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1. 发明申请

WO2016134378A1 LIVE ATTENUATED VACCINES FOR PNEUMOVIRUSES AND RELATED METHODS AND MATERIALS 审中-公开
标题翻译：用于肺炎链球菌的灭活疫苗及相关方法和材料
公开(公告)号：WO2016134378A1
公开(公告)日：2016-08-25
申请号：PCT/US2016/018975
申请日：2016-02-22
申请人： RESEARCH INSTITUTE AT NATIONWIDE CHILDREN'S HOSPITAL , OHIO STATE INNOVATION FOUNDATION
发明人： PEEPLES, Mark E. , LI, Jianrong , CAI, Hui , WANG, Rongzhang
IPC分类号： C12N7/04
CPC分类号： C12N7/045 , A61K39/12 , A61K2039/5254 , C07K14/005 , C07K2319/23 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18534 , C12N2760/18562
摘要： Described herein are mutant pneumoviruses comprising a nucleotide sequence which encodes a mutated zinc binding motif in an M2-1 protein of the pneumovirus, wherein the zinc binding motif is mutated relative to wild-type pneumovirus. The mutant pneumoviruses described herein grow to high titer in cell culture, are genetically stable, are attenuated in vitro and in vivo, and are highly immunogenic. Also described herein are vaccines and vaccine compositions comprising the live attenuated mutant pneumoviruses. Vaccine compositions can further comprise a pharmaceutically acceptable carrier, vehicle, excipient, and/or adjuvant. Methods for inducing a protective immune response in a subject against a pneumovirus infection are also described and disclosed. The vaccine compositions and methods described herein can be used to prevent metapneumovirus and respiratory syncytial virus infection in humans, respiratory syncytial virus infection in cattle, avian metapneumovirus infection in various avian species, and pneumonia virus of mice in rodents.
摘要翻译：本文描述的是突变型肺炎链球菌，其包含编码肺病毒M2-1蛋白中突变的锌结合基序的核苷酸序列，其中锌结合基序相对于野生型肺病毒突变。本文描述的突变型肺病毒在细胞培养物中生长高滴度，在遗传上是稳定的，在体外和体内减毒，并且是高度免疫原性的。本文还描述了包含活减毒突变型肺炎链球菌的疫苗和疫苗组合物。疫苗组合物还可以包含药学上可接受的载体，媒介物，赋形剂和/或佐剂。还描述和公开了在受试者中针对肺病毒感染诱导保护性免疫应答的方法。本文所述的疫苗组合物和方法可用于预防人类中的偏肺病毒和呼吸道合胞病毒感染，牛中的呼吸道合胞病毒感染，各种鸟类中的禽类间质肺病毒感染以及啮齿动物中的小鼠肺炎病毒。

2. 发明申请

WO2012170997A1 PARAMYXOVIRUS IMMUNOGENS AND RELATED MATERIALS AND METHODS 审中-公开
标题翻译： PARAMYXOVIRUS免疫原及相关材料与方法
公开(公告)号：WO2012170997A1
公开(公告)日：2012-12-13
申请号：PCT/US2012/041878
申请日：2012-06-11
申请人： THE OHIO STATE UNIVERSITY , LI, Jianrong , MA, Yuanmei , ZHANG, Yu
发明人： LI, Jianrong , MA, Yuanmei , ZHANG, Yu
IPC分类号： C12N7/00 , A61K39/155
CPC分类号： A61K39/155 , A61K38/45 , A61K39/12 , A61K2039/5254 , A61K2039/542 , A61K2039/543 , C12N7/00 , C12N2760/18334 , C12N2760/18362 , C12N2760/18534 , C12N2760/18562 , C12N2760/18634 , C12N2760/18662 , C12Y207/07006
摘要： The present invention includes methyltransferase (MTase) -defective recombinant viruses as live vaccine candidates for human metapneumovirus (hMPV), human respiratory syncytial virus (hRSV), and human parainfluenza virus type 3 (PIV3). Here the inventors provide the technical description for generating MTase-defective paramyxoviruses useful as immunogens, as well as related materials and methods.
摘要翻译：本发明包括甲基转移酶（MTase） - 有效重组病毒作为人类偏肺病毒（hMPV），人呼吸道合胞病毒（hRSV）和人副流感病毒3型（PIV3）的活疫苗候选物。本发明人提供了用于产生可用作免疫原的MTase缺陷型副粘病毒的技术描述，以及相关的材料和方法。

3. 发明申请

WO2017075125A1 Chimeric RSV, Immunogenic Compositions, and Methods of Use 审中-公开
标题翻译：嵌合RSV，免疫原性组合物和使用方法
公开(公告)号：WO2017075125A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058976
申请日：2016-10-27
申请人： EMORY UNIVERSITY
发明人： MOORE, Martin L. , ROSTAD, Christina
IPC分类号： C07K14/005
CPC分类号： C07K14/005 , A61K39/12 , A61K2039/5254 , C12N7/00 , C12N2760/18521 , C12N2760/18534 , C12N2760/18562
摘要： This disclosure relates to chimeric respiratory syncytial virus (RSV), live attenuated vaccine and immunogenic compositions, and methods of use. In certain embodiments, the chimeric respiratory syncytial virus has a mutated gene pattern encoding an RSV F protein having M at position 79, R at position 191, K at position 357, and/or Y at position 371.
摘要翻译：本公开涉及嵌合呼吸道合胞病毒（RSV），减毒活疫苗和免疫原性组合物以及使用方法。在某些实施方案中，嵌合呼吸道合胞病毒具有编码79位M，191位R，357位K和/或371位Y的RSV F蛋白的突变基因模式。

4. 发明申请

WO2014124238A8 ATTENUATION OF HUMAN RESPIRATORY SYNCYTIAL VIRUS BY GENOME SCALE CODON-PAIR DEOPTIMIZATION 审中-公开
标题翻译：人类呼吸道同源病毒通过基因定量鉴定鉴定失败
公开(公告)号：WO2014124238A8
公开(公告)日：2015-09-24
申请号：PCT/US2014015274
申请日：2014-02-07
申请人： US HEALTH , MUELLER STEFFEN , WIMMER ECKARD
发明人： MUELLER STEFFEN , WIMMER ECKARD , COLLINS PETER L , LE NOUËN CYRIL , BROCK LINDA G , BUCHHOLZ URSULA J , DINAPOLI JOSHUA MARC
IPC分类号： C12N7/00 , A61K39/155 , C12N15/86
CPC分类号： C12N7/00 , A61K39/155 , A61K2039/5254 , A61K2039/53 , A61K2039/55 , C07K14/005 , C12N2760/00021 , C12N2760/00034 , C12N2760/00062 , C12N2760/18522 , C12N2760/18534 , C12N2760/18561 , C12N2760/18562
摘要： Described herein are RSV polynucleotide sequences that make use of multiple codons that are containing silent nucleotide substitutions engineered in multiple locations in the genome, wherein the substitutions introduce a numerous synonymous codons into the genome. Due to the large number of defects involved, the attenuated viruses disclosed herein provide a means of producing attenuated, live vaccines against RSV.
摘要翻译：本文描述的是RSV多核苷酸序列，其利用多个密码子，其包含在基因组中的多个位置工程改造的沉默核苷酸取代，其中所述取代在基因组中引入许多同义密码子。由于所涉及的大量缺陷，本文公开的减毒病毒提供了针对RSV产生减毒活体疫苗的方法。

5. 发明申请

WO2013154728A1 GENETICALLY STABLE LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINE AND ITS PRODUCTION 审中-公开
标题翻译：基因稳定的活体灭活呼吸道病毒疫苗及其生产
公开(公告)号：WO2013154728A1
公开(公告)日：2013-10-17
申请号：PCT/US2013/030836
申请日：2013-03-13
申请人： THE UNITED STATES OF AMERICA , as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： COLLINS, Peter, L. , LUONGO, Cindy, L. , BUCHHOLZ, Ursula, J. , MURPHY, Brian, R.
IPC分类号： A61K39/155 , C07K14/135 , C12N7/04
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , C07K14/005 , C12N7/00 , C12N2760/18521 , C12N2760/18522 , C12N2760/18534 , C12N2760/18562
摘要： Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
摘要翻译：本文提供了重组呼吸道合胞病毒，其包含使所公开的病毒具有吸引力的疫苗候选物的突变。所公开的病毒包含设计为具有增加的遗传和表型稳定性的减毒突变。可以进行这些突变的期望组合以达到期望的降低水平。描述了示例性疫苗候选物。还提供了能够编码所描述的病毒的多核苷酸，如作为生产病毒的方法以及使用方法的孔。

6. 发明申请

WO2010077717A1 MODIFIED RSV F PROTEINS AND METHODS OF THEIR USE 审中-公开
标题翻译：修饰的RSV F蛋白及其使用方法
公开(公告)号：WO2010077717A1
公开(公告)日：2010-07-08
申请号：PCT/US2009/067269
申请日：2009-12-09
申请人： NOVAVAX, INC. , PUSHKO, Peter , WU, Yingyun , MASSARE, Michael , LIU, Ye , SMITH, Gale , ZHOU, Bin
发明人： PUSHKO, Peter , WU, Yingyun , MASSARE, Michael , LIU, Ye , SMITH, Gale , ZHOU, Bin
IPC分类号： A61K39/155
CPC分类号： A61K39/155 , A61K9/0019 , A61K9/1075 , A61K39/00 , A61K39/12 , A61K39/39 , A61K2039/5258 , A61K2039/54 , A61K2039/545 , A61K2039/55 , A61K2039/55505 , A61K2039/57 , A61K2039/575 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , C12N2760/18562 , C12N2760/18571
摘要： The present invention is generally related to modified or mutated respiratory syncytial virus fusion (F) proteins and methods for making and using them, including immunogenic compositions such as vaccines for the treatment and/or prevention of RSV infection.
摘要翻译：本发明通常涉及修饰或突变的呼吸道合胞病毒融合（F）蛋白及其制备及使用方法，包括用于治疗和/或预防RSV感染的疫苗等免疫原性组合物。

7. 发明申请

WO2005080417A3 RECOMBINANT VIRUSES WITH HETEROLOGOUS ENVELOPE PROTEINS 审中-公开
标题翻译：重组病毒与外源性包膜蛋白
公开(公告)号：WO2005080417A3
公开(公告)日：2006-06-29
申请号：PCT/US2004041067
申请日：2004-12-10
申请人： UAB RESEARCH FOUNDATION , OOMENS ANTONIUS G P , WERTZ GAIL W , MEGAW ALEXANDER GEORGE
发明人： OOMENS ANTONIUS G P , WERTZ GAIL W , MEGAW ALEXANDER GEORGE
IPC分类号： A61K39/155 , C07K14/01 , C07K14/115 , C07K14/135 , C12N7/04 , C12N15/34 , C12N15/45 , C12N15/62 , C12N15/86 , G01N33/50
CPC分类号： C12N15/86 , A61K39/12 , A61K39/155 , A61K2039/5254 , A61K2039/5256 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18543 , C12N2760/18545 , C12N2760/18562 , C12N2810/60
摘要： The invention provides recombinant viruses comprising heterologous envelope proteins capable of mediating entry of the recombinant viruses into host cells. In one embodiment, a recombinant virus of the invention is a member of the Paramyxovirzdae family (e.g., a respiratory syncytial virus), and the heterologous envelope protein includes the ectodomain of a baculovirus envelope protein (e.g., the GP64 protein). In some cases, the heterologous envelope protein is provided in addition to homologous envelope proteins) which may or may not be functional. The heterologous protein can provide the recombinant virus with enhanced stability (e.g., at 4 °C, 22 °C, or 37 °C), and allows production of high-titer virus stocks. The heterologous protein can also impart temperature sensitivity to the replication of the recombinant virus. In addition, the recombinant virus can be designed to be infectious but incapable of spreading between host cells by providing the heterologous protein by complementation in trans. These features attenuate the disease-causing potential of the recombinant virus, therefore increasing its safety of use as vaccines.
摘要翻译：本发明提供了包含能够介导重组病毒进入宿主细胞的异源包膜蛋白的重组病毒。在一个实施方案中，本发明的重组病毒是副粘病毒科（例如呼吸道合胞病毒）的成员，异源包膜蛋白包括杆状病毒包膜蛋白（例如GP64蛋白）的胞外域。在一些情况下，异源包膜蛋白除了同源包膜蛋白外还提供），其可以是或不是功能性的。异源蛋白质可以提供具有增强的稳定性（例如在4℃，22℃或37℃）的重组病毒，并且允许产生高滴度病毒种群。异源蛋白质还可以赋予重组病毒复制的温度敏感性。此外，重组病毒可被设计为感染性的，但不能通过在反式中互补提供异源蛋白质而在宿主细胞之间扩散。这些特征减轻重组病毒的致病潜力，从而增加其作为疫苗使用的安全性。

8. 发明申请

WO2006042156A2 MODULATION OF REPLICATIVE FITNESS BY DEOPTIMIZATION OF SYNONYMOUS CODONS 审中-公开
标题翻译：通过识别同位素代码来选择适应症的调节
公开(公告)号：WO2006042156A2
公开(公告)日：2006-04-20
申请号：PCT/US2005036241
申请日：2005-10-07
申请人： US GOV HEALTH & HUMAN SERV , KEW OLEN M , BURNS CARA C , SHAW JING , CAMPAGNOLI RAYMOND , QUAY JACQUELINE
发明人： KEW OLEN M , BURNS CARA C , SHAW JING , CAMPAGNOLI RAYMOND , QUAY JACQUELINE
IPC分类号： C12N5/10
CPC分类号： A61K39/0258 , A61K39/00 , A61K2039/522 , A61K2039/5254 , C07K14/245 , C12N7/00 , C12N15/67 , C12N2710/16162 , C12N2710/16662 , C12N2710/16762 , C12N2760/16162 , C12N2760/18462 , C12N2760/18562 , C12N2770/20062 , C12N2770/24162 , C12N2770/32162 , C12N2770/32762 , C12N2770/36262
摘要： Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.
摘要翻译：公开了产生具有降低的复制适应性的病原体的方法，以及使用该方法产生的减毒病原体。在具体实例中，该方法包括对编码序列中的一个或多个密码子进行去优化，从而降低病原体的复制适应性。还公开了将减毒病原体用作免疫原性组合物的方法。

9. 发明申请

WO0244334A3 RECOMBINANT RSV VIRUS EXPRESSION SYSTEMS AND VACCINES 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：WO0244334A3
公开(公告)日：2004-08-26
申请号：PCT/US0144819
申请日：2001-11-28
申请人： AVIRON INC
发明人： JIN HONG , TANG RODERICK , LI SHENGQIANG , BRYANT MARTIN
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/155 , A61K48/00 , A61P11/00 , A61P31/14 , C07K14/135 , C12N7/00 , C12N7/01 , C12N7/04
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N2760/18522 , C12N2760/18562
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to teh attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译：本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

10. 发明申请

WO02044334A2 RECOMBINANT RSV VIRUS EXPRESSION SYSTEMS AND VACCINES 审中-公开
标题翻译：重组RSV病毒表达系统和疫苗
公开(公告)号：WO02044334A2
公开(公告)日：2002-06-06
申请号：PCT/US2001/044819
申请日：2001-11-28
IPC分类号： C12N15/09 , A61K31/7088 , A61K39/00 , A61K39/155 , A61K48/00 , A61P11/00 , A61P31/14 , C07K14/135 , C12N7/00 , C12N7/01 , C12N7/04 , C12N
CPC分类号： C07K14/005 , A61K2039/525 , C12N7/00 , C12N2760/18522 , C12N2760/18562
摘要： The present invention relates to genetically engineered recombinant respiratory syncytial viruses and viral vectors which contain deletions of various viral accessory gene(s) either singly or in combination. In accordance with the present invention, the recombinant respiratory syncytial viral vectors and viruses are engineered to contain complete deletions of the M2-2, NS1, NS2, or SH viral accessory genes or various combinations thereof. In addition, the present invention relates to teh attenuation of respiratory syncytial virus by mutagenisis of the M2-1 gene.
摘要翻译：本发明涉及遗传工程重组呼吸道合胞病毒和病毒载体，其含有单独或组合的各种病毒辅助基因的缺失。根据本发明，重组呼吸道合胞病毒载体和病毒被工程化以含有M2-2，NS1，NS2或SH病毒附属基因或其各种组合的完全缺失。此外，本发明涉及通过M2-1基因的诱变来减轻呼吸道合胞病毒。

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