： DAWSON, Claire, Elizabeth , RUSTON, Victoria, Jane , BLENCH, Toby, Jonathan
IPC分类号： C07C211/17
CPC分类号： A61K31/137 , A61K31/381 , C07C211/27 , C07C211/29 , C07C217/74 , C07C2603/74 , C07D333/20
摘要： The use of a compound of formula (1) wherein X is oxygen or (CR 11 R 12 ) n ; n is 0 or 1; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 11 and R 12 are independently selected from hydrogen, alkyl, aryl and non-aromatic heterocyclic groups, or each of one or more pair(s) thereof may together form a 3, 4, 5, 6, 7 or 8-membered ring containing 0, 1 or 2 heteroatom(s); R 9 is selected from alkyl, aryl and non-aromatic heterocyclic groups; and R 10 is selected from hydrogen, halogen, alkyl, aryl and non-aromatic heterocyclic groups; and pharmaceutically acceptable salts and prodrugs thereof, in therapy and the manufacture of amedicament for use in the treatment of a condition generally associated with abnormalities in glutamatergic transmission, particularly Alzheimer's disease, ischaemic stroke, haemorrhagic stroke, epilepsy, multiple sclerosis, pain, drug-induced optic neuritis, myelopathy, glaucoma, peripheral neuropathy, ischaemic retinopathy, traumatic brain or spinal injury, Parkinson's Disease and Huntington's Disease; and novel compounds of formula (1) per se .
摘要翻译：使用式（1）的化合物，其中X是氧或（CR 11 R 12）n; n为0或1; R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8，R 11和R 12独立地选自氢，烷基，芳基和非芳族杂环基，或者其一个或多个一个中的每一个可以一起形成含有0,1或2个杂原子的3,4,5,6,7或8元环; R9选自烷基，芳基和非芳族杂环基; R 10选自氢，卤素，烷基，芳基和非芳族杂环基; 特别是阿尔茨海默病，缺血性卒中，出血性中风，癫痫，多发性硬化，疼痛，药物治疗中的治疗和制造用于治疗通常与谷氨酸能传递异常有关的病症的麻醉药，诱发的视神经炎，脊髓病，青光眼，周围神经病变，缺血性视网膜病变，创伤性脑或脊髓损伤，帕金森病和亨廷顿氏病; 和式（1）的新化合物本身。

5. 发明申请

WO0236260A8 METHOD FOR CATALYTICALLY HYDRATING ORGANIC COMPOUNDS AND SUPPORTED CATALYST USED IN SAID METHOD 审中-公开
标题翻译： PROCESS FOR有机化合物和载体催化剂THEREFOR催化加氢
公开(公告)号：WO0236260A8
公开(公告)日：2002-09-19
申请号：PCT/EP0112043
申请日：2001-10-12
申请人： DEGUSSA
发明人： HAAS THOMAS , JAEGER BERND , SAUER JOERG , VANHEERTUM RUDOLF
IPC分类号： B01J23/46 , B01J35/10 , C07B61/00 , C07C29/141 , C07C31/20 , C07C209/72 , C07C211/17 , C07C211/36
CPC分类号： B01J23/462 , B01J35/1009 , C07C29/141 , C07C209/72 , C07C2601/14 , C07C211/17 , C07C31/10 , C07C31/205
摘要： The invention relates to a method for catalytically hydrating an organic compound, especially an unstable organic compound, in the presence of a supported catalyst that is provided with a coating that contains ruthenium as the active metal and a total of 0.01 to 30 % by weight of active metals. The aim of the invention is to increase stereoselectivity and catalyst service life. To this end, a supported catalyst is used whose oxide-, carbide-, nitride- or silicate-containing support material, prior to being charged with at least one active metal, has a BET(N2) surface of less than 10 m /g, preferably 0.1 to 5 m /g, with the exception of diatomaceous earth with a BET(N2) surface of greater 2 m /g, and whose ruthenium content constitutes at least 50 % by weight, preferably at least 99 % by weight, of the active metals. The invention further relates to the aforementioned supported catalysts. The method and catalysts according to the invention are especially suitable for hydrating polyfunctional compounds such as hydroxycarbonyl compounds and aromatic amines.
摘要翻译：本发明涉及一种用于有机化合物的催化氢化，特别是在含有钌作为活性金属和共活性金属涂层的0.01至30重量％的负载型催化剂的存在下不稳定有机化合物的方法。根据本发明，可与至少一种活性金属装载之前，使用负载的催化剂，该氧化物carbidisches，氮化的或硅酸盐载体材料时，具有BET的小于10μm<2> /克（N 2）的表面区域中获得更高的立体选择性和更高的催化剂寿命，特别优选为0.1〜5μm的<2> / g和具有BET硅藻土（N2）表面积大于2m <2> /克被排除，并且其钌中的至少50重量％含量，优选至少99 ％的.-％的活性金属。本发明还涉及上文所述的负载型催化剂。具体地说，该方法和用于多官能化合物，如羟基羰基化合物和芳香胺的氢化的催化剂。

6. 发明申请

WO99001416A2 1-AMINO-ALKYLCYCLOHEXANE NMDA RECEPTOR ANTAGONISTS 审中-公开
标题翻译： 1-AMINO-ALKYLCYCLOHEXANE NMDA受体拮抗剂
公开(公告)号：WO99001416A2
公开(公告)日：1999-01-14
申请号：PCT/EP1998/004026
申请日：1998-06-24
IPC分类号： A61P1/16 , A61K31/13 , A61K31/40 , A61P31/12 , A61P33/06 , A61P37/02 , A61P43/00 , C07C211/17 , C07C211/35 , C07D295/135 , C07C211/00
CPC分类号： C07D295/135 , A61K31/40 , C07C211/17 , C07C211/35 , C07C2601/14 , Y02A50/411
摘要： Certain 1-amino-alkylcyclohexanes are systemically-active uncompetitive NMDA receptor antagonists having rapid blocking/unblocking kinetics and strong voltage-dependency and are therefore useful in the alleviation of conditions resulting from disturbances of glutamatergic transmission giving them a wide range of utility in the treatment of CNS disorders involving the same, as well as in non-NMDA indications, due to their immunomodulatory, antimalarial, anti-Borna virus, and anti-Hepatitis C activities and utilities. Pharmaceutical compositions thereof and a method of treating conditions which are alleviated by the employment of an NMDA receptor antagonist, as well as the aforementioned non-NMDA indications, and a method for the preparation of the active 1-amino-alkylcyclohexane compounds involved.
摘要翻译：某些1-氨基 - 烷基环己烷是具有快速阻断/阻断动力学和强电压依赖性的系统活性的非竞争性NMDA受体拮抗剂，因此可用于缓解由谷氨酸能传递紊乱引起的病症，使其在治疗中具有广泛的用途由于其免疫调节，抗疟疾，抗 - 博尔纳病毒和抗丙型肝炎活动和功效，涉及相同的CNS疾病以及非NMDA指征。其药物组合物和通过使用NMDA受体拮抗剂缓解的病症以及上述非NMDA适应症的治疗方法以及涉及的活性1-氨基 - 烷基环己烷化合物的制备方法。

7. 发明申请

WO2011124619A1 VERFAHREN ZUR HERSTELLUNG VON UNSYMMETRISCHEN SEKUNDÄREN TERT-BUTYLAMINEN IN DER FLÜSSIGPHASE 审中-公开
标题翻译： PROCESS FOR IN液相PRODUCING不平衡SECONDARY叔丁基胺
公开(公告)号：WO2011124619A1
公开(公告)日：2011-10-13
申请号：PCT/EP2011/055372
申请日：2011-04-06
申请人： BASF SE , WIGBERS, Christof, Wilhelm , MÜLLER, Christoph , MELDER, Johann-Peter , STEIN, Bernd , MEISSNER, Harald , HADERLEIN, Gerd , GUTFRUCHT, Norbert
发明人： WIGBERS, Christof, Wilhelm , MÜLLER, Christoph , MELDER, Johann-Peter , STEIN, Bernd , MEISSNER, Harald , HADERLEIN, Gerd , GUTFRUCHT, Norbert
IPC分类号： C07C209/26 , C07C211/08 , C07C211/17 , C07C211/27
CPC分类号： C07C209/26 , C07C2601/14 , C07C211/17 , C07C211/27 , C07C211/08
摘要： Die vorliegende Anmeldung betrifft ein Verfahren zur Herstellung von unsymmetrischen sekundären tert-Butylaminen, die neben dem tert-Butylrest noch einen Alkyl-, Cyclo-alkyl- oder Benzylrest enthalten. Ihre Herstellung erfolgt durch Umsetzung entsprechender Aldehyde mit tert-Butylamin und Wasserstoff in Gegenwart von Hydrierkatalysatoren (reduktive Aminierung) in der Flüssigphase.
摘要翻译：本申请涉及一种用于生产非对称仲叔丁基胺的方法，该方法还含有除叔丁基的烷基基团，环烷基或苄基。它们通过相应的醛与液体相叔丁胺，和氢在氢化催化剂（还原胺化）的存在下反应来制备。

8. 发明申请

WO2009002407A1 METHODS OF INHIBITING ETHYLENE RESPONSES IN PLANTS USING CYCLOPROPENE AMINE COMPOUNDS 审中-公开
标题翻译：使用环丙烷胺化合物抑制植物中乙烯反应的方法
公开(公告)号：WO2009002407A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/007393
申请日：2008-06-13
申请人： NORTH CAROLINA STATE UNIVERSITY , SISLER, Edward, C.
发明人： SISLER, Edward, C.
IPC分类号： C07C13/04 , C07C211/17 , C07C211/45 , A01N27/00 , A01N3/02 , A01G7/06 , A01N33/04 , A23B7/14 , A23B7/144 , A23B7/153 , C07C211/25
CPC分类号： A01N33/04 , A23B7/144 , A23B7/154 , C07C211/25 , C07C211/45 , C07C211/48 , C07C2601/02
摘要： Methods of applying cyclopropene amine derivatives and compositions thereof to inhibit ethylene receptors in plants and plant material are disclosed. Methods include applying to the plant an effective ethylene response-inhibiting amount of at least one cyclopropene amine compound or composition thereof. Cyclopropene amine compounds, enantiomers, stereoisomers or salts thereof are also provided.
摘要翻译：公开了应用环丙烯胺衍生物及其组合物抑制植物和植物材料中的乙烯受体的方法。方法包括向植物施用有效的乙烯应答抑制量的至少一种环丙烷胺化合物或其组合物。还提供了环丙烷胺化合物，对映异构体，立体异构体或其盐。

9. 发明申请

WO9965855A3 COMBINATORIAL LIBRARIES OF GEMINALLY SUBSTITUTED AMINES 审中-公开
标题翻译：组合库宝石取代的胺
公开(公告)号：WO9965855A3
公开(公告)日：2003-12-11
申请号：PCT/EP9904255
申请日：1999-06-18
申请人： MERCK PATENT GMBH , BUCHHOLZ HERWIG , WELZ-BIERMANN URS
发明人： BUCHHOLZ HERWIG , WELZ-BIERMANN URS
IPC分类号： C07D295/02 , B01J31/02 , B01J31/12 , C07B61/00 , C07C209/66 , C07C209/68 , C07C209/78 , C07C211/05 , C07C211/06 , C07C211/08 , C07C211/16 , C07C211/17 , C07C211/21 , C07C211/22 , C07C211/27 , C07C211/35 , C07C211/48 , C07D295/023 , C07D295/03 , C07D295/06 , C07F7/10 , C40B40/04 , C40B50/00 , C07C211/00
CPC分类号： C07D295/023 , B01J31/0212 , B01J31/0237 , B01J31/0274 , B01J2231/40 , C07C209/66 , C07C209/68 , C07C2601/08 , C07C2601/14 , C07D295/03 , C07C211/08 , C07C211/16 , C07C211/17 , C07C211/21 , C07C211/27
摘要： The present invention relates to a combinatorial library that comprises amines of the general formula (I) in which R , R and R may be the same or different and represent hydrogen or a substituted or non-substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkinyl or aryl group, -Si(R)3, -Sn(R)3, -SR, -OR or -NRR'. The radicals R and R or R and R can also form together a cycloalkyl ring which may also contain, together with N, at least one other heteroatom, preferably N, O or S. The radicals R and R may be the same or different and represent a substituted or non-substituted alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkinyl or aryl group, -Si(R)3, -Sn(R)3, -SR, -OR or -NRR'. The radicals R and R can also form together a cycloalkyl ring which may also contain, together with N, at least one other heteroatom, preferably N, O or S. In the above-mentioned definition of radicals R to R , R and R' may be the same or different and represent a substituted or non-substituted alkyl radical or a substituted or non-substituted aryl radical.
摘要翻译：（I），组合文库，其包含通式的胺：其中，R <1>，R <2>和R <3>可以相同或不同，表示氢或取代或未取代的烷基，环烷基，烯基，环烯基基，炔基或芳基，-Si（R）3，-Sn（R）3，-SR，-OR，-NRR是“或基团R <1>和R <2>或R <2>和R < 3>任选以加成到N的至少一个另外的杂原子，优选N，O或S可含有形成环烷基; [R <4>和R <5>，相同或不同，表示取代或未取代的烷基，环烷基，烯基，环烯基，炔基或芳基，-Si（R）3，-Sn（R）3，是-SR，-OR，-NRR“或R <4>和R <5>可以优选含有Cycloakylring，在适用情况下，除了为N的至少一个其它杂原子N，O或S的形式，且其中R R“中的R <1>到R的定义<5>可以相同或不同，并表示取代或未取代的烷基或取代或未取代的芳基。

10. 发明申请

WO01064621A1 METHOD FOR PRODUCING AMINES BY THE HYDROAMINOMETHYLATION OF OLEFINS IN THE PRESENCE OF IONIC LIQUIDS 审中-公开
标题翻译：用于生产AMINES BY hydroaminomethylated烯烃在离子液体的存在
公开(公告)号：WO01064621A1
公开(公告)日：2001-09-07
申请号：PCT/EP2001/001826
申请日：2001-02-19
IPC分类号： C07D265/30 , C07B61/00 , C07C209/26 , C07C209/78 , C07C211/27 , C07C211/35 , C07D295/023 , C07C211/17 , C07C211/48 , C07D295/03
CPC分类号： C07D295/023 , C07C209/26
摘要： The invention relates to a method for producing amines by the catalytic hydroaminomethylation of olefins in the presence of an ionic fluid.
摘要翻译：本发明涉及通过烯烃的催化hydroaminomethylation在离子液体存在下制备胺的方法。

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