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1. 发明申请

WO2007067731A3 MICELLE- AND MICROEMULSION-ASSISTED PLANAR SEPARATIONS PLATFORM FOR PROTEOMICS 审中-公开
标题翻译： MICELLE和MICROEMULSION辅助平面分离平台
公开(公告)号：WO2007067731A3
公开(公告)日：2008-01-10
申请号：PCT/US2006046838
申请日：2006-12-08
申请人： PERKINELMER LAS INC , PATTON WAYNE F
发明人： PATTON WAYNE F
IPC分类号： C12Q1/68 , G01N27/26 , G01N33/53
CPC分类号： G01N27/44747 , G01N27/447 , G01N30/463 , G01N30/58 , G01N30/90 , G01N2030/582
摘要： A method of separating biomolecules includes providing a sample comprising one or more biomolecules, at least one of which is hydrophilic; wetting an amphiphilic planar stationary phase with a microemulsion or micelluar mobile phase; and creating an electrical field between first and second electrodes in electrical contact with opposing edges of the amphiphilic stationary phase, wherein the mobile phase advances across the length of the separation medium and one or more biomolecules are separated.
摘要翻译：分离生物分子的方法包括提供包含一种或多种生物分子的样品，其中至少一种是亲水性的; 用微乳液或微胶囊流动相润湿两亲平面固定相; 以及在所述两亲性固定相的相对边缘电接触的第一和第二电极之间产生电场，其中所述流动相跨越所述分离介质的长度并且分离一个或多个生物分子。

2. 发明申请

WO2005092013A3 SEPARATIONS PLATFORM BASED UPON ELECTROOSMOSIS-DRIVEN PLANAR CHROMATOGRAPHY 审中-公开
标题翻译：基于电磁驱动平面色谱的分离平台
公开(公告)号：WO2005092013A3
公开(公告)日：2006-08-17
申请号：PCT/US2005009210
申请日：2005-03-18
申请人： PERKINELMER LAS INC , PATTON WAYNE F , SCHERMER MACK J
发明人： PATTON WAYNE F , SCHERMER MACK J
IPC分类号： B01D15/08 , C07K1/26 , G01N27/447
CPC分类号： C07K1/26 , C07K1/285 , G01N27/44747 , G01N30/58 , G01N30/92 , G01N2030/8813 , G01N2030/945
摘要： The present invention describes a system and method for separation of proteins, peptides and glycans by one-dimensional or two-dimensional electroosmosis-driven planar chromatography. Separation is performed using amphiphilic polymeric membranes, amphiphilic thin-layer chromatography plates or other planar amphiphilic surfaces as the stationary phase with a combination of organic and/or aqueous buffers as the mobile phase. Systematic selection of stationary phase supports, mobile phase buffers and operating conditions allow for the adaptation of the invention to a broad range of applications in proteomics, mass spectrometry, drug discovery and the pharmaceutical sciences.
摘要翻译：本发明描述了通过一维或二维电渗驱动的平面色谱分离蛋白质，肽和聚糖的系统和方法。使用两亲聚合物膜，两亲性薄层色谱板或其它平面两亲性表面作为固定相进行分离，其中有机和/或含水缓冲液作为流动相。固定相载体，流动相缓冲液和操作条件的系统选择允许本发明适用于蛋白质组学，质谱，药物发现和药学科学领域的广泛应用。

3. 发明申请

WO99029388A1 ANNULAR CHROMATOGRAPH 审中-公开
标题翻译：环形色谱仪
公开(公告)号：WO99029388A1
公开(公告)日：1999-06-17
申请号：PCT/AT1998/000299
申请日：1998-12-09
IPC分类号： G01N30/06 , B01D15/00 , B01D15/08 , B01J8/02 , B01J8/04 , B01J47/02 , G01N30/58
CPC分类号： G01N30/58 , B01D15/1892 , B01D2215/022 , B01J8/02 , B01J8/025 , B01J8/0257 , B01J8/0453 , B01J8/0469 , G01N2030/587
摘要： The invention relates to an annular chromatograph with a particle bed in its annular gap. Said chromatograph is characterised in that at least one reaction zone for conducting the chemical reactions and at least one associated separation zone for the chromatographic separation are provided.
摘要翻译：本发明提供了在其环间隙，其特征在于，在至少一个反应区用于与被设置用于色谱分离的至少一个相关联的分离区进行化学反应的颗粒床的环形色谱仪。

4. 发明申请

WO99028740A1 ANNULAR CHROMATOGRAPH 审中-公开
标题翻译：环形色谱仪
公开(公告)号：WO99028740A1
公开(公告)日：1999-06-10
申请号：PCT/AT1998/000290
申请日：1998-11-30
IPC分类号： B01D15/02 , G01N30/02 , G01N30/46 , G01N30/52 , G01N30/58
CPC分类号： B01D15/1892 , B01D2215/022 , G01N30/02 , G01N30/463 , G01N30/52 , G01N30/58 , G01N2030/587 , B01D15/36 , B01D15/34 , B01D15/422 , G01N27/447
摘要： The present invention relates to an annular chromatograph comprising a coating in the shape of a particulate bed, wherein said chromatograph is characterised in that the particulate bed comprises at least two superimposed areas which contain different materials and which are separated from each other by at least one separation layer.
摘要翻译：本发明是在颗粒的床，其特征在于，颗粒床的形式进料的环形色谱仪包括含有单独的床材料的至少两个叠置的区域，并且彼此通过至少一个分离层优选分离。

5. 发明申请

WO1996000124A1 CONTINUOUS, STEADY-STATE, CHROMATOGRAPHIC SEPARATION OF GADOLINIUM ISOTOPES 审中-公开
标题翻译：连续，稳态，钆同系物的色谱分离
公开(公告)号：WO1996000124A1
公开(公告)日：1996-01-04
申请号：PCT/US1995007623
申请日：1995-06-16
申请人： WESTINGHOUSE ELECTRIC CORPORATION
发明人： WESTINGHOUSE ELECTRIC CORPORATION , SNYDER, Thomas, S. , PETERSON, Steven, H. , NAYAK, Umesh, P.
IPC分类号： B01D59/30
CPC分类号： B01D59/30 , G01N30/58 , Y10S423/07
摘要： A method and apparatus for the partial or complete continuous separation of isotopes of gadolinium, especially high thermal neutron capture cross section gadolinium isotopes, using continuous, steady-state, chromatography in which an ion exchange resin is the stationary phase, an aqueous solution of ions based on a mixture of gadolinium isotopes is the feed phase, and an aqueous acid eluant solution is the mobile phase. The method involves the mobile phase eluting or desorbing the gadolinium isotopic solute or ligand adsorbed on the stationary phase under conditions such that each of the various naturally occurring isotopes of gadolinium is primarily eluted in an elution volume distinct from the elution volumes of the other isotopes. In a preferred embodiment, the conditions are such that at least one of the elution volumes contains essentially only one isotope of gadolinium. The method is preferably conducted in a continuous, steady-state manner, and it is preferably conducted in a single operation in a continuous annular chromatograph (CAC).
摘要翻译：一种使用连续稳态色谱法（其中离子交换树脂为固定相），离子水溶液部分或完全连续分离钆同位素特别是高热中子俘获截面钆同位素的方法和装置基于钆同位素的混合物是进料相，含水酸性洗脱液是流动相。该方法包括流动相洗脱或解吸吸附在固定相上的钆同位素溶质或配体，条件是使得各种天然存在的钆的各种天然存在的同位素主要以与其它同位素的洗脱体积不同的洗脱体积洗脱。在优选的实施方案中，条件使得至少一个洗脱体积基本上仅含有一种钆同位素。该方法优选以连续，稳态的方式进行，优选在连续环状色谱（CAC）中一次操作。

6. 发明申请

WO1994006532A1 CONTINUOUS CHROMATOGRAPHY 审中-公开
标题翻译：连续色谱法
公开(公告)号：WO1994006532A1
公开(公告)日：1994-03-31
申请号：PCT/EP1993002583
申请日：1993-09-17
申请人： REUTER CHEMISCHER APPARATEBAU GMBH , REUTER, Karl
发明人： REUTER CHEMISCHER APPARATEBAU GMBH
IPC分类号： B01D15/08
CPC分类号： B01D15/08 , B01D2215/022 , G01N30/42 , G01N30/58
摘要： A process and device are disclosed for separating a mixture of substances. The mixture of substances to be separated is introduced into the separation chamber (3) between the surfaces of the sorption agents (1, 2). A medium in which the components of the mixture can be dissolved, dispersed and/or evaporated, fills an intermediate space located between the sorption agents (1, 2). The phases containing the sorption agents move in opposite directions, and the separated components of the mixture on the sorption agents are recovered after running through the separating section. The separation chamber (3) consists of at least two or several hollow, concentrically superimposed cylindrical disks (134, 135) ZA and ZB filled with structural elements. The cylindrical disks contain the separating media (PhA and PhB) which consist of or contain the sorption agents. The cylindrical disks (ZA and ZB) are arranged in alternation and turn around a common axis in opposite directions towards each other, so that the medium in the intermediate spaces is exchanged and the substances to be separated between the surfaces of the sorption agents (1, 2) are equilibrated.

7. 发明申请

WO2014125304A1 CHROMATOGRAPHY SYSTEM WITH TILT-PREVENTION STRUCTURE AND ASSOCIATED PROCESS 审中-公开
标题翻译：具有倾覆预防结构和相关过程的色谱系统
公开(公告)号：WO2014125304A1
公开(公告)日：2014-08-21
申请号：PCT/GB2014/050456
申请日：2014-02-17
申请人： BIOTECHFLOW LIMITED
发明人： HOFMANN, Martin, John
IPC分类号： G01N30/60 , G01N30/56
CPC分类号： B01D15/22 , B01D15/206 , G01N30/56 , G01N30/58 , G01N30/6021 , G01N30/6026 , G01N30/603
摘要： Chromatography apparatus and methods are described, especially for expanded bed adsorption. A column tube (1) has a process fluid input device (41) at the bottom and a movable piston (2) in the top. The piston (2) is enclosed in the column by a top cover plate (3). The piston body (21) has a peripheral inflatable seal (23), and is connected by an open frame (85) to a contact ring (81) above which carries another inflatable annular member (83) to contact the tube wall. Process fluid leaves the operating volume (13) through a central opening of the piston and flexible hose (9), through the enclosed space and out through the cover plate (3). The space (77) above the piston (2) can be pressurised to control piston movement. The contact ring (81) maintains piston alignment. The inflatable seals (23,83) can be inflated or deflated to fix the piston in position, allow it to slide or allow washing. The piston outlet may include a vortex-inhibitor. Bed and piston levels may be monitored by ultrasound sensors.
摘要翻译：描述了色谱装置和方法，特别是用于扩展床吸附。柱管（1）在底部具有工艺流体输入装置（41）和顶部的活动活塞（2）。活塞（2）通过顶盖板（3）封闭在柱中。活塞体（21）具有周边的可充气密封件（23），并且通过开放框架（85）连接到接触环（81）上，接触环（81）承载另一个可膨胀的环形构件（83）以与管壁接触。工作流体通过活塞和柔性软管（9）的中心开口离开操作容积（13），并通过封闭空间离开盖板（3）。可以对活塞（2）上方的空间（77）进行加压以控制活塞运动。接触环（81）保持活塞对准。可膨胀密封件（23,83）可以膨胀或放气以将活塞固定就位，允许其滑动或允许洗涤。活塞出口可以包括涡流抑制剂。床和活塞水平可以由超声波传感器监测。

8. 发明申请

WO2007067731A2 MICELLE- AND MICROEMULSION-ASSISTED PLANAR SEPARATIONS PLATFORM FOR PROTEOMICS 审中-公开
标题翻译： MICELLE和MICROEMULSION辅助平面分离平台
公开(公告)号：WO2007067731A2
公开(公告)日：2007-06-14
申请号：PCT/US2006/046838
申请日：2006-12-08
申请人： PERKINELMER LAS, INC. , PATTON, Wayne, F.
发明人： PATTON, Wayne, F.
IPC分类号： C12Q1/68 , G01N33/53
CPC分类号： G01N27/44747 , G01N27/447 , G01N30/463 , G01N30/58 , G01N30/90 , G01N2030/582
摘要： A method of separating biomolecules includes providing a sample comprising one or more biomolecules, at least one of which is hydrophilic; wetting an amphiphilic planar stationary phase with a microemulsion or micelluar mobile phase; and creating an electrical field between first and second electrodes in electrical contact with opposing edges of the amphiphilic stationary phase, wherein the mobile phase advances across the length of the separation medium and one or more biomolecules are separated.
摘要翻译：分离生物分子的方法包括提供包含一种或多种生物分子的样品，其中至少一种是亲水性的; 用微乳液或微胶囊流动相润湿两亲平面固定相; 以及在所述两亲性固定相的相对边缘电接触的第一和第二电极之间产生电场，其中所述流动相跨越所述分离介质的长度并且分离一个或多个生物分子。

9. 发明申请

WO01038866A1 ANNULAR CHROMATOGRAPH COMPRISING A FRACTION DETECTOR 审中-公开
标题翻译：具有群体探测器环形色谱仪
公开(公告)号：WO01038866A1
公开(公告)日：2001-05-31
申请号：PCT/EP2000/011944
申请日：2000-11-29
IPC分类号： G01N30/58 , G01N30/74
CPC分类号： G01N30/58 , G01N2030/587 , G01N30/74 , G01N30/78
摘要： The invention relates to a device and a method for detecting the escape of liquid from a particle bed (1) or a base plate (2) of a continuous annular chromatograph (20). In a preferred embodiment, detectors (27) are arranged in a detector plate (40) which is located downstream of a collecting ring (3) and is offset in relation to the latter. Each detector, together with a quartz tube forms a measuring cell. The measuring cells are connected to the outlets of the collecting ring via tube connections. In order to prevent the formation of bubbles, the eluate drain lines emanating from the collecting ring form a type of siphon.
摘要翻译：本申请涉及一种装置和方法，用于从一个粒子床（1）或一个连续的环形色谱仪（20）的底板（2）检测的液体泄漏。在一个优选的实施方案中，检测器被布置（27）远离的环（3），检测器的下游板（40）的集合。用石英制的管一起，每一个检测器上形成测量单元。这些传感器通过软管连接到集电环的出口相连接。为了防止形成Eluatableitungen从收集环一种类型的虹吸起动气泡的形成。

10. 发明申请

WO99047913A1 ANNULAR CHROMATOGRAPH 审中-公开
标题翻译：环形色谱仪
公开(公告)号：WO99047913A1
公开(公告)日：1999-09-23
申请号：PCT/AT1999/000075
申请日：1999-03-19
IPC分类号： G01N30/58
CPC分类号： G01N30/58 , G01N2030/582 , G01N2030/587
摘要： The invention relates to an annular chromatograph comprising a particle bed which rotates on a rotary plate (3), said plate having eluate drainage lines, with regard to a stationary base and a stationary feeder head (10) with continuous feeder lines. Said particle bed is configured between an inner cylinder (13) and a cylinder sleeve (6). The invention is characterized in that a central column (2) is provided on the rotary plate (3) and extends upwards and through the feeder head (10). In addition, a tightening device (16, 17) for pressing the feeder head (10) on the cylinder sleeve (6) is arranged on said column.
摘要翻译：公开了相对于一个环形色谱仪，通过馈电线固定底座和固定冒口（10）上的转台（3）与Eluatableitungen旋转颗粒床，该内筒（13）和气缸套（6）之间形成，其特征在于中心柱（2）设置在所述转盘（3），其通过在其上的夹紧装置（16，17），用于推压所述冒口（10），其布置在缸套的冒口（10）延伸，并且向上向上（6）是。

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