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1. 发明申请

WO2017155399A1 DOUBLE TUBULAR STRUCTURES 审中-公开
标题翻译：双管结构
公开(公告)号：WO2017155399A1
公开(公告)日：2017-09-14
申请号：PCT/NL2017/050145
申请日：2017-03-09
申请人： MIMETAS B.V.
发明人： VULTO, Paul , KUREK, Dorota Malgorzata , JOORE, Adrianus Theodorus , TRIETSCH, Sebastiaan Johannes , LANZ, Henriëtte Leonore
IPC分类号： C12N5/071 , B01L3/00
摘要： The present invention relates to a method of culturing and/or monitoring epithelial cells using a microfluidic cell culture system comprising a microfluidic channel network. In the method epithelial cells are lined, in the microfluidic cell culture system by cells of mesenchymal origin. The cells may form a tubular or tube-like structure, i.e. a.tube in a tube. The method allows for improved epithelial models suitable for a wide variety of applications, including but not limited to high-throughput screening and analysis of epithelium in health and disease.
摘要翻译：本发明涉及使用包含微流体通道网络的微流体细胞培养系统来培养和/或监测上皮细胞的方法。在该方法中，上皮细胞排列在间充质细胞的微流体细胞培养系统中。细胞可以形成管状或管状结构，即管中的管。该方法允许改进的上皮模型适用于各种各样的应用，包括但不限于高通量筛选和健康和疾病上皮的分析。

2. 发明申请

WO2020109421A1 DEVICE FOR ASSESSING MECHANICAL STRAIN INDUCED IN OR BY CELLS 审中-公开
公开(公告)号：WO2020109421A1
公开(公告)日：2020-06-04
申请号：PCT/EP2019/082803
申请日：2019-11-27
申请人： MIMETAS B.V.
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johanes , BURTON, Todd Peter
IPC分类号： C12M1/32 , C12M3/06 , C12N5/071 , B01L3/00
摘要： A microfluidic device comprising a microflidic network is described. The device comprises a base, a microfluidic channel and a cover, and the base comprises a diaphragm forming at least part of an inner surface of the microfluidic channel. The device finds use in methods for assessing mechanical strain induced in or by cells, such methods also being described.

3. 发明申请

WO2017091075A1 APPARATUS FOR INDUCING MICROFLUIDIC FLOW 审中-公开
标题翻译：用于诱发微流体流动的装置
公开(公告)号：WO2017091075A1
公开(公告)日：2017-06-01
申请号：PCT/NL2016/050835
申请日：2016-11-28
申请人： MIMETAS B.V.
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , NICOLAS, Arnaud Yannick Michel
IPC分类号： B01L9/00
CPC分类号： B01L9/527 , B01L3/50273 , B01L2200/025 , B01L2300/0809 , B01L2300/0816 , B01L2400/0457
摘要： The invention relates to an apparatus for inducing flow of a fluid in a microfluidic device that comprises at least one microfluidic channel, the apparatus comprising: a base, on which said microfluidic device is pivotally disposed, defining a first position in a first plane (I); and a selectively operable tilting element attached to said base, to pivot the microfluidic device with respect to the base, thereby inducing fluid flow through the at least one microfluidic channel; wherein the base accommodates the microfluidic device in a first position defining a first plane, wherein the tilting element pivots the microfluidic device from the first position to a second position defining a second plane (II), and wherein the microfluidic device is tilted about a pivoting axis bisecting the first plane, thereby defining an inclination angle α between the first plane and second plane.
摘要翻译：本发明涉及一种用于诱导微流体装置中的流体流动的设备，所述微流体设备包括至少一个微流体通道，所述设备包括：底座，所述微流体装置可枢转地设置在底座上，限定在第一平面（I）中的第一位置; 以及可选择性操作的倾斜元件，所述倾斜元件附接到所述基部，以使所述微流体装置相对于所述基部枢转，从而引起流体流过所述至少一个微流体通道; 其中所述基座将所述微流体装置容纳在限定第一平面的第一位置中，其中所述倾斜元件使所述微流体装置从所述第一位置枢转到限定第二平面（II）的第二位置，并且其中所述微流体装置围绕枢转轴平分第一平面，从而限定第一平面和第二平面之间的倾斜角度α。

4. 发明申请

WO2019166644A1 DEVICE FOR PERFORMING ELECTRICAL MEASUREMENTS 审中-公开
公开(公告)号：WO2019166644A1
公开(公告)日：2019-09-06
申请号：PCT/EP2019/055187
申请日：2019-03-01
申请人： MIMETAS B.V.
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , NICOLAS, Arnaud Yannick Michel , SCHAVEMAKER, Frederik Mathijs
IPC分类号： B01L3/00 , G01N27/00
摘要： A device for performing electrical measurements, for example electrical activity across a layer of epithelial cells are disclosed. The device comprises a cassette having first and second surfaces, the cassette configured to engage with a microtiter plate and comprising a plurality of electrodes extending from the first surface in the direction of the microtiter plate when the cassette is engaged with the microtiter plate; and a housing detachably attached to the second surface of the cassette, comprising one or more heat management elements, and a processor comprising a data acquisition module electrically connected to the electrodes and a data processing module. A method of in vitro method for measuring electrical properties of cells cultured in a microfluidic device, for example using the device is also described.

5. 发明申请

WO2017216113A3 CELL CULTURE DEVICE AND METHODS 审中-公开
公开(公告)号：WO2017216113A3
公开(公告)日：2017-12-21
申请号：PCT/EP2017/064302
申请日：2017-06-12
申请人： MIMETAS B.V.
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , NICOLAS, Arnaud
IPC分类号： C12M1/32 , C12M3/06 , C12N5/071
摘要： A method of vascularising a cell aggregate on a microfluidic device, microfluidic cell culture devices comprising perfusable vascular networks and kits and assays using the microfluidic cell culture devices are described. The microfluidic devices comprise one or more capillary pressure barriers allowing for formation of an extracellular matrix gel within a confined area of the network, in which cells can be cultured for different uses.

6. 发明申请

WO2017216113A2 CELL CULTURE DEVICE AND METHODS 审中-公开
标题翻译：细胞培养装置和方法
公开(公告)号：WO2017216113A2
公开(公告)日：2017-12-21
申请号：PCT/EP2017/064302
申请日：2017-06-12
申请人： MIMETAS B.V.
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , NICOLAS, Arnaud
IPC分类号： C12M1/32 , C12M3/06 , C12N5/071
摘要： A method of vascularising a cell aggregate on a microfluidic device, microfluidic cell culture devices comprising perfusable vascular networks and kits and assays using the microfluidic cell culture devices are described. The microfluidic devices comprise one or more capillary pressure barriers allowing for formation of an extracellular matrix gel within a confined area of the network, in which cells can be cultured for different uses.
摘要翻译：描述了在微流体装置上血管化细胞聚集体的方法，包括可灌注血管网络和试剂盒的微流体细胞培养装置以及使用微流体细胞培养装置的分析。微流体装置包括一个或多个毛细管压力屏障，其允许在网络的有限区域内形成细胞外基质凝胶，其中细胞可以培养用于不同用途。

7. 发明申请

WO2022258668A1 METHOD AND APPARATUS FOR FORMING A MICROFLUIDIC GEL STRUCTURE 审中-公开
公开(公告)号：WO2022258668A1
公开(公告)日：2022-12-15
申请号：PCT/EP2022/065506
申请日：2022-06-08
申请人： MIMETAS B.V.
发明人： AL-MARDINI, Claudia , BURTON, Todd Peter , TRIETSCH, Sebastiaan Johannes
IPC分类号： B29C39/02 , C12M3/06 , C12M1/12 , B01L3/00 , C12N11/04
摘要： A method for creating a lumenized gel structure is described. The method comprises introducing a first liquid comprising a gel precursor solution into a microfluidic network, the microfluidic network comprising a capillary pressure barrier at a position generally defining a boundary between first and second regions of the microfluidic network; allowing the first liquid to enter the first region of the microfluidic network and align itself along the capillary pressure barrier, thereby forming a liquid-air meniscus of the first liquid at the boundary between the first and second regions of the microfluidic network; forming a lumen through the first liquid by contacting the first liquid with a second liquid, wherein the second liquid has a viscosity which is lower than the viscosity of the first liquid; and allowing or causing the first liquid to gelate to form a gel structure comprising a lumen therethrough. Also described is an apparatus comprising a gel with a lumen extending therethrough, and uses of the apparatus and the lumenized gel structure in assays.

8. 发明申请

WO2022008733A1 MICROFLUIDIC CELL CULTURE DEVICE 审中-公开
公开(公告)号：WO2022008733A1
公开(公告)日：2022-01-13
申请号：PCT/EP2021/069205
申请日：2021-07-09
申请人： MIMETAS B.V.
发明人： TRIETSCH, Sebastiaan Johannes , NICOLAS, Arnaud Yannick Michel , VAN DEN BROEK, Leonarda Jacoba , KRAMER, Bart
IPC分类号： C12M1/32 , B01L3/00 , C12M3/06 , C12M1/42
摘要： A microfluidic cell culture device is described. The device comprises a microfluidic network comprising a base, a microfluidic channel, and a cover, and at least one perfusion compartment and at least one support compartment inside the microfluidic channel. The base and cover each comprise an aperture, thereby defining a conduit through the microfluidic channel. The aperture is in fluidic contact with the at least one support compartment, and with the at least one perfusion compartment through the at least one support compartment. Methods for creating a fluid-fluid interface and for investigating a cellular response to a stimulant using the device are also described.

9. 发明申请

WO2021091388A1 MICROFLUIDIC CELL CULTURE SYSTEM 审中-公开
公开(公告)号：WO2021091388A1
公开(公告)日：2021-05-14
申请号：PCT/NL2020/050701
申请日：2020-11-09
申请人： MIMETAS B.V.
发明人： BISHARD, Kristina , GRASEGGER, Julia , TRIETSCH, Sebastiaan Johannes
IPC分类号： B01L3/00 , C12M1/32 , C12M3/06 , C12M1/00
摘要： The present invention relates to a microfluidic cell culture system comprising at least one microfluidic structure, wherein the at least one microfluidic structure comprises a cell culture chamber, a first and second reservoir in fluid communication with each other via the cell culture chamber, wherein the microfluidic cell culture system further comprises a detachable seal for sealing the at least one microfluidic structure and wherein the microfluidic cell culture system is configured such that the first and second reservoir of the at least one microfluidic structure are in fluid communication with each other via a communication channel that does not comprise the cell culture chamber.

10. 发明申请

WO2017007325A1 BARRIER FUNCTION MEASUREMENTS 审中-公开
标题翻译：障碍物功能测量
公开(公告)号：WO2017007325A1
公开(公告)日：2017-01-12
申请号：PCT/NL2016/050502
申请日：2016-07-08
申请人： MIMETAS B.V.
发明人： VULTO, Paul , TRIETSCH, Sebastiaan Johannes , LANZ, Henriëtte Leonore , VORMANN, Marianne Katharina
IPC分类号： G01N33/50
CPC分类号： G01N33/5032 , G01N21/6428 , G01N21/6458 , G01N33/5008 , G01N33/5044 , G01N2021/6441
摘要： The current invention relates to an improved method for measuring modulating effects of compounds on epithelial cell barrier function. The methods allows for high throughput screening of test compounds individually or in combination. Compounds improving the epithelial barrier function or compounds negatively influencing epithelial barrier function can be analyzed with the method described herein.
摘要翻译：本发明涉及一种用于测量化合物对上皮细胞屏障功能的调节作用的改进方法。这些方法允许单独或组合地测试化合物的高通量筛选。可以用本文所述的方法分析改善上皮屏障功能的化合物或负面影响上皮屏障功能的化合物。

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