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1. 发明申请

WO2023062343A1 PREDICTION OF FADE OUTAGES 审中-公开
公开(公告)号：WO2023062343A1
公开(公告)日：2023-04-20
申请号：PCT/GB2022/052541
申请日：2022-10-07
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： KOUROGIORGAS, Charilaos , VENTOURAS, Spyridon
IPC分类号： H04B7/185
摘要： The disclosure relates to methods and apparatus for providing a prediction of fade outage of a feeder link between a satellite and a ground station within a prediction time interval. Rainfall forecast data for the gateway is received for a plurality of forecast time intervals which comprise a plurality of time intervals after the prediction time interval. The rainfall forecast data is then input to a trained fade outage model, which outputs the prediction of fade outage in response to the input.

2. 发明申请

WO2023036779A2 NUCLEIC ACID POLYMERASES 审中-公开
公开(公告)号：WO2023036779A2
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074749
申请日：2022-09-06
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： FREUND, Niklas , ARANGUNDY-FRANKLIN, Sebastian , HOLLIGER, Philipp
IPC分类号： C12N9/12 , C12N15/10 , C12P19/34
摘要： In an aspect, the invention relates to nucleic acid polymerases capable of producing non-DNA polymers. In addition, the invention relates to uses of said polymerases and to the resultant products.

3. 发明申请

WO2023036772A1 METHODS OF BIOMOLECULE DISPLAY 审中-公开
公开(公告)号：WO2023036772A1
公开(公告)日：2023-03-16
申请号：PCT/EP2022/074731
申请日：2022-09-06
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： POREBSKI, Benjamin , HOLLIGER, Philipp
IPC分类号： C12Q1/6806 , C12Q1/686
摘要： The invention relates to methods of displaying biomolecules on substrates, for instance on the surface of flow cells. The invention relates to upstream, downstream, or direct methods for displaying XNA molecules, RNA molecules, and/or polypeptides on the substrate. The invention further relates to substrates displaying biomolecules that are obtained or obtainable by the methods of the invention.

4. 发明申请

WO2022171972A1 CELL-PENETRATING PEPTIDE CONJUGATES AND METHODS OF THEIR USE 审中-公开
公开(公告)号：WO2022171972A1
公开(公告)日：2022-08-18
申请号：PCT/GB2021/050357
申请日：2021-02-12
申请人： OXFORD UNIVERSITY INNOVATION LIMITED , UNITED KINGDOM RESEARCH AND INNOVATION
发明人： WOOD, Matthew , MANZANO, Raquel , GODFREY, Caroline , MCCLOREY, Graham , RAZ, Richard , GAIT, Michael , ARZUMANOV, Andrey , O'DONOVAN, Liz , HAZELL, Gareth , HOLLAND, Ashling , VARELA, Miguel , BETTS, Corinne , BANERJEE, Subhashis
IPC分类号： A61K47/64 , A61P21/00 , A61K31/7125 , C12N15/113 , C12N15/87 , C07K7/08
摘要： Disclosed are conjugates of an oligonucleotide and a peptide covalently bonded or linked via a linker to the oligonucleotide, the peptide including at least one cationic domain comprising at least 4 amino acid residues and at least one hydrophobic domain comprising at least 3 amino acid residues, provided that the peptide includes a total of 7 to 40 amino acid residues and does not include any artificial amino acid residues; and the oligonucleotide including a total of 12 to 40 contiguous nucleobases, where at least 12 contiguous nucleobases are complementary to a target sequence in a human dystrophin gene.

5. 发明申请

WO2022090746A1 NMT INHIBITORS FOR TREATING SENESCENCE-ASSOCIATED DISEASES OR DISORDERS 审中-公开
公开(公告)号：WO2022090746A1
公开(公告)日：2022-05-05
申请号：PCT/GB2021/052833
申请日：2021-11-02
申请人： IMPERIAL COLLEGE INNOVATIONS LIMITED , UNITED KINGDOM RESEARCH AND INNOVATION
发明人： TATE, Edward , KALLEMEIJN, Wouter , GIL, Jesus , MCHUGH, Domhnall
IPC分类号： A61K31/416 , A61K31/437 , A61K31/496 , A61K45/06 , A61P3/00 , A61P9/00 , A61P11/00 , A61P17/00 , A61P19/02 , A61P25/00 , A61P27/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00
摘要： The present invention provides a NMT inhibitor for use in the prophylaxis or treatment of a senescence-associated disease or disorder.

6. 发明申请

WO2022046626A2 TWO COMPONENT CO-ASSEMBLING TWO DIMENSIONAL PROTEIN STRUCTURES 审中-公开
公开(公告)号：WO2022046626A2
公开(公告)日：2022-03-03
申请号：PCT/US2021/047136
申请日：2021-08-23
申请人： UNIVERSITY OF WASHINGTON , MEDICAL RESEARCH COUNCIL, AS PART OF UNITED KINGDOM RESEARCH AND INNOVATION
发明人： SASSON, Ariel Ben , BAKER, David , SHEFFLER, William H. , RUOHOLA-BAKER, Hannele , SOMASUNDARAM, Logeshwaran , DERIVERY, Emmanuel , WATSON, Joseph L.
IPC分类号： G16B15/20 , G16B30/20 , C07K14/00
摘要： The disclosure provides two-dimensional protein structures including first and second polypeptides that are different, each form homo-oligomers, and interact to form a rigid interface, polypeptide components of such two-dimensional protein structures, and uses thereof.

7. 发明申请

WO2021111144A1 METHOD AND SYSTEM FOR PRODUCING HYDROGEN 审中-公开
公开(公告)号：WO2021111144A1
公开(公告)日：2021-06-10
申请号：PCT/GB2020/053109
申请日：2020-12-04
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： DAVENNE, Tristan , GREENWOOD, Simeon , HUDDART, Adam
IPC分类号： C01B3/04 , C01B3/50
摘要： The present invention relates to a method of producing hydrogen from ammonia and to a system for producing hydrogen from ammonia.

8. 发明申请

WO2020070514A1 RAMAN SPECTROMETER 审中-公开
公开(公告)号：WO2020070514A1
公开(公告)日：2020-04-09
申请号：PCT/GB2019/052808
申请日：2019-10-04
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： MATOUSEK, Pavel , SOWOIDNICH, Kay , TOWRIE, Michael
IPC分类号： G01J3/02 , G01J3/44 , G01N21/65
摘要： There are disclosed methods and apparatus (10) for measuring Raman spectral features (52) of a sample (12), from which background light of variable intensity is also received, for example due to the incidence of ambient light (14) or due to variable fluorescence. Detection pixels (42) and storage pixels (44) are defined on a CCD device (40). Laser probe light (22) is directed to the sample. In a repeated cycle of first and second intervals, in each first interval background light is received at detection pixels, and in each second interval both background light and scattered laser probe light is received at the detection pixels. The accumulated signal from each of the first and second intervals is retained in the storage pixels during the second and first intervals respectively. In other aspects laser probe light is directed to the sample during both of the first and second intervals, but has a different wavelength in each interval.

9. 发明申请

WO2020058717A1 METHOD AND APPARATUS FOR DETERMINING A SCATTERING SPECTRUM OF AN EYE 审中-公开
公开(公告)号：WO2020058717A1
公开(公告)日：2020-03-26
申请号：PCT/GB2019/052637
申请日：2019-09-19
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： MARGRAIN, Tom
IPC分类号： A61B3/00 , A61B3/10
摘要： Embodiments of the present invention provide a computer- implemented method (100) of determining a scattering spectrum of an eye. The method comprises receiving data from a detector (240) indicative of a reflected wave of radiation (260) reflected from the retina, wherein the reflected wave of radiation (260) is formed by an incident wave (250) of masked radiation directed towards a retina of the eye, such that at least one region masked (430, 460) from the incident wave is present on the retina, determining (110, 1130) a first back scattering spectrum (500) indicative of light scattered from an optical media of the eye in dependence on a portion of the reflected wave of radiation corresponding to the at least one masked region (430, 460), determining (120, 1240) a second back scattering spectrum indicative of light scattered from a neural retina of the eye in dependence on retinal structure information (700) representative of neural retinal structure, and determining (130) the scattering spectrum of the eye in dependence on the first back scattering spectrum and the second back scattering spectrum.

10. 发明申请

WO2019150107A1 RADAR IMAGE PROCESSING 审中-公开
公开(公告)号：WO2019150107A1
公开(公告)日：2019-08-08
申请号：PCT/GB2019/050258
申请日：2019-01-30
申请人： UNITED KINGDOM RESEARCH AND INNOVATION
发明人： MCCANN, David
IPC分类号： G01S13/89 , G01S13/90 , G01S7/40
摘要： A method of remote sensing of a body of water comprising: using a radar apparatus installed on a vessel to obtain a plurality of radar intensity images of the surface of the body of water; registering a geographic location of each of the plurality of radar intensity images, wherein registering the geographic location of each of the plurality of radar intensity images comprises: applying one or more of the following calibration offsets to increase image sharpness: an azimuthal alignment error (α) corresponding to an angular offset between a heading recorded by a navigation unit installed on the vessel and a true heading of the vessel; a start range error (β) corresponding to an error in a distance from an antenna to a data processing unit of the radar apparatus for a first range bin in the plurality of radar intensity images; and/or a system time error (γ) corresponding to a total time delay resulting from a time delay due to communication of data between the radar apparatus and the data processing unit and/or a computer-induced time stamp delay between a true image recording time and an image time-stamp; and generating one or more time-integrated images of the surface of the body of water.

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