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    • 2. 发明申请
    • DENDRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES AS OPHTHALMIC SEALANTS AND LENSES
    • 透明聚合物,交联凝胶,及其用作眼科密封剂和镜片
    • WO2006031358A2
    • 2006-03-23
    • PCT/US2005/029097
    • 2005-08-15
    • HYPERBRANCH MEDICAL TECHNOLOGY, INC.GRINSTAFF, Mark, W.CARNAHAN, Michael, A.
    • GRINSTAFF, Mark, W.CARNAHAN, Michael, A.
    • A61K31/785
    • A61L27/14A61L24/04A61L26/0009C08L89/00C09J189/00C09J201/005
    • The present invention provides compositions and methods for sealing a wound and preparing a lens. The methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine-, cysteine-, isocysteine-residue or other nucleophilic group attached to the periphery of the dendrimer: Addition of a compound containing two or more electrophilic groups such as aldehydes, activated esters, or acrylates to the lysine-, cysteine-, or isocysteine-capped dendrimers produces a polymeric compound that can form a seal or a lens. Another aspect of the invention relates to a method of treating disease using the pharmaceutical compositions of the invention. Other aspects of the invention relate to kits for sealing a wound or preparing a lens, delivery devices, and methods for controlling the polymerization of a hydrogel system.
    • 本发明提供了用于密封伤口并制备透镜的组合物和方法。 本发明的方法利用通过用光或连接化合物处理树枝状化合物形成的树枝状大分子。 在某些情况下,树枝状化合物具有连接到树枝状大分子周围的赖氨酸,半胱氨酸,异半胱氨酸残基或其它亲核基团:加入含有两个或多个亲电基团如醛,活化酯或丙烯酸酯的化合物, 赖氨酸,半胱氨酸或半胱氨酸封端的树枝状大分子产生可形成密封或透镜的聚合物。 本发明的另一方面涉及使用本发明的药物组合物治疗疾病的方法。 本发明的其它方面涉及用于密封伤口或制备镜片的装置,递送装置以及用于控制水凝胶体系聚合的方法。
    • 5. 发明申请
    • DENDRITIC POLYMERS, CROSSLINKED GELS, AND THEIR USES AS OPHTHALMIC SEALANTS AND LENSES
    • 树枝状聚合物,交联凝胶及其作为眼科密封剂和镜片的用途
    • WO2006031358A3
    • 2006-11-16
    • PCT/US2005029097
    • 2005-08-15
    • HYPERBRANCH MEDICAL TECHNOLOGYGRINSTAFF MARK WCARNAHAN MICHAEL A
    • GRINSTAFF MARK WCARNAHAN MICHAEL A
    • A61L15/22
    • A61L27/14A61L24/04A61L26/0009C08L89/00C09J189/00C09J201/005
    • The present invention provides compositions and methods for sealing a wound and preparing a lens. The methods of the invention utilize dendritic macromolecules formed by treating a dendritic compound with light or a linking compound. In certain instances, the dendritic compounds have a lysine-, cysteine-, isocysteine-residue or other nucleophilic group attached to the periphery of the dendrimer: Addition of a compound containing two or more electrophilic groups such as aldehydes, activated esters, or acrylates to the lysine-, cysteine-, or isocysteine-capped dendrimers produces a polymeric compound that can form a seal or a lens. Another aspect of the invention relates to a method of treating disease using the pharmaceutical compositions of the invention. Other aspects of the invention relate to kits for sealing a wound or preparing a lens, delivery devices, and methods for controlling the polymerization of a hydrogel system.
    • 本发明提供了用于密封伤口并制备透镜的组合物和方法。 本发明的方法利用通过用光或连接化合物处理树枝状化合物而形成的树枝状大分子。 在某些情况下,树枝状化合物具有连接到树枝状大分子外围的赖氨酸 - ,半胱氨酸 - ,异半胱氨酸 - 残基或其它亲核基团:将含有两个或更多个亲电子基团如醛,活化酯或丙烯酸酯的化合物添加到 赖氨酸 - ,半胱氨酸 - 或异半胱氨酸 - 封端的树枝状大分子产生可形成密封或透镜的聚合化合物。 本发明的另一个方面涉及使用本发明的药物组合物治疗疾病的方法。 本发明的其它方面涉及用于密封伤口或制备透镜的试剂盒,递送装置和用于控制水凝胶体系聚合的方法。