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1. 发明申请

WO2003015690A3 METHOD FOR TREATING PRIMARY INSOMNIA 审中-公开
公开(公告)号：WO2003015690A3
公开(公告)日：2003-02-27
申请号：PCT/IL2002/000662
申请日：2002-08-12
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , ZISAPEL, Nava
发明人： ZISAPEL, Nava
IPC分类号： A61K9/20
摘要： The invention relates to a medicament, for treating and improving the restorative quality of sleep, in a patient suffering from primary insomnia, which comprises at least one compound selected from melatonin, other melatonergic agents, melatonin agonists and melatonin antagonists, in an effective amount within the range of 0.0025 to 50 mg, and optionally one or more other therapeutically active agents.

2. 发明申请

WO2023057879A1 METHODS AND PRODUCTS FOR TREATING SUBJECTS WITH AUTISM SPECTRUM DISORDERS 审中-公开
公开(公告)号：WO2023057879A1
公开(公告)日：2023-04-13
申请号：PCT/IB2022/059429
申请日：2022-10-03
申请人： NEURIM PHARMACEUTICALS (1991) LTD.
发明人： ZISAPEL, Nava , LAUDON, Moshe
IPC分类号： A61K31/519 , A61K9/107 , A61K9/19 , A61K9/20 , A61K47/42 , A61K45/06 , A61P43/00 , A61K31/198 , A61K31/685 , A61K33/06 , A61K33/30 , A61K9/0056 , A61K9/006 , A61K9/1075 , A61K9/2013 , A61K9/2018 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K9/2063 , A61P25/00
摘要： Methods and products for treating a subject diagnosed with an autism spectrum disorder, an intellectual disability, an anxiety disorder, a mood disorder, a disorder of social interaction, irritability, aggression, self-injurious behavior, hyperactivity, inattention, or Fragile X syndrome or brain neuroinflammation by administering a tablet or liquid or a solid ODT or ODF or SMEDDS containing a ticagrelor or ticagrelor salt or combination with a second agent which may include a magnesium ion containing-compound, a zinc ion containing-compound, a lysine or lysine salt, an arginine or arginine salt, lecithin, or a combination thereof, wherein the ODT or ODF or SMEDDS releases >50% of the ticagrelor or a pharmaceutically acceptable salt thereof and >50% of the second agent within 15 minutes.

3. 发明申请

WO2009007934A2 CD44 SPLICE VARIANTS IN NEURODEGENERATIVE DISEASES 审中-公开
标题翻译： CD44 SPLICE变量在神经损伤性疾病中的应用
公开(公告)号：WO2009007934A2
公开(公告)日：2009-01-15
申请号：PCT/IB2008/052786
申请日：2008-07-10
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , PINNER, Elhanan , LAUDON, Moshe , ZISAPEL, Nava
发明人： PINNER, Elhanan , LAUDON, Moshe , ZISAPEL, Nava
IPC分类号： C12Q1/68
CPC分类号： C07K14/70585 , C07K16/2884 , C07K2317/76 , C12Q1/6883 , C12Q2600/158 , G01N33/6896 , G01N2800/2814 , G01N2800/2821 , G01N2800/2835
摘要： There is provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression of ribonucleic acid (RNA) encoded by a nucleic acid, wherein the nucleic acid is selected from a group that includes a contiguous nucleotide sequence being at least 90% homologous to at least 20 nucleotides of: SEQ ID NO: 1, SEQ ID NO: 3, SEQ ID NO: 5, SEQ ID NO: 7, or any combination thereof. There is further provided a method of treating or preventing a neurodegenerative disease, which includes administration of a composition that includes a reagent capable of modulating expression and/or activity of a polypeptide, wherein the sequence of the polypeptide is selected from a group that includes a contiguous amino acid sequence being at least 90% homologous to at least 10 amino acid of: SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8, or any combination thereof.
摘要翻译：提供了治疗或预防神经变性疾病的方法，其包括给予包含能够调节由核酸编码的核糖核酸（RNA）表达的试剂的组合物，其中所述核酸选自包括与SEQ ID NO：1，SEQ ID NO：3，SEQ ID NO：5，SEQ ID NO：7或其任何组合的至少20个核苷酸至少90％同源的连续核苷酸序列。还提供了治疗或预防神经变性疾病的方法，其包括施用包含能够调节多肽的表达和/或活性的试剂的组合物，其中所述多肽的序列选自包括连续氨基酸序列与SEQ ID NO：2，SEQ ID NO：4，SEQ ID NO：6，SEQ ID NO：8或其任何组合的至少10个氨基酸至少90％同源。

4. 发明申请

WO2008041140A2 SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS 审中-公开
标题翻译：取代的芳基吲哚化合物及其作为治疗剂的KUNURENINE / KYNURAMINE-样代谢物
公开(公告)号：WO2008041140A2
公开(公告)日：2008-04-10
申请号：PCT/IB2007/004306
申请日：2007-10-03
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , PELEG-SHULMAN, Tal , LAUDON, Moshe , DAILY, Dvorah
发明人： PELEG-SHULMAN, Tal , LAUDON, Moshe , DAILY, Dvorah
CPC分类号： C07D209/16 , C07C225/22 , C07C255/58 , C07C317/36 , C07D209/14
摘要： This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3β kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders.
摘要翻译：本发明涉及取代的芳基化合物，其通过各种接头与取代的吲哚部分连接，以及这些试剂的犬尿氨酸/犬尿胺样代谢物，它们的制备和含有这些化合物的药物组合物。本发明进一步涉及化合物用于抑制GSK3β激酶和/或调节N-甲基-D-天冬氨酸（NMDA）通道活性以治疗神经变性和其他疾病的药物用途。

5. 发明申请

WO1996023496A1 USE OF MELATONIN FOR TREATING PATIENTS SUFFERING FROM DRUG ADDICTION 审中-公开
标题翻译：使用美沙酮治疗药物滥用患者
公开(公告)号：WO1996023496A1
公开(公告)日：1996-08-08
申请号：PCT/IB1996000082
申请日：1996-01-29
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , DAVIS, Stanley, Joseph , ZISAPEL, Nava
发明人： NEURIM PHARMACEUTICALS (1991) LTD. , DAVIS, Stanley, Joseph
IPC分类号： A61K31/40
CPC分类号： A61K31/4045
摘要： Melatonin is used in the manufacture of a medicament for treating a multidrug addict, or a patient who has symptoms of having become dependent on, tolerant of, or addicted to a benzodiazepine drug, or for treating a patient who has been clinically diagnosed as having a condition susceptible to alleviation by administration of a benzodiazepine drug, while simultaneously preventing the occurrence in the patient of symptoms of dependence on, tolerance of, or addiction to said benzodiazepine drug. The invention further relates to a pharmaceutical formulation for the above-stated purposes, which comprises at least one diluent, carrier or adjuvant and as active ingredients a benzodiazepine drug and melatonin.
摘要翻译：褪黑素用于制造用于治疗多药上瘾剂或具有已经变得依赖于，耐受或沉迷于苯二氮卓类药物的症状的药物的药物，或用于治疗已被临床诊断为具有条件易于通过施用苯并二氮类药物而减轻，同时防止患者对所述苯二氮卓类药物依赖，耐受或成瘾的症状的发生。本发明还涉及用于上述目的的药物制剂，其包含至少一种稀释剂，载体或佐剂，以及作为苯并二氮杂药物和褪黑激素的活性成分。

6. 发明申请

WO2004096118A2 COMPOSITION FOR IMPROVING COGNITION AND MEMORY 审中-公开
标题翻译：用于改善认知和记忆的组合物
公开(公告)号：WO2004096118A2
公开(公告)日：2004-11-11
申请号：PCT/IL2004/000330
申请日：2004-04-15
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , ZISAPEL, Nava , LAUDON, Moshe
发明人： ZISAPEL, Nava , LAUDON, Moshe
IPC分类号： A61K
CPC分类号： A61K31/465 , A61K9/2009 , A61K9/2027 , A61K9/7061 , A61K31/4045 , A61K45/06 , A61K2300/00
摘要： The invention relates to a pharmacologically active combination, having utility in treating insomnia patients, which comprises: (a) at least one first active ingredient selected from melatonin, other melatonergic agents, melatonin agonists and melatonin antagonists; and (b) at least one second active ingredient selected from nicotine and nicotine receptor agonists; to use of a medicament containing component (a) with or without component (b) for alleviation of at least one adverse effect which occurs in a patient in the course of nicotine replacement therapy, or otherwise, selected from impairment of the quality of sleep, impairment of cognition and impairment of memory, as well as to a kit having utility in treating insomnia patients, which comprises components (a) and (b) in unit dosage form.
摘要翻译：本发明涉及一种治疗失眠症患者的药理活性组合，其包括：（a）至少一种选自褪黑激素，其他褪黑激素剂，褪黑素激动剂和褪黑素拮抗剂的第一活性成分; 和（b）至少一种选自尼古丁和尼古丁受体激动剂的第二活性成分; 使用含有或不含组分（b）的组分（a）的药物用于减轻在尼古丁替代疗法中发生在患者中的至少一种不良反应，或以其他方式选择睡眠质量的损害，损伤认知和记忆障碍，以及用于治疗失眠症患者的试剂盒，其包含单位剂量形式的组分（a）和（b）。

7. 发明申请

WO2022238905A1 METHOD FOR DIAGNOSING AND TREATING SUBJECTS HAVING SINGLE NUCLEOTIDE POLYMORPHISMS IN CHROMOSOME 2, 2:107,510,000-107,540,000 LOCUS 审中-公开
公开(公告)号：WO2022238905A1
公开(公告)日：2022-11-17
申请号：PCT/IB2022/054347
申请日：2022-05-10
申请人： NEURIM PHARMACEUTICALS (1991) LTD.
发明人： ZISAPEL, Nava , LAUDON, Moshe
IPC分类号： C12Q1/6883 , G01N33/68 , A61P25/00 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , G01N2800/28 , G01N2800/2821 , G01N2800/302 , G01N2800/52 , G01N2800/56
摘要： Methods and products for identifying individuals who are likely to respond in a positive (benefit) or negative (harm) manner to a pharmacological drug treatment intended for treating or preventing a neuropsychiatric disorder, neurodegeneration, sleep-wake cycles such including and not limited to Alzheimer's disease, schizophrenia, autism and attention disorders based on single nucleotide polymorphisms (SNP) chromosome 2, 2: 107,510,000-107,540,000 locus (as disclosed in the Genome Reference Consortium Human genome build 37 (GRCh37)).

8. 发明申请

WO2018037295A1 METHOD FOR TREATING PRURITUS AND/OR ITCH 审中-公开
标题翻译：治疗瘙痒和/或ITCH的方法
公开(公告)号：WO2018037295A1
公开(公告)日：2018-03-01
申请号：PCT/IB2017/053989
申请日：2017-06-30
申请人： NEURIM PHARMACEUTICALS (1991) LTD.
发明人： LAUDON, Moshe
IPC分类号： A61K31/351 , A61K31/4045 , A61P17/04
摘要： The invention relates to a medicament for treating pruritus and itch in a patient suffering from dermatological and non-dermatological conditions leading to such symptoms, which comprises at least one compound selected from a pyrone-indole derivative, in an effective amount, and optionally one or more other therapeutically active agents.
摘要翻译：本发明涉及一种用于治疗患有导致这些症状的皮肤病和非皮肤病的患者的瘙痒症和瘙痒的药物，其包含至少一种选自吡喃酮 - 吲哚衍生物，有效量和任选的一种或多种其他治疗活性剂。

9. 发明申请

WO2012127475A1 NEUROPROTECTIVE PEPTIDES 审中-公开
标题翻译：神经保护肽
公开(公告)号：WO2012127475A1
公开(公告)日：2012-09-27
申请号：PCT/IL2012/050104
申请日：2012-03-22
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , PINNER, Elhanan , ZISAPEL, Nava
发明人： PINNER, Elhanan , ZISAPEL, Nava
IPC分类号： A61K38/17 , A61P25/28
CPC分类号： C07K14/70585 , A61K38/177
摘要： A method of treating a neurodegenerative disorder is disclosed. The method comprises administering to the subject a therapeutically effective amount of an isolated peptide comprising at least 3 amino acids of a CD44V10 amino acid sequence no more than 20 amino acids of said CD44V10 amino acid sequence and comprising a neuroprotective activity.
摘要翻译：公开了治疗神经变性疾病的方法。该方法包括向受试者施用治疗有效量的包含至少3个氨基酸的CD44V10氨基酸序列的不超过20个氨基酸的CD44V10氨基酸序列并包含神经保护活性的分离肽。

10. 发明申请

WO2007093880A2 NOVEL PYRONE-INDOLE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：新型吡喃酮吲哚衍生物及其制备方法
公开(公告)号：WO2007093880A2
公开(公告)日：2007-08-23
申请号：PCT/IB2007/000330
申请日：2007-02-13
申请人： NEURIM PHARMACEUTICALS (1991) LTD. , LAUDON, Moshe , PELEG-SHULMAN, Tal
发明人： LAUDON, Moshe , PELEG-SHULMAN, Tal
IPC分类号： C07D405/12 , A61K31/4045 , A61K31/351 , A61P3/10 , A61P25/20
CPC分类号： C07D405/12
摘要： The present invention relates to novel pyrone-indole derivatives, pharmaceutical formulations containing them, and use of the compounds in the manufacture of Medicaments for treating or preventing various diseases.
摘要翻译：本发明涉及新的吡喃酮 - 吲哚衍生物，含有它们的药物制剂，以及这些化合物在制备治疗或预防各种疾病的药物中的用途。

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