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1. 发明申请

WO2017173229A1 METHODS AND COMPOSITIONS FOR PREVENTING INFECTION BY A VIBRIO SPECIES 审中-公开
标题翻译：预防纤维虫种类感染的方法和组合物
公开(公告)号：WO2017173229A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/025305
申请日：2017-03-31
申请人： TUFTS UNIVERSITY
发明人： CAMILLI, Andrew , CAIRNS, Lynne , YEN, Minmin
IPC分类号： C12R1/91 , A01N63/02 , C12N7/00
摘要： Compositions and methods are provided for preventing, ameliorating, or treating a disease caused by a species of bacterial genus Vibrio, for example, cholera caused by V. cholerae, the compositions containing two or more strains of lytic bacteriophage that infect and kill Vibrio cells. The bacteriophage are virulent, which replicate intracellularly and lyse and kill the bacteria. Use of two or more strains in a single treatment, as a result of a rate of mutation of the bacteria to simultaneous resistance to all of the bacteriophage to be so low as to be negligible, reduces appearance of phage-resistant bacteria to statistical negligibility. Normal human microbial flora species were not affected. In alternative embodiments of the method and the composition, antibiotic agents or other treatment agents can be administered with a cocktail of the plurality of bacteriophage strains.
摘要翻译：提供组合物和方法用于预防，改善或治疗由弧菌属细菌种类引起的疾病，例如由霍乱弧菌引起的霍乱，含有两种或更多种溶解菌株的组合物噬菌体感染和杀死弧菌细胞。噬菌体是强毒的，它在细胞内复制并裂解并杀死细菌。由于细菌突变率与同时对所有噬菌体的抗性低至可忽略不计的程度，使得在单一处理中使用两种或更多种菌株，从而减少了抗噬菌体细菌出现统计学上的可忽略性。正常的人类微生物菌群不受影响。在该方法和组合物的可选实施方案中，抗生素剂或其他治疗剂可以与多种噬菌体菌株的混合物一起施用。

2. 发明申请

WO2017095782A1 SILK-BASED ADHESIVES 审中-公开
标题翻译：基于丝绸的粘合剂
公开(公告)号：WO2017095782A1
公开(公告)日：2017-06-08
申请号：PCT/US2016/063932
申请日：2016-11-29
申请人： TUFTS UNIVERSITY
发明人： BURKE, Kelly A. , KAPLAN, David L.
IPC分类号： A61L27/36 , A61L33/06
CPC分类号： A61L24/0005
摘要： In some embodiments, the present invention provides compositions including silk fibroin, at least one hydrophilic agent, and at least one catechol donating agent, wherein the at least one hydrophilic agent and at least one catechol donating agent are conjugated to the silk fibroin. According to various embodiments, at least a portion of the silk fibroin may be crosslinked. In some embodiments, the silk fibroin is at least 50% (e.g., 60%, 70%, 80%, 90%, 95% or more) crosslinked. In some embodiments, the present invention also provides methods for making such compositions.
摘要翻译：在一些实施方案中，本发明提供包含丝心蛋白，至少一种亲水剂和至少一种儿茶酚供体剂的组合物，其中所述至少一种亲水剂和至少一种儿茶酚供体剂是与丝素蛋白缀合。根据各种实施方案，丝素蛋白的至少一部分可以交联。在一些实施方案中，丝素蛋白是交联的至少50％（例如，60％，70％，80％，90％，95％或更多）。在一些实施方案中，本发明还提供了制备这种组合物的方法。

3. 发明申请

WO2017083338A1 OXIDATIVE CONVERSION OF METHANE TO OXYGENATES 审中-公开
标题翻译：甲烷氧化转化为氧化物
公开(公告)号：WO2017083338A1
公开(公告)日：2017-05-18
申请号：PCT/US2016/061064
申请日：2016-11-09
申请人： TUFTS UNIVERSITY
发明人： SHAN, Junjun , FLYTZANI-STEPHANOPOULOS, Maria , LI, Mengwei
IPC分类号： C07C29/48 , C07C31/04 , B01J29/40 , B01J29/44 , B01J29/46 , C07C51/15 , C07C51/16 , C07C53/02 , C07C53/08
CPC分类号： B01J29/44 , B01J29/46 , B01J35/002 , B01J2229/18 , C07C29/50 , C07C51/215 , Y02P20/52 , C07C31/04 , C07C53/08 , C07C53/02
摘要： A method of converting methane to an oxygenate. The method includes converting methane to an oxygenate with a transition metal ion loaded zeolite catalyst in an aqueous medium in the presence of gaseous O 2 and CO at a temperature lower than 200°C. Also disclosed are a two-metal ion zeolite catalyst for converting methane to methanol and a method for preparing the two-metal ion zeolite catalyst.
摘要翻译：甲烷转化为含氧化合物的方法。所述方法包括在低于200℃的温度下，在气态O 2和CO存在下，在含水介质中用加载有过渡金属离子的沸石催化剂将甲烷转化为含氧化合物。还公开了用于将甲烷转化为甲醇的双金属离子沸石催化剂和制备双金属离子沸石催化剂的方法。

4. 发明申请

WO2017023727A1 THREAD-BASED INTEGRATED FUNCTIONAL DEVICES 审中-公开
标题翻译：基于螺纹的集成功能设备
公开(公告)号：WO2017023727A1
公开(公告)日：2017-02-09
申请号：PCT/US2016/044639
申请日：2016-07-29
申请人： TUFTS UNIVERSITY
发明人： SONKUSALE, Sameer , MOSTAFALU, Pooria
IPC分类号： A61M25/00 , A61B5/00 , A61L29/02 , A61L29/04 , B82Y30/00
CPC分类号： A61B5/00 , A61B1/00105 , A61B5/01 , A61B5/14532 , A61B5/6804 , A61B5/6851 , A61B2560/0443 , A61M25/00
摘要： A composite thread includes first and second segments joined to each other. The first segment comprises a functional segment that interacts with an environment of the thread. The second segment communicates information between the first segment and a point external to said composite thread.
摘要翻译：复合螺纹包括彼此连接的第一和第二段。第一段包括与线程的环境相互作用的功能段。第二段在第一段和所述复合线外部的点之间传送信息。

5. 发明申请

WO2017011454A1 ELECTROACTIVE SCAFFOLDS, METHODS OF MAKING ELECTROACTIVE SCAFFOLDS, AND METHODS OF USING ELECTROACTIVE SCAFFOLDS 审中-公开
标题翻译：电化学法，制备电解法的方法和使用电化学法的方法
公开(公告)号：WO2017011454A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/041893
申请日：2016-07-12
申请人： THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. , TUFTS UNIVERSITY
发明人： HARDY, John , SCHMIDT, Christine, E. , KAPLAN, David, L.
IPC分类号： C07D487/22
CPC分类号： C08L65/00 , A61L27/18 , A61L27/3834 , A61L27/46 , A61L27/50 , C08G61/124 , C08G61/126 , C08G63/6852 , C08G2261/1424 , C08G2261/1426 , C08G2261/143 , C08G2261/1452 , C08G2261/3221 , C08G2261/3223 , C08G2261/43 , C08G2261/51 , C08L67/04
摘要： Embodiments of the present disclosure provide for structures including an electroactive scaffold, methods of making the structure, method of using structure, and the like.
摘要翻译：本公开的实施例提供了包括电活性支架，制造结构的方法，使用结构的方法等的结构。

6. 发明申请

WO2016033444A1 COMPOSITIONS, METHODS AND KITS FOR TREATING COMPLEMENT RELATED DISORDERS 审中-公开
标题翻译：用于治疗补充相关疾病的组合物，方法和试剂盒
公开(公告)号：WO2016033444A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/047405
申请日：2015-08-28
申请人： TUFTS UNIVERSITY
发明人： KUMAR-SINGH, Rajendra , LEADERER, Derek , CASHMAN, Siobhan
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , C07K14/745 , C07K14/705 , C07K19/00
CPC分类号： A61K38/177 , A47K7/026 , A61K45/06 , A61P37/00 , B08B7/02 , B25G1/04 , B25G1/06 , C07K14/70596 , G01N33/6893 , G01N2333/4716
摘要： Compositions, methods and kits are provided for treating complement related disorders in a subject with protein in combination having protein fusions of at least two of a CD46 protein, a CD55 protein and a CD59 protein or with a recombinant chimeric protein having at least two of a CD46 protein, a CD55 protein and a CD59 protein or with nucleic acids encoding these proteins. The composition negatively modulates classical and alternative complement pathways thereby treating complement related disorder such as macular degeneration, age-related macular degeneration, diabetic retinopathy, inflammatory bowel disease, thyroiditis, cryoglobulinaemia, fetal loss, organ graft rejection, cancer, etc.
摘要翻译：提供组合物，方法和试剂盒，用于治疗受试者中补体相关疾病，其中蛋白质组合具有至少两种CD46蛋白，CD55蛋白和CD59蛋白的蛋白质融合物，或与具有至少两种 CD46蛋白，CD55蛋白和CD59蛋白或编码这些蛋白的核酸。组合物负调节经典和替代补体途径，从而治疗补体相关疾病如黄斑变性，年龄相关性黄斑变性，糖尿病性视网膜病变，炎性肠病，甲状腺炎，冷球蛋白血症，胎儿丧失，器官移植排斥，癌症等。

7. 发明申请

WO2015134865A1 BIOPOLYMER-BASED PRESERVATION OF PERISHABLE PRODUCTS 审中-公开
标题翻译：基于生物聚合物的可持续产品的保存
公开(公告)号：WO2015134865A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/019163
申请日：2015-03-06
申请人： TUFTS UNIVERSITY
发明人： OMENETTO, Fiorenzo , KAPLAN, David , MARELLI, Benedetto , BRENCKLE, Mark
IPC分类号： A23L3/3526 , A01N3/00 , C07K14/425 , C07K14/435 , C07K14/78
CPC分类号： A23B7/16 , A01N3/00 , A23B7/154 , A23L3/3463 , A23L3/3526 , A23V2002/00 , C07K14/43586
摘要： Disclosed herein are biopolymer-based coatings and products incorporating such coatings. Related methods and use are also provided.
摘要翻译：本文公开了基于生物聚合物的涂层和结合这种涂层的产品。还提供了相关的方法和用途。

8. 发明申请

WO2015048527A1 OPTICALLY TRANSPARENT SILK HYDROGELS 审中-公开
标题翻译：光学透明硅胶
公开(公告)号：WO2015048527A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/057832
申请日：2014-09-26
申请人： TUFTS UNIVERSITY
发明人： OMENETTO, Fiorenzo , KAPLAN, David , MARELLI, Benedetto , MITROPOULOS, Alexander, Nicholas
IPC分类号： A61K9/10 , C07K2/00 , B82Y5/00
CPC分类号： A61K9/06 , B82Y5/00 , C07K14/43563
摘要： The present application relates to silk fibroin-based hydrogels, methods for making and using the same.
摘要翻译：本申请涉及基于丝素蛋白的水凝胶，其制造和使用方法。

9. 发明申请

WO2015048433A1 SYNTHESIS OF SILK FIBROIN MICRO- AND SUBMICRON SPHERES USING A CO-FLOW METHOD 审中-公开
标题翻译：使用共同流动方法合成丝状纤维素微球和亚细胞球
公开(公告)号：WO2015048433A1
公开(公告)日：2015-04-02
申请号：PCT/US2014/057701
申请日：2014-09-26
申请人： TUFTS UNIVERSITY
发明人： OMENETTO, Fiorenzo , PEROTTO, Giovanni , MARELLI, Benedetto , KAPLAN, David , MITROPOULOS, Alexander
IPC分类号： A61K9/16 , A61K47/42 , A61L17/10 , B01F5/06 , B82B1/00 , B82Y5/00
CPC分类号： C08J3/12 , A61K9/5169 , B01F3/0807 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B01F2215/0454 , B82Y5/00 , C07K1/02 , C07K14/43504 , C08J2389/00
摘要： This application relates to silk fibroin particles that are structurally uniform. Related methods are also disclosed.
摘要翻译：本申请涉及结构均匀的丝素蛋白颗粒。还公开了相关方法。

10. 发明申请

WO2014197093A2 ALL WATER-BASED NANOPATTERNING 审中-公开
标题翻译：所有基于水的纳米技术
公开(公告)号：WO2014197093A2
公开(公告)日：2014-12-11
申请号：PCT/US2014/029571
申请日：2014-03-14
申请人： TUFTS UNIVERSITY
发明人： OMENETTO, Fiorenzo G. , KAPLAN, David L. , KIM, Sunghwan , MARELLI, Benedetto
IPC分类号： G03F7/004 , G03F7/00 , B82B3/00
CPC分类号： G03F7/039 , G03F7/0037 , G03F7/038 , G03F7/162 , G03F7/168 , G03F7/2059 , G03F7/32
摘要： The present application provides novel methods for the fabrication of nanostructures. More specifically, the invention relates to direct electron beam lithography with the use of silk fibroin as "green" resists.
摘要翻译：本申请提供了制造纳米结构的新方法。更具体地，本发明涉及使用丝素蛋白作为“绿色”抗蚀剂的直接电子束光刻。

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