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1. 发明申请

WO0054573A8 GEMINIVIRUS RESISTANT TRANSGENIC PLANTS 审中-公开
标题翻译： GEMINIVIRIS抗性转基因植物
公开(公告)号：WO0054573A8
公开(公告)日：2001-12-27
申请号：PCT/US0006759
申请日：2000-03-15
申请人： UNIV NORTH CAROLINA , HANLEY BOWDOIN LINDA , OROZCO BEVERLY M , KONG LING JIE
发明人： HANLEY-BOWDOIN LINDA , OROZCO BEVERLY M , KONG LING-JIE
IPC分类号： C07K14/01 , C12N9/12 , C12N15/33 , C12N15/82 , A01H1/00 , C07H21/04 , C07K14/005 , C12N5/04 , C12N5/14 , C12N15/00
CPC分类号： C12N9/1252 , C07K14/005 , C12N15/8283 , C12N2750/12022
摘要： Transgenic plants with increased resistance to geminivirus infection, and nucleic acid constructs useful in producing such plants, are described. The transgenic plants express a mutant AL1/C1 geminivirus protein, which increases resistance to infection by at least one geminivirus, compared to a non-transformed control plant.
摘要翻译：描述了对双重病毒感染的抗性增加的转基因植物和用于生产这种植物的核酸构建体。与未转化的对照植物相比，转基因植物表达突变型AL1 / C1双系病毒蛋白，其增加至少一种双因子病毒感染的抗性。

2. 发明申请

WO00053784A1 METHODS OF USING VIRAL REPLICASE 审中-公开
标题翻译：使用病毒复制的方法
公开(公告)号：WO00053784A1
公开(公告)日：2000-09-14
申请号：PCT/US2000/006163
申请日：2000-03-09
IPC分类号： C07K14/01 , C12N9/12 , C12N15/34 , C12N15/82
CPC分类号： C12N9/127 , C07K14/005 , C12N15/8261 , C12N2750/12022 , Y02A40/146
摘要： The invention provides methods of using viral replicase polypeptides and polynucleotides. Included are methods for modulating endoreduplication and increasing crop yield.
摘要翻译：本发明提供使用病毒复制酶多肽和多核苷酸的方法。包括调节内吞重复和提高作物产量的方法。

3. 发明申请

WO1997039110A1 TRANSGENIC PLANTS EXPRESSING GEMINIVIRUS GENES 审中-公开
标题翻译：表达GEMINIVIRUS基因的转基因植物
公开(公告)号：WO1997039110A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006300
申请日：1997-04-15
申请人： SEMINIS VEGETABLE SEEDS, INC. , WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人： SEMINIS VEGETABLE SEEDS, INC. , WISCONSIN ALUMNI RESEARCH FOUNDATION , STOUT, John, T. , LUU, Hang, T. , HANSON, Steven, F. , MAXWELL, Douglas, P. , AHLQUIST, Paul, G.
IPC分类号： C12N05/14
CPC分类号： C07K14/005 , A61K38/00 , C12N15/8283 , C12N2750/12022
摘要： The invention involves production of transgenic plants containing DNA encoding AC1/C1 wildtype and mutant sequences that negatively interfere in trans with geminiviral replication during infection. The transgenic plants produced by the invention are resistant to viral infection.
摘要翻译：本发明涉及生产含有编码AC1 / C1野生型DNA的转基因植物和在感染期间与双重病毒复制反向干扰的突变序列。由本发明生产的转基因植物耐病毒感染。

4. 发明申请

WO1996008573A1 PHYTOPATHOGENIC DNA VIRUS RESISTANT TRANSGENIC PLANTS AND SEEDS AND METHODS FOR OBTAINING SAME 审中-公开
标题翻译：植物病原DNA抗病毒转基因植物和种子及其获取方法
公开(公告)号：WO1996008573A1
公开(公告)日：1996-03-21
申请号：PCT/FR1995001192
申请日：1995-09-15
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , GRONENBORN, Bruno
发明人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
IPC分类号： C12N15/82
CPC分类号： C07K14/005 , C12N9/90 , C12N15/8283 , C12N2750/12022
摘要： Use of nucleotide sequences produced by mutation (also known as mutant nucleotide sequences) of nucleotide sequences present in a pathogenic DNA virus genome in plants. The mutant nucleotide sequences comprise one or more mutations capable of producing a dominant negative phenotype for the replication of the pathogenic virus, and/or its diffusion in a plant, and/or its spread from one plant to another, especially through vectors such as insects, the mutant nucleotide sequences being capable of fully or partially inhibiting the replication and/or diffusion and/or spread of the pathogenic virus. The invention is for producing phytopathogenic DNA virus resistant or tolerant transgenic plants.
摘要翻译：使用由植物病原DNA病毒基因组中存在的核苷酸序列的突变（也称为突变核苷酸序列）产生的核苷酸序列。突变核苷酸序列包含一个或多个突变能够产生用于复制病原性病毒的显性阴性表型，和/或其在植物中的扩散，和/或其从一种植物扩散到另一种植物，特别是通过载体如昆虫突变核苷酸序列能够完全或部分抑制致病病毒的复制和/或扩散和/或扩散。本发明用于产生抗病毒DNA病毒抗性或耐受性的转基因植物。

5. 发明申请

WO2017004123A1 ANTICANCER DRUG-CONTAINING PLANT VIRUS PARTICLES 审中-公开
标题翻译：含有药物的药物植物病毒颗粒
公开(公告)号：WO2017004123A1
公开(公告)日：2017-01-05
申请号：PCT/US2016/039961
申请日：2016-06-29
申请人： CASE WESTERN RESERVE UNIVERSITY , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： STEINMETZ, Nicole F. , LIPPARD, Stephen J. , CZAPAR, Anna , ZHENG, Yaorong
IPC分类号： A61P35/00 , A61K47/48 , A61K45/00
CPC分类号： A61K31/555 , A61K9/0019 , A61K9/5184 , A61K39/12 , A61K47/6901 , C12N2750/12022 , C12N2750/12023 , C12N2770/32022 , C12N2770/32023
摘要： Anticancer virus particles are described. Anticancer virus particles are filamentous or rod-shaped plant virus particle containing an anticancer agent within the interior of the virus particle. The anticancer agent can be attached either covalently or non-covalently within the interior of the virus particle. A therapeutically effective amount of an anticancer virus particle can be administered to a subject identified as having cancer to provide a method of cancer treatment.
摘要翻译：描述了抗癌病毒颗粒。抗癌病毒颗粒是在病毒颗粒内部含有抗癌剂的丝状或棒状植物病毒颗粒。抗癌剂可以在病毒颗粒内部共价或非共价连接。可将治疗有效量的抗癌病毒颗粒施用于被鉴定为具有癌症的受试者，以提供癌症治疗的方法。

6. 发明申请

WO01036595A2 METHODS FOR CONDITIONAL TRANSGENE EXPRESSION AND TRAIT REMOVAL IN PLANTS 审中-公开
标题翻译：用于条件转移表达和植物去除的方法
公开(公告)号：WO01036595A2
公开(公告)日：2001-05-25
申请号：PCT/US2000/031600
申请日：2000-11-16
IPC分类号： A01H1/00 , A61K47/48 , C07K14/01 , C07K17/08 , C12N5/10 , C12N15/09 , C12N15/82 , C12N5/00
CPC分类号： C07K14/005 , A61K47/60 , A61K47/62 , C07K17/08 , C12N15/8203 , C12N15/8209 , C12N15/8213 , C12N15/8216 , C12N15/8217 , C12N15/8222 , C12N15/8237 , C12N15/8238 , C12N15/8289 , C12N2750/12022 , C12N2770/00022 , C12N2770/40022
摘要： This invention relates to constructs for the conditional or regulated expression or excision of transgenes in plants using site-specific recombinase systems. The constructs comprise a variety of constitutive, inducible, tissue specific or developmental stage-specific promoters operably linked to either a transgene or the elements of one or more site-specific recombinase system. By matching promoters, responsive to various inducers, plant tissues or plant developmental states with the recombinase systems, stop fragments and transgenes, virtually any trait may be expressed or excised at any plant development stage or in any plant generation.
摘要翻译：本发明涉及使用位点特异性重组酶系统用于条件或调节表达或转化植物中转基因的构建体。构建体包含与转基因或一个或多个位点特异性重组酶系统的元件可操作地连接的各种组成型，诱导型，组织特异性或发育阶段特异性启动子。通过匹配启动子，响应于各种诱导剂，植物组织或植物发育状态与重组酶系统，停止片段和转基因，实际上任何性状可以在任何植物发育阶段或任何植物生成中表达或切除。

7. 发明申请

WO00056895A1 COTTON LEAF CURL VIRUS (CLCuV) PROMOTER AND ITS USE 审中-公开
公开(公告)号：WO00056895A1
公开(公告)日：2000-09-28
申请号：PCT/CN2000/000030
申请日：2000-02-18
IPC分类号： C07K14/01 , C12N15/33 , C12N15/82 , A01H5/00 , C07H21/04 , C07K14/005
CPC分类号： C07K14/005 , C12N15/8216 , C12N15/8222 , C12N15/8225 , C12N15/8226 , C12N15/8227 , C12N2750/12022
摘要： The invention provides a cotton leaf curl virus (CLCuV) bidirectional promoter, a method of expressing foreign genes in various plant tissues at high level using the cotton leaf curl virus bidirectional promoter, and an AC2 protein factor from CLCuV genome to improve the expression intensity of the coat protein-coding gene promoter which is in the bidirectional promoter. It is possible to improve the expression of foreign genes in plants using the present invention materials and methods.

8. 发明申请

WO00043520A2 MATERIALS AND METHODS FOR PRODUCING GEMINIVIRUS RESISTANT PLANTS 审中-公开
标题翻译：生产耐药植物的材料与方法
公开(公告)号：WO00043520A2
公开(公告)日：2000-07-27
申请号：PCT/US2000/001612
申请日：2000-01-25
IPC分类号： C07K14/01 , C12N15/34 , C12N15/82 , A01H5/00 , A01H5/10
CPC分类号： C07K14/005 , C12N15/8283 , C12N2750/12022
摘要： The subject invention pertains to materials and methods for producing plants that are resistant to infection by geminiviruses and other related viruses. Methods of the invention comprise transforming a plant with a polynucleotide wherein when the polynucleotide is expressed in the plant, the transformed plant exhibits resistance to plant viral infections. Exemplified herein is the use of a polynucleotide encoding a Rep protein derived from tomato mottle geminivirus. The methods of the invention can be used to provide resistance to viral infection in plants such as tomato and tobacco. The present invention also concerns transformed and transgenic plants in plant tissue that express a polynucleotide encoding a plant virus Rep protein, or a fragment or variant thereof.
摘要翻译：本发明涉及用于产生耐双雄病毒和其他相关病毒感染的植物的材料和方法。本发明的方法包括用多核苷酸转化植物，其中当多核苷酸在植物中表达时，转化的植物表现出对植物病毒感染的抗性。本文示例的是使用编码来自番茄斑驳双因素病毒的Rep蛋白的多核苷酸。本发明的方法可用于提供植物如番茄和烟草中病毒感染的抗性。本发明还涉及植物组织中表达编码植物病毒Rep蛋白的多核苷酸或其片段或变体的转化和转基因植物。

9. 发明申请

WO00017365A2 BINARY VIRAL EXPRESSION SYSTEM IN PLANTS 审中-公开
标题翻译：植物中的二进制病毒表达系统
公开(公告)号：WO00017365A2
公开(公告)日：2000-03-30
申请号：PCT/US1999/021989
申请日：1999-09-22
IPC分类号： C07K14/01 , C12N15/34 , C12N15/82 , C12N15/40
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8217 , C12N15/8237 , C12N15/8238 , C12N2750/12022
摘要： The invention relates to plant transgene expression systems comprising chromosomally-integrated components that are individually heritable. The systems are useful for the regulated expression of foreign genes through gene amplification in plant tissue.
摘要翻译：本发明涉及包含单独遗传的染色体整合的组分的植物转基因表达系统。该系统可用于通过植物组织中的基因扩增来调控外源基因的表达。

10. 发明申请

WO0149844A9 COMPOSITIONS AND METHODS FOR GENE SILENCING 审中-公开
标题翻译：用于基因沉默的组合物和方法
公开(公告)号：WO0149844A9
公开(公告)日：2002-10-31
申请号：PCT/US0100126
申请日：2001-01-02
申请人： UNIV RUTGERS , DRISCOLL MONICA , TAVERNARAKIS NEKTARIOS
发明人： DRISCOLL MONICA , TAVERNARAKIS NEKTARIOS
IPC分类号： A01H1/00 , A01K67/033 , A61K48/00 , C07H21/04 , C07K14/435 , C12N15/113 , C12N15/63 , C12N15/82 , C12N15/11 , C07H21/02 , C12N15/70 , C12N15/85 , C12N15/86 , C12P19/34
CPC分类号： A01K67/0336 , A01K2217/05 , A01K2217/058 , A01K2227/703 , A01K2267/03 , C07K14/43545 , C12N15/113 , C12N15/63 , C12N2310/111 , C12N2310/14 , C12N2750/12022 , C12N2830/002
摘要： DNA constructs are provided for disrupting gene expression in targeted organisms.
摘要翻译：提供DNA构建体用于破坏靶向生物体中的基因表达。

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