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1. 发明申请

WO2022187658A1 INHIBITORS OF SGLT-1 AND USES THEREOF 审中-公开
公开(公告)号：WO2022187658A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/018958
申请日：2022-03-04
申请人： THE REGENTS OF THE UNIVERSITY OF MICHIGAN , WAYNE STATE UNIVERSITY
发明人： XU, Jie , ZHANG, Kezhong , LIANG, Xiubin , CHEN, Yuqing Eugene
IPC分类号： A61K31/351 , A61K31/357 , A61K31/70 , A61K31/7034
摘要： This invention is in the field of medicinal pharmacology. In particular, the present invention relates to pharmaceutical agents which function as inhibitors of sodium-glucose cotransporter 1 (SGLT-1) activity. The invention further relates to methods of treating and/or ameliorating symptoms related to cystic fibrosis-related liver disease and diseases characterized with increased SGLT-1 activity, increased endoplasmic reticulum (ER) stress response, and/or increased hepatic inflammation.

2. 发明申请

WO2022150353A1 RAMAN-BASED SYSTEMS AND METHODS FOR MATERIAL IDENTIFICATION 审中-公开
公开(公告)号：WO2022150353A1
公开(公告)日：2022-07-14
申请号：PCT/US2022/011273
申请日：2022-01-05
申请人： WAYNE STATE UNIVERSITY , SERAPH BIOSCIENCES, INC.
发明人： MAJIDI, Ehsan , HUANG, Changhe , AUNER, Gregory William
IPC分类号： G01N21/65
摘要： Apparatuses, systems, and methods for analyzing a sample are provided. In some embodiments, a system includes a test assembly that comprises: a sample analyzer configured to provide data related to the sample; and a processing unit configured to analyze the data provided by the sample analyzer. The system is configured to identify at least one target in the sample.

3. 发明申请

WO2022032181A1 BLACK METALLIC NANOROD ARRAYS AND METHOD OF MANUFACTURING THEREOF 审中-公开
公开(公告)号：WO2022032181A1
公开(公告)日：2022-02-10
申请号：PCT/US2021/045083
申请日：2021-08-06
申请人： WAYNE STATE UNIVERSITY
发明人： DENG, Da , BAE, Minjun
IPC分类号： H01M4/131 , B82Y30/00 , B82Y40/00 , H01M4/134 , H01M4/1391 , H01M4/1395 , H01M4/66 , H01M10/052 , C23C18/52 , A61L27/06 , B64C1/00 , H01M2004/021 , H01M2004/025 , H01M4/628 , H01M4/661 , H01M4/667 , H01M4/70
摘要： A device may include a metallic substrate and a plurality of nanorod arrays arranged on the substrate. The nanorod arrays may be made of porous metallic nanostructures and may appear black in color.

4. 发明申请

WO2021236922A1 ZWITTERIONIC POLYMER PARTICLE COMPOSITIONS AND RELATED METHODS 审中-公开
公开(公告)号：WO2021236922A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/033393
申请日：2021-05-20
申请人： WAYNE STATE UNIVERSITY
发明人： CAO, Zhiqiang
IPC分类号： A61K38/00 , A61K47/50 , A61P3/10
摘要： Compositions and methods for oral and/or mucosal administration of a biologically active agent are provided according to aspects of the present disclosure which include: a plurality of particles, wherein each particle has an exterior surface, the exterior surface defining a particle interior, the exterior surface having at least one type of zwitterionic polymer and/or zwitterionic copolymer disposed thereon and/or extending therefrom; and a biologically active agent disposed on the exterior surface and/or in the particle interior, wherein the biologically active agent is or includes a protein, peptide, or dietary supplement. According to particular aspects, compositions and methods for oral and/or mucosal administration of an anti diabetes biological agent, such as insulin and/or an insulin analog.

5. 发明申请

WO2021178813A1 CHARGED-STATE LITHIUM-ION BATTERIES CONSTRUCTED USING LITHIUM-FREE BINARY FE/MN-BASED CATHODE MATERIALS 审中-公开
公开(公告)号：WO2021178813A1
公开(公告)日：2021-09-10
申请号：PCT/US2021/021108
申请日：2021-03-05
申请人： WAYNE STATE UNIVERSITY
发明人： DENG, Da , PUNYAPU, Venkata
IPC分类号： H01M4/58 , H01M4/36 , H01M4/136 , H01M4/50 , H01M10/0525
摘要： A lithium-ion battery may include a lithium-free cathode, a lithiated anode, and a separator/electrolyte between the lithium-free cathode and the lithiated anode. The lithium-free cathode may include FeOF and MnO2. The FeOF may be in the form of nanorods, and the MnO2 may be in the form of monolayer nanosheets. The FeOF nanorods may be sandwiched or wrapped by the monolayer MnO2 nanosheets.

6. 发明申请

WO2021167776A1 DEPOSITION OF TELLURIUM-CONTAINING THIN FILMS 审中-公开
公开(公告)号：WO2021167776A1
公开(公告)日：2021-08-26
申请号：PCT/US2021/016015
申请日：2021-02-01
申请人： APPLIED MATERIALS, INC. , WAYNE STATE UNIVERSITY
发明人： KNISLEY, Thomas , WOODS, Keenan N. , SALY, Mark , WINTER, Charles H. , UPADHYAY, Apoorva
IPC分类号： C23C16/455 , C23C16/28 , C23C16/40 , C23C16/42 , C23C16/30 , C23C16/56
摘要： Methods for depositing tellurium-containing films on a substrate are described. The substrate is exposed to a tellurium precursor and a reactant to form the tellurium-containing film (e.g., elemental tellurium, tellurium oxide, tellurium carbide, tellurium silicide, germanium telluride, antimony telluride, germanium antimony telluride). The exposures can be sequential or simultaneous.

7. 发明申请

WO2018195466A1 SYSTEM AND METHOD FOR CHARACTERIZATION OF A BRAIN TISSUE SAMPLE USING RAMAN MARKER REGIONS 审中-公开
公开(公告)号：WO2018195466A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028628
申请日：2018-04-20
申请人： HENRY FORD HEALTH SYSTEM , WAYNE STATE UNIVERSITY
发明人： AUNER, Gregory William , BRUSATORI, Michelle , KALKANIS, Steven N. , SCARPACE, Lisa
IPC分类号： G01N21/65 , G01N21/64
摘要： A system for characterization of a brain tissue sample includes a laser having an excitation fiber and a probe coupled to the excitation fiber for irradiating the brain tissue sample with light at an excitation wavelength. The probe further includes a plurality of return fibers for receiving light scattered from the brain tissue sample, wherein each return fiber includes a microfilter that permits light to pass for a different, spaced apart marker region. A Raman spectrometer is in communication with the plurality of return fibers, and a processor is in communication with the Raman spectrometer for analyzing Raman spectra within the marker regions to identify a tissue type of the brain tissue sample as one of normal white matter brain tissue, normal grey matter brain tissue, brain tumor tissue, infiltrating tumor tissue, and necrotic tissue.

8. 发明申请

WO2018187738A1 NEOMYCIN AND PAROMOMYCIN DERIVATIVES 审中-公开
公开(公告)号：WO2018187738A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/026547
申请日：2018-04-06
申请人： WAYNE STATE UNIVERSITY , UNIVERSITAT ZURICH
发明人： CRICH, David , SATI, Girish , SONOUSI, Amr , YANG, Guanyu , MANDHAPATI, Appi Reddy , PIRRONE, Michael G. , KATO, Takayuki , SARPE, Vikram , VASELLA, Andrea , BOTTGER, Erik C. , HOBBIE, Sven N.
IPC分类号： C07H15/232 , C07H15/23 , C07H15/222 , A61K31/7036 , A61P31/04
CPC分类号： C07H15/232 , A61K31/7036 , A61P31/04 , C07H15/222 , C07H15/23
摘要： The present disclosure relates to derivatives of neamine-based aminoglycoside antibacterial drugs modified in position C6', C2' and/or C5''. The modifications impart favorable properties regarding activity against ESKAPE pathogens, evasion of resistance traits and increased selectivity, enabling systemic use of the compounds.

9. 发明申请

WO2018148251A1 METHOD AND APPARATUS FOR DETERMINING BLOOD PRESSURE ON MEASURED HEART SOUNDS 审中-公开
公开(公告)号：WO2018148251A1
公开(公告)日：2018-08-16
申请号：PCT/US2018/017178
申请日：2018-02-07
申请人： WAYNE STATE UNIVERSITY
发明人： LYMAN, William D. , KAPUR, Gaurav , XU, Yong , WU, Sean F. , CHEN, Lingguang
IPC分类号： A61B5/021 , A61B7/04
CPC分类号： A61B5/021 , A61B7/04
摘要： A system and method of determining blood pressure includes measuring heart sounds, separating the measured heart sounds into a first heart sound (S 1 ) and a second heart sound (S 2 ), mathematically characterizing S 1 and S 2 , and determining a blood pressure based on the characterization.

10. 发明申请

WO2017176985A1 ISOLATION AND ANALYSIS OF FETAL DNA FROM EXTRAVILLOUS TROPHOBLAST CELLS RETRIEVED FROM THE ENDOCERVICAL CANAL 审中-公开
标题翻译：从宫颈管上皮细胞回收的胎盘DNA的分离与分析
公开(公告)号：WO2017176985A1
公开(公告)日：2017-10-12
申请号：PCT/US2017/026335
申请日：2017-04-06
申请人： WAYNE STATE UNIVERSITY
发明人： DREWLO, Sascha , ARMANT, Randall, D.
IPC分类号： C12N15/10 , C12Q1/68 , G01N33/50
摘要： Methods of isolating DNA of a fetus of an ongoing pregnancy are provided according to the present invention which include obtaining a maternal endocervical sample containing maternal cells and fetal extravillous trophoblast cells from a pregnant subject; isolating fetal extravillous trophoblast cells from the maternal endocervical sample, producing isolated fetal extravllous trophoblast cells contaminated with maternal DNA; lysing the isolated fetal extravillous trophoblast cells; isolating fetal nuclei from the lysed fetal extravillous trophoblast cells, producing isolated fetal nuclei, thereby removing at least a portion of the contaminating maternal DNA; and purifying genomic DNA from the isolated fetal nuclei, producing purified fetal genomic DNA. The purified fetal genomic DNA can be assayed to determine a characteristic of a genomic DNA sequence of the purified fetal genomic DNA, thereby determining a characteristic of DNA of a fetus of an ongoing pregnancy.
摘要翻译：根据本发明提供了分离持续妊娠胎儿的DNA的方法，其包括获得含有来自怀孕受试者的母体细胞和胎儿绒毛外滋养层细胞的母体宫颈内膜样品; 从母体宫颈内样品中分离胎儿绒毛外滋养层细胞，产生被母体DNA污染的分离的胎儿外绒毛滋养层细胞; 裂解分离的胎儿绒毛外滋养层细胞; 从裂解的胎儿绒毛外滋养细胞分离胎儿核，产生分离的胎儿细胞核，由此除去至少一部分污染的母体DNA; 并从分离的胎儿细胞核中纯化基因组DNA，产生纯化的胎儿基因组DNA。可以测定纯化的胎儿基因组DNA以确定纯化的胎儿基因组DNA的基因组DNA序列的特征，从而确定正在进行的妊娠的胎儿DNA的特征。

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