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    • 6. 发明申请
    • COMPOSITION FOR IMPROVING COGNITION AND MEMORY
    • 用于改善认知和记忆的组合物
    • WO2004096118A2
    • 2004-11-11
    • PCT/IL2004/000330
    • 2004-04-15
    • NEURIM PHARMACEUTICALS (1991) LTD.ZISAPEL, NavaLAUDON, Moshe
    • ZISAPEL, NavaLAUDON, Moshe
    • A61K
    • A61K31/465A61K9/2009A61K9/2027A61K9/7061A61K31/4045A61K45/06A61K2300/00
    • The invention relates to a pharmacologically active combination, having utility in treating insomnia patients, which comprises: (a) at least one first active ingredient selected from melatonin, other melatonergic agents, melatonin agonists and melatonin antagonists; and (b) at least one second active ingredient selected from nicotine and nicotine receptor agonists; to use of a medicament containing component (a) with or without component (b) for alleviation of at least one adverse effect which occurs in a patient in the course of nicotine replacement therapy, or otherwise, selected from impairment of the quality of sleep, impairment of cognition and impairment of memory, as well as to a kit having utility in treating insomnia patients, which comprises components (a) and (b) in unit dosage form.
    • 本发明涉及一种治疗失眠症患者的药理活性组合,其包括:(a)至少一种选自褪黑激素,其他褪黑激素剂,褪黑素激动剂和褪黑素拮抗剂的第一活性成分; 和(b)至少一种选自尼古丁和尼古丁受体激动剂的第二活性成分; 使用含有或不含组分(b)的组分(a)的药物用于减轻在尼古丁替代疗法中发生在患者中的至少一种不良反应,或以其他方式选择睡眠质量的损害, 损伤认知和记忆障碍,以及用于治疗失眠症患者的试剂盒,其包含单位剂量形式的组分(a)和(b)。