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1. 发明申请

WO2009048397A1 METHOD FOR ASSISTING FLOW IN A HEART 审中-公开
标题翻译：在心脏中辅助流动的方法
公开(公告)号：WO2009048397A1
公开(公告)日：2009-04-16
申请号：PCT/SE2008/000591
申请日：2008-10-13
申请人： MILUX HOLDING SA , FORSELL, Peter
发明人： FORSELL, Peter
IPC分类号： A61M1/10 , A61N1/362
CPC分类号： A61N1/36514 , A61M1/1005 , A61M1/1008 , A61M1/1056 , A61M1/106 , A61M1/1067 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/3334 , A61M2205/8243 , A61N1/3627 , A61N1/36564 , A61N1/36578 , A61N1/3787
摘要： There is provided a method for controlling a flow of blood in a lume formed by a tissue wall of a patient's heart. The method comprises gently compressing (i.e., without substantially hampering the blood circulation in the tissue wall) at least one portion of the tissue wall to influence the flow in the lumen, and stimulating the compressed wall portion to cause contraction of the wall portion to further influence the flow in the lumen. The method can be used for restricting or stopping the flow in the lumen, or for actively moving the blood in the lumen, with a low risk of injuring the heart.
摘要翻译：提供了一种用于控制由患者心脏的组织壁形成的香气中的血液流动的方法。该方法包括轻轻压缩（即，基本上不妨碍组织壁内的血液循环）组织壁的至少一部分以影响内腔中的流动，并且刺激压缩壁部分以使壁部分收缩以进一步影响管腔内的流动。该方法可用于限制或停止内腔中的流动，或用于主动移动内腔中的血液，并且心脏受伤的风险低。

2. 发明申请

WO2005099374A2 METHOD AND APPARATUS FOR THE SURGICAL TREATMENT OF CONGESTIVE HEART FAILURE 审中-公开
标题翻译：用于手术治疗心绞痛失败的方法和装置
公开(公告)号：WO2005099374A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/011269
申请日：2005-04-05
申请人： GENESEE BIOMEDICAL, INC. , BUCKNER, J., Kern , WRIGHT, John, T., M.
发明人： BUCKNER, J., Kern , WRIGHT, John, T., M.
IPC分类号： A61B17/00 , A61B17/04 , A61F2/00 , A61M1/10
CPC分类号： A61B17/00234 , A61B17/0469 , A61B2017/00243 , A61B2017/0406 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/2448 , A61F2/2487 , A61M1/1008 , A61M1/1056 , A61M1/1068 , A61M1/12
摘要： An apparatus implantable in a heart ventricle includes a frame configured to engage an inner circumferential periphery of the ventricle and to expand and contract between an expanded state corresponding to a desired end diastolic diameter of the ventricle and a contracted state corresponding to a desired end systolic diameter of the ventricle. Assisting means are operatively associated with the frame for mechanically assisting movement of the ventricle toward at least one of an end systolic diameter during systole and an end diastolic diameter during diastole. The assisting means may be integrally formed of the frame. The frame may be configured to have expanded and contracted bistable states for assisting both systole and diastole. A method of implanting the apparatus in a heart ventricle includes surgically accessing a ventricle, inserting the apparatus in the ventricle and attaching the device to a portion of myocardium defining an inner circumferential periphery of the ventricle.
摘要翻译：可植入心室的装置包括框架，其构造成与心室的内圆周接合并且在对应于心室的期望舒张末期直径的扩张状态和对应于期望的收缩末期直径的收缩状态之间扩张和收缩的心室。辅助装置与框架可操作地相关联，用于机械地辅助心室朝向收缩期的收缩末期直径和舒张期期间的舒张末期直径中的至少一个运动。辅助装置可以由框架一体地形成。框架可以被配置为具有扩张和收缩双稳态以帮助收缩和舒张。将装置植入心室的方法包括手术进入心室，将装置插入心室，并将装置附接到限定心室内周周缘的一部分心肌。

3. 发明申请

WO2004008940A2 A FLEXIBLE, TORSIONABLE CARDIAC FRAMEWORK FOR HEART WALL ACTUATION OF THE NATURAL HEART 审中-公开
标题翻译：自然心脏的心脏壁灵活，扭转的心脏框架
公开(公告)号：WO2004008940A2
公开(公告)日：2004-01-29
申请号：PCT/US2003/022053
申请日：2003-07-16
申请人： THE UNIVERSITY OF CINCINNATI
发明人： MELVIN, David, Boyd
IPC分类号： A61B
CPC分类号： A61M1/1067 , A61M1/1008 , A61M1/1053 , A61M1/1056 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： An actuation system for assisting the operation of a natural heart is disclosed. The actuation system includes a framework (50) for interfacing with the natural heart and an actuator mechanism that can be coupled to the framework. The framework includes internal framework (52) and external framework (70) elements. The actuator mechanism is operable for deforming at least one framework element (52, 70) for varying the shape of the heart. The framework includes a set of interconnected, passive, intracardiac and extracardiac elements (52, 70) and their interconnections that deform, bend and/or twist in response to movements induced by the actuation system. Some or all of these elements, and the connections between them, are specifically intended to be flexible, in that they may be bent or twisted by means of motion induced by an associated mechanical actuation system (76).
摘要翻译：公开了一种用于辅助自然心脏的操作的致动系统。致动系统包括用于与自然心脏相接触的框架（50）和可以联接到框架的致动器机构。该框架包括内部框架（52）和外部框架（70）元素。致动器机构可操作用于使至少一个框架元件（52,70）变形以改变心脏的形状。该框架包括响应于致动系统引起的运动而变形，弯曲和/或扭曲的一组互连的，被动的，心内的和心外的元件（52,70）及其互连。这些元件中的一些或全部以及它们之间的连接具体地旨在是灵活的，因为它们可以通过由相关联的机械致动系统（76）引起的运动而弯曲或扭曲。

4. 发明申请

WO2019152882A1 BLOOD PUMP DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2019152882A1
公开(公告)日：2019-08-08
申请号：PCT/US2019/016410
申请日：2019-02-01
申请人： NUPULSECV, INC.
发明人： JEEVANANDAM, Valluvan
IPC分类号： A61M1/10 , A61M1/12
CPC分类号： A61M1/107 , A61M1/1008 , A61M1/1037 , A61M1/1055 , A61M1/1056 , A61M1/106 , A61M1/1086 , A61M1/1087 , A61M1/122 , A61M1/125 , A61M39/02 , A61M2205/0216 , A61M2205/0266 , A61M2205/3523 , A61M2230/06
摘要： The present technology provides a blood pump device and associated systems and methods of use thereof to assist blood circulation in a patient. The blood pump device includes a flexible member disposed within a housing. Movement of the flexible member in the housing varies the volume of chambers within the housing and effectuates pumping of blood to and from a vessel in fluid connection with a chamber of the blood pump device.

5. 发明申请

WO2009009131A3 CARDIAC ASSIST SYSTEM USING HELICAL ARRANGEMENT OF CONTRACTILE BANDS AND HELICALLY-TWISTING CARDIAC ASSIST DEVICE 审中-公开
标题翻译：使用螺旋安排带状螺旋和螺旋心脏辅助装置的心脏辅助系统
公开(公告)号：WO2009009131A3
公开(公告)日：2009-07-23
申请号：PCT/US2008008539
申请日：2008-07-11
申请人： CALIFORNIA INST OF TECHN , GHARIB MORTEZA , KHERADVAR ARASH , GROSBERG ANNA
发明人： GHARIB MORTEZA , KHERADVAR ARASH , GROSBERG ANNA
IPC分类号： A61M1/10
CPC分类号： A61M1/1068 , A61F2/2478 , A61F2/2481 , A61F2/915 , A61M1/1003 , A61M1/1048 , A61M1/1049 , A61M1/1056 , A61M1/1058 , A61M1/12 , A61M1/122 , A61M1/127 , A61M1/36 , A61M2205/0283 , A61N1/36 , A61N1/3627 , A61N1/36514 , A61N1/36521
摘要： A cardiac assist system using a helical arrangement of contractile bands and a helically-twisting cardiac assist device are disclosed. One embodiment discloses a cardiac assist system comprising at least one contractile elastic band helically arrangement around a periphery of a patient's heart, where upon an actuation the band contracts helically, thereby squeezing the heart and assisting the pumping function of the heart. Another embodiment discloses a helically twisting cardiac-apex assist device comprising an open, inverted, substantially conical chamber with two rotatable ring portions of different diameters located at the base and apex of the chamber, with a plurality of substantially helical connecting elements positioned substantially flush with the chamber wall and connecting the two rotatable ring portions, whereby a relative twisting motion of the two rings causes a change in volume of the chamber thereby assisting the cardiac pumping function.
摘要翻译：公开了一种使用螺旋排列的收缩带和螺旋扭转心脏辅助装置的心脏辅助系统。一个实施例公开了一种心脏辅助系统，其包括至少一个围绕患者心脏的外周呈螺旋状排列的收缩弹性带，其中在致动时，带以螺旋状收缩，由此挤压心脏并协助心脏的泵送功能。另一实施例公开了一种螺旋扭转心尖辅助装置，其包括开放的倒置的基本上圆锥形的腔室，该腔室具有位于腔室的基部和顶点处的具有不同直径的两个可旋转环部分，多个基本上螺旋状的连接元件定位成与室壁并连接两个可旋转的环部分，由此两个环的相对扭转运动引起室的体积变化，从而有助于心脏泵送功能。

6. 发明申请

WO2009048395A1 METHOD FOR CONTROLLING FLOW OF BLOOD IN A VESSEL 审中-公开
标题翻译：用于控制血管中血液流动的方法
公开(公告)号：WO2009048395A1
公开(公告)日：2009-04-16
申请号：PCT/SE2008/000589
申请日：2008-10-13
申请人： MILUX HOLDING SA , FORSELL, Peter
发明人： FORSELL, Peter
IPC分类号： A61N1/36 , A61B17/12 , A61F2/06
CPC分类号： A61N1/36514 , A61B17/12009 , A61B17/1355 , A61B2017/00163 , A61B2017/00212 , A61B2017/00221 , A61B2017/00411 , A61B2017/00535 , A61B2017/00991 , A61F2002/068 , A61M1/1005 , A61M1/1008 , A61M1/1049 , A61M1/1056 , A61M1/106 , A61M1/1067 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/3334 , A61M2205/8243 , A61N1/05 , A61N1/3605 , A61N1/36564 , A61N1/36578 , A61N1/403
摘要： There is provided a method for controlling a flow of blood and/or other bodily matter in a blood vessel. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the wall of the blood vessel) at least one portion of the wall of the blood vessel to influence the flow in the blood vessel, and stimulating the constricted wall portion to cause contraction of the at least one portion of the wall to further influence the flow in the blood vessel. The method can be used for restricting or stopping the flow in the blood vessel, or for actively moving the blood in the blood vessel, with a low risk of injuring the blood vessel.
摘要翻译：提供了一种用于控制血管和/或其他身体物质在血管中的流动的方法。该方法包括轻轻收缩（即，基本上不妨碍血管壁中的血液循环）血管壁的至少一部分以影响血管中的流动，并且刺激收缩的壁部分引起壁的至少一部分的收缩以进一步影响血管中的流动。该方法可以用于限制或停止血管中的流动，或用于主动移动血管中的血液，同时以低血管损伤的风险。

7. 发明申请

WO2004008941A3 A PROTECTIVE SHEATH APPARATUS AND METHOD FOR USE WITH A HEART WALL ACTUATION SYSTEM FOR THE NATURAL HEART 审中-公开
标题翻译：一种用于天然心脏的心脏壁动作系统的保护性护理装置和方法
公开(公告)号：WO2004008941A3
公开(公告)日：2004-07-08
申请号：PCT/US0322054
申请日：2003-07-16
申请人： UNIV CINCINNATI
发明人： MELVIN DAVID BOYD
IPC分类号： A61M1/10
CPC分类号： A61M1/1068 , A61M1/1046 , A61M1/1056 , A61M1/12
摘要： An actuation system (82) for assisting the operation of the natural heart includes a framework (70) for interfacing with a natural heart and which is coupled with tissue of the heart. An actuator element (86) is adapted to be coupled to the framework (70) and is configured for extending along a portion of a heart wall exterior surface. The actuator element (86) is operable for deforming the portion of the heart wall to effect a reduction in the volume of the heart. A protective sheath (84) is configured to extend along the heart wall between the actuator element and the heart wall portion for protecting the heart wall portion from damage by the actuator element. The protective sheath (84) is flexible and operable to transmit, to the heart wall portion, a force thereon by the actuator element (86) for indenting the heart wall portion.
摘要翻译：用于辅助自然心脏的操作的致动系统（82）包括用于与自然心脏接合并与心脏的组织耦合的框架（70）。致动器元件（86）适于联接到框架（70）并且构造成用于沿心壁外表面的一部分延伸。致动器元件（86）可操作用于使心脏壁的部分变形以实现心脏体积的减小。保护套（84）构造成沿致动器元件和心壁部分之间的心壁延伸，以保护心壁部分免受致动元件的损伤。保护套（84）是柔性的并且可操作地通过致动器元件（86）向心壁部分传递其上的力以压缩心壁部分。

8. 发明申请

WO01067985A1 EXPANDABLE CARDIAC HARNESS FOR TREATING CONGESTIVE HEART FAILURE 审中-公开
标题翻译：用于治疗焦虑性心脏衰竭的可扩展心脏线束
公开(公告)号：WO01067985A1
公开(公告)日：2001-09-20
申请号：PCT/US2001/005017
申请日：2001-02-16
IPC分类号： A61N1/05 , A61B17/00 , A61F2/00 , A61F2/24 , A61N1/362 , A61N1/375
CPC分类号： A61F2/2481 , A61F2002/0072 , A61F2002/2484 , A61M1/1003 , A61M1/1008 , A61M1/1046 , A61M1/1048 , A61M1/1056 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/0266 , A61M2205/33 , A61M2205/3303 , A61M2205/3523 , A61M2205/8206 , A61M2205/8243 , A61N1/0587 , A61N1/3627 , Y10T29/49995
摘要： A cardiac harness for treating congestive heart failure is disclosed. The harness applies elastic, compressive reinforcement on the left ventricle to reduce deleterious wall tension and to resist shape change of the ventricle during the mechanical cardiac cycle. Rather than imposing a dimension beyond which the heart cannot expand, the harness provides no hard limit over the range of diastolic expansion of the ventricle. Instead, the harness follows the contour of the heart throughout diastole and continuously exerts gentle resistance to stretch. Also disclosed is a method of delivering the cardiac harness to the heart minimally invasively.
摘要翻译：公开了用于治疗充血性心力衰竭的心脏线束。线束在左心室施加弹性，压缩增强以减少有害的壁张力并抵抗机械心动周期中心室的形状变化。而不是强加超出心脏不能膨胀的维度，该线束对心室的舒张扩张范围没有限制。相反，线束遵循整个心脏舒张期的心脏轮廓，并持续施加轻微的拉伸阻力。还公开了一种将心脏线束递送至心脏的方法。

9. 发明申请

WO2017015469A1 ACTUATED EXTRA-VENOUS VALVE 审中-公开
标题翻译：致动的超静音阀
公开(公告)号：WO2017015469A1
公开(公告)日：2017-01-26
申请号：PCT/US2016/043357
申请日：2016-07-21
申请人： BOSTON SCIENTIFIC SCIMED, INC.
发明人： RIZQ, Raen N. , SUTERMEISTER, Derek C.
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61B2017/00743 , A61B2017/00783 , A61F2210/0014 , A61F2230/0006 , A61F2250/0001 , A61F2250/001 , A61M1/1008 , A61M1/1056 , A61M1/1067 , A61M1/1086 , A61M1/1087 , A61M1/12 , A61M2205/33 , A61M2205/3303 , A61M2230/04 , A61M2230/205 , A61M2230/42
摘要： An extravenous valve may include a constricting member configured to surround a body lumen or blood vessel and actuate between a lumen or vessel-occluding configuration and a non-lumen or non-vessel-occluding configuration, the constricting member including a base material and a shape memory material coupled to the base material, a power source in communication with the constricting member, and a controller configured to receive bio-feedback from a patient. The controller may reversibly actuate the constricting member between the lumen or vessel-occluding configuration and the non-lumen or non-vessel-occluding configuration in response to the bio-feedback. The constricting member may be sized and configured to be delivered to the treatment location through the body lumen or blood vessel.
摘要翻译：静脉瓣可以包括收缩构件，其构造成围绕体腔或血管并且在管腔或血管阻塞构型和非内腔或非血管闭塞构造之间致动，所述收缩构件包括基底材料和形状耦合到基材的记忆材料，与收缩构件连通的电源以及被配置为从患者接收生物反馈的控制器。响应于生物反馈，控制器可以可逆地致动管腔或血管阻塞构型和非内腔或非血管闭塞构造之间的收缩构件。收缩构件的尺寸和构造可以通过体腔或血管被输送到治疗位置。

10. 发明申请

WO2016156866A1 CARDIAC ASSIST DEVICE 审中-公开
标题翻译：心脏辅助装置
公开(公告)号：WO2016156866A1
公开(公告)日：2016-10-06
申请号：PCT/GB2016/050925
申请日：2016-04-01
申请人： UNIVERSITY OF LEICESTER
发明人： ADLAM, David , PIYAL, Samara-Ratna
IPC分类号： A61M1/10
CPC分类号： A61M1/122 , A61M1/1008 , A61M1/1056 , A61M1/1058 , A61M1/106 , A61M1/1068 , A61M1/107 , A61M1/1086 , A61M1/1096 , A61M1/12 , A61M1/127
摘要： A device for providing assistance to ventricular systole, the device comprising a pressuriser and a driver, wherein the pressuriser is adapted to be able to apply localised pressure to only the external wall of one ventricle, or a portion thereof, and the driver is operatively linked to the pressuriser so as to be able to drive a cycle of increased and decreased pressure applied by the pressuriser. The invention also relates to a method of implanting the device and a method of treating cardiac pump failure in which the device is used.
摘要翻译：一种用于提供对心室收缩的辅助的装置，该装置包括加压器和驱动器，其中该加压器适于仅对一个脑室或其一部分的外壁施加局部压力，并且驾驶员可操作地连接以便能够驱动由加压器施加的增加和减小的压力的循环。本发明还涉及一种植入该装置的方法和一种治疗使用该装置的心脏泵衰竭的方法。

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