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1. 发明申请

WO2010105334A1 AUTOMATED PHARMACY ADMIXTURE SYSTEM 审中-公开
标题翻译：自动化药物系统
公开(公告)号：WO2010105334A1
公开(公告)日：2010-09-23
申请号：PCT/CA2010/000073
申请日：2010-01-25
申请人： INTELLIGENT HOSPITAL SYSTEMS LTD. , ELIUK, Walter W. , ROB, Ronald, H. , MLODZINSKI, Lance, R. , REINHARDT, Alex H. , DOHERTY, Thom , DECK, Dustin
发明人： ELIUK, Walter W. , ROB, Ronald, H. , MLODZINSKI, Lance, R. , REINHARDT, Alex H. , DOHERTY, Thom , DECK, Dustin
IPC分类号： B65B3/00 , B65B3/26 , B65B37/16 , B65B57/00 , B65B65/08 , B65G1/137
CPC分类号： A61J1/20 , A61J1/10 , A61J1/201 , A61J1/2096 , A61J3/002 , A61J2200/10 , A61M5/3286 , A61M5/3291 , B01F13/1072
摘要： In a preferred implementation, an automated pharmacy admixture system (APAS) prepares intermediary IV bags as drug sources for creating highly diluted patient doses in syringes. During the compounding process the APAS may align needles with a vial seal opening so as to ensure repeated entry through the same vial puncture site via precise control of needle position, needle bevel orientation, and needle entry speed. These techniques can in certain implementations substantially improve bung pressure sealing and reduced particulate generation. The APAS optionally creates drug order queues for incoming drug orders wherein the orders can be sorted by priority, drug type or patient location A phantom queue can be combined with the incoming drug order queues to include frequently used medicaments to minimize operator loading of the APAS.
摘要翻译：在优选实施方案中，自动化药剂混合系统（APAS）制备中间体IV袋作为在注射器中产生高度稀释的患者剂量的药物来源。在复合过程中，APAS可以将针与小瓶密封开口对准，以便通过精确控制针位置，针斜度方向和针入口速度来确保重复进入相同的小瓶穿刺部位。这些技术在某些实施方式中可以显着改善密封压力和减少颗粒物的产生。 APAS可选地为进入的药物订单创建药物订单队列，其中可以按优先级排序订单，药物类型或患者位置。幻影队列可以与进入的药物订单队列组合以包括经常使用的药物以最小化APAS的操作者负担。

2. 发明申请

WO2008058280A3 CONTROL OF FLUID TRANSFER OPERATIONS 审中-公开
标题翻译：流体输送操作的控制
公开(公告)号：WO2008058280A3
公开(公告)日：2008-09-18
申请号：PCT/US2007084332
申请日：2007-11-09
申请人： INTELLIGENT HOSPITAL SYSTEMS L , DOHERTY THOM , ELIUK WALTER W , JONES RICHARD L
发明人： DOHERTY THOM , ELIUK WALTER W , JONES RICHARD L
IPC分类号： A61J1/00 , B67D7/02
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2044 , A61J1/2055 , A61J1/2065 , A61J3/002 , A61J2200/10 , B65B3/003
摘要： Some methods and related apparatus for manipulating a fluid conduit for insertion into a substantially re-sealable membrane include determining an orientation and position of a fluid conduit relative to the membrane. In an illustrative example, a syringe needle having a beveled leading edge may be manipulated by an automated device to be oriented and aligned with an aperture made upon a previous insertion of a needle into a membrane. In some examples, a predetermined number of insertions may be made in the same aperture by aligning and orienting one or more needles with the aperture. In some examples, multiple needle insertions may be controlled to produce apertures that are substantially spaced apart. Such procedures may, for example, advantageously extend the integrity of the membrane against leakage and/or contamination.
摘要翻译：用于操纵流体导管以插入基本上可再密封的膜中的一些方法和相关设备包括确定流体导管相对于膜的取向和位置。在说明性实例中，具有斜切前缘的注射器针头可由自动化装置操纵以定向并与先前将针头插入膜片时制造的孔对准。在一些示例中，可以通过将一个或多个针与孔对准并定向来在相同的孔中进行预定次数的插入。在一些示例中，可以控制多个针插入以产生基本上间隔开的孔。例如，这样的程序可以有利地延长膜的完整性以防止泄漏和/或污染。

3. 发明申请

WO2008058280A2 CONTROL OF FLUID TRANSFER OPERATIONS 审中-公开
标题翻译：流体传输操作控制
公开(公告)号：WO2008058280A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/084332
申请日：2007-11-09
申请人： INTELLIGENT HOSPITAL SYSTEMS LTD. , DOHERTY, Thom , ELIUK, Walter W. , JONES, Richard L.
发明人： DOHERTY, Thom , ELIUK, Walter W. , JONES, Richard L.
IPC分类号： A61B19/00
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2044 , A61J1/2055 , A61J1/2065 , A61J3/002 , A61J2200/10 , B65B3/003
摘要： Some methods and related apparatus for manipulating a fluid conduit for insertion into a substantially re-sealable membrane include determining an orientation and position of a fluid conduit relative to the membrane. In an illustrative example, a syringe needle having a beveled leading edge may be manipulated by an automated device to be oriented and aligned with an aperture made upon a previous insertion of a needle into a membrane. In some examples, a predetermined number of insertions may be made in the same aperture by aligning and orienting one or more needles with the aperture. In some examples, multiple needle insertions may be controlled to produce apertures that are substantially spaced apart. Such procedures may, for example, advantageously extend the integrity of the membrane against leakage and/or contamination.
摘要翻译：用于操纵用于插入基本上可再密封的膜的流体导管的一些方法和相关装置包括确定流体导管相对于膜的取向和位置。在一个说明性的例子中，具有倾斜前缘的注射器针可以通过自动化装置来操作，以被定向并与先前将针插入膜中时制成的孔对齐。在一些示例中，可以通过使一个或多个针与孔对准和定向来在相同的孔中形成预定数量的插入。在一些实例中，可以控制多个针插入物以产生基本间隔开的孔。这样的程序可以例如有利地延长膜的完整性以防止泄漏和/或污染。

4. 发明申请

WO2006138184A3 SAFETY FLUID TRANSFER CANNULA 审中-公开
标题翻译：安全流体转运肛门
公开(公告)号：WO2006138184A3
公开(公告)日：2007-03-29
申请号：PCT/US2006022626
申请日：2006-06-09
申请人： INVIRO MEDICAL INC , SHARP FRASER R
发明人： SHARP FRASER R
IPC分类号： A61B19/00
CPC分类号： A61J1/2096 , A61J1/201 , A61J2200/10
摘要： A cannula for transferring fluid relative to a vial or intravenous port having an elastomeric membrane includes: a cannula body having first and second opposite ends; the first end terminating in a tip for penetrating the elastomeric membrane; the body having a passage opening through the second end and extending within the cannula body towards the first end, the passage opening through at least one horizontal-oriented port through a side surface of the cannula body thereby to enable flow of fluid along the passage and between the opening through the second end and the side port. . An axial width of the port is smaller than a thickness dimension of a vial through which the cannula tip is to be inserted. A related method is also described.
摘要翻译：用于相对于具有弹性体膜的小瓶或静脉内端口传送流体的插管包括：具有第一和第二相对端的插管主体; 第一端终止于用于穿透弹性膜的尖端; 所述主体具有通过所述第二端的通道，并且在所述套管主体内朝向所述第一端延伸，所述通道通过穿过所述套管主体的侧表面的至少一个水平取向的端口，从而能够沿着所述通道流动流体，在通过第二端的开口和侧端口之间。。端口的轴向宽度小于套管尖端要插入的小瓶的厚度尺寸。还描述了相关方法。

5. 发明申请

WO2006083646A3 NON-CORING NEEDLES AND METHODS OF MANUFACTURING SAME 审中-公开
标题翻译：非牙齿针及其制造方法
公开(公告)号：WO2006083646A3
公开(公告)日：2007-01-11
申请号：PCT/US2006002607
申请日：2006-01-25
申请人： BOSTON SCIENT SCIMED INC , HARRIS CHAD G , HAWK MATTHEW , ROONEY JACOB , SMITH MARK S , OSTROOT TIMOTHY A
发明人： HARRIS CHAD G , HAWK MATTHEW , ROONEY JACOB , SMITH MARK S , OSTROOT TIMOTHY A
IPC分类号： A61M5/32 , A61J1/00
CPC分类号： A61M5/3286 , A61J1/201 , A61J1/2096 , A61J2200/10 , A61M2205/195
摘要： Needles (10, 200, 300, 400, 500, 600) configured to prevent or reduce contact of tissue or other material with the heel (80) of the needle to prevent coring of the tissue or other material by the heel of the needle. Also provided are needles having no heels or blunted heels. The prevent invention also provides methods of manufacturing needles having obstructed or blunted heels.
摘要翻译：被配置为防止或减少组织或其他材料与针的跟部（80）的接触的针（10,200,300,400,500,600），以防止针的跟部使组织或其他材料的取芯。还提供了没有高跟或钝的高跟鞋的针。防止发明还提供了制造具有阻塞或钝的高跟鞋的针的方法。

6. 发明申请

WO0193923A3 CANNULA FOR USE WITH A MEDICAL SYRINGE 审中-公开
标题翻译：用于医疗式注射器的鼻窦
公开(公告)号：WO0193923A3
公开(公告)日：2002-05-02
申请号：PCT/CA0100864
申请日：2001-06-08
申请人： INVIRO MEDICAL DEVICES LTD , SHARP FRASER R , SHEEHAN NEIL
发明人： SHARP FRASER R , SHEEHAN NEIL
IPC分类号： A61B17/34 , A61M5/162 , A61M5/32 , A61M5/34 , A61M5/46 , A61M5/158 , A61M39/02
CPC分类号： A61M5/32 , A61J2200/10 , A61M5/162 , A61M5/322 , A61M5/329 , A61M5/347 , A61M5/46
摘要： A blunt needle plastic cannula for a syringe has a central axial passage terminating in a tip opening axially through one end thereof. Different axial sections along the cannula have respective differential resistances to movement relative to a membrane upon insertion of the cannula into the membrane. The opposite end of the cannula may have a Luer fit or Luer lock or may have integrally formed therewith an adapter for releasably connecting the adapter and cannula to the distal end of the barrel of the syringe. A syringe plunger and the adapter have connective structure whereby the adapter and cannual can be withdrawn into the interior of the barrel. The opposite ends of the barrel are sealed by portions of the plunger.
摘要翻译：用于注射器的钝针塑料套管具有中心轴向通道，其终止于轴向穿过其一端的尖端开口。沿着插管的不同轴向部分具有相对于将套管插入膜中时相对于膜移动的差别电阻。套管的相对端可以具有一个Luer配合或Luer锁，或者可以与其一体地形成适配器，用于将适配器和套管可释放地连接到注射器的枪管的远端。注射器柱塞和适配器具有连接结构，由此适配器和插管可以撤回到筒的内部。筒的相对端被柱塞的一部分密封。

7. 发明申请

WO1991005581A1 PRE-SLIT INJECTION SITE 审中-公开
标题翻译：预先注入网站
公开(公告)号：WO1991005581A1
公开(公告)日：1991-05-02
申请号：PCT/US1990006071
申请日：1990-10-22
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , DUDAR, Thomas, E. , JEPSON, Steven, C. , DOBBIE, Robert, P. , GRAHAM, Peter, L. , FINLEY, Michael, J. , ROLLINS, Richard, A.
IPC分类号： A61M39/04
CPC分类号： A61M5/162 , A61J1/10 , A61J1/1406 , A61J1/1475 , A61J1/201 , A61J1/2037 , A61J1/2044 , A61J1/2055 , A61J1/2089 , A61J1/2096 , A61J2200/10 , A61M39/045 , A61M39/14 , A61M2039/1027 , A61M2039/1033 , A61M2039/1066 , A61M2039/1072 , A61M2039/1077 , A61M2205/195 , A61M2205/197
摘要： A pre-slit injection site (710) includes a housing (712) with a flow path (728) therethrough. A first end (714) of the housing (712) carries a pre-slit septum (718). A second end (716) of the housing carries a coupling component (736) to adapt the site to standard vials. The coupling component (736), a vial adapter, includes an adapter spike (752) with openings (758) allowing for the drainage of fluid in the vial through the spike (752) and into the injection site (710). The vial adapter (736) is provided with a skirt housing unit (734, 744) which protects the adapter spike (752) in manufacturing and use. The skirt housing unit (734, 744) also provides features to lockingly engage the adapter (700) with injection site (710) to standard vials, despite dimensional variations in vial closures. Another embodiment of the coupling component (814) is a spike (816) having a barb feature (818) capable of insertion into a standard vial or port and resisting disengagement. A blunt cannula (730) is usable with the injection site (710) combined with the coupling components (736, 814).
摘要翻译：预狭缝注射部位（710）包括具有穿过其中的流动路径（728）的壳体（712）。壳体（712）的第一端（714）承载预狭缝隔垫（718）。壳体的第二端（716）承载耦合部件（736），以使部位适应标准样品瓶。联接部件（736），小瓶适配器，包括具有开口（758）的适配器尖钉（752），允许小瓶中的流体通过尖峰（752）排出并进入注射部位（710）。小瓶适配器（736）设置有裙部壳体单元（734,744），其在制造和使用中保护适配器尖峰（752）。尽管裙部容纳单元（734,744）还提供了将具有注射部位（710）的适配器（700）锁定到标准瓶中的特征，尽管小瓶封闭件中的尺寸变化。耦合部件（814）的另一实施例是具有能够插入标准小瓶或端口并抵抗脱离接触的倒钩特征（818）的钉（816）。钝头插管（730）可与注射部位（710）结合使用，耦合部件（736,814）。

8. 发明申请

WO1990003536A1 SLIDING RECONSTITUTION DEVICE WITH SEAL 审中-公开
标题翻译：具有密封的滑动重新配置设备
公开(公告)号：WO1990003536A1
公开(公告)日：1990-04-05
申请号：PCT/US1989003915
申请日：1989-09-14
申请人： BAXTER INTERNATIONAL INC.
发明人： BAXTER INTERNATIONAL INC. , ZDEB, Brian, D.
IPC分类号： F16L37/28
CPC分类号： A61J1/2089 , A61J1/10 , A61J1/1475 , A61J1/201 , A61J1/2013 , A61J1/2051 , A61J1/2065 , A61J2200/10 , Y10T137/87957
摘要： A coupling device for establishing fluid communication between a first container and a second container is provided. The device includes a first sleeve member including at a first end thereof, a member (60) for connecting and securing the first sleeve member to a first container. A second sleeve member (22) is provided and is so constructed and arranged that it receives a portion of the first sleeve, and is operatively adapted for axial sliding engagement thereon, including at one axial end thereof a member (30) for releasably engaging and securing the second sleeve member to a second container. Piercing members (54, 56) located within an area defined by the first and second sleeves are provided for providing fluid flow from the first container to the second container. The coupling device includes a resilient seal (70) for sealing an end of the second sleeve member, located in said second sleeve member at said end adapted to be connected to said second container.

9. 发明申请

WO2014145313A3 CONTROLLED NON-CLASSIFIED FILLING DEVICE AND METHOD 审中-公开
标题翻译：控制非分类填充装置及方法
公开(公告)号：WO2014145313A3
公开(公告)日：2015-01-29
申请号：PCT/US2014030052
申请日：2014-03-15
申请人： PY INST LLC DR
发明人： PY DANIEL
IPC分类号： B65B3/00
CPC分类号： B65B55/04 , A61J1/05 , A61J1/1406 , A61J1/1425 , A61J1/201 , A61J1/2089 , A61J3/002 , A61J2200/10 , A61M5/002 , A61M5/1782 , B65B3/003 , B65B7/16 , B65B39/12 , B65B43/42
摘要： An injection member penetrates an elastic septum of a device defining a sealed, empty, sterile chamber in fluid communication with the septum. During penetrating, an annular interface is formed between the septum and the injection member extending axially between a penetration point on an interior surface of the septum in fluid communication with the sterile chamber, and an exterior surface of the septum engaging the injection member. The injection member is de-contaminated by (i) friction between the septum and injection member at the annular interface, and (ii) elongation of the septum at the annular interface. A substance is introduced through the injection member and into the sterile chamber of the device, the injection member is then withdrawn from the septum, the septum reseals itself at the resulting penetration aperture, and the chamber is maintained sterile throughout the foregoing steps.
摘要翻译：注射构件穿过限定与隔膜流体连通的密封的空的无菌室的装置的弹性隔膜。在穿透期间，在隔膜和注射构件之间形成环形界面，所述注射构件在与无菌室流体连通的隔膜的内表面上的穿透点和与注射构件接合的隔膜的外表面之间轴向延伸。注射构件被（i）环形界面处的隔膜和注射构件之间的摩擦和（ii）在环形界面处的隔膜伸长而被去污染。物质通过注射构件引入并进入装置的无菌室中，然后将注射构件从隔膜中取出，隔膜在所得到的穿透孔处重新吸收，并且在整个上述步骤中腔室保持无菌。

10. 发明申请

WO2007079048A3 MEDICAL VIAL ADAPTER WITH REDUCED DIAMETER CANNULA AND ENLARGED VENT LUMEN 审中-公开
标题翻译：具有减少直径肛门和放大通风灯的医用六角适配器
公开(公告)号：WO2007079048A3
公开(公告)日：2008-12-24
申请号：PCT/US2006049165
申请日：2006-12-22
申请人： CARDINAL HEALTH 303 INC , WALSH MARY K
发明人： WALSH MARY K
IPC分类号： A61B19/00 , A61M5/32
CPC分类号： A61J1/2096 , A61J1/201 , A61J1/2055 , A61J1/2075 , A61J1/2082 , A61J2200/10 , A61M39/10 , A61M39/22 , A61M2205/7518 , A61M2205/7527
摘要： A vented vial adapter for reconstitution of a medicament in a vial includes a vent lumen and a medicament lumen. The vent lumen has a cross-sectional area equal to or greater than that of the medicament lumen so that the fluid flow rate through the vent lumen is equal to or greater than that of the medicament lumen. As a result aerosols of the medicament outside the adapter are avoided as is the withdrawal of air bubbles from the vial as the reconstituted medicament is withdrawn from the vial. To maintain the diameter of the sharpened cannula of the vial adapter as small as possible, the vent lumen includes a concave wall facing the medicament lumen and a convex outer wall. In one embodiment, the vent lumen is in the shape of a polygon.
摘要翻译：用于在小瓶中重建药物的通气小瓶适配器包括通气腔和药物腔。通气腔具有等于或大于药物腔的横截面面积，使得通过排气腔的流体流速等于或大于药物腔的流体流速。因此，避免了适配器外面的药物的气溶胶，当从小瓶中取出重构的药物时，气瓶从小瓶中取出。为了保持小瓶适配器的尖锐插管的直径尽可能小，通气腔包括面向药物内腔的凹壁和凸出的外壁。在一个实施例中，排气腔呈多边形。

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