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1. 发明申请

WO2013050156A8 PROCESS LINE FOR THE PRODUCTION OF FREEZE-DRIED PARTICLES 审中-公开
标题翻译：生产冷冻干燥颗粒的生产线
公开(公告)号：WO2013050156A8
公开(公告)日：2013-06-13
申请号：PCT/EP2012004162
申请日：2012-10-04
申请人： SANOFI PASTEUR S A
发明人： LUY BERNHARD , PLITZKO MATTHIAS , STRUSCHKA MANFRED
IPC分类号： F26B5/06 , A61K9/16
CPC分类号： F26B5/06 , F26B5/065
摘要： A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.
摘要翻译：一种用于在封闭条件下生产冷冻干燥颗粒的生产线（300），该生产线包括至少一个用于液滴产生和冷冻凝结以形成颗粒的喷雾腔室（302）以及用于冷冻的散装冷冻干燥器（304）干燥颗粒，冷冻干燥器（304）包括用于接收颗粒的旋转鼓。此外，提供传送部分（308）用于从喷雾室（302）到冷冻干燥器（304）的产品传送。为了在端对端封闭条件下生产颗粒，每个装置（302,304）和传送部分（308）分别适于操作以保持待冷冻干燥的产品的无菌性和/或容器。

2. 发明申请

WO2013050156A1 PROCESS LINE FOR THE PRODUCTION OF FREEZE-DRIED PARTICLES 审中-公开
标题翻译：生产冻干颗粒的工艺流程
公开(公告)号：WO2013050156A1
公开(公告)日：2013-04-11
申请号：PCT/EP2012/004162
申请日：2012-10-04
申请人： SANOFI PASTEUR S A
发明人： LUY, Bernhard , PLITZKO, Matthias , STRUSCHKA, Manfred
IPC分类号： F26B5/06 , A61K9/16
CPC分类号： F26B5/06 , F26B5/065
摘要： A process line (300) for the production of freeze-dried particles under closed conditions comprising at least a spray chamber (302) for droplet generation and freeze congealing of the liquid droplets to form particles and a bulk freeze-dryer (304) for freeze drying the particles, the freeze-dryer (304) comprising a rotary drum for receiving the particles. Further, a transfer section (308) is provided for a product transfer from the spray chamber (302) to the freeze-dryer (304). For the production of the particles under end-to-end closed conditions each of the devices (302, 304) and of the transfer section (308) is separately adapted for operation preserving sterility of the product to be freeze-dried and/or containment.
摘要翻译：一种用于在封闭条件下生产冷冻干燥颗粒的生产线（300），其包括用于液滴产生的至少一个喷雾室（302），并且液滴冷冻凝结以形成颗粒，并且用于冻结的本体冷冻干燥器（304）干燥颗粒，冷冻干燥器（304）包括用于接收颗粒的旋转滚筒。此外，设置有用于从喷雾室（302）到冷冻干燥机（304）的产品转印的转印部（308）。为了在端对端封闭条件下生产颗粒，每个装置（302,304）和转移部分（308）分别适用于保持要冷冻干燥和/或遏制的产品的无菌性的操作。

3. 发明申请

WO2010146043A3 SYSTEM FOR THE HETEROLOGOUS EXPRESSION OF A VIRAL PROTEIN IN A CILIATE HOST CELL 审中-公开
标题翻译：病毒宿主细胞中病毒表达的系统
公开(公告)号：WO2010146043A3
公开(公告)日：2011-02-17
申请号：PCT/EP2010058360
申请日：2010-06-15
申请人： CILIAN AG , SANOFI PASTEUR S A A CONSEIL D ADMINISTRATION , HARTMANN MARCUS , SACHSE CHRISTINE , APELT JENNY , BOCKAU ULRIKE
发明人： HARTMANN MARCUS , SACHSE CHRISTINE , APELT JENNY , BOCKAU ULRIKE
IPC分类号： C12N7/02 , A61K39/145 , C07K14/11
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/145 , C07K14/005 , C12N2760/16051 , C12N2760/16122 , C12N2760/16134 , C12N2760/16222 , C12N2760/16234
摘要： The present invention relates to a system for the heterologous expression of a viral protein or a fragment thereof, said system comprising a) a ciliate host cell, b) at least one cDNA encoding for a viral protein, or a fragment thereof, and c) a promoter operably linked to said cDNA.
摘要翻译：本发明涉及用于异源表达病毒蛋白或其片段的系统，所述系统包含a）细胞宿主细胞，b）至少一种编码病毒蛋白或其片段的cDNA，和c）与所述cDNA可操作地连接的启动子。

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