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    • 3. 发明申请
    • 'pi'-BOND AROMATIC VITAMIN CHELATES
    • pi pi。。。。。。。
    • WO1994004141A1
    • 1994-03-03
    • PCT/US1993007098
    • 1993-07-28
    • ALBION INTERNATIONAL, INC.
    • ALBION INTERNATIONAL, INC.ASHMEAD, Harvey, H.
    • A61K31/24
    • C07F13/00A61K31/44A61K31/455A61K31/505A61K31/51A61K31/525A61K31/555C07F1/08C07F3/00C07F3/06C07F15/02C07F19/00
    • Vitamin and mineral absorption in warm-blooded animals is promoted by means of a class of vitamin chelates where at least one of the bonds between the metal ion and the vitamin ligand is formed between the ion and an electron rich (pi)-cloud of an aromatic ring of the water soluble vitamin. The chelate, containing a total of from one to three ligands, may contain from one up to three vitamin ligands which form a (pi)-bond with the mineral and, when present, one or two amino acid, dipeptide or tripeptide ligands. The mineral is selected from the group consisting of Fe, Cu, Zn, Mg, Mn and Ca. The water soluble vitamin ligand is preferably a residue of nicotinamide, nicotinic acid, pyridoxine, thiamine, riboflavin and folic acid. The amino acid may be any of the naturally occuring (alpha)-amino acids such as glycine. The (pi)-bond vitamin chelates are absorbed more readily from both the gastric and intestinal areas of the GI tract than vitamins or minerals administered separately or as mixtures.
    • 通过一类维生素螯合物促进温血动物中的维生素和矿物质吸收,其中金属离子和维生素配体之间的至少一个键形成在离子和富含电荷的(pi) - 云之间 芳香环的水溶性维生素。 含有总共1至3个配体的螯合物可以含有一个至多三个维生素配体,其与矿物质形成(pi)键,并且当存在一个或两个氨基酸的二肽或三肽配体时。 矿物选自Fe,Cu,Zn,Mg,Mn和Ca。 水溶性维生素配体优选为烟酰胺,烟酸,吡哆醇,硫胺素,核黄素和叶酸的残基。 氨基酸可以是任何天然存在的(α) - 氨基酸,例如甘氨酸。 (pi)键的维生素螯合物比胃肠道胃肠道和胃肠道区域更容易被吸收,而不仅仅是单独使用或混合使用的维生素或矿物质。