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1. 发明申请

WO2016042546A3 METHODS AND DEVICES FOR THERMAL TISSUE VAPORIZATION AND COMPRESSION 审中-公开
标题翻译：用于热组织蒸发和压缩的方法和装置
公开(公告)号：WO2016042546A3
公开(公告)日：2016-05-26
申请号：PCT/IL2015050924
申请日：2015-09-10
申请人： NOVOXEL LTD
发明人： SLATKINE MICHAEL , SHAVIT RONEN , SHAVIT RAPHAEL
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B18/14 , A61B2017/00526 , A61B2018/00041 , A61B2018/00148 , A61B2018/0047 , A61B2018/143
摘要： A method of producing an array of sharp tips including a biocompatible coating, wherein the biocompatible coating is thicker at a sharp end of the sharp tips than at a broader section of the sharp tips, the method including providing an array of sharp tips, and coating the sharp end of the sharp tips differentially from coating the broader section of the sharp tips. A method of treating skin including producing a hollow in the skin by heating and mechanically compressing epidermis while retaining a covering of stratum corneum. A method of treating tissue including heating a tip to a temperature suitable for producing a crater in the tissue, advancing the tip toward the tissue, detecting when the tip comes into contact with the tissue by detecting a change in mechanical resistance to the advancing, and measuring the mechanical resistance to the advancing. Related apparatus and methods are also described.
摘要翻译：一种生产包括生物相容性涂层的尖锐尖端阵列的方法，其中生物相容性涂层在锋利尖端的尖端比在尖锐尖端的更宽部分更厚，所述方法包括提供尖锐阵列阵列和涂层锋利尖端的锋利端部与涂布锋利尖端的较宽部分不同。一种治疗皮肤的方法，包括在保留角质层覆盖物的同时通过加热和机械压缩表皮而在皮肤中产生空洞。一种治疗组织的方法，包括将尖端加热到适于在组织中产生火山口的温度，使尖端朝向组织前进，通过检测针对前进的机械阻力的变化来检测尖端何时与组织接触，以及测量前进的机械阻力。还描述了相关的装置和方法。

2. 发明申请

WO2016042546A2 METHODS AND DEVICES FOR THERMAL TISSUE VAPORIZATION AND COMPRESSION 审中-公开
标题翻译：用于热组织蒸发和压缩的方法和装置
公开(公告)号：WO2016042546A2
公开(公告)日：2016-03-24
申请号：PCT/IL2015/050924
申请日：2015-09-10
申请人： NOVOXEL LTD.
发明人： SLATKINE, Michael , SHAVIT, Ronen , SHAVIT, Raphael
IPC分类号： A61B18/14
CPC分类号： A61B18/1477 , A61B18/14 , A61B2017/00526 , A61B2018/00041 , A61B2018/00148 , A61B2018/0047 , A61B2018/143
摘要： A method of producing an array of sharp tips including a biocompatible coating, wherein the biocompatible coating is thicker at a sharp end of the sharp tips than at a broader section of the sharp tips, the method including providing an array of sharp tips, and coating the sharp end of the sharp tips differentially from coating the broader section of the sharp tips. A method of treating skin including producing a hollow in the skin by heating and mechanically compressing epidermis while retaining a covering of stratum corneum. A method of treating tissue including heating a tip to a temperature suitable for producing a crater in the tissue, advancing the tip toward the tissue, detecting when the tip comes into contact with the tissue by detecting a change in mechanical resistance to the advancing, and measuring the mechanical resistance to the advancing. Related apparatus and methods are also described.
摘要翻译：一种生产锋利尖端阵列的方法，其包括生物相容性涂层，其中生物相容性涂层在锋利尖端的尖端比在尖锐尖端的较宽部分更厚，该方法包括提供锋利尖端阵列和涂层锋利尖端的尖端与涂覆尖锐尖端的较宽部分有差异。一种治疗皮肤的方法，包括通过加热和机械压缩表皮同时保留角质层的覆盖物在皮肤中产生中空部分。一种治疗组织的方法，包括将尖端加热到适于在组织中产生火山口的温度，使尖端朝向组织推进，通过检测机械抵抗前进的变化来检测尖端与组织接触的时间;以及测量机械抵抗力。还描述了相关装置和方法。

3. 发明申请

WO2015092791A3 DEVICES AND METHODS FOR TISSUE VAPORIZATION 审中-公开
标题翻译：用于组织蒸发的装置和方法
公开(公告)号：WO2015092791A3
公开(公告)日：2015-09-11
申请号：PCT/IL2014051103
申请日：2014-12-16
申请人： NOVOXEL LTD
发明人： SLATKINE MICHAEL , SHAVIT RAPHAEL , ZLOCHOVER JACOB
IPC分类号： A61B18/08
CPC分类号： A61B18/082 , A61B18/08 , A61B18/14 , A61B2018/00148 , A61B2018/0019 , A61B2018/00196 , A61B2018/00452 , A61B2018/00625 , A61B2018/00916 , A61B2018/00994 , A61B2018/143
摘要： In accordance with some embodiments of the invention there is provided a device for vaporizing one or more holes in tissue, comprising an array of vaporizing elements and a heating element configured to heat the vaporizing elements, wherein a geometry of at least a portion of the vaporizing elements is configured to prevent excessive penetration of other vaporizing elements into the tissue. In some embodiments, the vaporizing elements are heated to a temperature ranging between 300- 600 degrees Celsius.
摘要翻译：根据本发明的一些实施例，提供了用于蒸发组织中的一个或多个孔的装置，其包括蒸发元件阵列和配置成加热蒸发元件的加热元件，其中蒸发的至少一部分元件被构造成防止其他汽化元件过度渗透到组织中。在一些实施例中，汽化元件被加热到300-600摄氏度之间的温度。

4. 发明申请

WO2020245833A1 SYSTEM AND METHOD FOR TREATING BLEPHARITIS USING TISSUE STRESSING 审中-公开
公开(公告)号：WO2020245833A1
公开(公告)日：2020-12-10
申请号：PCT/IL2020/050632
申请日：2020-06-05
申请人： NOVOXEL LTD.
发明人： SHAVIT, Ronen
IPC分类号： A61B18/08 , A61B18/04 , A61B18/00
摘要： Dermal conditioning device for creating at least one pressure point on at least an external surface of an eyelid, comprising at least one skin tissue lesion generator, at least one controller, a power supply and a housing, the controller coupled to the skin tissue lesion generator, a power supply coupled to the skin tissue lesion generator and the controller and the housing encasing the skin tissue lesion generator and the controller, wherein the controller controls the skin tissue lesion generator to generate at least one signal and to apply the signal to stress the external surface of an outer layer of the eyelid, the stress causing a formation of the pressure point on the eyelid without tissue coagulation, thereby activating at least one of a corneal reflex, a menace reflex and a lacrimation reflex of the eyelid by activating at least one nociceptor on the eyelid.

5. 发明申请

WO2018178976A4 SYSTEM, DEVICE AND METHOD FOR INTRADERMAL SOLUTION DELIVERY 审中-公开
公开(公告)号：WO2018178976A4
公开(公告)日：2018-10-04
申请号：PCT/IL2018/050350
申请日：2018-03-27
申请人： NOVOXEL LTD.
发明人： SHAVIT, Ronen
IPC分类号： A61B18/08 , A61B18/04
摘要： A dermal conditioning device for creating at feast one fissure, in a stratum corneum layer of an area of skirt, comprising: a non-invasive fissuring generator; a controller coupled to the non-invasive skin fissuring generator; a power supply coupled to the non-invasive skin fissuring generator and the controller; and a housing encasing the non-invasive skin fissuring generator and the controller, wherein the controller controls the non-invasive skin fissuring generator to: generate at least one signal, and apply the at least one signal to dehydrate the area of skin, and stress the external surface of the stratum corneum layer of the area of skin, the stress calibrated to produce a strain on the stratum corneum layer causing a formation of at least one fissure in the stratum corneum layer when the area of skin is dehydrated, while maintaining a pre-fissure immune status of the area of skin.

6. 发明申请

WO2018178976A1 SYSTEM, DEVICE AND METHOD FOR INTRADERMAL SOLUTION DELIVERY 审中-公开
公开(公告)号：WO2018178976A1
公开(公告)日：2018-10-04
申请号：PCT/IL2018/050350
申请日：2018-03-27
申请人： NOVOXEL LTD.
发明人： SHAVIT, Ronen
IPC分类号： A61B18/08 , A61B18/04
摘要： A dermal conditioning device for creating at feast one fissure, in a stratum corneum layer of an area of skirt, comprising: a non-invasive fissuring generator; a controller coupled to the non-invasive skin fissuring generator; a power supply coupled to the non-invasive skin fissuring generator and the controller; and a housing encasing the non-invasive skin fissuring generator and the controller, wherein the controller controls the non-invasive skin fissuring generator to: generate at least one signal, and apply the at least one signal to dehydrate the area of skin, and stress the external surface of the stratum corneum layer of the area of skin, the stress calibrated to produce a strain on the stratum corneum layer causing a formation of at least one fissure in the stratum corneum layer when the area of skin is dehydrated, while maintaining a pre-fissure immune status of the area of skin.

7. 发明申请

WO2016042547A1 METHODS AND DEVICES FOR THERMAL SURGICAL VAPORIZATION AND INCISION OF TISSUE 审中-公开
标题翻译：用于热外科气泡和组织浸润的方法和装置
公开(公告)号：WO2016042547A1
公开(公告)日：2016-03-24
申请号：PCT/IL2015/050925
申请日：2015-09-10
申请人： NOVOXEL LTD.
发明人： SLATKINE, Michael , SHAVIT, Ronen , SHAVIT, Raphael
IPC分类号： A61B18/08 , A61B18/28 , A61B18/22 , A61B19/00
CPC分类号： A61B18/08 , A61B18/22 , A61B18/28 , A61B2018/0019 , A61B2018/00196 , A61B2018/00452 , A61B2090/065
摘要： A device for thermal incision of tissue including a tissue heating element, an oscillatory mechanism that advances the tissue heating element toward tissue and retracts the tissue heating element from tissue, a detector that detects when the tissue heating element contacts the tissue, and a heat controller that controls heating of the tissue heating element, wherein the heat controller for the tissue heating element controls heating the tissue heating element based on detecting when the tissue heating element contacts tissue. Related apparatus and methods are also described.
摘要翻译：一种用于热切割组织的装置，包括组织加热元件，将组织加热元件朝向组织推进并使组织加热元件从组织缩回的振荡机构，检测组织加热元件何时接触组织的检测器，以及热控制器其控制组织加热元件的加热，其中组织加热元件的热控制器基于检测组织加热元件何时接触组织而控制加热组织加热元件。还描述了相关装置和方法。

8. 发明申请

WO2015092791A2 DEVICES AND METHODS FOR TISSUE VAPORIZATION 审中-公开
标题翻译：用于组织蒸发的装置和方法
公开(公告)号：WO2015092791A2
公开(公告)日：2015-06-25
申请号：PCT/IL2014/051103
申请日：2014-12-16
申请人： NOVOXEL LTD.
发明人： SLATKINE, Michael , SHAVIT, Raphael , ZLOCHOVER, Jacob
IPC分类号： A61B18/04
CPC分类号： A61B18/082 , A61B18/08 , A61B18/14 , A61B2018/00148 , A61B2018/0019 , A61B2018/00196 , A61B2018/00452 , A61B2018/00625 , A61B2018/00916 , A61B2018/00994 , A61B2018/143
摘要： In accordance with some embodiments of the invention there is provided a device for vaporizing one or more holes in tissue, comprising an array of vaporizing elements and a heating element configured to heat the vaporizing elements, wherein a geometry of at least a portion of the vaporizing elements is configured to prevent excessive penetration of other vaporizing elements into the tissue. In some embodiments, the vaporizing elements are heated to a temperature ranging between 300- 600 degrees Celsius.
摘要翻译：根据本发明的一些实施例，提供了一种用于蒸发组织中的一个或多个孔的装置，包括蒸发元件阵列和构造成加热汽化元件的加热元件，其中蒸发的至少一部分的几何形状元件构造成防止其它蒸发元件过度渗透到组织中。在一些实施方案中，蒸发元件被加热到在300-600摄氏度之间的温度。

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