专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2022136260A1 ASSAY FOR DETECTING COLLAGEN XI BIOMARKERS 审中-公开
公开(公告)号：WO2022136260A1
公开(公告)日：2022-06-30
申请号：PCT/EP2021/086770
申请日：2021-12-20
申请人： NORDIC BIOSCIENCE A/S
发明人： WILLUMSEN, Nicholas , NISSEN, Neel, Ingemann , KARSDAL, Morten, Asser
IPC分类号： A61P35/00 , C07K16/18 , G01N33/68
摘要： Disclosed herein are monoclonal antibodies that specifically recognise and binds to a C-terminus of a peptide comprising the C-terminus neo-epitope formed on cleavage of the N- terminal pro-peptide of the α1-chain of type XI collagen at A'511↓, and immunoassay methods and kits using and comprising said antibodies. The immunoassay methods may be used for detecting and/or monitoring and/or assessing the severity or prognosis of diseases, such as but not limited to cancer.

2. 发明申请

WO2021191167A1 TYPE XIX COLLAGEN ASSAY 审中-公开
公开(公告)号：WO2021191167A1
公开(公告)日：2021-09-30
申请号：PCT/EP2021/057319
申请日：2021-03-22
申请人： NORDIC BIOSCIENCE A/S
发明人： WILLUMSEN, Nicholas , THORLACIUS-USSING, Jeppe
IPC分类号： C07K16/18 , G01N33/53 , G01N2333/78 , G01N33/57423 , G01N33/6887
摘要： The present invention relates to monoclonal antibodies that target collagen type XIX, and to immunoassays and kits employing said antibodies. The assays of the invention can be used in the diagnosis and monitoring of cancer.

3. 发明申请

WO2021043945A1 ASSAY FOR ASSESSING HEART FAILURE 审中-公开
公开(公告)号：WO2021043945A1
公开(公告)日：2021-03-11
申请号：PCT/EP2020/074685
申请日：2020-09-03
申请人： NORDIC BIOSCIENCE A/S
发明人： SUN, Shu , REESE-PETERSEN, Alexander, Lynge , GENOVESE, Federica , KARSDAL, Morten
IPC分类号： G01N33/68 , C07K16/18
摘要： Disclosed herein are immunoassays, in particular immunoassays for detecting and/or monitoring cardiovascular disease, such as heart failure. Also disclosed are monoclonal antibodies and kits for use in said assays. The assays, antibodies and kits target a C-terminal epitope of type XXVIII collagen.

4. 发明申请

WO2019154909A1 ELASTIN ASSAY 审中-公开
公开(公告)号：WO2019154909A1
公开(公告)日：2019-08-15
申请号：PCT/EP2019/053003
申请日：2019-02-07
申请人： NORDIC BIOSCIENCE A/S
发明人： GUDMANN, Karoline, Natasja, Stæhr , SAND, Jannie, Marie, Bülow , MANON-JENSEN, Tina , ØRSNES-LEEMING, Diana , KARSDAL, Morten
IPC分类号： G01N33/577 , G01N33/68
CPC分类号： G01N33/577 , G01N33/6887 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Described herein are monoclonal antibodies, assay kits and immumoassay methods for quantifying elastin fragments having a C-terminus amino acid sequence LPGGYGLPYT (SEQ ID NO: 1) in a patient biofluid sample, and uses thereof for detecting or quantifying fibrotic diseases such as chronic obstructive lung disease (COPD).

5. 发明申请

WO2012038331A1 ASSAY FOR A TYPE II COLLAGEN BIOMARKER 审中-公开
标题翻译：一种II型胶原生物标记物的测定
公开(公告)号：WO2012038331A1
公开(公告)日：2012-03-29
申请号：PCT/EP2011/066076
申请日：2011-09-16
申请人： NORDIC BIOSCIENCE A/S , JENSEN, Anne-Christine, Bay , LIU, Qi , WANG, Jianxia
发明人： JENSEN, Anne-Christine, Bay , LIU, Qi , WANG, Jianxia
IPC分类号： G01N33/68 , C07K16/18
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/6878 , G01N2333/78 , G01N2800/105
摘要： An assay for Type II collagen fragments in serum, plasma, or synovial fluid obtains a quantitative measure of the concentration of all protein fragments in a serum, plasma, or synovial fluid sample that are reactive with an antibody, or immunoreactive antibody fragment, having specific reactivity with a C-terminal epitope present in the amino acid sequence GPPGRDGAAG and lacking specific reactivity with an amino acid sequence comprising the amino acid sequence GPPGRDGAAGV, which may be Mab NB44-3C1 as produced by the cell line deposited in HPA Culture Collection Logistics Office with Accession Number 10091402.
摘要翻译：在血清，血浆或滑液中的II型胶原片段的测定法获得与抗体或免疫反应性抗体片段反应的血清，血浆或滑液样品中所有蛋白质片段的浓度的定量测量，所述抗体或免疫反应性抗体片段具有特异性与存在于氨基酸序列GPPGRDGAAG中的C-末端表位的反应性，并且与包含氨基酸序列GPPGRDGAAGV的氨基酸序列缺乏特异性反应性，所述氨基酸序列可以是由存储在HPA培养物理处所的细胞系产生的Mab NB44-3C1 登录号10091402。

6. 发明申请

WO2010055064A1 ASSESSMENT OF PROTEIN DEGRADATION BY MEASUREMENT OF COLLAGEN FRAGMENTS 审中-公开
标题翻译：通过测量胶原蛋白来评估蛋白质降解
公开(公告)号：WO2010055064A1
公开(公告)日：2010-05-20
申请号：PCT/EP2009/064997
申请日：2009-11-11
申请人： NORDIC BIOSCIENCE A/S , LEEMING, Diana Julie , BYRJALSEN, Inger , QVIST, Per , KARSDAL, Morten Asser
发明人： LEEMING, Diana Julie , BYRJALSEN, Inger , QVIST, Per , KARSDAL, Morten Asser
IPC分类号： G01N33/564
CPC分类号： G01N33/6887 , G01N2800/105
摘要： A method of assay measuring in a biological sample fragments of a protein that contain an N-terminal neo-epitope and a C- terminal neo-epitope, each generated by protease cleavage of said protein, comprises binding the N-terminal neo-epitope with a first specific antibody and binding the C-terminal neo-epitope with a second specific antibody, and detecting the extent of dual binding of said antibodies.
摘要翻译：通过所述蛋白质的蛋白酶切割产生的含有N-末端新表位和C-末端新表位的蛋白质的生物样品片段的测定方法包括将所述N-末端新表位与第一特异性抗体并结合C-末端新表位与第二特异性抗体，并检测所述抗体的双重结合的程度。

7. 发明申请

WO2008058897A2 DIPHYLLIN AND OTHER LIGNANS AS A MEDICAMENT FOR V-ATPASE MEDIATED DISEASE 审中-公开
标题翻译： DIPHLLLIN和其他LIGNANS作为V-ATPase介导的疾病药物
公开(公告)号：WO2008058897A2
公开(公告)日：2008-05-22
申请号：PCT/EP2007/062081
申请日：2007-11-08
申请人： NORDIC BIOSCIENCE A/S , SØRENSEN, Mette Grøndahl , HENRIKSEN, Kim , KARSDAL, Morten Asser
发明人： SØRENSEN, Mette Grøndahl , HENRIKSEN, Kim , KARSDAL, Morten Asser
IPC分类号： A61K31/365 , A61P1/04 , A61P31/04 , A61P11/00 , A23L1/30
CPC分类号： A61K31/365 , A23L33/105
摘要： A V-ATPase or gastric proton pump inhibiting lignan such as diphyllin and related glycosides and derivatives, for use as a medicament in the treatment of excessive osteoclast action or in the treatment of excessive gastric acidification, suitably of the general formula: wherein : R b and R c may together form an alkylene bridge; R d and R e also may together form an alkylene bridge; and each dotted bond independently is present or absent; and wherein the lactone ring is optionally opened and is optionally esterified.
摘要翻译：抑制木素素的V-ATP酶或胃质子泵如苦参素及相关糖苷及其衍生物，用作治疗过度破骨细胞作用的药物或用于治疗过度胃酸化的适当的通式：其中：而且可以一起形成亚烷基桥; R d和R e也可以一起形成亚烷基桥; 每个虚线键独立存在或不存在; 并且其中所述内酯环任选地打开并任选地被酯化。

8. 发明申请

WO2007090892A1 BREAST TISSUE DENSITY MEASURE 审中-公开
标题翻译：乳腺组织密度测量
公开(公告)号：WO2007090892A1
公开(公告)日：2007-08-16
申请号：PCT/EP2007/051284
申请日：2007-02-09
申请人： NORDIC BIOSCIENCE A/S , RAUNDAHL, Jakob , LOOG, Marco , NIELSEN, Mads
发明人： RAUNDAHL, Jakob , LOOG, Marco , NIELSEN, Mads
IPC分类号： G06K9/52 , G06K9/62
CPC分类号： G06K9/527 , G06K9/6223
摘要： Mammogram images are processed by computer to derive automatically a value for a parameter useful in detecting differences in breast tissue in subsequent images of the same breast or relative to a control group of such images, said derived parameter being a parameter that changes alongside changes in breast density and is hence useful in assessing cancer risk. The method comprises the steps of processing each image of at least part of a breast by: computing for pixels of the image a quotient value representative of the aspect ratio of tissue structures depicted in the image; using a trained classifier to classify said pixels according to their respective said quotient values and assigning a score to the respective pixels representing their classification with respect to at least two classes; deriving said parameter that changes alongside changes in breast density based on the aggregate pixel membership scores of said classes. The classifier may be trained either by unsupervised learning or by supervised learning.
摘要翻译：计算机处理乳房X线照片图像以自动导出用于检测同一乳房的后续图像或相对于这样的图像的对照组的乳房组织中的差异的参数的值，所述导出参数是随乳房变化而变化的参数密度，因此有助于评估癌症风险。该方法包括以下步骤：通过以下步骤处理乳房的至少一部分的每个图像：计算图像中像素的代表图像中描绘的组织结构的纵横比的商值; 使用经过训练的分类器根据其相应的商值对所述像素进行分类，并且将分数分配给相对于至少两个类别表示其分类的各个像素; 导出所述参数随着所述类别的聚集像素成分分数而随着乳房密度的变化而变化。分类器可以通过无监督学习或受监督学习进行训练。

9. 发明申请

WO2006128729A3 A METHOD OF DERIVING A QUANTITATIVE MEASURE OF A DEGREE OF CALCIFICATION OF AN AORTA 审中-公开
公开(公告)号：WO2006128729A3
公开(公告)日：2006-12-07
申请号：PCT/EP2006/005317
申请日：2006-06-02
申请人： NORDIC BIOSCIENCE A/S , DE BRUIJNE, Marleen , NIELSEN, Mads , CHRISTIANSEN, Claus , CONRAD-HANSEN, Lars Arne , LAUZE, François
发明人： DE BRUIJNE, Marleen , NIELSEN, Mads , CHRISTIANSEN, Claus , CONRAD-HANSEN, Lars Arne , LAUZE, François
IPC分类号： G06T5/00 , G06T7/00
摘要： A method of deriving a quantitative measure of a degree of calcification of a blood vessel such as an aorta by processing an image such as an X-ray image of at least a part of the blood vessel containing said calcification comprises: taking a starting set of digital data representative of an image of at least part of a blood vessel containing a calcification set against a background; estimating the boundary of the calcification; using inpainting to replace digital data in said starting set representing the calcification with data extrapolating the boundary of the background to extend over the area of calcification, and so generating an inpainted set of digital data; and computing the difference between the starting set of digital data and the inpainted set of digital data to obtain a quantitative measure of the degree of calcification of the blood vessel.

10. 发明申请

WO2003076947A3 METHOD FOR MONITORING COLLAGEN TYPE II DEGRADATION IN CARTILAGE 审中-公开
公开(公告)号：WO2003076947A3
公开(公告)日：2003-09-18
申请号：PCT/EP2003/002561
申请日：2003-03-12
申请人： NORDIC BIOSCIENCE A/S , REGINSTER, Jean-Yves , DEBERG, Michèlle , HENROTIN, Yves , CHRISTGAU, Stephan
发明人： REGINSTER, Jean-Yves , DEBERG, Michèlle , HENROTIN, Yves , CHRISTGAU, Stephan
IPC分类号： G01N33/68
摘要： A method for improving the diagnostic assessment of cartilage degenerative processes, and to provide means of monitoring the effects of therapeutical measures taken towards arthritic diseases in most mammals ultizes an immunoassay to detect fragments of collagen type II resulting from collagenase activity comprising an antibody directed against an epitope comprised in the amino acid sequence HRGYPGLDG, located in the helical region of collagen type II.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式