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1. 发明申请

WO2020111936A1 MAGNETIC FIELD PROBE FOR DETERMINING A DISPOSITION OF AN IMPLANTABLE MAGNETIC MARKER 审中-公开
公开(公告)号：WO2020111936A1
公开(公告)日：2020-06-04
申请号：PCT/NL2019/050708
申请日：2019-10-28
申请人： SIRIUS MEDICAL SYSTEMS B.V.
发明人： MARTENS, Hubert Cécile Francois , SCHERMERS, Bram , KANEKO, Takeshi , FRANKEN, Jeroen Hendrik
IPC分类号： A61B5/06 , A61B5/1495
摘要： During both invasive and non-invasive treatments and therapies, inaccuracies in locating the areas of interest mean that not all the area is treated, or the treatment is incomplete. A magnetic field probe 100, 1010, 102, 103 is provided that improves determination of a disposition of an implantable magnetic marker 200, the probe comprising a first 110, 120 and second 110, 120 magnetic sensor, substantially disposed along a transverse axis intersecting the longitudinal axis of the probe 150. The first 110, 20 and second 110, 120 magnetic sensors are close to the distal end 160 of the probe, and are separated by a minor sensor separation. A third 120, 130 magnetic sensor is provided close to the proximal end 165,separated by a major sensor separation from the second magnetic sensor 110, 120 close to the distal end 160, the major sensor separation being larger than the minor sensor separation; and the ratio of the major sensor separation to the minor sensor separation is in the range 1.25 to 40, preferably in the range 1.6 to 7.6. In this example, the second magnetic sensor is functionally configured and arranged to co-operate with both the first magnetic sensor and the third magnetic sensor. This may be implemented using three or more magnetic sensors. This provides a probe capable of accurately determining one or more dispositions of the implantable magnetic marker when the distal end of the probe is close to the marker and also when it is further away. In particular, including the pair of sensors close to the distal end may increase the sensitivity and accuracy of the probe.

2. 发明申请

WO2022018607A2 IMPROVED IMPLANTABLE MARKER AND A KIT OF PARTS 审中-公开
公开(公告)号：WO2022018607A2
公开(公告)日：2022-01-27
申请号：PCT/IB2021/056493
申请日：2021-07-19
申请人： SIRIUS MEDICAL SYSTEMS B.V.
发明人： SCHERMERS, Bram , VAN LEIJSEN, Adrianus Cornelis Petrus , MARTENS, Hubert Cécile François
IPC分类号： A61B90/00 , A61B2034/2051 , A61B2090/3954 , A61B2090/3987 , A61B2090/3991 , A61B2503/40 , A61B5/062 , A61B90/39 , H01F7/0205
摘要： Implantable magnetic markers (seeds) provide a higher degree of flexibility and convenience. In general, a larger marker is easier to locate. Larger diameter markers may be used, but they should be much smaller than the average tumor size if they are to provide a useful degree of localization. An implantable magnetic marker is provided with two or more permanent magnets connected by a mechanical connector to resiliently retain a first orientation when deployed and a second orientation during implantation. This allows complex magnetic configurations to be implanted, while retaining a simplified implantation method independent of the number of magnetic elements used. The transverse extent of the magnetic marker may be significantly reduced, allowing smaller needle diameters to be used or a larger number of smaller marker elements to be implanted. In addition, the two or more magnetic elements may be aligned to increase the transverse extent after implantation. This may increase detectability.

3. 发明申请

WO2021124300A1 MAGNETIC FIELD PROBE FOR DETERMINING A DISPOSITION OF AN IMPLANTABLE MARKER USING TWO OR MORE DETECTION ZONES 审中-公开
公开(公告)号：WO2021124300A1
公开(公告)日：2021-06-24
申请号：PCT/IB2020/062259
申请日：2020-12-20
申请人： SIRIUS MEDICAL SYSTEMS B.V.
发明人： MARTENS, Hubert , SCHERMERS, Bram , KANEKO, Takeshi , FALGARI, Pietro
IPC分类号： A61B34/20 , A61B2034/2046 , A61B2034/2051 , A61B2090/3954 , A61B2090/3958 , A61B90/39
摘要： During both invasive and non-invasive treatments and therapies, health professionals need to accurately locate areas of interest. Inaccuracies may mean that not all the area is treated, or the treatment is incomplete. Electro-magnetic and RFID (Radio-Frequency Identification) markers have been developed, but these are bulky and prone to failure. For example, any inaccuracy may result in an incomplete resection or removal of the lesion, requiring additional treatments. A magnetic field probe 100, 101 is provided for determining an angular disposition 180, 190 of an implantable magnetic marker 200, the probe comprising: a first magnetic sensor 110 close to the distal end 160, and a second magnetic sensor 120, closer to a proximal end 165, configured to determine two or more magnetic field vectors of the marker 200; the probe being further configured: to define two or more marker detection zones 170, 171, 172, 173, 174, extending from the distal end 160; to determine the angular disposition 180, 190 to the implantable marker 200; and to determine whether the angular disposition 180, 190 substantially coincides with one of the two or more marker detection zones 170, 171, 172, 173, 174, thereby determining that the marker falls within the one marker detection zones. By defining two or more marker detection zones, and configuring the probe to determine whether the magnetic marker appears to be within the one marker detection zone, a simplified and intuitive decision algorithm is provided for indicating the disposition of the marker relative to the probe.

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