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1. 发明申请

WO2018223065A1 ERGOLINE DERIVATIVES FOR USE IN MEDICINE 审中-公开
公开(公告)号：WO2018223065A1
公开(公告)日：2018-12-06
申请号：PCT/US2018/035701
申请日：2018-06-01
申请人： XOC PHARMACEUTICALS, INC.
发明人： ARMER, Thomas , BORLAND, Scott , GUZMAN, Miguel
IPC分类号： C07D457/12 , A61P25/16 , A61P25/06 , A61K31/48
摘要： The present invention provides novel neuromodulatory compounds and compositions thereof. The invention also relates to methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; as well as intermediates for the preparation compounds.

2. 发明申请

WO2016118541A1 ERGOLINE COMPOUNDS AND USES THEREOF 审中-公开
标题翻译： ERGOLINE化合物及其用途
公开(公告)号：WO2016118541A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/013980
申请日：2016-01-20
申请人： XOC PHARMACEUTICALS, INC
发明人： ARMER, Thomas , MCKINLEY, Geoff , BORLAND, Scott , GUZMAN, Miguel , SZABOLCS, Armin , GERENCSER, Janos
IPC分类号： C07D457/12 , A61P25/16 , A61K31/48 , A61P25/06
CPC分类号： C07D471/06 , C07D495/06
摘要： Provided herein are ergoline compounds and pharmaceutical compositions thereof. In some embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT 1A , 5-HT 1B and 5-HT 1D receptors without agonizing the 5-HT 2B receptor using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HT 2B adrenergic alpha 2A and/or the alpha 2B receptors using the compounds and pharmaceutical compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the D2 and D3 receptor using the compounds and pharmaceutical compositions disclosed herein.
摘要翻译：本文提供麦角灵化合物及其药物组合物。在一些实施方案中，本文提供了使用本文公开的化合物和药物组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和药物组合物来激发受体（例如5-HT 1A，5-HT 1 B和5-HT 1 D）受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和药物组合物来拮抗5-HT 2B的肾上腺素α2A和/或α2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和药物组合物拮抗D2和D3受体的方法。

3. 发明申请

WO2016118540A1 TREATING AND/OR PREVENTING EMESIS AND/OR NAUSEA INCLUDING ACUTE AND/OR DELAYED NAUSEA AND/OR EMESIS 审中-公开
标题翻译：治疗和/或预防EMESIS和/或NAUSEA，包括急性和/或延迟的NAUSEA和/或EMESIS
公开(公告)号：WO2016118540A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/013979
申请日：2016-01-20
申请人： XOC PHARMACEUTICALS, INC.
发明人： ARMER, Thomas , MCKINLEY, Geoff , BORLAND, Scott , GUZMAN, Miguel
IPC分类号： A61K31/439 , A61K9/12 , A61P1/08
CPC分类号： A61K31/473 , A61K9/0043 , A61K9/0075 , A61K9/0078 , A61K9/008
摘要： Methods for treating and/or preventing nausea and emesis including acute and/or delayed nausea and/or acute and/or delayed emesis in a subject are provided herein. The methods include administering to the subject in need thereof a therapeutically effective amount of a 5HT 3 antagonist or a pharmaceutical composition thereof by nasal inhalation and/or oral inhalation.
摘要翻译：本文提供了治疗和/或预防恶心和呕吐的方法，包括受试者中急性和/或延迟的恶心和/或急性和/或延迟性呕吐。所述方法包括向有需要的受试者施用治疗有效量的5HT3拮抗剂或其药物组合物，其通过鼻吸入和/或口服吸入。

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