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    • 5. 发明申请
    • POLYVINYLIDENE FLUORIDE MICROPOROUS MEMBRANE AND METHOD
    • 聚乙烯氟化物微孔膜及方法
    • WO1993022034A1
    • 1993-11-11
    • PCT/US1993004352
    • 1993-05-06
    • COSTAR CORPORATION
    • COSTAR CORPORATIONPACHECO, Manuel, M.PACHECO, John, F.
    • B01D61/02
    • B01D71/34B01D67/0009B01D67/0011B01D67/0016B01D69/02B01D2323/12B01D2325/20
    • Methods for making microporous membranes from vinylidene fluoride polymers and the products produced by these methods are described. The microporous membranes have a significantly faster flow rate at a given pore size as compared to equally-sized microporous membranes made by conventional procedures. The microporous membranes of the invention also can have significantly smaller pore sizes than conventional microporous polyvinylidene fluoride membranes. The membranes of the invention have unique macrostructural features responsible in part for their unique functional properties. The process includes dissolving the polymer in a liquid that includes a solvent and a co-solvent for the polymer. The dissolution of the polymer can be at temperatures ranging from about 20 DEG C to about 50 DEG C while the formation of the microporous membrane can be at temperatures ranging from about -10 DEG C to 50 DEG C. Selection of appropriate operating parameters of temperature and solvent/co-solvent concentration can optimize the membrane at a given nominal pore size, flow rate, and polymer distribution.
    • 描述了从偏二氟乙烯聚合物制备微孔膜的方法和通过这些方法制备的产品。 与通过常规方法制备的等尺寸微孔膜相比,微孔膜在给定孔径下具有明显更快的流速。 本发明的微孔膜也可以具有比常规微孔聚偏二氟乙烯膜显着更小的孔径。 本发明的膜具有独特的宏观结构特征,部分原因是它们独特的功能特性。 该方法包括将聚合物溶解在包含用于聚合物的溶剂和共溶剂的液体中。 聚合物的溶解可以在约20℃至约50℃的温度范围内,而微孔膜的形成可以在约-10℃至50℃的温度范围内。选择合适的温度操作参数 溶剂/共溶剂浓度可以在给定的标称孔径,流速和聚合物分布下优化膜。
    • 6. 发明申请
    • DISH FOR IN VITRO FERTILIZATION
    • 用于体外受精的药物
    • WO1991006624A1
    • 1991-05-16
    • PCT/US1990006019
    • 1990-10-19
    • COSTAR CORPORATION
    • COSTAR CORPORATIONLYMAN, GeorgeNARDONE, Joanne
    • C12M01/22
    • C12M23/22C12M21/06C12M23/10C12M23/12
    • The invention provides a novel dish (22) for use in conducting in vitro fertilization procedures. The dish has a first well (24) including a flat transparent bottom (28) and a surrounding side wall (30) constructed and arranged to channel an egg or embryo toward the bottom wall (28) to eliminate surfaces capable of trapping an egg or embryo, and to facilitate access to all sides of an egg or embryo positioned at the periphery of the bottom wall (28). A second well (26) is attached adjacent to the first well (24) for containing a volume of humidification fluid. The first well (24) may include a volumetric marking preferably formed by the junction (46) of two side wall portions (42, 44).
    • 本发明提供了一种用于进行体外受精程序的新型菜肴(22)。 盘具有第一井(24),其包括平坦的透明底部(28)和周围的侧壁(30),其构造和布置成将鸡蛋或胚胎引向底壁(28),以消除能捕获鸡蛋的表面 胚胎,并且便于进入位于底壁(28)的周边处的卵或胚胎的所有侧面。 邻近第一井(24)附接第二井(26),用于容纳一定体积的加湿流体。 第一孔(24)可以包括优选地由两个侧壁部分(42,44)的接合部(46)形成的体积标记。
    • 8. 发明申请
    • REVERSIBLE MEMBRANE INSERT FOR GROWING TISSUE CULTURES
    • 用于生长组织培养的可逆膜插件
    • WO1997006240A1
    • 1997-02-20
    • PCT/US1996012635
    • 1996-08-02
    • CORNING COSTAR CORPORATION
    • CORNING COSTAR CORPORATIONMATHUS, Gregory
    • C12M03/06
    • C12M25/04Y10S435/809
    • A device and method for growing tissue or cells on both sides of a membrane includes a cylindrical body which may be stood on either end in a culture well. A frame is slidably mounted in the body and carries a membrane, on both sides of which tissue or cells are to be grown. A tissue or cell sample is placed on the upper surface of the membrane and media is supplied to the well on the outside of the body. Passages at the bottom of the body allow the media to flow to the membrane and nurture the sample to cause its growth. When the first monolayer is grown, the body is inverted and the frame is pushed to the other end of the body, preferably by a jig supplied for that purpose. A second cell sample is deposited on the other side of the membrane, again on top of the membrane and it is nurtured by media supplied primarily from the reservoir on top and secondarily through the membrane.
    • 用于在膜的两侧生长组织或细胞的装置和方法包括可以位于培养井中的任一端的圆柱体。 框架可滑动地安装在主体中并且在其组织或细胞将要生长的两侧上带有膜。 将组织或细胞样品放置在膜的上表面上,并将介质提供给身体外部的孔。 身体底部的通道允许介质流到膜上并培养样品以使其生长。 当第一单层生长时,主体被倒置并且框架被推动到主体的另一端,优选地通过为此目的提供的夹具。 第二个细胞样品沉积在膜的另一侧,再次沉积在膜的顶部,并且由主要从储存器供应的介质在上部和第二次通过膜培养。
    • 9. 发明申请
    • PIPETTER
    • 移液器
    • WO1991005609A1
    • 1991-05-02
    • PCT/US1990005800
    • 1990-10-10
    • COSTAR CORPORATION
    • COSTAR CORPORATIONLABRIOLA, Anthony, M.
    • B01L03/02
    • B01L3/0224
    • A hand-held, manually operated pipetter having a variable volume controlled by a rotating spindle (76) and adjusting screw (48) that control the position of a stop (70) which limits the upper end of the stroke of the pipetter piston (53). The lower end of the stroke is controlled by a movable stop (80) urged to a first position by a blow-out spring (114) which may be overcome with additional force applied to the pipetter piston (53) when the lower stop (80) is engaged. The pipetter also includes a stripper (181) which surrounds the tip holder (26) and which is actuated by a rod (152) movable in the body (20) of the pipetter along a path parallel to the path of the pipetter piston (53). The pipetter piston (53) and the stripper rod (181) are controlled by separate actuators (58, 154) which may readily be engaged by the thumb of the hand which holds the body (20) of the device.
    • 具有由旋转主轴(76)控制的可变体积的手持式手动操作的移液器和用于控制止动件(70)的位置的调节螺钉(48),其限制移液器活塞(53)的冲程的上端 )。 行程的下端由通过吹出弹簧(114)推动到第一位置的可移动止动件(80)来控制,当可移动止动件(80)通过施加到移液器活塞(53)的附加力而被克服时,下部止动件 )参与。 所述移液器还包括围绕所述末端保持器(26)并且由杆(152)致动的汽提器(181),所述杆(152)沿着与所述移液管活塞(53)的路径平行的路径在所述移液管的主体(20) )。 移液器活塞(53)和脱模杆(181)由单独的致动器(58,154)控制,致动器(58,154)可以容易地由保持装置的主体(20)的手的拇指接合。