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    • 9. 发明申请
    • CONTROL OF CANINE VOLUNTARY FOOD INTAKE
    • 控制犬自由食物摄入
    • WO2005123102A1
    • 2005-12-29
    • PCT/US2005/020814
    • 2005-06-14
    • KEMIN INDUSTRIES, INC.MATTSSON, DonaldDEFFENBAUGH, Lynn
    • MATTSSON, DonaldDEFFENBAUGH, Lynn
    • A61K35/78
    • A61K36/48A23K50/40A61K36/81A61K38/56
    • Proteinase inhibitors are found to be a satiety aid when orally administered to dogs prior to a meal. Specifically, potato proteinase inhibitor 2 (PI2) by daily oral administration to groups of dogs showed a reduction in daily food intake in a crossover study. Analysis of food intake data during three separate treatment periods showed that animals that received the highest dose of PI2 ate significantly less on average than untreated animals. Analysis of food intake data confirmed that food intake decreased in a dose response manner with PI2 treatment. Therefore, a dietary aid for pets that incorporates PI2 could provide a pet owner with an additional resource to help their pet consume less food.
    • 发现蛋白酶抑制剂是在饭前口服给予狗时的饱腹感。 具体地说,通过每日口服给狗组的马铃薯蛋白酶抑制剂2(PI2)在交叉研究中显示出每日食物摄取量的减少。 在三个单独的治疗期间对食物摄取数据的分析显示,接受最高剂量的PI2的动物平均比未处理的动物显着减少。 食物摄入数据分析证实,采用PI2处理的剂量反应方式摄食量下降。 因此,结合PI2的宠物的膳食援助可以为宠物主人提供额外的资源,以帮助宠物消费更少的食物。