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1. 发明申请

WO2018102506A1 TYROSINE DERIVATIVES AND COMPOSITIONS COMPRISING THEM 审中-公开
公开(公告)号：WO2018102506A1
公开(公告)日：2018-06-07
申请号：PCT/US2017/063865
申请日：2017-11-30
申请人： TYME, INC.
发明人： HOFFMAN, Steven
IPC分类号： A61K45/06 , A61K31/195 , A61P35/00
摘要： Compositions and kits comprising a tyrosine hydroxylase inhibitor and an anticancer agent that is chemically bonded to, or physically associated with, the tyrosine hydroxylase inhibitor are provided. Also provided are methods for reducing cell proliferation in a subject comprising administering to a subject in need thereof a composition comprising a tyrosine hydroxylase inhibitor and an anticancer agent that is chemically bonded to, or physically associated with, the tyrosine hydroxylase inhibitor.

2. 发明申请

WO2021146506A2 TYROSINE DERIVATIVES FOR MODULATING CANCER 审中-公开
公开(公告)号：WO2021146506A2
公开(公告)日：2021-07-22
申请号：PCT/US2021/013555
申请日：2021-01-15
申请人： TYME, INC.
发明人： HOFFMAN, Steven
IPC分类号： A61K31/198 , A61K31/00 , A61P35/00 , A61P35/02 , A61K31/4166 , A61K31/436 , A61K31/55 , A61K45/06 , A61P35/04
摘要： The present inventions provide compositions and methods for modulating cancer using a tyrosine derivative.

3. 发明申请

WO2020197875A1 D-METYROSINE COMPOSITIONS AND METHODS FOR PREPARING SAME 审中-公开
公开(公告)号：WO2020197875A1
公开(公告)日：2020-10-01
申请号：PCT/US2020/023299
申请日：2020-03-18
申请人： TYME, INC. , ZUCARO, John
发明人： ZUCARO, John
IPC分类号： C07C49/255 , C07C227/18 , C07C237/20 , C07C255/43
摘要： The disclosure provides processes for preparing a compound of formula I, comprising reacting a compound of formula II with an aqueous acid in a solvent and at a temperature sufficient for at least about 48 hours to produce a compound of formula I: wherein, R 1 -R 5 are defined herein. Also provided are D-metyrosine prepared according to the processes described herein and compositions comprising the D-metyrosine provided herein.

4. 发明申请

WO2022006366A1 CRYSTALLINE FORMS OF METYROSINE 审中-公开
公开(公告)号：WO2022006366A1
公开(公告)日：2022-01-06
申请号：PCT/US2021/040035
申请日：2021-07-01
申请人： TYME, INC.
发明人： ZUCARO, John
IPC分类号： C07C227/18 , C07C237/20 , C07C255/43 , C07B2200/13 , C07C227/42 , C07C229/36
摘要： The disclosure provides crystalline compositions comprising D-metyrosine and L- metyrosine, pharmaceutical formulation comprising one or more crystalline composition described herein and a pharmaceutically acceptable excipient, methods for treating cancer in a patient in need thereof, the method comprising administering to the patient one or more composition described herein, and methods for preparing the compositions described herein.

5. 发明申请

WO2021231931A1 METHODS OF TREATING SARS-COV-2 INFECTIONS 审中-公开
公开(公告)号：WO2021231931A1
公开(公告)日：2021-11-18
申请号：PCT/US2021/032557
申请日：2021-05-14
申请人： TYME, INC. , HOFFMAN, Steven , ROTHMAN, John
发明人： HOFFMAN, Steven , ROTHMAN, John
IPC分类号： A61K31/575 , A01N45/00 , A61P31/14
摘要： The disclosure is directed to methods of using UDCA, or a pharmaceutically acceptable salt thereof, or a derivative thereof, for the treatment of SARS-CoV-2 infections.

6. 发明申请

WO2021076723A1 ALKYLESTERS OF ALPHA-METHYL-DL-TYROSINE FOR USE IN TREATING CANCER 审中-公开
公开(公告)号：WO2021076723A1
公开(公告)日：2021-04-22
申请号：PCT/US2020/055727
申请日：2020-10-15
申请人： TYME, INC.
发明人： HOFFMAN, Steven
IPC分类号： A61K31/19 , A61K31/198 , A61P35/00 , A61K45/06 , A61K38/34
摘要： Pharmaceutical compositions and kits including an alkylester of α-methyl-DL-tyrosine (or salt thereol), for example, α-methyl-DL-tyrosine methyl ester hydrochloride, are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of an alkylester of α-methyl-DL-tyrosine (or salt thereof), for example, α-methyl-DL-tyrosine methyl ester hydrochloride, to the subject in need thereof.

7. 发明申请

WO2021119096A1 PHARMACEUTICAL COMPOSITIONS AND METHODS 审中-公开
公开(公告)号：WO2021119096A1
公开(公告)日：2021-06-17
申请号：PCT/US2020/063962
申请日：2020-12-09
申请人： TYME, INC.
发明人： HOFFMAN, Steven , ROTHMAN, John
IPC分类号： A61K31/575 , A61K47/10 , C08G65/00 , A61P35/00
摘要： Methods of treating cancer or reducing tumor size by contacting a patient's cancer cells or tumor with an effective amount of a pharmaceutical composition as further defined herein.

8. 发明申请

WO2020023191A1 TUMOR REDUCTION FORMULATIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2020023191A1
公开(公告)日：2020-01-30
申请号：PCT/US2019/040264
申请日：2019-07-02
申请人： TYME, INC
发明人： HOFFMAN, Steven , ROTHMAN, John
IPC分类号： A61K31/7088 , A61K38/00 , A61K38/17
摘要： The invention relates to tumor reducing compositions and methods thereof. Specifically, the invention relates to compositions comprising a combination of a sclerosing agent and a penetrating agent.

9. 发明申请

WO2019055747A1 TRANSDERMAL FORMULATIONS 审中-公开
公开(公告)号：WO2019055747A1
公开(公告)日：2019-03-21
申请号：PCT/US2018/051010
申请日：2018-09-14
申请人： TYME, INC.
发明人： HOFFMAN, Steven
IPC分类号： A61K9/00 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/22 , A61K9/08 , A61K31/26
摘要： The present disclosure is directed to transdermal compositions comprising isothiocyanates or isocyanates.

10. 发明申请

WO2015061256A1 HIGH-SPEED CENTRIFUGAL MIXING DEVICES AND METHODS OF USE 审中-公开
标题翻译：高速离心混合装置及其使用方法
公开(公告)号：WO2015061256A1
公开(公告)日：2015-04-30
申请号：PCT/US2014/061481
申请日：2014-10-21
申请人： TYME, INC.
发明人： HOFFMAN, Steven
IPC分类号： B01F9/10
CPC分类号： B01F9/0003 , A61K31/138 , A61K31/198 , A61K31/366 , A61K31/436 , A61K31/506 , B01F3/18 , B01F9/0001 , B01F9/0021 , B01F13/0052 , B01F2215/0032
摘要： A centrifugal mixing device can include a shaft assembly that is operably coupled to a motor such that the motor rotates the shaft assembly about a first axis. The devices can further include a turret that is rotatably coupled to the shaft assembly such that the turret rotates about the first axis relative to the shaft assembly. The turret can include a first support, a first canister rotatably coupled to the first support such that the first canister rotates about a second axis, and a second canister rotatably coupled to the first support such that the second canister rotates about a third axis. The turret is configured to rotate about the first axis in a first rotational direction and each of the first and second canisters is configured to rotate about the second and third axes, respectively, in a second rotational direction that is opposite the first rotational direction.
摘要翻译：离心混合装置可以包括轴组件，其可操作地联接到马达，使得马达使轴组件围绕第一轴线旋转。这些装置还可以包括可旋转地联接到轴组件的转台，使得转台相对于轴组件围绕第一轴线旋转。转台可以包括第一支撑件，可旋转地联接到第一支撑件的第一罐，使得第一罐绕第二轴线旋转，以及可旋转地联接到第一支撑件的第二罐，使得第二罐绕第三轴线旋转。转台被构造成在第一旋转方向上围绕第一轴线旋转，并且第一和第二罐中的每一个分别构造成在与第一旋转方向相反的第二旋转方向上围绕第二和第三轴线旋转。

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